{"id":"https://openalex.org/W1581948671","doi":"https://doi.org/10.1016/s0070-2161(08)60959-4","title":"Chapter 11 Regulatory Aspects of Apx, a Novel Na+ Channel with Connections to the Cytoskeleton","display_name":"Chapter 11 Regulatory Aspects of Apx, a Novel Na+ Channel with Connections to the Cytoskeleton","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1581948671","doi":"https://doi.org/10.1016/s0070-2161(08)60959-4","mag":"1581948671"},"language":"en","primary_location":{"id":"doi:10.1016/s0070-2161(08)60959-4","doi":"https://doi.org/10.1016/s0070-2161(08)60959-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0070-2161(08)60959-4","pdf_url":null,"source":{"id":"https://openalex.org/S156072706","display_name":"Current topics in membranes","issn_l":"1063-5823","issn":["1063-5823"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Membranes","raw_type":"book-chapter"},"volume":null,"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065381860","display_name":"Horacio F. Cantiello","orcid":"https://orcid.org/0000-0001-7973-0804","observed_orcids":["https://orcid.org/0000-0001-7973-0804"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Horacio F. Cantiello","raw_affiliation_strings":["The Renal Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Renal Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065381860"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.18360472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"177","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascorbate-peroxidase","display_name":"ascorbate peroxidase","score":0.8840000033378601},{"id":"https://openalex.org/keywords/enac","display_name":"epithelial sodium channel","score":0.7860000133514404},{"id":"https://openalex.org/keywords/amiloride-sensitive-na-channel","display_name":"amiloride-sensitive Na+ channel","score":0.9160000085830688},{"id":"https://openalex.org/keywords/renal-medulla","display_name":"renal medulla","score":0.8500000238418579},{"id":"https://openalex.org/keywords/a6-cells","display_name":"A6 cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.796999990940094},{"id":"https://openalex.org/keywords/antibody-cross-reactivity","display_name":"antibody cross-reactivity","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.8008159399032593},{"id":"https://openalex.org/C6507245","wikidata":"https://www.wikidata.org/wiki/Q424948","display_name":"Epithelial sodium channel","level":3,"score":0.665841817855835},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.665756344795227},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.5408203601837158},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5190154314041138},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5051327347755432},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.49163371324539185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40752291679382324},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.400692343711853},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3623257875442505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33294743299484253},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.15578466653823853},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0649476945400238},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0070-2161(08)60959-4","doi":"https://doi.org/10.1016/s0070-2161(08)60959-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0070-2161(08)60959-4","pdf_url":null,"source":{"id":"https://openalex.org/S156072706","display_name":"Current topics in membranes","issn_l":"1063-5823","issn":["1063-5823"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Membranes","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W51263613","https://openalex.org/W73570518","https://openalex.org/W267761924","https://openalex.org/W1489559813","https://openalex.org/W1506512444","https://openalex.org/W1507577640","https://openalex.org/W1515959868","https://openalex.org/W1526112307","https://openalex.org/W1532322015","https://openalex.org/W1550879731","https://openalex.org/W1566806987","https://openalex.org/W1583347987","https://openalex.org/W1606227954","https://openalex.org/W1915865029","https://openalex.org/W1969996729","https://openalex.org/W1973975116","https://openalex.org/W2009063887","https://openalex.org/W2024214678","https://openalex.org/W2051510829","https://openalex.org/W2054074597","https://openalex.org/W2064755934","https://openalex.org/W2073347694","https://openalex.org/W2074548865","https://openalex.org/W2075943905","https://openalex.org/W2080941290","https://openalex.org/W2086606537","https://openalex.org/W2086827936","https://openalex.org/W2087499467","https://openalex.org/W2090117730","https://openalex.org/W2120245762","https://openalex.org/W2132285093","https://openalex.org/W2396035301","https://openalex.org/W2406509533","https://openalex.org/W2409020021","https://openalex.org/W2411911810","https://openalex.org/W2413562571","https://openalex.org/W2418942336"],"related_works":["https://openalex.org/W2086827936","https://openalex.org/W1992417809","https://openalex.org/W2064755934","https://openalex.org/W1970832778","https://openalex.org/W51263613","https://openalex.org/W1550879731","https://openalex.org/W2132285093","https://openalex.org/W1539027745","https://openalex.org/W2058045896","https://openalex.org/W2044415802"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}