{"id":"https://openalex.org/W1577814070","doi":"https://doi.org/10.1111/j.1365-3083.2011.02531.x","title":"Immunogenicity and Protective Efficacy of a Fusion Protein Vaccine Consisting of Antigen Ag85B and HspX against Mycobacterium tuberculosis Infection in Mice","display_name":"Immunogenicity and Protective Efficacy of a Fusion Protein Vaccine Consisting of Antigen Ag85B and HspX against Mycobacterium tuberculosis Infection in Mice","publication_year":2011,"publication_date":"2011-02-15","ids":{"openalex":"https://openalex.org/W1577814070","doi":"https://doi.org/10.1111/j.1365-3083.2011.02531.x","mag":"1577814070","pmid":"https://pubmed.ncbi.nlm.nih.gov/21323695"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-3083.2011.02531.x","doi":"https://doi.org/10.1111/j.1365-3083.2011.02531.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-3083.2011.02531.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-3083.2011.02531.x","source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-3083.2011.02531.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Q. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Li","raw_affiliation_strings":["Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China","Institute of Pathophysiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]},{"raw_affiliation_string":"Institute of Pathophysiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047108686","display_name":"Hao Yu","orcid":"https://orcid.org/0000-0002-1892-7993","observed_orcids":["https://orcid.org/0000-0002-1892-7993"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Yu","raw_affiliation_strings":["Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Y. Zhang","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003831443","display_name":"B. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405277571","display_name":"Lanzhou Institute of Biological Products (China)","ror":"https://ror.org/035dm6k56","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210113926","https://openalex.org/I4405277571"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"B. Wang","raw_affiliation_strings":["Lanzhou Institute of Biological Products, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lanzhou Institute of Biological Products, Lanzhou, China","institution_ids":["https://openalex.org/I4405277571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059471676","display_name":"Wenwen Jiang","orcid":"https://orcid.org/0000-0001-6234-8385","observed_orcids":["https://orcid.org/0000-0001-6234-8385"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W. Jiang","raw_affiliation_strings":["Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054616934","display_name":"Zejiao Da","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z. Da","raw_affiliation_strings":["Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112163029","display_name":"Qingyun Xian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Xian","raw_affiliation_strings":["ABSL-3 Lab, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABSL-3 Lab, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028134298","display_name":"Yixiang Wang","orcid":"https://orcid.org/0000-0001-8386-7491","observed_orcids":["https://orcid.org/0000-0001-8386-7491"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Wang","raw_affiliation_strings":["ABSL-3 Lab, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABSL-3 Lab, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100352330","display_name":"Xin Liu","orcid":"https://orcid.org/0000-0003-3685-4852","observed_orcids":["https://orcid.org/0000-0003-3685-4852"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"X. Liu","raw_affiliation_strings":["Institute of Pathophysiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathophysiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101580733","display_name":"Bingdong Zhu","orcid":"https://orcid.org/0000-0001-8422-4594","observed_orcids":["https://orcid.org/0000-0001-8422-4594"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"B. Zhu","raw_affiliation_strings":["Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100352330","https://openalex.org/A5101580733"],"corresponding_institution_ids":["https://openalex.org/I76214153"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":3.5291,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.92083583,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"73","issue":"6","first_page":"568","last_page":"576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.902999997138977},{"id":"https://openalex.org/keywords/fusion-protein-vaccine","display_name":"fusion protein vaccine","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ag85b","display_name":"Ag85B","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hspx","display_name":"HspX","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mpt64","display_name":"MPT64","score":0.9190000295639038},{"id":"https://openalex.org/keywords/protein-subunit-vaccines","display_name":"subunit vaccine","score":0.8339999914169312},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.5720000267028809},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.628000020980835},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8399999737739563},{"id":"https://openalex.org/keywords/protective-efficacy","display_name":"protective efficacy","score":0.5509999990463257},{"id":"https://openalex.org/keywords/purified-protein-derivative","display_name":"purified protein derivative","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.871940016746521},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7562962770462036},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6187655925750732},{"id":"https://openalex.org/C2779078216","wikidata":"https://www.wikidata.org/wiki/Q7850848","display_name":"Tuberculosis vaccines","level":4,"score":0.5529029965400696},{"id":"https://openalex.org/C2778497218","wikidata":"https://www.wikidata.org/wiki/Q133447","display_name":"Mycobacterium bovis","level":4,"score":0.543999969959259},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5404605865478516},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5392540693283081},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5069110989570618},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.45281165838241577},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4510471522808075},{"id":"https://openalex.org/C2778288313","wikidata":"https://www.wikidata.org/wiki/Q798309","display_name":"BCG vaccine","level":3,"score":0.41507458686828613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3982105851173401},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39449000358581543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32149165868759155},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.3050324320793152},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013047","descriptor_name":"Specific Pathogen-Free Organisms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022223","descriptor_name":"Vaccines, Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D032581","descriptor_name":"Tuberculosis Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-3083.2011.02531.x","doi":"https://doi.org/10.1111/j.1365-3083.2011.02531.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-3083.2011.02531.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-3083.2011.02531.x","source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:21323695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21323695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/121485","doi":null,"is_oa":true,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/121485","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-3083.2011.02531.x","doi":"https://doi.org/10.1111/j.1365-3083.2011.02531.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-3083.2011.02531.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-3083.2011.02531.x","source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000152094","display_name":null,"funder_award_id":"2008zx1000301104","funder_id":"https://openalex.org/F4320335960","funder_display_name":"National Major Science and Technology Projects of China"}],"funders":[{"id":"https://openalex.org/F4320335773","display_name":"National High-tech Research and Development Program","ror":null},{"id":"https://openalex.org/F4320335960","display_name":"National Major Science and Technology Projects of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1577814070.pdf","grobid_xml":"https://content.openalex.org/works/W1577814070.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1597808424","https://openalex.org/W1821834644","https://openalex.org/W1980543107","https://openalex.org/W1996329907","https://openalex.org/W2002259830","https://openalex.org/W2010713857","https://openalex.org/W2017290044","https://openalex.org/W2037816663","https://openalex.org/W2043952643","https://openalex.org/W2062672881","https://openalex.org/W2069014426","https://openalex.org/W2077071820","https://openalex.org/W2095130349","https://openalex.org/W2097421503","https://openalex.org/W2103110885","https://openalex.org/W2104941073","https://openalex.org/W2113853582","https://openalex.org/W2131947327","https://openalex.org/W2135922389","https://openalex.org/W2157559696","https://openalex.org/W2164944419"],"related_works":["https://openalex.org/W2601297368","https://openalex.org/W2002259830","https://openalex.org/W2375901527","https://openalex.org/W2068210663","https://openalex.org/W2092663056","https://openalex.org/W2061615999","https://openalex.org/W2056246244","https://openalex.org/W2903755548","https://openalex.org/W1498590626","https://openalex.org/W3136742387"],"abstract_inverted_index":{"Subunit":[0],"vaccines":[1,99,107],"have":[2],"the":[3,56,101,104,139,165,171,220,243,278],"potential":[4],"advantage":[5],"to":[6,86,258,265],"boost":[7],"Mycobacterium":[8,36,196],"bovis":[9],"Bacillus":[10],"Calmette-Gu\u00e9rin":[11],"(BCG)-primed":[12],"immunity":[13,262],"in":[14,23,28,219,247],"adults.":[15],"However,":[16],"most":[17],"candidates":[18],"are":[19],"antigens":[20,254],"highly":[21,245],"expressed":[22,246],"replicating":[24,256],"bacilli":[25,257],"but":[26],"not":[27],"dormant":[29,248],"or":[30,231],"persisting":[31],"bacilli,":[32,249],"which":[33,52],"exist":[34],"during":[35,277],"tuberculosis":[37,42,134,197],"infection.":[38],"We":[39],"constructed":[40],"M.":[41,133],"fusion":[43,105],"protein":[44,106,199],"Ag85B-Mpt64(190-198)":[45,49],"-HspX":[46],"(AMH)":[47],"and":[48,63,79,97,100,116,123,138,142,177,187,189,195,272],"-Mtb8.4":[50],"(AMM),":[51],"consist":[53],"of":[54,59,75,103,159,184,241],"Ag85B,":[55,95,120],"190-198":[57],"peptide":[58],"Mpt64,":[60],"HspX":[61],"(Rv2031c)":[62],"Mtb8.4":[64],"(Rv1174c),":[65],"respectively.":[66],"AMH":[67,96,126,154,176,180,213,230,239],"and/or":[68],"AMM":[69,98,122,124,178,211,232],"were":[70,91,112,145],"mixed":[71],"with":[72,94,114,119,132,153,164,169,174,210,229,253],"adjuvants":[73],"composed":[74],"dimethyl-dioctyldecyl":[76],"ammonium":[77],"bromide":[78],"BCG":[80,115,260],"polysaccharide":[81],"nucleic":[82],"acid":[83],"(DDA-BCG":[84],"PSN)":[85],"construct":[87],"subunit":[88],"vaccines.":[89],"Mice":[90],"immunized":[92,152],"thrice":[93],"immunogenicity":[102],"was":[108,148],"determined.":[109],"Then,":[110],"mice":[111,151,172,208,227],"primed":[113,261],"boosted":[117,173,209,228],"twice":[118],"AMH,":[121],"+":[125,179,212],"vaccines,":[127],"respectively,":[128],"followed":[129],"by":[130],"challenging":[131],"virulent":[135],"strain":[136],"H37Rv,":[137],"immune":[140],"responses":[141],"protective":[143],"effects":[144],"measured.":[146],"It":[147,203],"found":[149],"that":[150,206,238,275],"vaccine":[155],"generated":[156],"high":[157],"levels":[158,183],"antigen-specific":[160],"cell-mediated":[161],"responses.":[162],"Compared":[163],"group":[166],"injected":[167],"only":[168,207],"BCG,":[170,225],"AMM,":[175],"produced":[181],"higher":[182],"Ag85B-specific":[185],"IgG1":[186],"IgG2a":[188],"IFN-\u03b3-secreting":[190],"T":[191],"cells":[192],"upon":[193],"Ag85B":[194],"purified":[198],"derivative":[200],"(PPD)":[201],"stimulation.":[202],"is":[204],"interesting":[205],"had":[214],"significantly":[215],"lower":[216],"bacterial":[217],"count":[218],"lungs":[221],"than":[222],"those":[223],"receiving":[224],"whereas":[226],"did":[233],"not.":[234],"The":[235],"results":[236],"suggest":[237],"consisting":[240],"HspX,":[242],"antigen":[244],"could":[250],"be":[251],"combined":[252],"from":[255],"enhance":[259],"so":[263],"as":[264],"provide":[266],"better":[267],"protection":[268],"against":[269],"both":[270],"growing":[271],"non-growing":[273],"bacteria":[274],"occur":[276],"infection":[279],"process.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
