{"id":"https://openalex.org/W157842328","doi":null,"title":"Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions","display_name":"Expression and regulation of liver regeneration associated protein ALR under patho-physiological conditions","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W157842328","mag":"157842328"},"language":"en","primary_location":{"id":"pmh:oai:epub.uni-regensburg.de:13099","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/13099/1/Dissertation_R_Dayoub_Beidseitig.pdf","pdf_url":"https://epub.uni-regensburg.de/13099/1/Dissertation_R_Dayoub_Beidseitig.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://epub.uni-regensburg.de/13099/1/Dissertation_R_Dayoub_Beidseitig.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059691983","display_name":"Rania Dayoub","orcid":"https://orcid.org/0000-0001-5848-5571","observed_orcids":["https://orcid.org/0000-0001-5848-5571"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rania Dayoub","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5848-5571","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059691983"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/augmenter-of-liver-regeneration","display_name":"augmenter of liver regeneration","score":0.8169999718666077},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.8669999837875366},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.6769999861717224},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.699999988079071},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/foxa2","display_name":"FOXA2","score":0.746999979019165},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8930000066757202},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8100000023841858},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8119999766349792},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9190000295639038},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.9369999766349792},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.6757693886756897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6052819490432739},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5710292458534241},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5411931276321411},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.474604070186615},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4579554796218872},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4455554485321045},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.43571439385414124},{"id":"https://openalex.org/C148397407","wikidata":"https://www.wikidata.org/wiki/Q21107432","display_name":"FOXA2","level":4,"score":0.4248332679271698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39362287521362305},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32273587584495544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2673545777797699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21063023805618286},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21041962504386902},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11014699935913086}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:epub.uni-regensburg.de:13099","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/13099/1/Dissertation_R_Dayoub_Beidseitig.pdf","pdf_url":"https://epub.uni-regensburg.de/13099/1/Dissertation_R_Dayoub_Beidseitig.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-018883342","doi":null,"is_oa":false,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:355-opus-13359","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},{"id":"mag:157842328","doi":null,"is_oa":false,"landing_page_url":"https://d-nb.info/1001202872/34","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:epub.uni-regensburg.de:13099","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/13099/1/Dissertation_R_Dayoub_Beidseitig.pdf","pdf_url":"https://epub.uni-regensburg.de/13099/1/Dissertation_R_Dayoub_Beidseitig.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W157842328.pdf","grobid_xml":"https://content.openalex.org/works/W157842328.grobid-xml"},"referenced_works_count":178,"referenced_works":["https://openalex.org/W27120614","https://openalex.org/W28865656","https://openalex.org/W34216334","https://openalex.org/W53503538","https://openalex.org/W113377209","https://openalex.org/W155763523","https://openalex.org/W186732618","https://openalex.org/W335422122","https://openalex.org/W343881469","https://openalex.org/W906807094","https://openalex.org/W1486230207","https://openalex.org/W1500509569","https://openalex.org/W1515566386","https://openalex.org/W1515994079","https://openalex.org/W1516859873","https://openalex.org/W1525086545","https://openalex.org/W1549520365","https://openalex.org/W1556867369","https://openalex.org/W1562668848","https://openalex.org/W1571688087","https://openalex.org/W1572976756","https://openalex.org/W1588270487","https://openalex.org/W1667518891","https://openalex.org/W1799405090","https://openalex.org/W1833153827","https://openalex.org/W1844312938","https://openalex.org/W1878624693","https://openalex.org/W1890568935","https://openalex.org/W1895240886","https://openalex.org/W1902168152","https://openalex.org/W1907608182","https://openalex.org/W1909763738","https://openalex.org/W1924905604","https://openalex.org/W1966241991","https://openalex.org/W1968911944","https://openalex.org/W1971486535","https://openalex.org/W1974652824","https://openalex.org/W1977648900","https://openalex.org/W1978143120","https://openalex.org/W1979484538","https://openalex.org/W1980055557","https://openalex.org/W1980464176","https://openalex.org/W1982239761","https://openalex.org/W1982766793","https://openalex.org/W1986572315","https://openalex.org/W1987473368","https://openalex.org/W1989776482","https://openalex.org/W1990146329","https://openalex.org/W1994375896","https://openalex.org/W1995328828","https://openalex.org/W1995378553","https://openalex.org/W2001104440","https://openalex.org/W2002630364","https://openalex.org/W2003867270","https://openalex.org/W2005034776","https://openalex.org/W2006545650","https://openalex.org/W2008259160","https://openalex.org/W2008399598","https://openalex.org/W2008680658","https://openalex.org/W2009624062","https://openalex.org/W2009775095","https://openalex.org/W2011850567","https://openalex.org/W2013296666","https://openalex.org/W2016472363","https://openalex.org/W2019250081","https://openalex.org/W2019544860","https://openalex.org/W2020866554","https://openalex.org/W2023092687","https://openalex.org/W2024393702","https://openalex.org/W2026847938","https://openalex.org/W2028966545","https://openalex.org/W2029107720","https://openalex.org/W2029189134","https://openalex.org/W2029889193","https://openalex.org/W2031338420","https://openalex.org/W2031403700","https://openalex.org/W2034269086","https://openalex.org/W2035245289","https://openalex.org/W2035331137","https://openalex.org/W2036044995","https://openalex.org/W2036318835","https://openalex.org/W2039412091","https://openalex.org/W2039641284","https://openalex.org/W2042159165","https://openalex.org/W2042179969","https://openalex.org/W2043180366","https://openalex.org/W2043842458","https://openalex.org/W2044230889","https://openalex.org/W2044245946","https://openalex.org/W2045181115","https://openalex.org/W2045939581","https://openalex.org/W2046158662","https://openalex.org/W2047124703","https://openalex.org/W2048106438","https://openalex.org/W2048356148","https://openalex.org/W2048723908","https://openalex.org/W2048789360","https://openalex.org/W2051367437","https://openalex.org/W2053943052","https://openalex.org/W2054946698","https://openalex.org/W2056013984","https://openalex.org/W2057140892","https://openalex.org/W2058588777","https://openalex.org/W2060928333","https://openalex.org/W2062167511","https://openalex.org/W2062572320","https://openalex.org/W2062692717","https://openalex.org/W2062870849","https://openalex.org/W2064280522","https://openalex.org/W2064677611","https://openalex.org/W2065799360","https://openalex.org/W2070172817","https://openalex.org/W2071602052","https://openalex.org/W2072038245","https://openalex.org/W2073885973","https://openalex.org/W2075014424","https://openalex.org/W2075504134","https://openalex.org/W2075532352","https://openalex.org/W2076583198","https://openalex.org/W2077045783","https://openalex.org/W2078341087","https://openalex.org/W2082472137","https://openalex.org/W2086204811","https://openalex.org/W2087367170","https://openalex.org/W2088250547","https://openalex.org/W2088656604","https://openalex.org/W2090554418","https://openalex.org/W2092460504","https://openalex.org/W2094173220","https://openalex.org/W2098015360","https://openalex.org/W2101363158","https://openalex.org/W2107066838","https://openalex.org/W2109170983","https://openalex.org/W2113002082","https://openalex.org/W2114341896","https://openalex.org/W2115076347","https://openalex.org/W2115506085","https://openalex.org/W2118777827","https://openalex.org/W2119322483","https://openalex.org/W2126995384","https://openalex.org/W2128298103","https://openalex.org/W2132757051","https://openalex.org/W2133049684","https://openalex.org/W2134319231","https://openalex.org/W2142026128","https://openalex.org/W2143766403","https://openalex.org/W2144097363","https://openalex.org/W2144836511","https://openalex.org/W2146137488","https://openalex.org/W2146445411","https://openalex.org/W2147786790","https://openalex.org/W2149489859","https://openalex.org/W2149755295","https://openalex.org/W2153429744","https://openalex.org/W2159770815","https://openalex.org/W2161356660","https://openalex.org/W2165901622","https://openalex.org/W2166888255","https://openalex.org/W2167923772","https://openalex.org/W2169980652","https://openalex.org/W2170411747","https://openalex.org/W2171411510","https://openalex.org/W2278793656","https://openalex.org/W2364368765","https://openalex.org/W2370030054","https://openalex.org/W2375540959","https://openalex.org/W2378962103","https://openalex.org/W2394803908","https://openalex.org/W2396242620","https://openalex.org/W2398137194","https://openalex.org/W2398703988","https://openalex.org/W2399768078","https://openalex.org/W2408763487","https://openalex.org/W2410120652","https://openalex.org/W2410664358","https://openalex.org/W2418215355","https://openalex.org/W2420219782","https://openalex.org/W4210397629"],"related_works":["https://openalex.org/W2019325902","https://openalex.org/W2035245289","https://openalex.org/W2043539725","https://openalex.org/W4210403887","https://openalex.org/W1986572315","https://openalex.org/W2045939581","https://openalex.org/W2621908646","https://openalex.org/W2024393702","https://openalex.org/W2906171798","https://openalex.org/W2561218216"],"abstract_inverted_index":{"Liver":[0,32],"regeneration":[1,39,354,367],"is":[2,9,35,61,116,172,360,398],"a":[3,255,262,298,350,389],"multistep":[4],"and":[5,48,64,99,115,136,144,194,205,211,219,241,297,304,325,331,359],"well-orchestrated":[6],"process":[7,183],"which":[8,90,177,396],"initiated":[10],"by":[11,175,246,338,362],"injuries":[12],"like":[13,46,368],"tissue":[14],"loss,":[15],"infectious":[16],"or":[17],"toxic":[18],"insults.":[19],"It":[20],"has":[21,232],"been":[22,233],"shown":[23,107,346],"that":[24,129,170,215,314,347,374,384],"expression":[25,69,81,104,135,152,238,316,319,328,376],"of":[26,31,53,70,82,87,112,139,154,184,192,239,265,320,329,336,356,365,386],"the":[27,75,80,133,151,182,189,226,237,318,321,327,334,378],"hepatotrophic":[28],"factor":[29],"\ufffdAugmenter":[30],"Regeneration\ufffd":[33],"(ALR)":[34],"increased":[36,117],"within":[37],"liver":[38,44,49,88,97,366],"as":[40,42,96],"well":[41],"in":[43,84,118,141,158,284,287,342,352,395],"diseases":[45,394],"cirrhosis":[47],"carcinoma.":[50],"The":[51],"aim":[52],"this":[54,242,343],"thesis":[55,344],"was":[56,244,345,372],"to":[57,108,122,180,225,235,295,302,307],"analyze":[58],"how":[59],"ALR":[60,71,83,102,140,159,171,193,227,252,266,271,315,348,375,387],"expressed,":[62],"regulated":[63,173,361],"what":[65],"impact":[66],"an":[67,279,292],"altered":[68,280],"might":[72],"have":[73],"on":[74],"liver.":[76],"Therefore,":[77],"we":[78,187,213,275,312],"investigated":[79],"experimental":[85],"models":[86],"injury":[89],"resemble":[91],"hepatic":[92,353],"patho-physiological":[93],"disorders":[94],"such":[95],"fibrosis":[98],"non-alcoholic":[100],"steatohepatitis.":[101],"mRNA":[103,134],"could":[105,161,222,276],"be":[106,109,162],"upregulated":[110],"independent":[111,355],"different":[113],"insults":[114],"HCC":[119],"tissues":[120],"compared":[121,306],"normal":[123],"tissues.":[124],"Furthermore,":[125,311],"our":[126],"results":[127],"showed":[128],"IL-6":[130,217],"rapidly":[131],"induces":[132,317],"protein":[137],"level":[138],"human":[142],"hepatocytes":[143],"hepatoma":[145],"cells,":[146],"whereas":[147],"IL-1":[148],"beta":[149,221],"reduces":[150,326],"levels":[153,160],"ALR.":[155,339],"No":[156],"changes":[157],"observed":[163],"after":[164],"stimulation":[165],"with":[166],"growth":[167],"factors":[168,176,364],"suggesting":[169,383],"only":[174],"are":[178],"known":[179],"initiate":[181],"regeneration.":[185],"Further,":[186],"analyzed":[188],"promoter":[190,253],"sequence":[191],"identified":[195],"putative":[196],"regulatory":[197],"elements":[198],"for":[199,393],"FOXA2,":[200],"IL":[201],"6":[202],"RE":[203],"BP":[204],"C/EBP":[206,220],"beta.":[207],"Using":[208,270],"luciferase":[209],"assays":[210],"EMSA,":[212],"demonstrated":[214,313,373],"both":[216],"RE-BP":[218],"not":[223,277],"transactivate/bind":[224],"promoter.":[228],"In":[229,340],"contrast,":[230],"FOXA2":[231],"found":[234],"regulate":[236],"ALR,":[240],"regulation":[243],"amplified":[245],"simultaneously":[247],"activation":[248],"using":[249],"IL-6.":[250],"Additionally,":[251],"exhibits":[254],"nearly":[256],"conserved":[257],"Nrf2":[258],"binding":[259],"site":[260],"underlining":[261],"hepatoprotective":[263],"function":[264],"against":[267],"oxidative":[268],"stress.":[269],"overexpressing":[272],"HepG2":[273],"cells":[274,290],"detect":[278],"proliferation":[281],"rate":[282],"neither":[283],"vitro":[285],"nor":[286],"vivo.":[288],"ALR-overexpressing":[289],"displayed":[291],"enhanced":[293],"acquirement":[294],"adhere":[296],"significant":[299],"lower":[300],"ability":[301],"migrate":[303],"invade":[305],"wild":[308],"type":[309],"cells.":[310],"adhesion":[322],"molecule":[323],"E-cadherin":[324,337],"MMP-3":[330],"SNAIL":[332],"explaining":[333],"modulation":[335],"conclusion,":[341],"plays":[349],"role":[351],"its":[357],"cause":[358],"upstream":[363],"cytokines.":[369],"Addionally,":[370],"it":[371],"counteracts":[377],"epithelial":[379],"mesenchymal":[380],"transition":[381],"(EMT)":[382],"application":[385],"represents":[388],"promising":[390],"therapeutical":[391],"strategy":[392],"EMT":[397],"involved.":[399]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}