{"id":"https://openalex.org/W1578199258","doi":null,"title":"Reduction of intraocular pressure in mouse eyes treated with latanoprost.","display_name":"Reduction of intraocular pressure in mouse eyes treated with latanoprost.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W1578199258","mag":"1578199258","pmid":"https://pubmed.ncbi.nlm.nih.gov/11773025"},"language":"en","primary_location":{"id":"pmid:11773025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11773025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053803582","display_name":"Makoto Aihara","orcid":"https://orcid.org/0000-0001-6810-0583","observed_orcids":["https://orcid.org/0000-0001-6810-0583"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Makoto Aihara","raw_affiliation_strings":["Glaucoma Center, University of California San Diego, La Jolla, California 92093-0946, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaucoma Center, University of California San Diego, La Jolla, California 92093-0946, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112204907","display_name":"James D. Lindsey","orcid":"https://orcid.org/0000-0001-6329-5473","observed_orcids":["https://orcid.org/0000-0001-6329-5473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James D Lindsey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043994887","display_name":"Robert Neal Weinreb","orcid":"https://orcid.org/0000-0001-9553-3202","observed_orcids":["https://orcid.org/0000-0001-9553-3202","https://orcid.org/0000-0003-4217-4853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert N Weinreb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0458,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.96705178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"43","issue":"1","first_page":"146","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/latanoprost","display_name":"latanoprost","score":1.0},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.9950000047683716},{"id":"https://openalex.org/keywords/topical-ocular-administration","display_name":"topical ocular administration","score":0.6510000228881836},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6370000243186951},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6510000228881836},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.5809999704360962},{"id":"https://openalex.org/keywords/prostamide","display_name":"prostamide","score":0.5400000214576721},{"id":"https://openalex.org/keywords/aqueous-humor-outflow","display_name":"aqueous humor outflow","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2776740260","wikidata":"https://www.wikidata.org/wiki/Q634959","display_name":"Latanoprost","level":3,"score":0.9931803345680237},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.8208694458007812},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6662758588790894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5584170818328857},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.5293337106704712},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4458056688308716},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.26978081464767456}],"mesh":[{"descriptor_ui":"D000077338","descriptor_name":"Latanoprost","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009883","descriptor_name":"Ophthalmic Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011461","descriptor_name":"Prostaglandins F, Synthetic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011461","descriptor_name":"Prostaglandins F, Synthetic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11773025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11773025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:1578199258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11773025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4845869435","display_name":"Eicosanoids and the Outflow Pathways of the Eye","funder_award_id":"R01EY005990","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1494253197","https://openalex.org/W1512574313","https://openalex.org/W1524686653","https://openalex.org/W1820659610","https://openalex.org/W1963522904","https://openalex.org/W1997490996","https://openalex.org/W2006726419","https://openalex.org/W2043923159","https://openalex.org/W2076260416","https://openalex.org/W2100591986","https://openalex.org/W4301035371"],"related_works":["https://openalex.org/W2059101684","https://openalex.org/W2000935282","https://openalex.org/W2045830688","https://openalex.org/W2062118902","https://openalex.org/W2084169631","https://openalex.org/W2888602107","https://openalex.org/W2054394116","https://openalex.org/W2147039100","https://openalex.org/W2943296817","https://openalex.org/W2130771173"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"whether":[3],"topical":[4,27,131,168],"treatment":[5,169,226],"of":[6,29,75,96,119,267],"mouse":[7,128,250,257],"eyes":[8,89,129,157,203],"with":[9,170,227],"latanoprost":[10,35,78,97,208],"alters":[11],"intraocular":[12],"pressure":[13,59],"(IOP).":[14],"METHODS:":[15],"In":[16,127],"a":[17,25,52,58,99,195,253,260],"masked":[18],"study":[19],"design,":[20],"NIH":[21],"Swiss":[22],"mice":[23],"received":[24],"2-microL":[26],"instillation":[28],"0.00015%,":[30],"0.0006%,":[31],"0.0025%,":[32],"or":[33,36,44,172,206,233],"0.01%":[34,101,207,228],"vehicle":[37],"(phosphate-buffered":[38],"saline":[39],"[PBS]).":[40],"After":[41],"1,":[42],"2,":[43],"3":[45,188],"hours,":[46],"the":[47,64,67,83,91,114,117,133,215,265],"animals":[48],"were":[49,200],"anesthetized,":[50],"and":[51,87,109,155,158,161,186,214,244],"fluid-filled":[53],"glass":[54],"microneedle":[55],"connected":[56],"to":[57,70],"transducer":[60],"was":[61,80,103,124,136,147,221,239],"inserted":[62],"through":[63],"cornea":[65],"into":[66],"anterior":[68],"chamber":[69],"measure":[71],"IOP.":[72,270],"The":[73,94,256],"reduction":[74],"IOP":[76,135,152,175,192,251],"after":[77,98,167,190,225,236],"measurement":[79],"calculated":[81],"by":[82,177],"comparison":[84],"between":[85,153,159],"treated":[86],"nontreated":[88],"in":[90,113,151,194,202,242,252],"same":[92],"mouse.":[93],"effect":[95,266],"single":[100],"dose":[102],"also":[104],"measured":[105],"at":[106,187],"6,":[107,231],"12,":[108,232],"24":[110,234],"hours.":[111],"As":[112],"previous":[115],"study,":[116],"identity":[118],"all":[120],"eye":[121],"drop":[122],"solutions":[123],"masked.":[125],"RESULTS:":[126],"receiving":[130,204],"PBS,":[132],"mean":[134],"14.8":[137],"+/-":[138,182,219],"2.2":[139],"mm":[140],"Hg":[141],"(n":[142],"=":[143],"173":[144],"males).":[145],"There":[146],"no":[148,240],"significant":[149,201],"difference":[150,241],"male":[154],"female":[156],"right":[160],"left":[162],"eyes.":[163,246],"At":[164,184,230],"1":[165],"hour":[166],"0.00015%":[171],"0.0025%":[173,205],"latanoprost,":[174],"increased":[176],"as":[178,180],"much":[179],"11%":[181],"7%.":[183],"2":[185,223],"hours":[189,224,235],"application,":[191],"decreased":[193],"dose-dependent":[196,254],"manner.":[197,255],"These":[198],"decreases":[199],"(P":[209],"<":[210],"0.05,":[211],"Student-Newman-Keuls":[212],"test)":[213],"largest":[216],"decrease":[217],"(14%":[218],"8%)":[220],"noted":[222],"latanoprost.":[229],"treatment,":[237],"there":[238],"latanoprost-":[243],"PBS-treated":[245],"CONCLUSIONS:":[247],"Latanoprost":[248],"reduces":[249],"may":[258],"be":[259],"useful":[261],"model":[262],"for":[263],"studying":[264],"drugs":[268],"on":[269]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
