{"id":"https://openalex.org/W1580311327","doi":"https://doi.org/10.1016/s0021-9258(19)74021-6","title":"Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase.","display_name":"Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase.","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W1580311327","doi":"https://doi.org/10.1016/s0021-9258(19)74021-6","mag":"1580311327","pmid":"https://pubmed.ncbi.nlm.nih.gov/1460017"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)74021-6","doi":"https://doi.org/10.1016/s0021-9258(19)74021-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)74021-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)74021-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001565617","display_name":"Jean A. Toner-Webb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Toner-Webb","raw_affiliation_strings":["Department of Chemistry, University of California, San Diego, La Jolla 92093-0654"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, San Diego, La Jolla 92093-0654","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090134368","display_name":"Scott M. Van Patten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.M. van Patten","raw_affiliation_strings":["Department of Chemistry, University of California, San Diego, La Jolla 92093-0654"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, San Diego, La Jolla 92093-0654","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103526511","display_name":"Donal A. Walsh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.A. Walsh","raw_affiliation_strings":["Department of Chemistry, University of California, San Diego, La Jolla 92093-0654"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, San Diego, La Jolla 92093-0654","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045962448","display_name":"Susan Serota Taylor","orcid":"https://orcid.org/0000-0002-7702-6108","observed_orcids":["https://orcid.org/0000-0002-7702-6108"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.S. Taylor","raw_affiliation_strings":["Department of Chemistry, University of California, San Diego, La Jolla 92093-0654"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, San Diego, La Jolla 92093-0654","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5231,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.82053856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"267","issue":"35","first_page":"25174","last_page":"25180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9760000109672546},{"id":"https://openalex.org/keywords/catalytic-subunit","display_name":"catalytic subunit","score":0.9629999995231628},{"id":"https://openalex.org/keywords/autophosphorylation","display_name":"autophosphorylation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/isoelectric-variants","display_name":"isoelectric variants","score":0.8920000195503235},{"id":"https://openalex.org/keywords/protein-kinase-activity","display_name":"protein kinase activity","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.904177188873291},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.7407756447792053},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5351216793060303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4426237940788269},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39979058504104614},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3732755184173584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3623753786087036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3382927179336548},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05752980709075928}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)74021-6","doi":"https://doi.org/10.1016/s0021-9258(19)74021-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)74021-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:1460017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1460017","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)74021-6","doi":"https://doi.org/10.1016/s0021-9258(19)74021-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)74021-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G361034356","display_name":null,"funder_award_id":"GM 19301","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W65617761","https://openalex.org/W117939021","https://openalex.org/W179113440","https://openalex.org/W184399086","https://openalex.org/W1490821933","https://openalex.org/W1494863926","https://openalex.org/W1505530830","https://openalex.org/W1515517002","https://openalex.org/W1524300050","https://openalex.org/W1533935767","https://openalex.org/W1551027803","https://openalex.org/W1560415311","https://openalex.org/W1568303936","https://openalex.org/W1585541396","https://openalex.org/W1591230411","https://openalex.org/W1592938589","https://openalex.org/W1598316265","https://openalex.org/W1602931525","https://openalex.org/W1607359602","https://openalex.org/W1954353020","https://openalex.org/W1968481822","https://openalex.org/W1973179766","https://openalex.org/W1976144416","https://openalex.org/W1978696795","https://openalex.org/W1985507910","https://openalex.org/W2010002190","https://openalex.org/W2012787501","https://openalex.org/W2031967907","https://openalex.org/W2040456790","https://openalex.org/W2056867084","https://openalex.org/W2061715965","https://openalex.org/W2064697586","https://openalex.org/W2065365579","https://openalex.org/W2067405360","https://openalex.org/W2080820380","https://openalex.org/W2083551757","https://openalex.org/W2085119576","https://openalex.org/W2091455173","https://openalex.org/W2100837269","https://openalex.org/W2106355009","https://openalex.org/W2134174979","https://openalex.org/W2206696718","https://openalex.org/W2222709349","https://openalex.org/W2409484155"],"related_works":["https://openalex.org/W1565601414","https://openalex.org/W2161999370","https://openalex.org/W2278746848","https://openalex.org/W1560415311","https://openalex.org/W1533101300","https://openalex.org/W2089378803","https://openalex.org/W1595781812","https://openalex.org/W4242742089","https://openalex.org/W1941291890","https://openalex.org/W1598699479"],"abstract_inverted_index":{"The":[0,124,236],"catalytic":[1,122,143,166,201,241],"subunit":[2,49,144,167,202,242],"of":[3,72,114,120,141,164,185,199,207,239],"cAMP-dependent":[4],"protein":[5],"kinase":[6],"contains":[7],"two":[8,65,116,154,161],"stable":[9,48,66],"phosphorylation":[10,67],"sites,":[11,68],"Thr-197":[12,32],"and":[13,22,38,56,88,256],"Ser-338":[14,52,93],"(Shoji,":[15],"S.,":[16],"Titani,":[17],"K.,":[18],"Demaille,":[19],"J.":[20,27],"G.,":[21],"Fischer,":[23],"E.":[24],"H.":[25],"(1979)":[26],"Biol.":[28],"Chem.":[29],"254,":[30],"6211-6214).":[31],"is":[33,50,53,110,168,172,191,227],"very":[34],"resistant":[35],"to":[36,63,97,175,187,214,233,246],"dephosphorylation":[37],"thus":[39],"cannot":[40],"typically":[41],"be":[42,58,132,215,234],"autophosphorylated":[43,133],"in":[44,183,194],"vitro":[45],"once":[46],"the":[47,102,115,121,127,137,142,153,158,165,181,195,200,220,224,240,247,253],"formed.":[51],"slowly":[54],"dephosphorylated":[55],"can":[57,131],"rephosphorylated":[59],"autocatalytically.":[60],"In":[61],"addition":[62],"these":[64],"a":[69,83,177,216],"new":[70],"site":[71],"autophosphorylation,":[73],"Ser-10,":[74],"was":[75],"identified.":[76],"Phosphorylation":[77,146],"at":[78,108,134,147,223],"Ser-10":[79,91,109,135,148,186,190,213,230],"does":[80,149],"not":[81,95,150,173,192,244],"have":[82],"major":[84,117],"effect":[85],"on":[86],"activity,":[87],"phosphates":[89],"from":[90],"or":[92,203,209],"are":[94],"transferred":[96],"physiological":[98],"substrates":[99],"such":[100],"as":[101],"type":[103,206],"II":[104],"regulatory":[105],"subunit.":[106,123],"Autophosphorylation":[107],"associated":[111],"with":[112],"one":[113],"isoelectric":[118,162],"variants":[119,163],"form":[125,140,198],"having":[126],"more":[128,138,196],"acidic":[129],"pI":[130],"while":[136],"basic":[139,197],"cannot.":[145],"account":[151],"for":[152,160,180,229,251],"isoenzyme":[155,237],"forms.":[156],"Since":[157],"reason":[159],"still":[169],"unknown,":[170],"it":[171],"possible":[174],"provide":[176],"structural":[178],"basis":[179],"difference":[182],"accessibility":[184],"phosphorylation.":[188],"Either":[189],"accessible":[193],"some":[204],"other":[205],"post-":[208],"cotranslational":[210],"modification":[211],"causes":[212],"poor":[217],"substrate.":[218],"Whether":[219],"myristoyl":[221],"group":[222],"amino-terminal":[225],"Gly":[226],"important":[228],"autophosphorylation":[231],"remains":[232],"established.":[235],"forms":[238],"do":[243],"correspond":[245],"gene":[248],"products":[249],"coded":[250],"by":[252],"C":[254,257],"alpha":[255],"beta":[258],"genes.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
