{"id":"https://openalex.org/W1580793746","doi":"https://doi.org/10.1212/wnl.82.10_supplement.p4.201","title":"The Pituitary Adenylate Cyclase Activating Polypeptide Levels are Associated with Pathological Features of Alzheimer\u2019s Disease (P4.201)","display_name":"The Pituitary Adenylate Cyclase Activating Polypeptide Levels are Associated with Pathological Features of Alzheimer\u2019s Disease (P4.201)","publication_year":2014,"publication_date":"2014-04-08","ids":{"openalex":"https://openalex.org/W1580793746","doi":"https://doi.org/10.1212/wnl.82.10_supplement.p4.201","mag":"1580793746"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.82.10_supplement.p4.201","doi":"https://doi.org/10.1212/wnl.82.10_supplement.p4.201","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.82.10_supplement.p4.201","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036784515","display_name":"Jiong Shi","orcid":"https://orcid.org/0000-0001-7694-1366","observed_orcids":["https://orcid.org/0000-0001-7694-1366"]},"institutions":[{"id":"https://openalex.org/I1324766304","display_name":"Barrow Neurological Institute","ror":"https://ror.org/01fwrsq33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324766304","https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiong Shi","raw_affiliation_strings":["Barrow Neurological Institute Phoenix AZ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barrow Neurological Institute Phoenix AZ United States","institution_ids":["https://openalex.org/I1324766304"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324766304","display_name":"Barrow Neurological Institute","ror":"https://ror.org/01fwrsq33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324766304","https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Han","raw_affiliation_strings":["Barrow Neurological Institute Phoenix AZ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barrow Neurological Institute Phoenix AZ United States","institution_ids":["https://openalex.org/I1324766304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064308365","display_name":"Leslie C. Baxter","orcid":"https://orcid.org/0000-0002-3971-863X","observed_orcids":["https://orcid.org/0000-0002-3971-863X"]},"institutions":[{"id":"https://openalex.org/I1324766304","display_name":"Barrow Neurological Institute","ror":"https://ror.org/01fwrsq33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324766304","https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Baxter","raw_affiliation_strings":["Barrow Neurological Institute Phoenix AZ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barrow Neurological Institute Phoenix AZ United States","institution_ids":["https://openalex.org/I1324766304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030868239","display_name":"Winnie S. Liang","orcid":"https://orcid.org/0000-0002-5698-7735","observed_orcids":["https://orcid.org/0000-0002-5698-7735"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Liang","raw_affiliation_strings":["Translational Genomics Research Institute (tgen), Phoenix, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Genomics Research Institute (tgen), Phoenix, AZ, United States","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067836200","display_name":"Zhiwei Tang","orcid":"https://orcid.org/0000-0001-9314-4465","observed_orcids":["https://orcid.org/0000-0001-9314-4465"]},"institutions":[{"id":"https://openalex.org/I1324766304","display_name":"Barrow Neurological Institute","ror":"https://ror.org/01fwrsq33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324766304","https://openalex.org/I1325481341","https://openalex.org/I2802827176"]},{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210114896","display_name":"The First Hospital of Kunming","ror":"https://ror.org/01hq7pd83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114896"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Z Tang","raw_affiliation_strings":["Barrow Neurological Institute Phoenix AZ United States","Department of Neurosurgery The First Hospital of Kunming Medical University, Kunmming China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barrow Neurological Institute Phoenix AZ United States","institution_ids":["https://openalex.org/I1324766304"]},{"raw_affiliation_string":"Department of Neurosurgery The First Hospital of Kunming Medical University, Kunmming China","institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4210114896","https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473203","display_name":"Junxiang Yin","orcid":"https://orcid.org/0000-0002-9675-3802","observed_orcids":["https://orcid.org/0000-0002-9675-3802"]},"institutions":[{"id":"https://openalex.org/I1324766304","display_name":"Barrow Neurological Institute","ror":"https://ror.org/01fwrsq33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324766304","https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Yin","raw_affiliation_strings":["Barrow Neurological Institute Phoenix AZ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barrow Neurological Institute Phoenix AZ United States","institution_ids":["https://openalex.org/I1324766304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072613176","display_name":"Thomas G. Beach","orcid":"https://orcid.org/0000-0003-3296-6128","observed_orcids":["https://orcid.org/0000-0003-3296-6128"]},"institutions":[{"id":"https://openalex.org/I4210145600","display_name":"Banner Sun Health Research Institute","ror":"https://ror.org/04gjkkf30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4210145600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Beach","raw_affiliation_strings":["Civin Laboratory for Neuropathology Banner Sun Health Research Institute Sun City AZ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Civin Laboratory for Neuropathology Banner Sun Health Research Institute Sun City AZ United States","institution_ids":["https://openalex.org/I4210145600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074086871","display_name":"Richard J. Caselli","orcid":"https://orcid.org/0000-0001-5784-2987","observed_orcids":["https://orcid.org/0000-0001-5784-2987"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Caselli","raw_affiliation_strings":["Department of Neurology Mayo Clinic Arizona Scottsdale AZ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Mayo Clinic Arizona Scottsdale AZ United States","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047768726","display_name":"Eric M. Reiman","orcid":"https://orcid.org/0000-0002-0705-3696","observed_orcids":["https://orcid.org/0000-0002-0705-3696"]},"institutions":[{"id":"https://openalex.org/I4387152203","display_name":"Banner Alzheimer\u2019s Institute","ror":"https://ror.org/023jwkg52","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4387152203"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Reiman","raw_affiliation_strings":["Banner Alzheimer\u2019s Institute Phoenix AZ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner Alzheimer\u2019s Institute Phoenix AZ United States","institution_ids":["https://openalex.org/I4387152203"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04560517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"10_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pituitary-adenylate-cyclase-activating-polypeptide","display_name":"pituitary adenylate cyclase-activating polypeptide","score":0.9580000042915344},{"id":"https://openalex.org/keywords/pacap","display_name":"PACAP","score":0.9599999785423279},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8790000081062317},{"id":"https://openalex.org/keywords/braak-staging","display_name":"Braak staging","score":0.6169999837875366},{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.9520000219345093},{"id":"https://openalex.org/keywords/middle-temporal-gyrus","display_name":"middle temporal gyrus","score":0.8610000014305115},{"id":"https://openalex.org/keywords/superior-frontal-gyrus","display_name":"superior frontal gyrus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/primary-visual-cortex","display_name":"primary visual cortex","score":0.878000020980835},{"id":"https://openalex.org/keywords/neurotrophin-expression","display_name":"neurotrophin expression","score":0.7429999709129333},{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.703000009059906},{"id":"https://openalex.org/keywords/alzheimer-s-disease-pathogenesis","display_name":"Alzheimer's disease pathogenesis","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.812268853187561},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.757358193397522},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.6826625466346741},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5401555299758911},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5352581143379211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47144994139671326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4608241319656372},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4088812470436096},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3639243245124817},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3275008797645569},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2830721139907837},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08835920691490173}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.82.10_supplement.p4.201","doi":"https://doi.org/10.1212/wnl.82.10_supplement.p4.201","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.82.10_supplement.p4.201","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2151616817","https://openalex.org/W2032994377","https://openalex.org/W2187577853","https://openalex.org/W1499255965","https://openalex.org/W1799010938","https://openalex.org/W7117101563","https://openalex.org/W2098511020","https://openalex.org/W4389439036","https://openalex.org/W7117102331","https://openalex.org/W2170104232"],"abstract_inverted_index":{"Objective:":[0],"We":[1,41,74],"investigated":[2,42],"the":[3,43,51,81,89,93,98,104,120,127,143,149],"relevance":[4],"of":[5,25,45,53,78,135,168],"Pituitary":[6],"Adenylate":[7],"Cyclase":[8],"Activating":[9],"Polypeptide":[10],"(PACAP)":[11],"in":[12,28,32,50,80,119,132,142,148],"Alzheimer\u2019s":[13,30,86,188],"disease":[14],"(AD).":[15],"Background:":[16],"PACAP":[17,46,137,159,169],"is":[18,22,139,184],"a":[19,129],"neurotrophin.":[20],"There":[21],"growing":[23],"evidence":[24],"its":[26],"efficacy":[27],"reducing":[29],"pathology":[31],"animal":[33],"models":[34],"but":[35,125],"human":[36],"studies":[37],"are":[38],"lacking.":[39],"Design/methods:":[40],"expression":[44,138,173],"mRNA":[47,170],"and":[48,103,123,161,171,191],"protein":[49,172],"brains":[52],"pathologically":[54],"confirmed":[55],"late":[56],"onset":[57],"AD":[58,162,177],"patients":[59],"compared":[60],"with":[61,113],"age":[62],"matched":[63],"cognitively":[64],"normal":[65],"controls":[66],"(n=33":[67],"for":[68,71],"mRNA,":[69],"n=23":[70],"protein).":[72],"Results:":[73],"discovered":[75],"reduced":[76],"levels":[77],"both":[79],"brain":[82],"regions":[83],"susceptible":[84],"to":[85,176],"pathology,":[87],"including":[88],"entorhinal":[90],"cortex":[91,107],"(ENT),":[92],"middle":[94],"temporal":[95],"gyrus":[96,101],"(MTG),":[97],"superior":[99],"frontal":[100],"(SFG)":[102],"primary":[105],"visual":[106],"(PVC),":[108],"This":[109,182],"reduction":[110,160],"inversely":[111],"correlated":[112],"amyloid":[114],"burden":[115],"(CERAD":[116],"plaque":[117],"density)":[118],"ENT,":[121],"MTG":[122],"SFG":[124],"not":[126],"PVC,":[128],"region":[130],"spared":[131],"most":[133],"cases":[134],"AD.":[136],"significantly":[140],"decreased":[141],"advanced":[144],"Braak":[145],"Stage":[146],"(V-VI)":[147],"moderate":[150],"stage":[151],"(III-IV).":[152],"Conclusions:":[153],"The":[154],"close":[155],"inverse":[156],"relationship":[157],"between":[158],"pathological":[163],"features":[164],"suggests":[165],"that":[166],"downregulation":[167],"may":[174],"contribute":[175],"pathogenesis.":[178],"Study":[179],"Supported":[180],"by:":[181],"work":[183],"funded":[185],"by":[186],"Arizona":[187],"Disease":[189],"Consortium":[190],"Barrow":[192],"Neurological":[193],"Foundation.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}