{"id":"https://openalex.org/W1577919656","doi":null,"title":"A Modified Mixing Test with a Proposed Cutoff Value to Screen for Clotting Factor Inhibitors","display_name":"A Modified Mixing Test with a Proposed Cutoff Value to Screen for Clotting Factor Inhibitors","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1577919656","mag":"1577919656"},"language":"th","primary_location":{"id":"pmh:oai:he01.tci-thaijo.org:article/19665","doi":null,"is_oa":true,"landing_page_url":"https://he01.tci-thaijo.org/index.php/JHematolTransfusMed/article/view/19665","pdf_url":"https://he01.tci-thaijo.org/index.php/JHematolTransfusMed/article/download/19665/17237","source":{"id":"https://openalex.org/S4306515622","display_name":"Journal of Hematology and Transfusion Medicine (\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e42\u0e25\u0e2b\u0e34\u0e15\u0e27\u0e34\u0e17\u0e22\u0e32\u0e41\u0e25\u0e30\u0e40\u0e27\u0e0a\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e1a\u0e23\u0e34\u0e01\u0e32\u0e23\u0e42\u0e25\u0e2b\u0e34\u0e15)","issn_l":"2985-2390","issn":["2985-2390","2985-2404"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2985-2390","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://he01.tci-thaijo.org/index.php/JHematolTransfusMed/article/download/19665/17237","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005421031","display_name":"Benjaporn Akkawat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]},{"id":"https://openalex.org/I2802209374","display_name":"King Chulalongkorn Memorial Hospital","ror":"https://ror.org/05jd2pj53","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I2802209374"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Benjaporn Akkawat","raw_affiliation_strings":["Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital","institution_ids":["https://openalex.org/I158708052","https://openalex.org/I2802209374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066150656","display_name":"Ponlapat Rojnuckarin","orcid":"https://orcid.org/0000-0001-7912-1996","observed_orcids":["https://orcid.org/0000-0001-7912-1996"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]},{"id":"https://openalex.org/I2802209374","display_name":"King Chulalongkorn Memorial Hospital","ror":"https://ror.org/05jd2pj53","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I2802209374"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Ponlapat Rojnuckarin","raw_affiliation_strings":["Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital"],"raw_orcid":"https://orcid.org/0000-0001-7912-1996","affiliations":[{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital","institution_ids":["https://openalex.org/I158708052","https://openalex.org/I2802209374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.06543194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"2","first_page":"137","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mixing-test","display_name":"mixing test","score":0.7670000195503235},{"id":"https://openalex.org/keywords/factor-viii-inhibitors","display_name":"factor VIII inhibitors","score":0.6470000147819519},{"id":"https://openalex.org/keywords/factor-ix-inhibitors","display_name":"factor IX inhibitors","score":1.0},{"id":"https://openalex.org/keywords/lupus-anticoagulant","display_name":"lupus anticoagulant","score":0.9190000295639038},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time-prolongation","display_name":"activated partial thromboplastin time prolongation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cutoff-values","display_name":"cut-off values","score":0.6819999814033508},{"id":"https://openalex.org/keywords/bleeding-disorders","display_name":"bleeding disorders","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.6896237134933472},{"id":"https://openalex.org/C2992139802","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Clotting factor","level":2,"score":0.6339975595474243},{"id":"https://openalex.org/C77171857","wikidata":"https://www.wikidata.org/wiki/Q5135593","display_name":"Clotting time","level":3,"score":0.6054792404174805},{"id":"https://openalex.org/C2778217198","wikidata":"https://www.wikidata.org/wiki/Q556977","display_name":"Cutoff","level":2,"score":0.49463388323783875},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.48877593874931335},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.44754329323768616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43014922738075256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42692673206329346},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4120931625366211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4010702669620514},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2887572944164276},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:he01.tci-thaijo.org:article/19665","doi":null,"is_oa":true,"landing_page_url":"https://he01.tci-thaijo.org/index.php/JHematolTransfusMed/article/view/19665","pdf_url":"https://he01.tci-thaijo.org/index.php/JHematolTransfusMed/article/download/19665/17237","source":{"id":"https://openalex.org/S4306515622","display_name":"Journal of Hematology and Transfusion Medicine (\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e42\u0e25\u0e2b\u0e34\u0e15\u0e27\u0e34\u0e17\u0e22\u0e32\u0e41\u0e25\u0e30\u0e40\u0e27\u0e0a\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e1a\u0e23\u0e34\u0e01\u0e32\u0e23\u0e42\u0e25\u0e2b\u0e34\u0e15)","issn_l":"2985-2390","issn":["2985-2390","2985-2404"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2985-2390","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1577919656","doi":null,"is_oa":true,"landing_page_url":"https://www.tci-thaijo.org/index.php/JHematolTransfusMed/article/download/19665/17237","pdf_url":null,"source":{"id":"https://openalex.org/S4306515622","display_name":"Journal of Hematology and Transfusion Medicine (\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e42\u0e25\u0e2b\u0e34\u0e15\u0e27\u0e34\u0e17\u0e22\u0e32\u0e41\u0e25\u0e30\u0e40\u0e27\u0e0a\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e1a\u0e23\u0e34\u0e01\u0e32\u0e23\u0e42\u0e25\u0e2b\u0e34\u0e15)","issn_l":"2985-2390","issn":["2985-2390","2985-2404"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hematology and Transfusion Medicine (\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e42\u0e25\u0e2b\u0e34\u0e15\u0e27\u0e34\u0e17\u0e22\u0e32\u0e41\u0e25\u0e30\u0e40\u0e27\u0e0a\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e1a\u0e23\u0e34\u0e01\u0e32\u0e23\u0e42\u0e25\u0e2b\u0e34\u0e15)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:he01.tci-thaijo.org:article/19665","doi":null,"is_oa":true,"landing_page_url":"https://he01.tci-thaijo.org/index.php/JHematolTransfusMed/article/view/19665","pdf_url":"https://he01.tci-thaijo.org/index.php/JHematolTransfusMed/article/download/19665/17237","source":{"id":"https://openalex.org/S4306515622","display_name":"Journal of Hematology and Transfusion Medicine (\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e42\u0e25\u0e2b\u0e34\u0e15\u0e27\u0e34\u0e17\u0e22\u0e32\u0e41\u0e25\u0e30\u0e40\u0e27\u0e0a\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e1a\u0e23\u0e34\u0e01\u0e32\u0e23\u0e42\u0e25\u0e2b\u0e34\u0e15)","issn_l":"2985-2390","issn":["2985-2390","2985-2404"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2985-2390","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1577919656.pdf","grobid_xml":"https://content.openalex.org/works/W1577919656.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W168978929","https://openalex.org/W1510189712","https://openalex.org/W1514108366","https://openalex.org/W1975122342","https://openalex.org/W1992454739","https://openalex.org/W2003195332","https://openalex.org/W2016464874","https://openalex.org/W2069797332","https://openalex.org/W2079878945","https://openalex.org/W2135696880","https://openalex.org/W2278553352","https://openalex.org/W2399915947","https://openalex.org/W2417920681","https://openalex.org/W2418842053"],"related_works":["https://openalex.org/W4395008351","https://openalex.org/W4220943235","https://openalex.org/W4413002815","https://openalex.org/W2966541221","https://openalex.org/W4318953840","https://openalex.org/W2801194961","https://openalex.org/W3119540775","https://openalex.org/W7088248483","https://openalex.org/W2806245178","https://openalex.org/W104075595"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Mixing":[2],"studies":[3],"are":[4],"helpful":[5],"for":[6,57,64,105,215,221,264],"clotting":[7,130,142,166,216,265],"factor":[8,65,167,217,228,266],"inhibitor":[9,35,168],"screening":[10,36,262],"in":[11,38,50],"cases":[12],"with":[13,112,124],"activated":[14],"partial":[15],"thromboplastin":[16],"time":[17,131,143],"(APTT)":[18],"prolongation.":[19],"However,":[20,268],"the":[21,117,145,151,195,233,242,248],"standard":[22],"consensus":[23],"procedure":[24],"is":[25,30,43],"lacking.":[26],"Objective:":[27],"The":[28,41,170,190,203,219,225],"aim":[29],"to":[31,46,85,144,178,275,278],"develop":[32],"a":[33,260],"sensitive":[34,261],"assay":[37],"bleeding":[39],"patients.":[40],"test":[42,113,119,263],"preferably":[44],"insensitive":[45],"lupus":[47],"anticoagulants":[48],"(LA)":[49],"this":[51],"setting.":[52],"Methods:":[53],"Plasma":[54],"samples":[55,183],"investigated":[56],"APTT":[58,87,118,157,196,210,272],"prolongation(N":[59],"=":[60],"90)":[61],"were":[62,102,108,159,163,186,230],"tested":[63],"VIII":[66],"or":[67,201],"IX":[68],"inhibitors":[69,127,139,229],"and":[70,120],"LA.":[71],"Positive":[72],"mixing":[73,204],"was":[74,173,194,223,236],"defined":[75],"as":[76,188],"an":[77],"ability":[78],"of":[79,82,88,91,134,156,184,199,209,227,241,271],"one":[80,89],"part":[81,90],"patient":[83],"plasma":[84,94,114],"prolong":[86],"pooled":[92],"normal":[93],"(PNP)":[95],"after":[96],"2-hour":[97],"incubation.":[98],"Two":[99],"controls,":[100,136],"which":[101],"also":[103],"incubated":[104],"2":[106,135,250],"hours,":[107],"1)":[109],"PNP":[110,122],"mixed":[111,123],"immediately":[115],"before":[116],"2)":[121],"buffer.":[125],"Time-dependent":[126],"showed":[128,212,252],"longer":[129,149],"than":[132,150],"those":[133],"while":[137,232],"time-independent":[138],"had":[140],"similar":[141],"first":[146],"control":[147],"but":[148,247],"second":[152],"control.":[153],"Three":[154],"lots":[155,208,251,270],"reagents":[158,211,273],"investigated.":[160],"Results:":[161],"There":[162],"18":[164],"(20%)":[165],"cases.":[169],"mean":[171],"titer":[172],"1.7":[174],"ranging":[175],"from":[176],"0.67":[177],"4.0":[179],"Bethesda":[180],"units.":[181],"Fifteen":[182],"LA":[185,222,234],"regarded":[187],"negative.":[189],"most":[191],"appropriate":[192],"cutoff":[193],"ratio":[197],"difference":[198],"0.10":[200],"higher.":[202],"study":[205],"using":[206],"any":[207],"100%":[213],"sensitivity":[214,220],"inhibitors.":[218,267],"lower.":[224],"majority":[226],"time-dependent,":[231],"inhibition":[235],"mostly":[237],"immediate.":[238],"One":[239],"lot":[240],"reagent":[243],"displayed":[244],"93.1%":[245],"specificity,":[246],"other":[249],"higher":[253],"false":[254],"positive":[255],"rates.":[256],"Conclusion:":[257],"We":[258],"described":[259],"optimal":[269],"need":[274],"be":[276],"determined":[277],"obtain":[279],"excellent":[280],"specificity.":[281]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}