{"id":"https://openalex.org/W1578683055","doi":"https://doi.org/10.1111/j.1476-5381.2011.01580.x","title":"Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis","display_name":"Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis","publication_year":2011,"publication_date":"2011-07-14","ids":{"openalex":"https://openalex.org/W1578683055","doi":"https://doi.org/10.1111/j.1476-5381.2011.01580.x","mag":"1578683055","pmid":"https://pubmed.ncbi.nlm.nih.gov/21740407","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3372722"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.2011.01580.x","doi":"https://doi.org/10.1111/j.1476-5381.2011.01580.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.2011.01580.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.2011.01580.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.2011.01580.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063215068","display_name":"Julie Massart","orcid":"https://orcid.org/0000-0001-8213-5459","observed_orcids":["https://orcid.org/0000-0001-8213-5459"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J Massart","raw_affiliation_strings":["INSERM, U991, Universit\u00e9 de Rennes 1, Rennes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U991, Universit\u00e9 de Rennes 1, Rennes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077219562","display_name":"MA Robin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"MA Robin","raw_affiliation_strings":["INSERM, U991, Universite\u0301 de Rennes 1, Rennes, France","INSERM, U991, Universit\u00e9 de Rennes 1, Rennes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U991, Universite\u0301 de Rennes 1, Rennes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"]},{"raw_affiliation_string":"INSERM, U991, Universit\u00e9 de Rennes 1, Rennes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078847591","display_name":"Fanny Noury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405285560","display_name":"PRISM","ror":"https://ror.org/05nvd9v97","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4405285560","https://openalex.org/I49451733","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F Noury","raw_affiliation_strings":["INSERM, U642, Universite\u0301 de Rennes 1, Rennes, France","PRISM, IFR140, Universite\u0301 de Rennes 1, Biogenouest, Rennes, France","INSERM, U642, Universit\u00e9 de Rennes 1, Rennes, France","PRISM, IFR140, Universit\u00e9 de Rennes 1, Biogenouest, Rennes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U642, Universite\u0301 de Rennes 1, Rennes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"]},{"raw_affiliation_string":"PRISM, IFR140, Universite\u0301 de Rennes 1, Biogenouest, Rennes, France","institution_ids":["https://openalex.org/I4405285560","https://openalex.org/I56067802"]},{"raw_affiliation_string":"INSERM, U642, Universit\u00e9 de Rennes 1, Rennes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"]},{"raw_affiliation_string":"PRISM, IFR140, Universit\u00e9 de Rennes 1, Biogenouest, Rennes, France","institution_ids":["https://openalex.org/I4405285560","https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010733094","display_name":"Alain Fautrel","orcid":"https://orcid.org/0000-0002-3449-0779","observed_orcids":["https://orcid.org/0000-0002-3449-0779"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Fautrel","raw_affiliation_strings":["INSERM, U991, Universite\u0301 de Rennes 1, Rennes, France","Plate-forme d'Histopathologie, IFR 140, Rennes, France","INSERM, U991, Universit\u00e9 de Rennes 1, Rennes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U991, Universite\u0301 de Rennes 1, Rennes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"]},{"raw_affiliation_string":"Plate-forme d'Histopathologie, IFR 140, Rennes, France","institution_ids":[]},{"raw_affiliation_string":"INSERM, U991, Universit\u00e9 de Rennes 1, Rennes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109251124","display_name":"Philippe Lett\u00e9ron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Lett\u00e9ron","raw_affiliation_strings":["INSERM, U773, Centre de Recherche Biome\u0301dicale Bichat Beaujon, UFR de Me\u0301decine Paris 7 \u2013 Denis Diderot, IFR02 Claude Bernard, Paris, France","INSERM, U773, Centre de Recherche Biom\u00e9dicale Bichat Beaujon, UFR de M\u00e9decine Paris 7 \u2013 Denis Diderot, IFR02 Claude Bernard, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U773, Centre de Recherche Biome\u0301dicale Bichat Beaujon, UFR de Me\u0301decine Paris 7 \u2013 Denis Diderot, IFR02 Claude Bernard, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154366"]},{"raw_affiliation_string":"INSERM, U773, Centre de Recherche Biom\u00e9dicale Bichat Beaujon, UFR de M\u00e9decine Paris 7 \u2013 Denis Diderot, IFR02 Claude Bernard, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013835342","display_name":"Andr\u00e9 Bado","orcid":"https://orcid.org/0000-0002-8007-1460","observed_orcids":["https://orcid.org/0000-0002-8007-1460"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Bado","raw_affiliation_strings":["INSERM, U773, Centre de Recherche Biome\u0301dicale Bichat Beaujon, UFR de Me\u0301decine Paris 7 \u2013 Denis Diderot, IFR02 Claude Bernard, Paris, France","INSERM, U773, Centre de Recherche Biom\u00e9dicale Bichat Beaujon, UFR de M\u00e9decine Paris 7 \u2013 Denis Diderot, IFR02 Claude Bernard, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U773, Centre de Recherche Biome\u0301dicale Bichat Beaujon, UFR de Me\u0301decine Paris 7 \u2013 Denis Diderot, IFR02 Claude Bernard, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154366"]},{"raw_affiliation_string":"INSERM, U773, Centre de Recherche Biom\u00e9dicale Bichat Beaujon, UFR de M\u00e9decine Paris 7 \u2013 Denis Diderot, IFR02 Claude Bernard, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087455794","display_name":"Pierre\u2010Antoine Eliat","orcid":"https://orcid.org/0000-0002-8082-4477","observed_orcids":["https://orcid.org/0000-0002-8082-4477"]},"institutions":[{"id":"https://openalex.org/I4405285560","display_name":"PRISM","ror":"https://ror.org/05nvd9v97","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4405285560","https://openalex.org/I49451733","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"PA Eliat","raw_affiliation_strings":["PRISM, IFR140, Universite\u0301 de Rennes 1, Biogenouest, Rennes, France","PRISM, IFR140, Universit\u00e9 de Rennes 1, Biogenouest, Rennes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PRISM, IFR140, Universite\u0301 de Rennes 1, Biogenouest, Rennes, France","institution_ids":["https://openalex.org/I4405285560","https://openalex.org/I56067802"]},{"raw_affiliation_string":"PRISM, IFR140, Universit\u00e9 de Rennes 1, Biogenouest, Rennes, France","institution_ids":["https://openalex.org/I4405285560","https://openalex.org/I56067802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021292416","display_name":"Bernard Fromenty","orcid":"https://orcid.org/0000-0003-2994-5465","observed_orcids":["https://orcid.org/0000-0003-2994-5465"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"B Fromenty","raw_affiliation_strings":["INSERM, U991, Universite\u0301 de Rennes 1, Rennes, France","INSERM, U991, Universit\u00e9 de Rennes 1, Rennes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U991, Universite\u0301 de Rennes 1, Rennes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"]},{"raw_affiliation_string":"INSERM, U991, Universit\u00e9 de Rennes 1, Rennes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021292416"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.6749,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.83561484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"165","issue":"5","first_page":"1361","last_page":"1374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pentoxifylline","display_name":"pentoxifylline","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/intestinal-glucose-uptake","display_name":"intestinal glucose absorption","score":0.7680000066757202},{"id":"https://openalex.org/keywords/glut2","display_name":"GLUT2","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hepatic-lipogenesis","display_name":"hepatic lipogenesis","score":0.875},{"id":"https://openalex.org/keywords/chrebp","display_name":"ChREBP","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.8080000281333923},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/postprandial-hyperglycemia","display_name":"postprandial hyperglycemia","score":0.8659999966621399},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7200000286102295},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5299999713897705},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2780404050","wikidata":"https://www.wikidata.org/wiki/Q416331","display_name":"Pentoxifylline","level":2,"score":0.9639807939529419},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.82117760181427},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8068580627441406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5799106955528259},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.5790208578109741},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5715564489364624},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.45737385749816895},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.22420620918273926},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000637","descriptor_name":"Transaminases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010431","descriptor_name":"Pentoxifylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050155","descriptor_name":"Lipogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050155","descriptor_name":"Lipogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051269","descriptor_name":"Sodium-Glucose Transporter 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051269","descriptor_name":"Sodium-Glucose Transporter 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051273","descriptor_name":"Glucose Transporter Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051273","descriptor_name":"Glucose Transporter Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051778","descriptor_name":"Basic Helix-Loop-Helix Leucine Zipper Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1476-5381.2011.01580.x","doi":"https://doi.org/10.1111/j.1476-5381.2011.01580.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.2011.01580.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.2011.01580.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3481479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3372722","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21740407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21740407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3372722","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3372722/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-00740120v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00740120","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Pharmacology, 2012, 165 (5), pp.1361-74. &#x27E8;10.1111/j.1476-5381.2011.01580.x&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.2011.01580.x","doi":"https://doi.org/10.1111/j.1476-5381.2011.01580.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.2011.01580.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.2011.01580.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1578683055.pdf","grobid_xml":"https://content.openalex.org/works/W1578683055.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W129443019","https://openalex.org/W1964624702","https://openalex.org/W1967275921","https://openalex.org/W1967286688","https://openalex.org/W1969870510","https://openalex.org/W1978045299","https://openalex.org/W1978881179","https://openalex.org/W1979340145","https://openalex.org/W1981248031","https://openalex.org/W1983310681","https://openalex.org/W1988736864","https://openalex.org/W1991898875","https://openalex.org/W1993113139","https://openalex.org/W1993266217","https://openalex.org/W1995375315","https://openalex.org/W1997317586","https://openalex.org/W2001689124","https://openalex.org/W2004406516","https://openalex.org/W2006123203","https://openalex.org/W2007022610","https://openalex.org/W2008697716","https://openalex.org/W2010746044","https://openalex.org/W2019472416","https://openalex.org/W2027588196","https://openalex.org/W2029739963","https://openalex.org/W2033957878","https://openalex.org/W2044842369","https://openalex.org/W2044921978","https://openalex.org/W2047257800","https://openalex.org/W2052589912","https://openalex.org/W2053285232","https://openalex.org/W2053500970","https://openalex.org/W2054900249","https://openalex.org/W2058027749","https://openalex.org/W2061958681","https://openalex.org/W2068012816","https://openalex.org/W2070036336","https://openalex.org/W2073438109","https://openalex.org/W2074503802","https://openalex.org/W2074662558","https://openalex.org/W2074889340","https://openalex.org/W2077692978","https://openalex.org/W2089983024","https://openalex.org/W2093065055","https://openalex.org/W2108188316","https://openalex.org/W2109132990","https://openalex.org/W2112291880","https://openalex.org/W2114472618","https://openalex.org/W2119615736","https://openalex.org/W2121836743","https://openalex.org/W2131553564","https://openalex.org/W2152931916","https://openalex.org/W2154505613","https://openalex.org/W2161533269","https://openalex.org/W2163544133","https://openalex.org/W2983514795","https://openalex.org/W2994464679","https://openalex.org/W4247235201","https://openalex.org/W4324262929"],"related_works":["https://openalex.org/W2143037319","https://openalex.org/W2510943652","https://openalex.org/W4292550299","https://openalex.org/W7120329258","https://openalex.org/W4380202141","https://openalex.org/W6991555224","https://openalex.org/W2503308256","https://openalex.org/W2022394079","https://openalex.org/W2349953260","https://openalex.org/W2059636361"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,214],"PURPOSE:":[2],"Pentoxifylline":[3,36,216],"is":[4],"in":[5,24,48,69,101,114,123,130,156,168,184,197,210,220,244],"clinical":[6],"trials":[7],"for":[8,42],"non-alcoholic":[9],"fatty":[10,109,218,242],"liver":[11,99,110,121,219,243],"disease":[12],"and":[13,17,30,50,59,77,87,111,208,231],"diabetic":[14],"nephropathy.":[15],"Metabolic":[16],"hepatic":[18,234],"effects":[19],"of":[20,28,94,145,161,174,192,205,233],"pentoxifylline":[21,95,107,183,202,239],"were":[22,62,71,82],"assessed":[23,72],"a":[25],"murine":[26],"model":[27],"obesity":[29],"type":[31],"2":[32,164],"diabetes.":[33],"EXPERIMENTAL":[34],"APPROACH:":[35],"(100":[37],"mg\u00b7kg(-1)":[38],"\u00b7day(-1))":[39],"was":[40,128,166,195],"administered":[41],"4":[43],"days":[44,93],"or":[45],"3":[46,105],"weeks":[47],"lean":[49,124],"obese/diabetic":[51],"ob/ob":[52,102,115,135,199,211,221],"mice.":[53,103,125,158,171,189,200],"Plasma":[54,126],"lipids,":[55],"glucose,":[56],"other":[57],"metabolites":[58],"relevant":[60],"enzymes":[61,194],"measured":[63],"by":[64,78],"standard":[65],"assays.":[66],"Hepatic":[67,80,172,190],"lipids":[68,100],"vivo":[70],"with":[73,85,138,238,247],"magnetic":[74],"resonance":[75],"spectroscopy":[76],"histology.":[79],"extracts":[81],"also":[83],"analysed":[84],"RT-PCR":[86],"Western":[88],"blotting.":[89],"KEY":[90],"RESULTS:":[91],"Four":[92],"treatment":[96,237],"slightly":[97],"increased":[98,153,167,181,228],"After":[104],"weeks,":[106],"exacerbated":[108,217],"plasma":[112],"transaminases":[113],"mice":[116,136,222],"but":[117,132,186],"did":[118],"not":[119,133,187],"induce":[120],"steatosis":[122],"glucose":[127,148,152,162,226],"highest":[129,196],"fed,":[131],"fasted,":[134],"treated":[137],"pentoxifylline.":[139],"During":[140],"the":[141],"first":[142],"10":[143],"min":[144],"an":[146],"oral":[147],"tolerance":[149],"test,":[150],"blood":[151],"more":[154],"rapidly":[155],"pentoxifylline-treated":[157,169,198],"Jejunal":[159],"expression":[160,191],"transporter":[163],"isoform":[165],"obese":[170],"activity":[173],"carbohydrate":[175],"response":[176],"element":[177],"binding":[178],"protein":[179],"(ChREBP)":[180],"after":[182],"ob/ob,":[185],"lean,":[188],"lipogenic":[193],"However,":[201],"reduced":[203],"markers":[204],"oxidative":[206],"stress":[207],"inflammation":[209],"liver.":[212],"CONCLUSION":[213],"IMPLICATIONS:":[215],"through":[223],"enhanced":[224],"intestinal":[225],"absorption,":[227],"postprandial":[229],"glycaemia":[230],"activation":[232],"lipogenesis.":[235],"Long-term":[236],"could":[240],"worsen":[241],"some":[245],"patients":[246],"pre-existing":[248],"hyperglycaemia.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
