{"id":"https://openalex.org/W1580428797","doi":null,"title":"WEE1 Is a Biological Target of the miR-17-92 Cluster in Leukemia","display_name":"WEE1 Is a Biological Target of the miR-17-92 Cluster in Leukemia","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1580428797","mag":"1580428797"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.luc.edu:luc_theses-1569","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.luc.edu/luc_theses/570","pdf_url":"https://ecommons.luc.edu/luc_theses/570","source":{"id":"https://openalex.org/S4306402030","display_name":"Loyola eCommons (Loyola University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1925986","host_organization_name":"Loyola University Chicago","host_organization_lineage":["https://openalex.org/I1925986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ecommons.luc.edu/luc_theses/570","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109975465","display_name":"Sonia Olikara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sonia Susan Olikara","raw_affiliation_strings":["#N#        Loyola University, Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#        Loyola University, Chicago","institution_ids":["https://openalex.org/I1925986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109975465"],"corresponding_institution_ids":["https://openalex.org/I1925986"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wee1","display_name":"WEE1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mir-17-92-cluster","display_name":"miR-17-92 cluster","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mll-rearrangement","display_name":"MLL rearrangement","score":0.906000018119812},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cell-cycle-kinases","display_name":"cell cycle kinases","score":0.6480000019073486},{"id":"https://openalex.org/keywords/mir-17","display_name":"miR-17","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mir-20a","display_name":"miR-20a","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mir-18a","display_name":"miR-18a","score":0.996999979019165},{"id":"https://openalex.org/keywords/mir-19a","display_name":"miR-19a","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mir-19b","display_name":"miR-19b","score":0.9670000076293945},{"id":"https://openalex.org/keywords/leukemia-cell-lines","display_name":"leukemia cell lines","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.5937155485153198},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43498462438583374},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36499083042144775},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3336677551269531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3029838800430298},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19811353087425232},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.05827245116233826}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ecommons.luc.edu:luc_theses-1569","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.luc.edu/luc_theses/570","pdf_url":"https://ecommons.luc.edu/luc_theses/570","source":{"id":"https://openalex.org/S4306402030","display_name":"Loyola eCommons (Loyola University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1925986","host_organization_name":"Loyola University Chicago","host_organization_lineage":["https://openalex.org/I1925986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},{"id":"mag:1580428797","doi":null,"is_oa":false,"landing_page_url":"https://ecommons.luc.edu/cgi/viewcontent.cgi?article=1569&context=luc_theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.luc.edu:luc_theses-1569","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.luc.edu/luc_theses/570","pdf_url":"https://ecommons.luc.edu/luc_theses/570","source":{"id":"https://openalex.org/S4306402030","display_name":"Loyola eCommons (Loyola University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1925986","host_organization_name":"Loyola University Chicago","host_organization_lineage":["https://openalex.org/I1925986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1580428797.pdf","grobid_xml":"https://content.openalex.org/works/W1580428797.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W14098964","https://openalex.org/W63001887","https://openalex.org/W144423133","https://openalex.org/W1483810504","https://openalex.org/W1524628399","https://openalex.org/W1545504546","https://openalex.org/W1750225402","https://openalex.org/W1916491745","https://openalex.org/W1920303762","https://openalex.org/W1964263352","https://openalex.org/W1965712798","https://openalex.org/W1966427699","https://openalex.org/W1969003435","https://openalex.org/W1976439451","https://openalex.org/W1977372263","https://openalex.org/W1979364059","https://openalex.org/W1980269624","https://openalex.org/W1981774463","https://openalex.org/W1982315838","https://openalex.org/W1985171686","https://openalex.org/W1985275860","https://openalex.org/W1995294841","https://openalex.org/W2014064723","https://openalex.org/W2033595939","https://openalex.org/W2038340312","https://openalex.org/W2042871287","https://openalex.org/W2050066317","https://openalex.org/W2055309264","https://openalex.org/W2062290101","https://openalex.org/W2064396597","https://openalex.org/W2065178008","https://openalex.org/W2071596792","https://openalex.org/W2078210863","https://openalex.org/W2082213106","https://openalex.org/W2082592723","https://openalex.org/W2083381199","https://openalex.org/W2084444853","https://openalex.org/W2086415805","https://openalex.org/W2090017296","https://openalex.org/W2093956363","https://openalex.org/W2094915354","https://openalex.org/W2095184701","https://openalex.org/W2098139456","https://openalex.org/W2100975741","https://openalex.org/W2103392842","https://openalex.org/W2104460981","https://openalex.org/W2107277218","https://openalex.org/W2111603892","https://openalex.org/W2112087352","https://openalex.org/W2121115564","https://openalex.org/W2121880378","https://openalex.org/W2126334907","https://openalex.org/W2135154556","https://openalex.org/W2135810600","https://openalex.org/W2138664009","https://openalex.org/W2139791626","https://openalex.org/W2146642335","https://openalex.org/W2147925889","https://openalex.org/W2149291473","https://openalex.org/W2163199119","https://openalex.org/W2163344214","https://openalex.org/W2164959344","https://openalex.org/W2166531817","https://openalex.org/W2167557255","https://openalex.org/W2169234352","https://openalex.org/W2235427389"],"related_works":["https://openalex.org/W2144946235","https://openalex.org/W2073394971","https://openalex.org/W2341524013","https://openalex.org/W2485652308","https://openalex.org/W2977428590","https://openalex.org/W1990583062","https://openalex.org/W2071707768","https://openalex.org/W2045998598","https://openalex.org/W2384806551","https://openalex.org/W1982948953"],"abstract_inverted_index":{"MicroRNAs":[0],"are":[1],"noncoding":[2],"RNAs":[3],"that":[4,26,59,80,141],"bind":[5],"to":[6,89,104],"the":[7,27,43,50,71,92,122,147],"3'":[8,93],"untranslated":[9],"region":[10],"of":[11,18,42,68,70,91,95,146],"their":[12],"mRNA":[13],"targets,":[14],"which":[15,30],"causes":[16],"downregulation":[17],"target":[19,67,86,101,145],"gene":[20],"expression.":[21],"Previous":[22],"studies":[23],"have":[24],"shown":[25],"miR-17-92":[28,119,134,148],"cluster,":[29],"encodes":[31],"six":[32,72],"miRNAs,":[33],"is":[34,143],"overexpressed":[35],"in":[36,121],"leukemias":[37],"arising":[38],"from":[39],"chromosomal":[40],"translocations":[41],"Mixed":[44],"Lineage":[45],"Leukemia":[46],"(MLL)":[47],"gene.":[48],"In":[49],"present":[51],"study,":[52],"prediction":[53],"algorithms":[54],"identified":[55],"WEE1,":[56,96],"a":[57,65,112,129,144],"kinase":[58],"inhibits":[60],"cell":[61,124],"cycle":[62],"progression,":[63],"as":[64],"possible":[66],"five":[69],"miRNAs.":[73],"Through":[74],"luciferase":[75],"reporter":[76],"assays,":[77],"we":[78,108,127],"found":[79],"miR-17,":[81],"miR-20a,":[82],"and":[83,99,118,135],"miR-18a":[84],"specifically":[85],"nucleotides":[87,102],"465":[88],"487":[90],"UTR":[94],"while":[97,107],"miR-19a":[98],"miR-19b":[100],"1069":[103],"1091.":[105],"Notably,":[106],"did":[109],"not":[110],"detect":[111],"relationship":[113],"between":[114,132],"MLL":[115],"rearrangement":[116],"status":[117],"expression":[120],"leukemia":[123],"lines":[125],"tested,":[126],"observed":[128],"negative":[130],"correlation":[131],"endogenous":[133,136],"WEE1.":[137],"These":[138],"results":[139],"suggest":[140],"WEE1":[142],"cluster.":[149]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}
