{"id":"https://openalex.org/W1581603526","doi":"https://doi.org/10.1523/jneurosci.14-10-06230.1994","title":"Monoclonal autoantibodies promote central nervous system repair in an animal model of multiple sclerosis","display_name":"Monoclonal autoantibodies promote central nervous system repair in an animal model of multiple sclerosis","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W1581603526","doi":"https://doi.org/10.1523/jneurosci.14-10-06230.1994","mag":"1581603526","pmid":"https://pubmed.ncbi.nlm.nih.gov/7931575","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6576985"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.14-10-06230.1994","doi":"https://doi.org/10.1523/jneurosci.14-10-06230.1994","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.14-10-06230.1994","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1523/jneurosci.14-10-06230.1994","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113768570","display_name":"D J Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DJ Miller","raw_affiliation_strings":["Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108364642","display_name":"KS Sanborn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KS Sanborn","raw_affiliation_strings":["Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103941117","display_name":"JA Katzmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JA Katzmann","raw_affiliation_strings":["Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052262813","display_name":"Moses Rodriguez","orcid":"https://orcid.org/0000-0001-6328-6497","observed_orcids":["https://orcid.org/0000-0001-6328-6497"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Rodriguez","raw_affiliation_strings":["Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":6.3277,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.96843191,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"10","first_page":"6230","last_page":"6238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-autoantibodies","display_name":"monoclonal autoantibodies","score":0.9580000042915344},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.7450000047683716},{"id":"https://openalex.org/keywords/theiler-s-murine-encephalomyelitis-virus","display_name":"Theiler's murine encephalomyelitis virus","score":0.9559999704360962},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.878000020980835},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.7059999704360962},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/igm-autoantibodies","display_name":"IgM autoantibodies","score":0.6980000138282776},{"id":"https://openalex.org/keywords/sjl-j-mice","display_name":"SJL/J mice","score":0.7279999852180481},{"id":"https://openalex.org/keywords/cns-repair","display_name":"CNS repair","score":0.46700000762939453},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.5360000133514404},{"id":"https://openalex.org/keywords/myelin-sheath","display_name":"myelin sheath","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7945799827575684},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6919857859611511},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6672323942184448},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6240707039833069},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.5371044278144836},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4966588616371155},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.46406421065330505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.352430522441864},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33246153593063354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32766976952552795},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10790356993675232},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.056437402963638306}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009416","descriptor_name":"Nerve Regeneration","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017945","descriptor_name":"Theilovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.14-10-06230.1994","doi":"https://doi.org/10.1523/jneurosci.14-10-06230.1994","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.14-10-06230.1994","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6576985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6576985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:7931575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7931575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.14-10-06230.1994","doi":"https://doi.org/10.1523/jneurosci.14-10-06230.1994","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.14-10-06230.1994","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G333177766","display_name":"Immune Promotion of Remyelination","funder_award_id":"R01NS024180","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W26288924","https://openalex.org/W60810959","https://openalex.org/W325184201","https://openalex.org/W1964698371","https://openalex.org/W1966734628","https://openalex.org/W1982451723","https://openalex.org/W1983417635","https://openalex.org/W1996803533","https://openalex.org/W2000454394","https://openalex.org/W2011685153","https://openalex.org/W2012435874","https://openalex.org/W2016413004","https://openalex.org/W2020364400","https://openalex.org/W2025146338","https://openalex.org/W2030251570","https://openalex.org/W2034249407","https://openalex.org/W2034523279","https://openalex.org/W2038389367","https://openalex.org/W2077954268","https://openalex.org/W2082446175","https://openalex.org/W2119308919","https://openalex.org/W2138839431","https://openalex.org/W2315449683"],"related_works":["https://openalex.org/W2125547845","https://openalex.org/W1749137122","https://openalex.org/W2121961441","https://openalex.org/W2082374513","https://openalex.org/W2115978692","https://openalex.org/W2075195701","https://openalex.org/W325543948","https://openalex.org/W2041472472","https://openalex.org/W2011779800","https://openalex.org/W4253002305"],"abstract_inverted_index":{"Susceptible":[0],"strains":[1],"of":[2,63,68,76,82,128,141,164,203,208],"mice":[3,34,47,84],"infected":[4,49,118],"intracerebrally":[5],"with":[6,36,50,86,138,149],"Theiler's":[7,51],"murine":[8],"encephalomyelitis":[9],"virus":[10],"develop":[11],"a":[12,74,154,191],"chronic,":[13],"progressive,":[14],"immune-mediated":[15],"CNS":[16,41,69,110,121,209],"demyelinating":[17,70],"disease":[18,143],"similar":[19],"both":[20,56,177],"pathologically":[21],"and":[22,59,90,105,151,158,170,175,179,198],"clinically":[23],"to":[24,45,116,134,194],"multiple":[25],"sclerosis.":[26],"Previous":[27],"reports":[28],"indicated":[29],"that":[30,187],"polyclonal":[31],"immunoglobulins":[32],"from":[33,80,100],"injected":[35,85],"homogenized":[37,87],"spinal":[38,88],"cord":[39],"promote":[40],"remyelination":[42,111,152],"when":[43,114],"given":[44,115],"SJL/J":[46,83,119],"chronically":[48,117],"virus.":[52],"To":[53],"explore":[54],"further":[55],"the":[57,66,126,139,196,200,206],"mechanism(s)":[58,197],"potential":[60,202],"therapeutic":[61],"usefulness":[62],"antibodies":[64,78],"in":[65,205],"treatment":[67,148,207],"diseases,":[71],"we":[72],"made":[73],"panel":[75],"monoclonal":[77],"derived":[79],"splenocytes":[81],"cord,":[89],"screened":[91],"them":[92],"for":[93],"their":[94],"autoantigen-binding":[95],"capability.":[96],"Monoclonal":[97],"IgM":[98],"autoantibodies":[99,204],"two":[101],"clones,":[102],"designated":[103],"SCH94.03":[104,150,169],"SCH94.32,":[106],"promoted":[107,166],"fourfold":[108],"more":[109],"than":[112],"controls":[113],"mice.":[120],"remyelination,":[122],"assessed":[123],"morphologically":[124],"by":[125],"presence":[127],"abnormally":[129],"thin":[130],"myelin":[131],"sheaths":[132],"relative":[133],"axonal":[135],"diameter,":[136],"correlated":[137],"absence":[140],"clinical":[142],"progression.":[144],"In":[145],"titration":[146],"experiments,":[147],"had":[153],"positive":[155],"dose-response":[156],"relationship,":[157],"as":[159,161],"little":[160],"10":[162],"micrograms":[163],"antibody":[165],"remyelination.":[167],"Both":[168],"SCH94.32":[171],"showed":[172],"multiorgan":[173],"autoreactivity,":[174],"recognized":[176],"surface":[178],"cytoplasmic":[180],"determinants":[181],"on":[182],"glial":[183],"cells.":[184],"We":[185],"propose":[186],"this":[188],"model":[189],"provides":[190],"unique":[192],"system":[193],"elucidate":[195],"test":[199],"reparative":[201],"injury.":[210]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
