{"id":"https://openalex.org/W1578720301","doi":null,"title":"ROLE OF THE REACTIVE OXYGEN SPECIES PEROXYNITRITE IN TRAUMATIC BRAIN INJURY","display_name":"ROLE OF THE REACTIVE OXYGEN SPECIES PEROXYNITRITE IN TRAUMATIC BRAIN INJURY","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1578720301","mag":"1578720301"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1670","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/667","pdf_url":"https://uknowledge.uky.edu/gradschool_diss/667","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/gradschool_diss/667","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012048939","display_name":"Ying Deng\u2010Bryant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ying Deng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012048939"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.09499158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.996999979019165},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.8370000123977661},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8880000114440918},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6100000143051147},{"id":"https://openalex.org/keywords/tempol","display_name":"tempol","score":0.7860000133514404},{"id":"https://openalex.org/keywords/calpain-mediated-proteolysis","display_name":"calpain-mediated proteolysis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/protein-nitration","display_name":"protein nitration","score":0.7900000214576721},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7979999780654907},{"id":"https://openalex.org/keywords/secondary-cell-death","display_name":"secondary cell death","score":0.6970000267028809},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.7179999947547913},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.8644137382507324},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6235300302505493},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.5795698165893555},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4627886116504669},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4274408221244812},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4089137315750122},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3422028422355652},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.24352982640266418},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19789353013038635},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1430153250694275},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1670","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/667","pdf_url":"https://uknowledge.uky.edu/gradschool_diss/667","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},{"id":"mag:1578720301","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1670&context=gradschool_diss","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1670","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/667","pdf_url":"https://uknowledge.uky.edu/gradschool_diss/667","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1578720301.pdf","grobid_xml":"https://content.openalex.org/works/W1578720301.grobid-xml"},"referenced_works_count":221,"referenced_works":["https://openalex.org/W17855639","https://openalex.org/W18740259","https://openalex.org/W28619635","https://openalex.org/W70578846","https://openalex.org/W85036947","https://openalex.org/W103126585","https://openalex.org/W115497294","https://openalex.org/W118575355","https://openalex.org/W150246076","https://openalex.org/W263652742","https://openalex.org/W302992813","https://openalex.org/W1494460016","https://openalex.org/W1502536868","https://openalex.org/W1503545438","https://openalex.org/W1505685265","https://openalex.org/W1507112934","https://openalex.org/W1509127316","https://openalex.org/W1533321987","https://openalex.org/W1566636169","https://openalex.org/W1576914487","https://openalex.org/W1580653784","https://openalex.org/W1583699416","https://openalex.org/W1587360940","https://openalex.org/W1592323860","https://openalex.org/W1598606175","https://openalex.org/W1603434131","https://openalex.org/W1626297236","https://openalex.org/W1758246291","https://openalex.org/W1821918060","https://openalex.org/W1835993868","https://openalex.org/W1958560494","https://openalex.org/W1963778474","https://openalex.org/W1964826110","https://openalex.org/W1966571561","https://openalex.org/W1967021011","https://openalex.org/W1967315269","https://openalex.org/W1969023471","https://openalex.org/W1970110059","https://openalex.org/W1971216963","https://openalex.org/W1973671786","https://openalex.org/W1973831188","https://openalex.org/W1974335287","https://openalex.org/W1976710020","https://openalex.org/W1977328014","https://openalex.org/W1978890792","https://openalex.org/W1978910437","https://openalex.org/W1980818239","https://openalex.org/W1980933002","https://openalex.org/W1981023844","https://openalex.org/W1981082943","https://openalex.org/W1982877190","https://openalex.org/W1983030859","https://openalex.org/W1983455034","https://openalex.org/W1983751530","https://openalex.org/W1984583542","https://openalex.org/W1984635194","https://openalex.org/W1984732054","https://openalex.org/W1986568749","https://openalex.org/W1986586932","https://openalex.org/W1987999833","https://openalex.org/W1988240216","https://openalex.org/W1988414146","https://openalex.org/W1989392302","https://openalex.org/W1990956265","https://openalex.org/W1990994673","https://openalex.org/W1992282049","https://openalex.org/W1992604303","https://openalex.org/W1992890638","https://openalex.org/W1993128970","https://openalex.org/W1993426725","https://openalex.org/W1994455025","https://openalex.org/W1998689433","https://openalex.org/W1998919607","https://openalex.org/W1999649376","https://openalex.org/W1999916601","https://openalex.org/W2000243807","https://openalex.org/W2001032753","https://openalex.org/W2001399124","https://openalex.org/W2002984543","https://openalex.org/W2003633558","https://openalex.org/W2003689183","https://openalex.org/W2005374900","https://openalex.org/W2006574262","https://openalex.org/W2007354513","https://openalex.org/W2007922486","https://openalex.org/W2008186920","https://openalex.org/W2008259954","https://openalex.org/W2008712625","https://openalex.org/W2009032298","https://openalex.org/W2010814445","https://openalex.org/W2012485229","https://openalex.org/W2013898334","https://openalex.org/W2016293448","https://openalex.org/W2017136647","https://openalex.org/W2018465654","https://openalex.org/W2018869064","https://openalex.org/W2018888883","https://openalex.org/W2020565401","https://openalex.org/W2020997228","https://openalex.org/W2021191189","https://openalex.org/W2021812228","https://openalex.org/W2022458326","https://openalex.org/W2023400600","https://openalex.org/W2023468397","https://openalex.org/W2024746592","https://openalex.org/W2024862570","https://openalex.org/W2026747237","https://openalex.org/W2026779396","https://openalex.org/W2027833389","https://openalex.org/W2028531025","https://openalex.org/W2028689205","https://openalex.org/W2028790828","https://openalex.org/W2029508003","https://openalex.org/W2029545906","https://openalex.org/W2030496404","https://openalex.org/W2030582963","https://openalex.org/W2031244297","https://openalex.org/W2031582116","https://openalex.org/W2033365056","https://openalex.org/W2033624750","https://openalex.org/W2034679108","https://openalex.org/W2034728684","https://openalex.org/W2036127346","https://openalex.org/W2036599441","https://openalex.org/W2041254205","https://openalex.org/W2041976200","https://openalex.org/W2043948461","https://openalex.org/W2045777403","https://openalex.org/W2045925277","https://openalex.org/W2046110964","https://openalex.org/W2046714588","https://openalex.org/W2049232502","https://openalex.org/W2049875635","https://openalex.org/W2051010051","https://openalex.org/W2051600991","https://openalex.org/W2054875031","https://openalex.org/W2055257936","https://openalex.org/W2055269961","https://openalex.org/W2056250939","https://openalex.org/W2057520074","https://openalex.org/W2059379142","https://openalex.org/W2059580764","https://openalex.org/W2059982861","https://openalex.org/W2061144992","https://openalex.org/W2061314122","https://openalex.org/W2061792582","https://openalex.org/W2062253540","https://openalex.org/W2062322625","https://openalex.org/W2062341643","https://openalex.org/W2062483277","https://openalex.org/W2064217918","https://openalex.org/W2065459000","https://openalex.org/W2066497363","https://openalex.org/W2066758060","https://openalex.org/W2068725250","https://openalex.org/W2069359956","https://openalex.org/W2070334277","https://openalex.org/W2071550630","https://openalex.org/W2072593376","https://openalex.org/W2073119484","https://openalex.org/W2073591032","https://openalex.org/W2076825885","https://openalex.org/W2077921614","https://openalex.org/W2078603857","https://openalex.org/W2078929761","https://openalex.org/W2079388247","https://openalex.org/W2079849987","https://openalex.org/W2080695699","https://openalex.org/W2082376575","https://openalex.org/W2083313397","https://openalex.org/W2083952664","https://openalex.org/W2084523293","https://openalex.org/W2085366528","https://openalex.org/W2085396235","https://openalex.org/W2085414692","https://openalex.org/W2085691746","https://openalex.org/W2086070682","https://openalex.org/W2087916050","https://openalex.org/W2090544950","https://openalex.org/W2090704317","https://openalex.org/W2091154394","https://openalex.org/W2091380103","https://openalex.org/W2093076184","https://openalex.org/W2093163969","https://openalex.org/W2093387485","https://openalex.org/W2093489232","https://openalex.org/W2094093148","https://openalex.org/W2095999492","https://openalex.org/W2101577668","https://openalex.org/W2101955048","https://openalex.org/W2103105379","https://openalex.org/W2104730217","https://openalex.org/W2109893157","https://openalex.org/W2111066165","https://openalex.org/W2113807212","https://openalex.org/W2117909173","https://openalex.org/W2118581975","https://openalex.org/W2123217554","https://openalex.org/W2124634545","https://openalex.org/W2126473492","https://openalex.org/W2127221621","https://openalex.org/W2128727709","https://openalex.org/W2131437696","https://openalex.org/W2135380777","https://openalex.org/W2135781323","https://openalex.org/W2141258007","https://openalex.org/W2141950542","https://openalex.org/W2142836104","https://openalex.org/W2143046500","https://openalex.org/W2148464749","https://openalex.org/W2154127217","https://openalex.org/W2171154502","https://openalex.org/W2172495278","https://openalex.org/W2172527495","https://openalex.org/W2173429194","https://openalex.org/W2179702494","https://openalex.org/W2271272206","https://openalex.org/W2344992701","https://openalex.org/W2395675726","https://openalex.org/W2410075643","https://openalex.org/W4234012592"],"related_works":["https://openalex.org/W1982877190","https://openalex.org/W1558049762","https://openalex.org/W1992890638","https://openalex.org/W7096097546","https://openalex.org/W1494460016","https://openalex.org/W2509524200","https://openalex.org/W2049983438","https://openalex.org/W242728265","https://openalex.org/W2602999961","https://openalex.org/W7132986225"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species":[2],"(ROS)":[3],"is":[4,10,31,70,189,199,210,228,287,311],"cytotoxic":[5],"to":[6,12,14,52,75,106,131,192,201,232,313,328],"the":[7,32,55,71,85,115,222,253,274,283,288,296,308],"cell":[8,16,77,271,293],"and":[9,39,42,147,157,165,178,195,264,278],"known":[11],"contribute":[13],"secondary":[15,292],"death":[17,294],"following":[18,91],"primary":[19],"traumatic":[20],"brain":[21],"injury":[22,317],"(TBI).":[23],"We":[24],"described":[25],"in":[26,291,295,338],"our":[27,108,236],"study":[28,82,105,277,280],"that":[29,63,67,172,187,207,285],"PN":[30,286,321],"main":[33],"mediator":[34,290],"for":[35,97,128,162],"both":[36],"lipid":[37],"peroxidation":[38],"protein":[40,140],"nitration,":[41],"occurred":[43],"almost":[44],"immediately":[45],"after":[46],"injury.":[47],"As":[48],"a":[49,103,118,216,242,266,342],"downstream":[50,316],"factor":[51],"oxidative":[53,134,166,176,197,305],"damage,":[54,177],"peak":[56],"of":[57,64,87,95,111,117,123,144,153,219,224,269,303,344],"Ca2+-dependent,":[58],"calpainmediated":[59,208],"cytoskeletal":[60],"proteolysis":[61,69,209],"preceded":[62],"neurodegeneration,":[65],"suggesting":[66],"calpain-mediated":[68],"common":[72],"pathway":[73],"leading":[74],"neuronal":[76,270],"death.":[78,272],"The":[79],"time":[80,275],"course":[81,276],"clearly":[83],"elucidated":[84],"interrelationship":[86],"these":[88],"cellular":[89],"changes":[90],"TBI,":[92],"provided":[93],"window":[94],"opportunity":[96],"pharmacological":[98,104,279],"intervention.":[99],"Furthermore,":[100],"we":[101,113,205,249],"conducted":[102],"solidify":[107],"hypothesis.":[109],"First":[110],"all,":[112],"tested":[114],"potency":[116],"membrane":[119,194],"permeable,":[120],"catalytic":[121],"scavenger":[122],"PN-derived":[124],"free":[125],"radicals,":[126],"tempol":[127,173,188,225,240],"its":[129,329],"ability":[130],"antagonize":[132],"PN-induced":[133],"damage.":[135],"Tempol":[136],"successfully":[137],"inhibited":[138],"PNinduced":[139],"nitration":[141],"at":[142,212,260],"dosages":[143],"30,":[145],"100":[146],"300mg/kg.":[148],"Moreover,":[149,301],"early":[150,213],"single":[151,217],"dose":[152,218,238],"300mg/kg":[154],"was":[155],"administered":[156],"isolated":[158],"mitochondria":[159],"were":[160],"examined":[161],"respiratory":[163],"function":[164,181],"damage":[167,198,306],"level.":[168],"Our":[169],"data":[170],"showed":[171,241],"reduced":[174,211],"mitochondrial":[175,180,193,196,202],"maintained":[179],"within":[182],"normal":[183],"limits,":[184],"which":[185],"suggested":[186],"efficiently":[190],"permeable":[191],"essential":[200],"dysfunction.":[203],"Next,":[204],"found":[206],"treatment":[214],"with":[215,252,307],"tempol.":[220],"However,":[221,319],"effect":[223,245],"on":[226,246],"calpain":[227],"short-lived":[229],"possibly":[230],"due":[231,327],"systematic":[233],"elimination.":[234],"In":[235],"multiple":[237,315,345],"study,":[239],"significant":[243,267],"inhibitory":[244],"SBDPs.":[247],"Consequently,":[248],"measured":[250],"neuordegeneration":[251],"de":[254],"Olmos":[255],"aminocupric":[256],"silver":[257],"staining":[258],"method":[259],"7":[261],"days":[262],"post-injury":[263],"detected":[265],"decrease":[268],"Together,":[273],"strongly":[281],"support":[282],"hypothesis":[284],"upstream":[289],"CCI":[297],"TBI":[298],"mouse":[299],"model.":[300],"inhibition":[302],"PN-mediated":[304],"antioxidant,":[309],"tempol,":[310],"able":[312],"attenuate":[314],"mechanisms.":[318],"targeting":[320],"alone":[322],"may":[323,335],"be":[324,336],"clinically":[325],"impractical":[326],"limited":[330],"therapeutic":[331,346],"window.":[332],"This":[333],"limitation":[334],"overcome":[337],"future":[339],"studies":[340],"by":[341],"combination":[343],"strategies.":[347]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
