{"id":"https://openalex.org/W1577585281","doi":"https://doi.org/10.1111/j.1743-6109.2010.01979.x","title":"Prostate-Specific Antigen Levels are Associated with Arterial Stiffness in Essential Hypertensive Patients","display_name":"Prostate-Specific Antigen Levels are Associated with Arterial Stiffness in Essential Hypertensive Patients","publication_year":2010,"publication_date":"2010-08-17","ids":{"openalex":"https://openalex.org/W1577585281","doi":"https://doi.org/10.1111/j.1743-6109.2010.01979.x","mag":"1577585281","pmid":"https://pubmed.ncbi.nlm.nih.gov/20722777"},"language":"en","primary_location":{"id":"doi:10.1111/j.1743-6109.2010.01979.x","doi":"https://doi.org/10.1111/j.1743-6109.2010.01979.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1743-6109.2010.01979.x","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109321798","display_name":"Gregory P. Vyssoulis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Gregory Vyssoulis","raw_affiliation_strings":["Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital , Athens , Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital , Athens , Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110114992","display_name":"Eva A. Karpanou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117383","display_name":"Onassis Cardiac Surgery Center","ror":"https://ror.org/02gan0k07","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210117383"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eva Karpanou","raw_affiliation_strings":["1st Cardiology Clinic Onassis Cardiosurgery Center , Athens , Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Cardiology Clinic Onassis Cardiosurgery Center , Athens , Greece","institution_ids":["https://openalex.org/I4210117383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111499311","display_name":"Stella-Maria Kyvelou","orcid":"https://orcid.org/0000-0001-7484-2313","observed_orcids":["https://orcid.org/0000-0001-7484-2313"]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Stella-Maria Kyvelou","raw_affiliation_strings":["Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital , Athens , Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital , Athens , Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032584545","display_name":"Charalambos V. Vlachopoulos","orcid":"https://orcid.org/0000-0002-9904-3558","observed_orcids":["https://orcid.org/0000-0002-9904-3558"]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Charalambos Vlachopoulos","raw_affiliation_strings":["Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital , Athens , Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital , Athens , Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000387439","display_name":"Vanessa Tzamou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vanessa Tzamou","raw_affiliation_strings":["Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital , Athens , Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital , Athens , Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005228083","display_name":"Christodoulos Stefanadis","orcid":"https://orcid.org/0000-0001-5974-6454","observed_orcids":["https://orcid.org/0000-0001-5974-6454","https://orcid.org/0000-0002-5388-2735"]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christodoulos Stefanadis","raw_affiliation_strings":["Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital , Athens , Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital , Athens , Greece","institution_ids":["https://openalex.org/I4210165841"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111499311"],"corresponding_institution_ids":["https://openalex.org/I4210165841"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":1.2845,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.81405145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"9","issue":"12","first_page":"3205","last_page":"3210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":1.0},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.996999979019165},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/augmentation-index","display_name":"augmentation index","score":0.8339999914169312},{"id":"https://openalex.org/keywords/aortic-stiffness","display_name":"aortic stiffness","score":0.7379999756813049},{"id":"https://openalex.org/keywords/waist-to-hip-ratio","display_name":"waist-to-hip ratio","score":0.8429999947547913},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6899999976158142},{"id":"https://openalex.org/keywords/untreated-hypertension","display_name":"untreated hypertension","score":0.6610000133514404},{"id":"https://openalex.org/keywords/male-patients","display_name":"male patients","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.7824479341506958},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.6557843685150146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6133301854133606},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5498325228691101},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5104779005050659},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.46529754996299744},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43559834361076355},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.32130587100982666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3127380609512329},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.20408710837364197},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.04686468839645386}],"mesh":[{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D049629","descriptor_name":"Waist-Hip Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059289","descriptor_name":"Vascular Stiffness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D063177","descriptor_name":"Pulse Wave Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1743-6109.2010.01979.x","doi":"https://doi.org/10.1111/j.1743-6109.2010.01979.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1743-6109.2010.01979.x","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},{"id":"pmid:20722777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20722777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of sexual medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1956140863","https://openalex.org/W1963764466","https://openalex.org/W1966257567","https://openalex.org/W1970155659","https://openalex.org/W1976928579","https://openalex.org/W1985809560","https://openalex.org/W1990359844","https://openalex.org/W2007422108","https://openalex.org/W2012363939","https://openalex.org/W2016747974","https://openalex.org/W2020928870","https://openalex.org/W2021261102","https://openalex.org/W2027925208","https://openalex.org/W2031314819","https://openalex.org/W2031383072","https://openalex.org/W2031720640","https://openalex.org/W2040776282","https://openalex.org/W2067833505","https://openalex.org/W2070681318","https://openalex.org/W2070769230","https://openalex.org/W2072138004","https://openalex.org/W2083296849","https://openalex.org/W2085368059","https://openalex.org/W2093505601","https://openalex.org/W2097164835","https://openalex.org/W2119070547","https://openalex.org/W2125914602","https://openalex.org/W2126530985","https://openalex.org/W2131793954","https://openalex.org/W2134892659","https://openalex.org/W2138209376","https://openalex.org/W2138812648","https://openalex.org/W2147994802","https://openalex.org/W2151007116","https://openalex.org/W2152783641","https://openalex.org/W2153814743","https://openalex.org/W2157053766","https://openalex.org/W2157399284","https://openalex.org/W2165730407","https://openalex.org/W2171311902","https://openalex.org/W2296131486","https://openalex.org/W2303651371","https://openalex.org/W2334588493","https://openalex.org/W2521801794","https://openalex.org/W3009055627","https://openalex.org/W3016405830"],"related_works":["https://openalex.org/W2038240926","https://openalex.org/W2518784456","https://openalex.org/W2347541340","https://openalex.org/W2950385047","https://openalex.org/W4402610637","https://openalex.org/W1993911586","https://openalex.org/W2070713229","https://openalex.org/W2021429632","https://openalex.org/W1993638391","https://openalex.org/W2082311851"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Prostate-specific":[1],"antigen":[2],"(PSA)":[3],"has":[4],"been":[5],"recently":[6],"related":[7],"to":[8,39,171,257],"cardiovascular":[9,22],"system":[10],"in":[11,27,50,175,243],"a":[12,18,76,212],"multifactorial":[13],"way.":[14],"Arterial":[15],"stiffness":[16,48,88,242,255],"is":[17,25],"independent":[19],"predictor":[20],"of":[21,30,34,84,215],"events":[23],"and":[24,79,89,103,157,196,240,253],"involved":[26],"the":[28,35,127,176],"pathogenesis":[29],"hypertension.":[31,55,72],"The":[32,57,230],"aim":[33],"present":[36,231],"study":[37,58,232],"was":[38,94,131],"investigate":[40],"whether":[41],"PSA":[42,85,130,172,210,238,252],"values,":[43],"are":[44],"associated":[45,133],"with":[46,52,68,113,134,180],"arterial":[47,54,90,254],"indices":[49],"patients":[51,63,74,174],"essential":[53,71,245],"METHODS:":[56],"comprised":[59],"150":[60],"consecutive":[61],"male":[62],"(mean":[64],"age":[65],"60":[66],"years)":[67],"uncomplicated":[69],"never-treated":[70],"All":[73],"underwent":[75],"complete":[77],"clinical":[78],"laboratory":[80],"evaluation,":[81],"including":[82],"measurement":[83],"levels.":[86],"Aortic":[87],"wave":[91,101],"reflection":[92],"assessment":[93],"made":[95],"by":[96],"using":[97],"carotid-femoral":[98],"(PWVc-f)":[99],"pulse":[100],"velocity":[102],"aortic":[104,241],"augmentation":[105],"index":[106],"corrected":[107],"for":[108,207],"heart":[109],"rate":[110],"(AIx75).":[111],"Patients":[112],"prostate":[114,118],"cancer":[115],"or":[116],"benign":[117],"hyperplasia":[119],"(PSA":[120],">":[121],"4":[122],"ng/mL)":[123],"were":[124],"excluded":[125],"from":[126],"study.":[128],"RESULTS:":[129],"positively":[132],"waist-to-hip":[135],"ratio":[136,184],"(r":[137,144,151],"=":[138,141,145,152,155,164,186,220,224],"0.235,":[139],"P":[140,147,154,166,226],"0.04),":[142],"PWVc-f":[143,188,216],"0.426,":[146],"<":[148,167,190,194,199,227],"0.001),":[149,156],"AIx75":[150,192],"0.264,":[153],"high":[158],"sensitivity":[159],"C-reactive":[160],"protein":[161],"(hsCRP;":[162],"r":[163],"0.376,":[165],"0.001).":[168,228],"In":[169,202],"categorization":[170],"quartiles,":[173],"higher":[177,181],"quartile":[178],"presented":[179],"waist-to":[182],"hip":[183],"(P":[185,189,193,198],"0.009),":[187],"0.00001),":[191],"0.001)":[195,200],"hsCRP":[197],"values.":[201],"multivariate":[203],"analysis":[204],"after":[205],"adjustment":[206],"various":[208],"confounders":[209],"remained":[211],"significant":[213],"determinant":[214],"values":[217],"(beta":[218],"[SE]":[219],"0.477":[221],"[0.13],":[222],"R(2)":[223],"0.405,":[225],"CONCLUSION:":[229],"points":[233],"towards":[234],"an":[235],"association":[236],"between":[237,251],"levels":[239],"untreated":[244],"hypertensive":[246],"males.":[247],"Potential":[248],"causal":[249],"relationships":[250],"remain":[256],"be":[258],"further":[259],"explored.":[260]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}