{"id":"https://openalex.org/W158024441","doi":"https://doi.org/10.1023/a:1015950215230","title":"Intestinal 5-Fluorouracil Absorption: Use of Ussing Chambers to Assess Transport and Metabolism","display_name":"Intestinal 5-Fluorouracil Absorption: Use of Ussing Chambers to Assess Transport and Metabolism","publication_year":1988,"publication_date":"1988-09-01","ids":{"openalex":"https://openalex.org/W158024441","doi":"https://doi.org/10.1023/a:1015950215230","mag":"158024441","pmid":"https://pubmed.ncbi.nlm.nih.gov/3247323"},"language":"en","primary_location":{"id":"doi:10.1023/a:1015950215230","doi":"https://doi.org/10.1023/a:1015950215230","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1015950215230","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102913268","display_name":"Philip L. Smith","orcid":"https://orcid.org/0000-0003-2420-8570","observed_orcids":["https://orcid.org/0000-0003-2420-8570"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip Smith","raw_affiliation_strings":["Department of Drug Delivery, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania 19406-0939","Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Delivery, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania 19406-0939","institution_ids":[]},{"raw_affiliation_string":"Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019123596","display_name":"Christopher K. Mirabelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Mirabelli","raw_affiliation_strings":["Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania","Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania","institution_ids":[]},{"raw_affiliation_string":"Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061382970","display_name":"Joseph D. Fondacaro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Fondacaro","raw_affiliation_strings":["Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania","Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania","institution_ids":[]},{"raw_affiliation_string":"Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111386474","display_name":"Frederick M. Ryan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederick Ryan","raw_affiliation_strings":["Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania","Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania","institution_ids":[]},{"raw_affiliation_string":"Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia,","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"John Dent","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Dent","raw_affiliation_strings":["Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania","Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania","institution_ids":[]},{"raw_affiliation_string":"Departments of Drug Delivery, Molecular Pharmacology, and Gastrointestinal Pharmacology, Smith Kline and French Research Laboratories, Philadelphia,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":1.9709,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.86530582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"5","issue":"9","first_page":"598","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.13269999623298645,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9620000123977661},{"id":"https://openalex.org/keywords/intestinal-absorption","display_name":"intestinal absorption","score":0.8859999775886536},{"id":"https://openalex.org/keywords/drug-transport","display_name":"drug transport","score":0.621999979019165},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.7310000061988831},{"id":"https://openalex.org/keywords/ussing-chamber","display_name":"Ussing chamber","score":0.7269999980926514},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.6949999928474426},{"id":"https://openalex.org/keywords/colon","display_name":"colon","score":0.9290000200271606},{"id":"https://openalex.org/keywords/sodium-dependent-transport","display_name":"sodium-dependent transport","score":0.7360000014305115},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.7110000252723694},{"id":"https://openalex.org/keywords/unidirectional-flux","display_name":"unidirectional flux","score":0.7419999837875366},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.7350000143051147},{"id":"https://openalex.org/keywords/rabbit-intestine","display_name":"rabbit intestine","score":0.5189999938011169},{"id":"https://openalex.org/keywords/short-circuit-conditions","display_name":"short-circuit conditions","score":0.597000002861023},{"id":"https://openalex.org/keywords/ouabain","display_name":"ouabain","score":0.4880000054836273},{"id":"https://openalex.org/keywords/sodium-concentration","display_name":"sodium concentration","score":0.5230000019073486},{"id":"https://openalex.org/keywords/uridine-5-monophosphate","display_name":"uridine 5'-monophosphate","score":0.7099999785423279},{"id":"https://openalex.org/keywords/thiopurines","display_name":"thiopurines","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2779932011","wikidata":"https://www.wikidata.org/wiki/Q581885","display_name":"Ussing chamber","level":3,"score":0.7678649425506592},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.606522798538208},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5499465465545654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5020806789398193},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49784278869628906},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4543461501598358},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3027515411376953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29499149322509766},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23600998520851135},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.13683149218559265},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1015950215230","doi":"https://doi.org/10.1023/a:1015950215230","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1015950215230","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},{"id":"pmid:3247323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3247323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1597726107","https://openalex.org/W1828423173","https://openalex.org/W1983367347","https://openalex.org/W1985463875","https://openalex.org/W2007598338","https://openalex.org/W2025793626","https://openalex.org/W2059271194","https://openalex.org/W2065769255","https://openalex.org/W2066166392","https://openalex.org/W2082429146","https://openalex.org/W2083313025","https://openalex.org/W2084994118","https://openalex.org/W2093304278","https://openalex.org/W2287727922","https://openalex.org/W2290024232","https://openalex.org/W2412204369","https://openalex.org/W2415076282","https://openalex.org/W2470973611","https://openalex.org/W2920633646"],"related_works":["https://openalex.org/W2321880694","https://openalex.org/W2058976525","https://openalex.org/W2395033425","https://openalex.org/W2515961669","https://openalex.org/W1993292680","https://openalex.org/W2133683916","https://openalex.org/W6964512495","https://openalex.org/W2040087503","https://openalex.org/W119846671","https://openalex.org/W2441940391"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}