{"id":"https://openalex.org/W158169487","doi":null,"title":"Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus.","display_name":"Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus.","publication_year":1992,"publication_date":"1992-05-01","ids":{"openalex":"https://openalex.org/W158169487","mag":"158169487","pmid":"https://pubmed.ncbi.nlm.nih.gov/1573849"},"language":"en","primary_location":{"id":"pmid:1573849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1573849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111876806","display_name":"Kenneth H. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K H Johnson","raw_affiliation_strings":["Department of Veterinary PathoBiology, University of Minnesota, St. Paul"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary PathoBiology, University of Minnesota, St. Paul","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114377333","display_name":"Timothy D. O\u2019Brien","orcid":"https://orcid.org/0000-0001-9742-0930","observed_orcids":["https://orcid.org/0000-0001-9742-0930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T D O'Brien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051005847","display_name":"Christer Betsholtz","orcid":"https://orcid.org/0000-0002-8494-971X","observed_orcids":["https://orcid.org/0000-0002-8494-971X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Betsholtz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075368078","display_name":"Per Westermark","orcid":"https://orcid.org/0000-0002-2756-4995","observed_orcids":["https://orcid.org/0000-0002-2756-4995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Westermark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7046,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.93117066,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"66","issue":"5","first_page":"522","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amylin","display_name":"amylin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amyloidogenesis","display_name":"amyloidogenesis","score":0.921999990940094},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.8939999938011169},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8119999766349792},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.7580000162124634},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.746999979019165},{"id":"https://openalex.org/keywords/fibril-formation","display_name":"fibril formation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/glucose-regulation","display_name":"glucose regulation","score":0.5109999775886536},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hepatic-glucose-production","display_name":"hepatic glucose production","score":0.9350000023841858},{"id":"https://openalex.org/keywords/anorexigenic-effect","display_name":"anorectic effect","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2780705028","wikidata":"https://www.wikidata.org/wiki/Q424643","display_name":"Amylin","level":4,"score":0.887124240398407},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.7108692526817322},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.6094932556152344},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6094231605529785},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5806232690811157},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5430523753166199},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5290987491607666},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5226123929023743},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49328702688217163},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.455301970243454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.435105562210083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.393338143825531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12442231178283691},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08129659295082092},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1573849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1573849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:158169487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1573849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7382816272","display_name":"DIABETES MELLITUS &ISLET AMYLOID POLYPEPTIDE (IAAP)","funder_award_id":"R01DK036734","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009937460","https://openalex.org/W2157872153","https://openalex.org/W1974854551","https://openalex.org/W7100180005","https://openalex.org/W7098980123","https://openalex.org/W93178243","https://openalex.org/W1977150735","https://openalex.org/W1968375951","https://openalex.org/W168100418","https://openalex.org/W2020141992"],"abstract_inverted_index":{"Amyloid":[0],"deposits":[1],"characteristically":[2],"associated":[3],"with":[4,54,72,146],"pancreatic":[5],"islets":[6],"of":[7,19,31,112,120,131,134,140,150,171,179,195,203,244,260,268,283,324,354],"those":[8,198],"species":[9,180],"(e.g.,":[10],"humans,":[11],"cats,":[12],"and":[13,28,47,69,78,95,142,163,205,212,225,249,303,321,344,363],"monkeys)":[14],"that":[15,107,119,161,233,252,334,345],"develop":[16],"age-associated":[17],"forms":[18],"diabetes":[20,357],"have":[21,231,294],"been":[22,291,330],"shown":[23,232],"to":[24,61,76,90,99,106,157,184,214,222,264,285,293,318,351],"represent":[25],"a":[26,32,44,124,175,276],"concentrated":[27],"polymerized":[29],"form":[30,286],"previously":[33],"unknown":[34],"islet-derived":[35],"protein":[36],"identified":[37],"either":[38],"as":[39,87,304],"IAPP":[40,97,115,127,141,151,162,172,196,207,261,269,284,289,313,335,346],"or":[41],"amylin.":[42],"IAPP,":[43],"highly":[45],"conserved":[46],"carboxy-terminally":[48],"amidated":[49],"37":[50],"amino":[51,57,92,186,234],"acid":[52,58,93,187,235],"polypeptide":[53],"approximately":[55],"45%":[56],"sequence":[59,220],"identity":[60],"CGRP,":[62],"is":[63,70,82,153,181,208],"produced":[64],"by":[65,102,341,358,364],"islet":[66,287],"beta":[67,85,255,342],"cells":[68,86],"cosecreted":[71],"insulin":[73,121,135,143,164,339,367],"in":[74,84,109,155,173,191,210,237,247,254,270,297,312],"response":[75,156],"glucose":[77,298,319,361],"other":[79],"secretagogues.":[80],"Prepro-IAPP":[81],"synthesized":[83],"an":[88,265,305],"89":[89],"93":[91],"molecule,":[94],"mature":[96],"appears":[98,213],"be":[100,215],"formed":[101],"enzymatic":[103],"processing":[104],"similar":[105],"involved":[108],"the":[110,132,185,192,216,223,242,271,280,322,352],"formation":[111],"insulin.":[113],"Glucose-stimulated":[114],"secretion":[116,144,340],"generally":[117],"parallels":[118],"and,":[122],"on":[123],"molar":[125],"basis,":[126],"represents":[128],"about":[129],"1%":[130],"amount":[133],"secreted.":[136],"A":[137],"significant":[138],"dissociation":[139],"(associated":[145],"relatively":[147],"greater":[148],"upregulation":[149],"secretion)":[152],"observed":[154],"marked":[158],"hyperglycemia,":[159],"suggesting":[160],"expression":[165],"are":[166],"differentially":[167],"regulated.":[168],"The":[169,200,308],"amyloidogenicity":[170,243],"only":[174],"very":[176],"limited":[177],"number":[178],"importantly":[182],"related":[183],"residues":[188],"inherently":[189],"found":[190],"20-29":[193],"region":[194,202,239],"from":[197],"species.":[199],"25-28":[201],"human":[204,224],"cat":[206],"identical":[209],"structure":[211],"most":[217],"important":[218],"amyloidogenic":[219],"common":[221],"cat.":[226],"In":[227],"vitro":[228],"fibrillogenesis":[229],"studies":[230],"substitutions":[236],"this":[238],"especially":[240],"affect":[241],"IAPP.":[245],"Studies":[246],"dogs":[248],"cats":[250],"suggest":[251],"aberrations":[253],"cell":[256],"synthesis":[257],"(or":[258],"processing)":[259],"may":[262],"lead":[263],"increased":[266],"concentration":[267],"local":[272],"milieu,":[273],"thus":[274],"providing":[275],"second":[277],"prerequisite":[278],"for":[279],"self":[281],"aggregation":[282],"amyloid.":[288],"has":[290,329],"implicated":[292],"physiological":[295],"roles":[296],"regulation,":[299],"hemodynamics,":[300],"calcium":[301],"homeostasis,":[302],"anorectic":[306],"agent.":[307],"major":[309],"current":[310],"interest":[311],"concerns":[314],"its":[315],"potential":[316],"relationships":[317],"metabolism":[320],"development":[323],"type":[325,355],"2":[326,356],"diabetes.":[327],"Evidence":[328],"provided":[331],"which":[332],"indicates":[333],"can":[336,347],"inhibit":[337],"glucose-stimulated":[338],"cells,":[343],"also":[348],"potentially":[349],"contribute":[350],"pathogenesis":[353],"increasing":[359],"hepatic":[360],"output":[362],"inducing":[365],"peripheral":[366],"resistance.(ABSTRACT":[368],"TRUNCATED":[369],"AT":[370],"400":[371],"WORDS)":[372]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}