{"id":"https://openalex.org/W1581317022","doi":"https://doi.org/10.4049/jimmunol.158.5.2340","title":"Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils","display_name":"Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W1581317022","doi":"https://doi.org/10.4049/jimmunol.158.5.2340","mag":"1581317022","pmid":"https://pubmed.ncbi.nlm.nih.gov/9036983"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.158.5.2340","doi":"https://doi.org/10.4049/jimmunol.158.5.2340","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.158.5.2340","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040731065","display_name":"Joji Kitayama","orcid":"https://orcid.org/0000-0002-5708-7130","observed_orcids":["https://orcid.org/0000-0002-5708-7130"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Kitayama","raw_affiliation_strings":["Center for Blood Research, Harvard Medical School, Department of Pathology , Boston, MA 02115,","Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Department of Pathology , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014999055","display_name":"Michelle Woldemar Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M W Carr","raw_affiliation_strings":["Center for Blood Research, Harvard Medical School, Department of Pathology , Boston, MA 02115,","Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Department of Pathology , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011718438","display_name":"Stephen J. Roth","orcid":"https://orcid.org/0000-0003-3578-4944","observed_orcids":["https://orcid.org/0000-0003-3578-4944"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S J Roth","raw_affiliation_strings":["Center for Blood Research, Harvard Medical School, Department of Pathology , Boston, MA 02115,","Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Department of Pathology , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022486684","display_name":"Janet M. Buccola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Buccola","raw_affiliation_strings":["Center for Blood Research, Harvard Medical School, Department of Pathology , Boston, MA 02115,","Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Department of Pathology , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003615852","display_name":"Timothy A. Springer","orcid":"https://orcid.org/0000-0001-6627-2904","observed_orcids":["https://orcid.org/0000-0001-6627-2904"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T A Springer","raw_affiliation_strings":["Center for Blood Research, Harvard Medical School, Department of Pathology , Boston, MA 02115,","Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Department of Pathology , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":5.9719,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.9673383,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"158","issue":"5","first_page":"2340","last_page":"2349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transendothelial-migration","display_name":"transendothelial migration","score":0.8640000224113464},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.796999990940094},{"id":"https://openalex.org/keywords/heterologous-desensitization","display_name":"heterologous desensitization","score":0.8709999918937683},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8040000200271606},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":1.0},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.7379999756813049},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.8309999704360962},{"id":"https://openalex.org/keywords/monocyte-chemotactic-protein-3","display_name":"MCP-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cxcl1","display_name":"CXCL1","score":0.8840000033378601},{"id":"https://openalex.org/keywords/actin-polymerization","display_name":"actin polymerization","score":0.9309999942779541},{"id":"https://openalex.org/keywords/chemokine-receptor-signaling","display_name":"chemokine receptor signaling","score":0.671999990940094},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.8612709045410156},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.8214927911758423},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.8035740852355957},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.522887647151947},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.519814133644104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3718467354774475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33607545495033264},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08439996838569641},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0687853991985321},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002630","descriptor_name":"Chemotactic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009240","descriptor_name":"N-Formylmethionine Leucyl-Phenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009240","descriptor_name":"N-Formylmethionine Leucyl-Phenylalanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015936","descriptor_name":"Complement C5a","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015936","descriptor_name":"Complement C5a","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054360","descriptor_name":"Chemokine CXCL1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.158.5.2340","doi":"https://doi.org/10.4049/jimmunol.158.5.2340","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.158.5.2340","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:9036983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9036983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6032462363","display_name":"INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE","funder_award_id":"P01HL048675","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1551543540","https://openalex.org/W1780460389","https://openalex.org/W1835961422","https://openalex.org/W1973436145","https://openalex.org/W2043970437","https://openalex.org/W2083788792","https://openalex.org/W2100330873","https://openalex.org/W2106068114","https://openalex.org/W2141924291","https://openalex.org/W2176220887","https://openalex.org/W2312870247","https://openalex.org/W2442449839"],"related_works":["https://openalex.org/W305754995","https://openalex.org/W2059009993","https://openalex.org/W1625526711","https://openalex.org/W2096208791","https://openalex.org/W2162885959","https://openalex.org/W4243258808","https://openalex.org/W4230705047","https://openalex.org/W7024400084","https://openalex.org/W7098813896","https://openalex.org/W1998844296"],"abstract_inverted_index":{"At":[0],"inflammatory":[1,241],"sites":[2],"in":[3,20,153,195,216,221,240],"vivo,":[4],"leukocytes":[5],"may":[6,229],"confront":[7],"multiple,":[8],"competing":[9,206],"chemoattractive":[10],"signals.":[11],"We":[12,168],"found":[13],"significant":[14],"differences":[15],"between":[16],"eosinophils":[17,48,154,171],"and":[18,65,68,74,85,114,123,155,182,193],"neutrophils":[19,93,156,196,222],"transendothelial":[21,45],"chemotaxis":[22,110,120,129,137,181],"to":[23,36,49,75,83,104,111,121,130,138,147,205],"a":[24,32,76,201],"chemoattractant":[25,33],"diffusing":[26],"from":[27],"the":[28,59,62,160,187,224,234],"lower":[29],"chamber,":[30],"when":[31],"that":[34,165,170],"binds":[35],"another":[37],"receptor":[38],"is":[39],"present":[40],"at":[41,173],"uniform":[42],"concentration.":[43],"The":[44,95],"migration":[46,82],"of":[47,61,97,163,203,208,236],"FMLP,":[50,191],"C5a,":[51,112,192],"RANTES,":[52],"or":[53,149],"MCP-3":[54,69],"was":[55,157],"totally":[56,127],"inhibited":[57,118,136,145],"by":[58,159],"presence":[60,96],"homologous":[63],"chemoattractant,":[64],"only":[66,100,134],"RANTES":[67,84],"showed":[70],"mutual":[71],"inhibition.":[72],"C5a":[73,117,211],"lesser":[77],"extent":[78],"FMLP":[79,98,105,148,209],"chemokinetically":[80],"stimulated":[81],"MCP-3,":[86],"without":[87],"stimulating":[88],"random":[89],"migration.":[90],"Results":[91],"with":[92,200,218],"contrasted.":[94],"not":[99],"abrogated":[101,128],"neutrophil":[102,119],"transmigration":[103,146],"but":[106,132],"also":[107],"strongly":[108],"decreased":[109],"IL-8,":[113],"Gro-alpha.":[115,124],"Similarly,":[116],"IL-8":[122,125,141,213],"almost":[126],"Gro-alpha,":[131,215],"Gro-alpha":[133,143],"moderately":[135],"IL-8.":[139],"Neither":[140],"nor":[142],"significantly":[144],"C5a.":[150],"Actin":[151],"polymerization":[152],"desensitized":[158,166],"same":[161],"combinations":[162],"chemoattractants":[164],"chemotaxis.":[167],"conclude":[169],"have":[172,230],"least":[174],"three":[175],"noninterfering":[176],"receptor-signal":[177],"transduction":[178],"pathways":[179,189],"for":[180,190,233],"actin":[183],"polymerization.":[184],"In":[185],"contrast,":[186],"signaling":[188],"IL-8/Gro-alpha":[194],"are":[197],"heterologously":[198],"cross-desensitized,":[199],"hierarchy":[202],"resistance":[204],"signals":[207],">":[210,212,214],"agreement":[217],"previous":[219],"results":[220,228],"on":[223],"Ca2+-mobilizing":[225],"response.":[226],"These":[227],"important":[231],"implications":[232],"behavior":[235],"these":[237],"cell":[238],"types":[239],"sites.":[242]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
