{"id":"https://openalex.org/W1578737646","doi":"https://doi.org/10.1016/s0021-9258(17)31562-4","title":"Mutational analysis of proprotein processing, subunit association, and shedding of the LAR transmembrane protein tyrosine phosphatase.","display_name":"Mutational analysis of proprotein processing, subunit association, and shedding of the LAR transmembrane protein tyrosine phosphatase.","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W1578737646","doi":"https://doi.org/10.1016/s0021-9258(17)31562-4","mag":"1578737646","pmid":"https://pubmed.ncbi.nlm.nih.gov/8089133"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)31562-4","doi":"https://doi.org/10.1016/s0021-9258(17)31562-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31562-4","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31562-4","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)31562-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041567201","display_name":"Carles Serra\u2010Pages","orcid":"https://orcid.org/0000-0001-9015-2494","observed_orcids":["https://orcid.org/0000-0001-9015-2494"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Serra-Pages","raw_affiliation_strings":["Departments of $Medicine. l!Biolopical Chemistry and Molecular Pharmacology, and IJ'athology, Harvard Medical School, Boston, Massachusetts-02115","From the $Llivision of Thmor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of $Medicine. l!Biolopical Chemistry and Molecular Pharmacology, and IJ'athology, Harvard Medical School, Boston, Massachusetts-02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the $Llivision of Thmor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103399445","display_name":"Haruo Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Saito","raw_affiliation_strings":["Departments of $Medicine. l!Biolopical Chemistry and Molecular Pharmacology, and IJ'athology, Harvard Medical School, Boston, Massachusetts-02115","From the $Llivision of Thmor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of $Medicine. l!Biolopical Chemistry and Molecular Pharmacology, and IJ'athology, Harvard Medical School, Boston, Massachusetts-02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the $Llivision of Thmor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044564994","display_name":"Michel Streuli","orcid":"https://orcid.org/0000-0001-8566-4065","observed_orcids":["https://orcid.org/0000-0001-8566-4065"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Streuli","raw_affiliation_strings":["Llivision of Thmor Immunology , Dana Farber Cancer Institute , Boston , Massachusetts 02115","Departments of $Medicine. l!Biolopical Chemistry and Molecular Pharmacology, and IJ'athology, Harvard Medical School, Boston, Massachusetts-02115","From the $Llivision of Thmor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Llivision of Thmor Immunology , Dana Farber Cancer Institute , Boston , Massachusetts 02115","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Departments of $Medicine. l!Biolopical Chemistry and Molecular Pharmacology, and IJ'athology, Harvard Medical School, Boston, Massachusetts-02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the $Llivision of Thmor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.1209,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.92763915,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"269","issue":"38","first_page":"23632","last_page":"23641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proprotein-processing","display_name":"proprotein processing","score":0.8159999847412109},{"id":"https://openalex.org/keywords/protein-shedding","display_name":"protein shedding","score":0.6669999957084656},{"id":"https://openalex.org/keywords/subunit-association","display_name":"subunit association","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ig-like-domains","display_name":"immunoglobulin-like domains","score":0.8379999995231628},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.6832900643348694},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6286734938621521},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6284138560295105},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5840135812759399},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5020010471343994},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.41063880920410156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41009584069252014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36032968759536743},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3369380235671997},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2729666233062744},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12933441996574402},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09473422169685364}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010703","descriptor_name":"Phorbol Esters","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)31562-4","doi":"https://doi.org/10.1016/s0021-9258(17)31562-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31562-4","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31562-4","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8089133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8089133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)31562-4","doi":"https://doi.org/10.1016/s0021-9258(17)31562-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31562-4","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31562-4","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3019228553","display_name":null,"funder_award_id":"CA-55547","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G923724864","display_name":"SIGNAL TRANSDUCTION VIA PROTEIN TYROSINE PHOSPHATASES","funder_award_id":"R01CA055547","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1578737646.pdf","grobid_xml":"https://content.openalex.org/works/W1578737646.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W93389695","https://openalex.org/W136427227","https://openalex.org/W246090348","https://openalex.org/W263790276","https://openalex.org/W1215858103","https://openalex.org/W1483233569","https://openalex.org/W1487612553","https://openalex.org/W1493485729","https://openalex.org/W1513543887","https://openalex.org/W1527044047","https://openalex.org/W1540558042","https://openalex.org/W1547367445","https://openalex.org/W1550868339","https://openalex.org/W1553375567","https://openalex.org/W1563019217","https://openalex.org/W1578843331","https://openalex.org/W1580902493","https://openalex.org/W1585140570","https://openalex.org/W1608455044","https://openalex.org/W1674557579","https://openalex.org/W1747312855","https://openalex.org/W1749453950","https://openalex.org/W1750913658","https://openalex.org/W1771535640","https://openalex.org/W1919586931","https://openalex.org/W1928515771","https://openalex.org/W1950041808","https://openalex.org/W1964764518","https://openalex.org/W1979993280","https://openalex.org/W1984247755","https://openalex.org/W1992628345","https://openalex.org/W1995528115","https://openalex.org/W2001564505","https://openalex.org/W2004200027","https://openalex.org/W2012514869","https://openalex.org/W2014397920","https://openalex.org/W2016571619","https://openalex.org/W2031209863","https://openalex.org/W2037196975","https://openalex.org/W2038312038","https://openalex.org/W2040611554","https://openalex.org/W2042248645","https://openalex.org/W2046741212","https://openalex.org/W2047671583","https://openalex.org/W2053544216","https://openalex.org/W2058148903","https://openalex.org/W2059452371","https://openalex.org/W2062902938","https://openalex.org/W2064910445","https://openalex.org/W2065322825","https://openalex.org/W2067705633","https://openalex.org/W2070591676","https://openalex.org/W2070925035","https://openalex.org/W2071993841","https://openalex.org/W2074838372","https://openalex.org/W2079096224","https://openalex.org/W2083800765","https://openalex.org/W2084171672","https://openalex.org/W2085634797","https://openalex.org/W2096372770","https://openalex.org/W2101862196","https://openalex.org/W2109202813","https://openalex.org/W2115701574","https://openalex.org/W2121070193","https://openalex.org/W2126658684","https://openalex.org/W2127227377","https://openalex.org/W2127775544","https://openalex.org/W2130708019","https://openalex.org/W2153343124","https://openalex.org/W2160421139","https://openalex.org/W2169027329","https://openalex.org/W2172937773","https://openalex.org/W2182204751","https://openalex.org/W2410395399","https://openalex.org/W2414903038","https://openalex.org/W4236478138"],"related_works":["https://openalex.org/W246090348","https://openalex.org/W4388225271","https://openalex.org/W7098004185","https://openalex.org/W2414903038","https://openalex.org/W2167059178","https://openalex.org/W136427227","https://openalex.org/W2022565296","https://openalex.org/W1575383536","https://openalex.org/W2041189807","https://openalex.org/W1711354540"],"abstract_inverted_index":{"The":[0,25,58],"LAR":[1,59,77,84,135,152,155],"transmembrane":[2,50,176],"protein":[3],"tyrosine":[4],"phosphatase":[5],"(PTPase)":[6],"is":[7,62,157],"expressed":[8],"on":[9],"the":[10,31,35,42,49,53,65,95,104,109,127,171,175],"cell":[11,66],"surface":[12],"as":[13],"a":[14,23,46,73,120,161,167],"complex":[15],"of":[16,30,97,101,163],"two":[17,54,118],"noncovalently":[18],"associated":[19],"subunits":[20],"derived":[21],"from":[22,64],"proprotein.":[24],"150-kDa":[26],"E-subunit":[27],"contains":[28,45],"most":[29],"extracellular":[32,60],"region,":[33],"including":[34],"immunoglobulin-like":[36],"and":[37,52,89,107,123],"fibronectin":[38],"type-III-like":[39],"domains,":[40],"whereas":[41],"85-kDa":[43],"P-subunit":[44,110,172],"short":[47],"ectodomain,":[48],"peptide,":[51],"intracellular":[55],"PTPase":[56,78],"domains.":[57],"region":[61],"released":[63],"surface,":[67],"suggesting":[68],"that":[69,130,146],"shedding":[70,90,156],"may":[71],"be":[72,160],"mechanism":[74],"to":[75,126,159],"regulate":[76],"function.":[79],"Functional":[80],"regions":[81],"necessary":[82],"for":[83,133],"proprotein":[85,136],"processing,":[86],"subunit":[87,153],"association,":[88],"were":[91,116,143],"determined":[92],"by":[93],"analyzing":[94],"effect":[96],"amino":[98,113,140],"acid":[99,114,141],"substitutions":[100],"residues":[102,115,142],"surrounding":[103],"cleavage":[105,128,165],"site":[106,169],"scanning":[108],"ectodomain.":[111],"Three":[112],"identified,":[117],"within":[119,170],"penta-arginine":[121],"sequence":[122],"one":[124],"C-terminal":[125],"site,":[129],"are":[131],"essential":[132,149],"efficient":[134],"cleavage.":[137],"Several":[138],"noncontiguous":[139],"also":[144],"identified":[145],"play":[147],"an":[148],"role":[150],"in":[151],"association.":[154],"shown":[158],"consequence":[162],"proteolytic":[164],"at":[166],"second":[168],"ectodomain":[173],"near":[174],"peptide.":[177]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}