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t":[107],"activation.":[109],"There":[110,274],"increasing":[112],"evidence":[113],"upregulation":[115],"this":[117],"pathway":[118],"COPD.Aims:":[120],"(1)":[121,180,258,349],"To":[122,155],"test":[123],"safety":[125,191],"inhaled":[130,188],"exacerbation":[142],"investigate":[145,156],"systemic":[147,196,280],"airway":[149,194,224,308],"inflammatory":[150],"response":[151],"vivo.":[153],"(2)":[154,206,296,379],"action":[158],"inhibitors":[163,213,241,300,346,383],"dexamethasone":[165,215,243,322],"vitro":[167,393],"on":[168,216,244,363],"stable":[176,227,251,317,336],"state":[177,318,337],"exacerbations.Methods:":[179],"12":[181],"mild":[184],"moderate":[186],"5\ufffdg":[189],"LPS;":[190],"measurements":[192],"biomarkers":[197],"were":[198],"collected":[199],"up":[200],"24":[202],"hours":[203],"post":[204],"inhalation.":[205],"The":[207,235],"effect":[208,236],"MMP-9":[217,303],"ROS":[219,305,388],"release":[220,246,306,327,391],"from":[221,226,247,250,307,312,328,331],"peripheral":[222,248,310,329],"neutrophils":[225,249,311,330],"was":[231,254,275,338],"examined":[232],"vitro.":[234],"cytokine":[245,390],"also":[255,339],"investigated.":[256],"Results:":[257],"(5\ufffdg)":[261],"caused":[262],"significant":[264,294],"fall":[265],"FEV1":[267],"increase":[269,278],"sputum":[271],"neutrophil":[272,386],"numbers.":[273],"an":[276],"associated":[277],"IL-6,":[281],"CRP":[282],"CC-16,":[284],"all":[285],"differing":[287],"temporal":[288],"patterns.":[289],"No":[290],"reported":[292],"any":[293],"symptoms.":[295],"significantly":[301,340],"reduced":[302],"exacerbations;":[321],"had":[323],"minimal":[324],"effect.":[325],"Cytokine":[326],"inhibited":[341],"dexamethasone.Conclusions:":[348],"safe":[358],"induce":[361],"acute":[362],"chronic":[364],"therefore":[368,396],"could":[369],"be":[370],"study":[376],"reduce":[384],"MMP-9,":[387],"promising":[399],"pharmacotherapy.":[402]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
