{"id":"https://openalex.org/W1581079296","doi":"https://doi.org/10.1016/s0021-9258(17)44621-7","title":"The interaction of F-actin with phosphorylated and unphosphorylated myosins IA and IB from Acanthamoeba castellanii.","display_name":"The interaction of F-actin with phosphorylated and unphosphorylated myosins IA and IB from Acanthamoeba castellanii.","publication_year":1983,"publication_date":"1983-08-01","ids":{"openalex":"https://openalex.org/W1581079296","doi":"https://doi.org/10.1016/s0021-9258(17)44621-7","mag":"1581079296","pmid":"https://pubmed.ncbi.nlm.nih.gov/6136503"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)44621-7","doi":"https://doi.org/10.1016/s0021-9258(17)44621-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44621-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)44621-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026272619","display_name":"Joseph P. Albanesi","orcid":"https://orcid.org/0000-0002-6864-8140","observed_orcids":["https://orcid.org/0000-0002-6864-8140"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J P Albanesi","raw_affiliation_strings":["From the Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077641368","display_name":"John A. Hammer","orcid":"https://orcid.org/0000-0002-2496-5179","observed_orcids":["https://orcid.org/0000-0002-2496-5179"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Hammer","raw_affiliation_strings":["From the Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056320284","display_name":"Edward D. Korn","orcid":"https://orcid.org/0000-0003-3867-6295","observed_orcids":["https://orcid.org/0000-0003-3867-6295"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E D Korn","raw_affiliation_strings":["From the Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.8476,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.95856073,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"258","issue":"16","first_page":"10176","last_page":"10181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.5830000042915344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.5830000042915344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.19589999318122864,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.09790000319480896,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acanthamoeba-castellanii","display_name":"Acanthamoeba castellanii","score":0.9419999718666077},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.8399999737739563},{"id":"https://openalex.org/keywords/myosin-heavy-chain-phosphorylation","display_name":"myosin heavy chain phosphorylation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/actomyosin-atpase","display_name":"actomyosin ATPase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mg2-atpase","display_name":"Mg2+-ATPase","score":0.7919999957084656},{"id":"https://openalex.org/keywords/actin-binding","display_name":"actin binding","score":0.6740000247955322},{"id":"https://openalex.org/keywords/atpase-kinetics","display_name":"ATPase kinetics","score":0.7549999952316284},{"id":"https://openalex.org/keywords/vmax","display_name":"Vmax","score":0.5770000219345093},{"id":"https://openalex.org/keywords/myosin-isozymes","display_name":"myosin isoenzymes","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.730657696723938},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6647809147834778},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.601252019405365},{"id":"https://openalex.org/C2778868110","wikidata":"https://www.wikidata.org/wiki/Q1152218","display_name":"Acanthamoeba","level":2,"score":0.47313016653060913},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4658188819885254},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.4360054135322571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35747551918029785},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3291943669319153},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.19085568189620972}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000656","descriptor_name":"Amoeba","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017301","descriptor_name":"Ca(2+) Mg(2+)-ATPase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)44621-7","doi":"https://doi.org/10.1016/s0021-9258(17)44621-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44621-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:6136503","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6136503","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)44621-7","doi":"https://doi.org/10.1016/s0021-9258(17)44621-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44621-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W100430351","https://openalex.org/W1482573511","https://openalex.org/W1490562986","https://openalex.org/W1496082479","https://openalex.org/W1508180802","https://openalex.org/W1510486443","https://openalex.org/W1523935457","https://openalex.org/W1535851215","https://openalex.org/W1548538265","https://openalex.org/W1556587164","https://openalex.org/W1567369841","https://openalex.org/W1573417299","https://openalex.org/W1573789567","https://openalex.org/W1589930724","https://openalex.org/W1603276847","https://openalex.org/W1606723080","https://openalex.org/W1651271817","https://openalex.org/W1830355994","https://openalex.org/W1995513403","https://openalex.org/W1998687037","https://openalex.org/W2020867437","https://openalex.org/W2033317179","https://openalex.org/W2045425113","https://openalex.org/W2059082631","https://openalex.org/W2059908035","https://openalex.org/W2073879684","https://openalex.org/W2085453941","https://openalex.org/W2087235842","https://openalex.org/W2088049715","https://openalex.org/W2100837269","https://openalex.org/W2128635872","https://openalex.org/W2320600355","https://openalex.org/W2409770357","https://openalex.org/W2437808312"],"related_works":["https://openalex.org/W1553370289","https://openalex.org/W1579490087","https://openalex.org/W1523935457","https://openalex.org/W1545414317","https://openalex.org/W1485407235","https://openalex.org/W1977878435","https://openalex.org/W1496082479","https://openalex.org/W1536680810","https://openalex.org/W1606723080","https://openalex.org/W1523812006"],"abstract_inverted_index":{"Myosins":[0],"IA":[1,162,205],"and":[2,41,78,117,163,206,223],"IB":[3,207],"from":[4,98,136],"Acanthamoeba":[5],"castellanii":[6],"are":[7,82,147],"single-headed":[8],"molecules":[9],"which,":[10],"upon":[11],"phosphorylation":[12,202],"of":[13,54,70,90,140,157,170,182,192,203,214,226],"their":[14],"heavy":[15,173],"chains":[16],"by":[17],"a":[18,35,51,177],"specific":[19],"kinase,":[20],"express":[21],"actin-activated":[22],"Mg2+-ATPase":[23],"activity.":[24],"These":[25],"myosins":[26,204],"show":[27],"no":[28,187],"tendency":[29],"to":[30,44,84,150,194],"self-associate":[31],"under":[32],"assay":[33],"conditions,":[34],"property":[36],"which":[37,94,175],"allows":[38],"unambiguous":[39],"kinetic":[40,142],"actin-binding":[42],"data":[43],"be":[45],"obtained.":[46],"Both":[47],"myosin":[48,110,115,122,127,161,167,172,193],"isoenzymes":[49],"exhibit":[50],"complex":[52],"dependence":[53,64],"actomyosin":[55,184,216],"ATPase":[56,218],"activity":[57],"on":[58,189],"F-actin":[59,71,75],"concentration.":[60],"A":[61],"conventional":[62],"hyperbolic":[63],"is":[65],"observed":[66],"at":[67,73,220],"low":[68,222],"concentrations":[69,225],"but":[72],"higher":[74],"concentrations,":[76],"inhibition":[77],"then":[79],"apparent":[80],"reactivation":[81,138],"seen":[83],"occur.":[85],"From":[86],"those":[87],"early":[88],"portions":[89],"the":[91,105,137,141,151,171,183,190,199,215],"velocity":[92],"profiles":[93],"do":[95],"not":[96],"deviate":[97],"simple":[99],"Michaelis-Menten":[100],"type":[101],"kinetics,":[102],"values":[103,133,146],"for":[104,109,114,121,126,160,166],"Vmax":[106,132],"(10":[107],"s-1":[108,113],"IA,":[111,123],"18":[112],"IB)":[116,128],"KATPase":[118,145],"(0.25":[119],"microM":[120,125,159,165],"0.30":[124],"were":[129,134],"calculated.":[130],"Similar":[131],"obtained":[135],"segment":[139],"data.":[143],"The":[144],"very":[148],"similar":[149],"directly":[152],"measured":[153],"dissociation":[154],"constants":[155],"(KD)":[156],"0.10":[158],"0.25":[164],"IB.":[168],"Phosphorylation":[169],"chain,":[174],"elicits":[176],"greater":[178],"than":[179],"20-fold":[180],"activation":[181],"ATPase,":[185],"has":[186],"effect":[188],"binding":[191],"F-actin.":[195,227],"This":[196],"finding":[197],"supports":[198],"conclusion":[200],"that":[201],"accelerates":[208],"one":[209],"or":[210],"more":[211],"catalytic":[212],"steps":[213],"I":[217],"reaction":[219],"both":[221],"high":[224]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
