{"id":"https://openalex.org/W158151709","doi":"https://doi.org/10.1096/fasebj.21.5.a721-d","title":"Altered nitric oxide availability contributes to copper deficiency\u2010induced teratogenicity","display_name":"Altered nitric oxide availability contributes to copper deficiency\u2010induced teratogenicity","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W158151709","doi":"https://doi.org/10.1096/fasebj.21.5.a721-d","mag":"158151709"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a721-d","doi":"https://doi.org/10.1096/fasebj.21.5.a721-d","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a721-d","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087539572","display_name":"Soo Jin Yang","orcid":"https://orcid.org/0000-0001-7892-7648","observed_orcids":["https://orcid.org/0000-0001-7892-7648","https://orcid.org/0000-0003-1860-7831"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soo Jin Yang","raw_affiliation_strings":["Nutrition University of California Davis, One Shields Ave Davis CA 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition University of California Davis, One Shields Ave Davis CA 95616","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030171634","display_name":"Louise Lanoue","orcid":"https://orcid.org/0000-0003-2779-0391","observed_orcids":["https://orcid.org/0000-0003-2779-0391"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louise Lanoue","raw_affiliation_strings":["Nutrition University of California Davis, One Shields Ave Davis CA 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition University of California Davis, One Shields Ave Davis CA 95616","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043985150","display_name":"Carl L. Keen","orcid":"https://orcid.org/0000-0001-6602-4417","observed_orcids":["https://orcid.org/0000-0001-6602-4417"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl L Keen","raw_affiliation_strings":["Nutrition University of California Davis, One Shields Ave Davis CA 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition University of California Davis, One Shields Ave Davis CA 95616","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015043500","display_name":"Robert B. Rucker","orcid":"https://orcid.org/0000-0002-7804-0278","observed_orcids":["https://orcid.org/0000-0002-7804-0278"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B Rucker","raw_affiliation_strings":["Nutrition University of California Davis, One Shields Ave Davis CA 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition University of California Davis, One Shields Ave Davis CA 95616","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110436647","display_name":"Janet Y. Uriu\u2010Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Y Uriu\u2010Adams","raw_affiliation_strings":["Nutrition University of California Davis, One Shields Ave Davis CA 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition University of California Davis, One Shields Ave Davis CA 95616","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04091481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copper-deficiency","display_name":"copper deficiency","score":1.0},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8349999785423279},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.828000009059906},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.9350000023841858},{"id":"https://openalex.org/keywords/yolk-sac-development","display_name":"yolk sac development","score":0.8109999895095825},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.902999997138977},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.828000009059906},{"id":"https://openalex.org/keywords/deta-nonoate","display_name":"DETA NONOate","score":0.9020000100135803},{"id":"https://openalex.org/keywords/developmental-anomalies","display_name":"developmental anomalies","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.8609830141067505},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.7545719742774963},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7135924100875854},{"id":"https://openalex.org/C2781321622","wikidata":"https://www.wikidata.org/wiki/Q181409","display_name":"Yolk","level":2,"score":0.6926646828651428},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6651463508605957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.632023811340332},{"id":"https://openalex.org/C2777043721","wikidata":"https://www.wikidata.org/wiki/Q369887","display_name":"Yolk sac","level":3,"score":0.6091765761375427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5778275728225708},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.5511189103126526},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5461091995239258},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5280460119247437},{"id":"https://openalex.org/C2779698670","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Endothelial NOS","level":5,"score":0.5060710310935974},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.47363701462745667},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.46614399552345276},{"id":"https://openalex.org/C2777106986","wikidata":"https://www.wikidata.org/wiki/Q1495005","display_name":"Copper deficiency","level":3,"score":0.42881375551223755},{"id":"https://openalex.org/C28452662","wikidata":"https://www.wikidata.org/wiki/Q422752","display_name":"Ceruloplasmin","level":2,"score":0.42641162872314453},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4172464609146118},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4109003245830536},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.40784692764282227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29604873061180115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24888327717781067},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.24689331650733948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12590712308883667},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.09733524918556213},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0896252989768982},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a721-d","doi":"https://doi.org/10.1096/fasebj.21.5.a721-d","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a721-d","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8765784686","display_name":"COPPER NUTRITION AND DEVELOPMENT","funder_award_id":"R01HD026777","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2037946071","https://openalex.org/W2200688660","https://openalex.org/W2307321931","https://openalex.org/W143405872","https://openalex.org/W2315305441","https://openalex.org/W2088950940","https://openalex.org/W2048226531","https://openalex.org/W2142993751","https://openalex.org/W3173649168","https://openalex.org/W2037017107"],"abstract_inverted_index":{"Copper":[0],"(Cu)":[1],"deficiency":[2,13],"can":[3,23,44],"result":[4],"in":[5,40,68,77,93,113,138,152,164,184,204,233],"embryonic":[6],"and":[7,18,74,85,123,226,236,253],"yolk":[8,86],"sac":[9,87],"developmental":[10,224,231],"anomalies.":[11],"Cu":[12,55,59,198,249],"decreases":[14],"superoxide":[15,20],"dismutase":[16],"activity,":[17],"increases":[19],"anions,":[21],"which":[22,43],"react":[24],"with":[25],"nitric":[26],"oxide":[27],"(NO)":[28],"to":[29,98,130,142,156,220,248],"form":[30],"peroxynitrite.":[31],"One":[32],"consequence":[33],"of":[34,133,166,172,207,216,230],"peroxynitrite":[35],"formation":[36],"is":[37],"a":[38,117,126],"decrease":[39],"NO":[41,91,128,194,209,218,245],"availability,":[42],"adversely":[45],"affect":[46],"development.":[47,257],"When":[48],"gestation":[49],"day":[50],"(GD)":[51],"8.5":[52],"embryos":[53,111,201,235],"from":[54,105],"adequate":[56],"(Cu+)":[57],"or":[58,70],"deficient":[60],"(Cu\u2212)":[61],"dams":[62],"were":[63,103,202],"cultured":[64,203],"for":[65,80],"48":[66],"h":[67],"Cu+":[69,108],"Cu\u2212":[71,110],"medium,":[72],"respectively,":[73],"subsequently":[75],"incubated":[76],"KRB":[78,139],"buffer":[79,140],"2":[81],"h,":[82],"Cu\u2212/Cu\u2212":[83,121,153,185,234],"embryo":[84,122,251],"(YS)":[88],"had":[89,125],"low":[90,151],"levels":[92,195],"the":[94,134,205,208,217,228,241],"conditioned":[95],"media":[96,222],"compared":[97,141,155],"Cu+/Cu+":[99,143,188],"controls.":[100,144,157],"Similar":[101],"results":[102],"obtained":[104],"GD":[106],"10.5":[107],"vs.":[109],"collected":[112],"vivo":[114],".":[115],"In":[116],"dose":[118],"response":[119,129],"study,":[120],"YS":[124,154,165,186,255],"blunted":[127],"increasing":[131],"doses":[132],"NOS":[135,146,159],"agonist,":[136],"acetylcholine":[137],"Endothelial":[145],"(eNOS)":[147],"mRNA":[148],"expression":[149],"was":[150,161,177,182],"Inducible":[158],"protein":[160,176],"not":[162],"detected":[163],"either":[167],"group":[168],"at":[169],"this":[170],"stage":[171],"gestation.":[173],"While":[174],"eNOS":[175,181],"similar,":[178],"phosphoSer":[179],"1177":[180],"lower":[183],"than":[187],"YS.":[189,237],"To":[190],"test":[191],"whether":[192],"altering":[193],"could":[196],"modulate":[197],"deficiency\u2010induced":[199,250],"teratogenicity,":[200],"presence":[206],"donor,":[210],"DETA/NONOate":[211],"(20":[212],"\u03bcM).":[213],"The":[214],"addition":[215],"donor":[219],"Cu\u2010":[221],"improved":[223],"score":[225],"decreased":[227],"incidence":[229],"anomalies":[232],"These":[238],"data":[239],"support":[240],"concept":[242],"that":[243],"altered":[244],"availability":[246],"contributes":[247],"abnormalities":[252],"impaired":[254],"vessel":[256],"(Supported":[258],"by":[259],"NIH":[260],"HD26777)":[261]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
