{"id":"https://openalex.org/W1579845729","doi":null,"title":"Alteracions epigen\u00e8tiques en c\u00e0ncer colorectal: canvis globals i identificaci\u00f3 de noves dianes","display_name":"Alteracions epigen\u00e8tiques en c\u00e0ncer colorectal: canvis globals i identificaci\u00f3 de noves dianes","publication_year":2008,"publication_date":"2008-01-25","ids":{"openalex":"https://openalex.org/W1579845729","mag":"1579845729"},"language":"ca","primary_location":{"id":"pmh:oai:www.tdx.cat:10803/1896","doi":null,"is_oa":true,"landing_page_url":"http://www.tdx.cat/TDX-0119109-114756","pdf_url":"http://www.tdx.cat/TDX-0119109-114756","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.tdx.cat/TDX-0119109-114756","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029130616","display_name":"J. Lumbiarres","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. Lumbiarres","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5029130616"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dna-hypomethylation","display_name":"DNA hypomethylation","score":0.949999988079071},{"id":"https://openalex.org/keywords/global-dna-methylation","display_name":"global DNA methylation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7149999737739563},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.7689999938011169},{"id":"https://openalex.org/keywords/alu-elements","display_name":"Alu elements","score":0.7979999780654907},{"id":"https://openalex.org/keywords/dna-methylation-analysis","display_name":"DNA methylation analysis","score":0.32600000500679016},{"id":"https://openalex.org/keywords/epigenetic-targets","display_name":"epigenetic targets","score":0.4560000002384186},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.4950000047683716},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.39100000262260437},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.6838623285293579},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.33175837993621826}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:www.tdx.cat:10803/1896","doi":null,"is_oa":true,"landing_page_url":"http://www.tdx.cat/TDX-0119109-114756","pdf_url":"http://www.tdx.cat/TDX-0119109-114756","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:diposit.ub.edu:2445/41915","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/41915","pdf_url":"http://hdl.handle.net/2445/41915","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Gen\u00e8tica","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:dnet:tdr_________::b3cc800ac588ecd2f0e59ee6e683e9ab","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/1896","pdf_url":"http://hdl.handle.net/10803/1896","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1579845729","doi":null,"is_oa":false,"landing_page_url":"http://diposit.ub.edu/dspace/bitstream/2445/41915/1/01.JRL_TESI_1de3.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.tdx.cat:10803/1896","doi":null,"is_oa":true,"landing_page_url":"http://www.tdx.cat/TDX-0119109-114756","pdf_url":"http://www.tdx.cat/TDX-0119109-114756","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1579845729.pdf","grobid_xml":"https://content.openalex.org/works/W1579845729.grobid-xml"},"referenced_works_count":349,"referenced_works":["https://openalex.org/W71597126","https://openalex.org/W115186932","https://openalex.org/W125009976","https://openalex.org/W153023584","https://openalex.org/W331618271","https://openalex.org/W652554816","https://openalex.org/W1482289695","https://openalex.org/W1486257535","https://openalex.org/W1504303645","https://openalex.org/W1509466986","https://openalex.org/W1513040830","https://openalex.org/W1516127391","https://openalex.org/W1522855936","https://openalex.org/W1528728961","https://openalex.org/W1533555842","https://openalex.org/W1535925642","https://openalex.org/W1540264737","https://openalex.org/W1554775680","https://openalex.org/W1556996865","https://openalex.org/W1567517848","https://openalex.org/W1571666545","https://openalex.org/W1575147957","https://openalex.org/W1576321535","https://openalex.org/W1577875429","https://openalex.org/W1593569677","https://openalex.org/W1602222199","https://openalex.org/W1603793127","https://openalex.org/W1605104953","https://openalex.org/W1625510017","https://openalex.org/W1637312052","https://openalex.org/W1643500256","https://openalex.org/W1652583010","https://openalex.org/W1669374546","https://openalex.org/W1729812787","https://openalex.org/W1755052449","https://openalex.org/W1784857457","https://openalex.org/W1792088282","https://openalex.org/W1835750525","https://openalex.org/W1845735905","https://openalex.org/W1874007049","https://openalex.org/W1924427056","https://openalex.org/W1965281877","https://openalex.org/W1965722916","https://openalex.org/W1967064280","https://openalex.org/W1967304777","https://openalex.org/W1967831804","https://openalex.org/W1968263601","https://openalex.org/W1968789240","https://openalex.org/W1968906704","https://openalex.org/W1968931043","https://openalex.org/W1969408132","https://openalex.org/W1969670934","https://openalex.org/W1969691479","https://openalex.org/W1969964108","https://openalex.org/W1971746394","https://openalex.org/W1974112332","https://openalex.org/W1974134624","https://openalex.org/W1974359182","https://openalex.org/W1974747095","https://openalex.org/W1975135992","https://openalex.org/W1976394361","https://openalex.org/W1976424678","https://openalex.org/W1977118826","https://openalex.org/W1977446702","https://openalex.org/W1977772936","https://openalex.org/W1978871519","https://openalex.org/W1981062376","https://openalex.org/W1981354816","https://openalex.org/W1982089215","https://openalex.org/W1982273994","https://openalex.org/W1982984103","https://openalex.org/W1983307705","https://openalex.org/W1983550639","https://openalex.org/W1983861034","https://openalex.org/W1984807040","https://openalex.org/W1984825396","https://openalex.org/W1985180051","https://openalex.org/W1986411314","https://openalex.org/W1986937402","https://openalex.org/W1987760376","https://openalex.org/W1989077825","https://openalex.org/W1989421786","https://openalex.org/W1990085600","https://openalex.org/W1990381590","https://openalex.org/W1993249182","https://openalex.org/W1993852989","https://openalex.org/W1994465394","https://openalex.org/W1994734776","https://openalex.org/W1994840217","https://openalex.org/W1995002306","https://openalex.org/W1995819860","https://openalex.org/W1996086595","https://openalex.org/W1996487270","https://openalex.org/W1997270596","https://openalex.org/W1998517881","https://openalex.org/W1999952815","https://openalex.org/W2000122597","https://openalex.org/W2000939708","https://openalex.org/W2001258296","https://openalex.org/W2002541386","https://openalex.org/W2002698073","https://openalex.org/W2002805960","https://openalex.org/W2002877822","https://openalex.org/W2004172747","https://openalex.org/W2004440539","https://openalex.org/W2004477171","https://openalex.org/W2004499293","https://openalex.org/W2004608668","https://openalex.org/W2005147516","https://openalex.org/W2005765694","https://openalex.org/W2006095114","https://openalex.org/W2006239354","https://openalex.org/W2006604860","https://openalex.org/W2007684630","https://openalex.org/W2008236933","https://openalex.org/W2010055084","https://openalex.org/W2011480379","https://openalex.org/W2011719683","https://openalex.org/W2011831296","https://openalex.org/W2013756789","https://openalex.org/W2015132841","https://openalex.org/W2015416439","https://openalex.org/W2015888582","https://openalex.org/W2017082182","https://openalex.org/W2017147713","https://openalex.org/W2017741900","https://openalex.org/W2017840637","https://openalex.org/W2018051857","https://openalex.org/W2019223361","https://openalex.org/W2019474060","https://openalex.org/W2020150463","https://openalex.org/W2021836517","https://openalex.org/W2022368730","https://openalex.org/W2023427658","https://openalex.org/W2024819383","https://openalex.org/W2025476423","https://openalex.org/W2026059246","https://openalex.org/W2027229185","https://openalex.org/W2027703149","https://openalex.org/W2029197798","https://openalex.org/W2029320889","https://openalex.org/W2029733458","https://openalex.org/W2029874395","https://openalex.org/W2029903254","https://openalex.org/W2030670272","https://openalex.org/W2030896232","https://openalex.org/W2031129569","https://openalex.org/W2033102369","https://openalex.org/W2033364737","https://openalex.org/W2034105248","https://openalex.org/W2034269086","https://openalex.org/W2035915355","https://openalex.org/W2036300762","https://openalex.org/W2036853135","https://openalex.org/W2037541952","https://openalex.org/W2039067014","https://openalex.org/W2040149948","https://openalex.org/W2040257851","https://openalex.org/W2040427612","https://openalex.org/W2042087070","https://openalex.org/W2043033879","https://openalex.org/W2044643325","https://openalex.org/W2044674250","https://openalex.org/W2045608427","https://openalex.org/W2045684167","https://openalex.org/W2046241907","https://openalex.org/W2046374350","https://openalex.org/W2048066469","https://openalex.org/W2048275837","https://openalex.org/W2048552527","https://openalex.org/W2049598074","https://openalex.org/W2050319565","https://openalex.org/W2050476689","https://openalex.org/W2050876777","https://openalex.org/W2051406511","https://openalex.org/W2052639867","https://openalex.org/W2052665087","https://openalex.org/W2053421436","https://openalex.org/W2053920029","https://openalex.org/W2054600961","https://openalex.org/W2055685287","https://openalex.org/W2056524601","https://openalex.org/W2058166280","https://openalex.org/W2059173951","https://openalex.org/W2059479474","https://openalex.org/W2060407209","https://openalex.org/W2060446375","https://openalex.org/W2060738758","https://openalex.org/W2061867473","https://openalex.org/W2062093164","https://openalex.org/W2062219202","https://openalex.org/W2062759109","https://openalex.org/W2063110349","https://openalex.org/W2063295806","https://openalex.org/W2064132534","https://openalex.org/W2067126209","https://openalex.org/W2067317023","https://openalex.org/W2067563155","https://openalex.org/W2069179692","https://openalex.org/W2069752613","https://openalex.org/W2070897057","https://openalex.org/W2071154937","https://openalex.org/W2071422117","https://openalex.org/W2071659391","https://openalex.org/W2071762384","https://openalex.org/W2072035127","https://openalex.org/W2072301590","https://openalex.org/W2072337838","https://openalex.org/W2073365346","https://openalex.org/W2074464947","https://openalex.org/W2074740541","https://openalex.org/W2074813718","https://openalex.org/W2075087486","https://openalex.org/W2075168304","https://openalex.org/W2075531719","https://openalex.org/W2075710011","https://openalex.org/W2076446466","https://openalex.org/W2076494331","https://openalex.org/W2076835726","https://openalex.org/W2077431712","https://openalex.org/W2078539443","https://openalex.org/W2080308138","https://openalex.org/W2080585376","https://openalex.org/W2083335540","https://openalex.org/W2084748297","https://openalex.org/W2085064863","https://openalex.org/W2085677283","https://openalex.org/W2085932408","https://openalex.org/W2088170764","https://openalex.org/W2088554411","https://openalex.org/W2088580222","https://openalex.org/W2089253191","https://openalex.org/W2090030959","https://openalex.org/W2091196623","https://openalex.org/W2091685314","https://openalex.org/W2091723114","https://openalex.org/W2092513068","https://openalex.org/W2093188241","https://openalex.org/W2093303627","https://openalex.org/W2093474396","https://openalex.org/W2093531978","https://openalex.org/W2093587470","https://openalex.org/W2093896423","https://openalex.org/W2096083625","https://openalex.org/W2096501714","https://openalex.org/W2099129395","https://openalex.org/W2100365251","https://openalex.org/W2101714106","https://openalex.org/W2102807020","https://openalex.org/W2103302926","https://openalex.org/W2104905992","https://openalex.org/W2106034419","https://openalex.org/W2106270511","https://openalex.org/W2106401558","https://openalex.org/W2106551806","https://openalex.org/W2106680700","https://openalex.org/W2106932225","https://openalex.org/W2107558453","https://openalex.org/W2107972234","https://openalex.org/W2109047753","https://openalex.org/W2110319986","https://openalex.org/W2110455745","https://openalex.org/W2111584908","https://openalex.org/W2112244712","https://openalex.org/W2114599216","https://openalex.org/W2115802074","https://openalex.org/W2115867970","https://openalex.org/W2117853791","https://openalex.org/W2118681186","https://openalex.org/W2119398179","https://openalex.org/W2120627772","https://openalex.org/W2121417064","https://openalex.org/W2121585544","https://openalex.org/W2122081519","https://openalex.org/W2122872131","https://openalex.org/W2123041729","https://openalex.org/W2123472832","https://openalex.org/W2123731635","https://openalex.org/W2123927456","https://openalex.org/W2124049725","https://openalex.org/W2124270614","https://openalex.org/W2125338577","https://openalex.org/W2126371676","https://openalex.org/W2127230663","https://openalex.org/W2127540087","https://openalex.org/W2128107471","https://openalex.org/W2128146359","https://openalex.org/W2130826348","https://openalex.org/W2131042193","https://openalex.org/W2131918846","https://openalex.org/W2132520995","https://openalex.org/W2133406385","https://openalex.org/W2133452708","https://openalex.org/W2134087142","https://openalex.org/W2134259738","https://openalex.org/W2134555277","https://openalex.org/W2135134693","https://openalex.org/W2135925928","https://openalex.org/W2136460560","https://openalex.org/W2136492640","https://openalex.org/W2137482891","https://openalex.org/W2140272554","https://openalex.org/W2141410747","https://openalex.org/W2141452262","https://openalex.org/W2143617373","https://openalex.org/W2143658931","https://openalex.org/W2143839770","https://openalex.org/W2144430600","https://openalex.org/W2146207911","https://openalex.org/W2146528880","https://openalex.org/W2147518722","https://openalex.org/W2149858761","https://openalex.org/W2150515158","https://openalex.org/W2152203766","https://openalex.org/W2153424791","https://openalex.org/W2153833981","https://openalex.org/W2154284135","https://openalex.org/W2154891376","https://openalex.org/W2155131966","https://openalex.org/W2155725346","https://openalex.org/W2155972116","https://openalex.org/W2156132739","https://openalex.org/W2158669467","https://openalex.org/W2159183769","https://openalex.org/W2159728415","https://openalex.org/W2161248563","https://openalex.org/W2161863335","https://openalex.org/W2162246288","https://openalex.org/W2162292699","https://openalex.org/W2162316859","https://openalex.org/W2162523651","https://openalex.org/W2162906882","https://openalex.org/W2163751473","https://openalex.org/W2163771097","https://openalex.org/W2164077501","https://openalex.org/W2165880713","https://openalex.org/W2165894156","https://openalex.org/W2168909179","https://openalex.org/W2169780620","https://openalex.org/W2170199675","https://openalex.org/W2170210082","https://openalex.org/W2170567064","https://openalex.org/W2171256063","https://openalex.org/W2171439874","https://openalex.org/W2189013505","https://openalex.org/W2325799722","https://openalex.org/W2401473574","https://openalex.org/W2413474154","https://openalex.org/W2415347727"],"related_works":["https://openalex.org/W7026570151","https://openalex.org/W2741961179","https://openalex.org/W2512238511","https://openalex.org/W1995988752","https://openalex.org/W7000218741","https://openalex.org/W2325347127","https://openalex.org/W7017749404","https://openalex.org/W1829050250","https://openalex.org/W2933273868","https://openalex.org/W3023735035"],"abstract_inverted_index":{"Tot":[0],"i":[1,6,65,75,121,140,225,275,363],"que":[2,32,40,47,67,126],"la":[3,12,27,53,73,76,91,136,142,162,179,190,236,266,277,285,294,312,353,397],"hipometilaci\u00f3":[4,74,137],"global":[5],"regional":[7],"del":[8,181,406],"DNA":[9,182],"va":[10,87,107,188],"ser":[11],"primera":[13],"alteraci\u00f3":[14],"epigen\u00e8tica":[15],"detectada":[16],"en":[17,21,33,42,79,98,133,138,165,183,199,238,284,297,315,321,327,361,391],"tumors,":[18,139],"les":[19,291,339,371,400],"dificultats":[20],"el":[22,114,122,200,223,302,324,404],"seu":[23],"estudi,":[24],"aix\u00ed":[25,396],"com":[26,187],"manca":[28,143],"de":[29,95,101,116,135,144,161,178,208,221,235,261,276,290,293,334,336,338,355,366,370,384,399],"metodologies":[30,145],"espec\u00edfiques":[31,146],"permetin":[34],"un":[35,316],"an\u00e0lisi":[36,105,241],"detallat,":[37],"han":[38],"fet":[39],"desconeguem":[41],"gran":[43],"mesura":[44],"els":[45,172,248],"efectes":[46],"aquest":[48,253,308,346],"fenomen":[49],"t\u00e9":[50],"per":[51,147],"a":[52,89,130,148,205,345,352],"c\u00e8l\u00b7lula":[54],"tumoral.":[55],"En":[56,83,252,307],"aquesta":[57,150],"tesi":[58],"ens":[59,106,153,211,227,244,349,379],"v\u00e0rem":[60,154],"proposar":[61,155],"realitzar":[62,149],"estudis":[63],"globals":[64,97],"espec\u00edfics":[66],"permetessin":[68],"establir":[69],"possibles":[70],"associacions":[71],"entre":[72,113],"inestabilitat":[77],"gen\u00e8tica":[78],"tumors":[80,102,119,209,328,362],"primaris":[81,120],"humans.":[82,184],"primer":[84],"lloc":[85],"es":[86,186],"dur":[88],"terme":[90],"caracteritzaci\u00f3":[92],"dels":[93,118,167,342],"patrons":[94,298,383],"metilaci\u00f3":[96,180,237,295,337],"una":[99,110,157,175,206,258,330],"s\u00e8rie":[100,207],"colorectals.":[103],"Aquest":[104],"permetre":[108],"observar":[109],"correlaci\u00f3":[111],"positiva":[112],"grau":[115],"desmetilaci\u00f3":[117],"nombre":[123],"d'alteracions":[124],"cromos\u00f2miques":[125],"aquests":[127],"acumulen.":[128],"Per":[129],"continuar":[131],"aprofundint":[132],"l'estudi":[134,288],"donada":[141],"mena":[151],"d'estudis,":[152],"desenvolupar":[156],"nova":[158,191,259],"metodologia":[159,192,260],"d'an\u00e0lisi":[160],"metilaci\u00f3,":[163],"centrada":[164],"l'an\u00e0lisi":[166],"elements":[168,215,231],"repetitius":[169,216],"dispersos":[170],"Alu,":[171],"quals":[173],"contenen":[174],"fracci\u00f3":[176],"important":[177],"Aix\u00ed":[185],"sorgir":[189],"Amplification":[193],"of":[194,271],"UnMethylated":[195,272],"Alu":[196,217,232,264,273],"(AUMA),":[197],"recollida":[198],"segon":[201],"treball.":[202],"L'aplicaci\u00f3":[203],"d'AUMA":[204],"colorectals":[210],"ha":[212,228,245,281,350,380],"perm\u00e8s":[213,229,246,381],"identificar":[214,230,382],"desmetilats":[218],"al":[219,375],"llarg":[220],"tot":[222],"genoma":[224],"tamb\u00e9":[226,257],"amb":[233,329,403],"alteracions":[234,292],"tumors.":[239],"Un":[240],"bioinform\u00e0tic":[242],"paral\u00b7lel":[243],"complementar":[247],"resultats":[249],"obtinguts":[250],"experimentalment.":[251],"treball":[254,304],"hem":[255,268,310],"desenvolupat":[256],"quantificaci\u00f3":[262],"d'elements":[263],"desmetilats,":[265],"qual":[267,278,325],"anomenat":[269],"Quantification":[270],"(QUMA)":[274],"no":[279],"hi":[280],"cap":[282],"precedent":[283],"literatura.":[286],"De":[287],"d'una":[289],"detectades":[296],"AUMA":[299],"n'ha":[300],"sorgit":[301],"tercer":[303],"d'aquesta":[305],"tesi.":[306],"cas":[309],"fixat":[311],"nostra":[313],"atenci\u00f3":[314],"element":[317,347],"repetitiu":[318],"MIR":[319,348],"desmetilat":[320],"teixit":[322],"normal,":[323],"s'hipermetila":[326],"elevada":[331],"freq\u00fc\u00e8ncia.":[332],"L'estudi":[333],"l'estat":[335],"illes":[340,358],"CpG":[341,359],"gens":[343,378],"adjacents":[344],"condu\u00eft":[351],"identificaci\u00f3":[354],"8":[356],"noves":[357],"hipermetilades":[360],"l\u00ednies":[364],"cel\u00b7lulars":[365],"c\u00e0ncer":[367],"colorectal.":[368],"L'an\u00e0lisi":[369],"modificacions":[372],"d'histones":[373],"associades":[374],"silenciament":[376],"d'aquests":[377],"cromatina":[385],"molt":[386],"semblants":[387],"als":[388],"descoberts":[389],"recentment":[390],"c\u00e8l\u00b7lules":[392,401],"mare":[393,402],"embrion\u00e0ries,":[394],"connectant":[395],"biologia":[398],"desenvolupament":[405],"c\u00e0ncer.":[407]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}