{"id":"https://openalex.org/W1577558588","doi":"https://doi.org/10.1002/jmv.21360","title":"Diverse IgG subclass responses to adeno\u2010associated virus infection and vector administration","display_name":"Diverse IgG subclass responses to adeno\u2010associated virus infection and vector administration","publication_year":2008,"publication_date":"2008-11-21","ids":{"openalex":"https://openalex.org/W1577558588","doi":"https://doi.org/10.1002/jmv.21360","mag":"1577558588","pmid":"https://pubmed.ncbi.nlm.nih.gov/19031458","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2782623"},"language":"en","primary_location":{"id":"doi:10.1002/jmv.21360","doi":"https://doi.org/10.1002/jmv.21360","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.21360","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2782623","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033076337","display_name":"Samuel L. Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel L. Murphy","raw_affiliation_strings":["Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058731290","display_name":"Hojun Li","orcid":"https://orcid.org/0000-0002-8129-0390","observed_orcids":["https://orcid.org/0000-0002-8129-0390"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hojun Li","raw_affiliation_strings":["Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049298836","display_name":"Federico Mingozzi","orcid":"https://orcid.org/0000-0003-0685-3752","observed_orcids":["https://orcid.org/0000-0003-0685-3752","https://orcid.org/0000-0002-6607-0058","https://orcid.org/0009-0002-9658-6466"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Federico Mingozzi","raw_affiliation_strings":["Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007360666","display_name":"Denise E. Sabatino","orcid":"https://orcid.org/0000-0002-6116-5453","observed_orcids":["https://orcid.org/0000-0002-6116-5453"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise E. Sabatino","raw_affiliation_strings":["Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004249526","display_name":"Daniel J. Hui","orcid":"https://orcid.org/0000-0002-3876-1847","observed_orcids":["https://orcid.org/0000-0002-3876-1847"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Hui","raw_affiliation_strings":["Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110240079","display_name":"Shyrie A. Edmonson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyrie A. Edmonson","raw_affiliation_strings":["Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060779925","display_name":"Katherine A. High","orcid":"https://orcid.org/0000-0002-0805-6223","observed_orcids":["https://orcid.org/0000-0002-0805-6223"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katherine A. High","raw_affiliation_strings":["Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","Howard Hughes Medical Institute, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060779925"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I1344073410"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":3.1771,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.92361968,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"81","issue":"1","first_page":"65","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.9629999995231628},{"id":"https://openalex.org/keywords/igg-subclasses","display_name":"IgG subclasses","score":0.8479999899864197},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.953000009059906},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.7009999752044678},{"id":"https://openalex.org/keywords/intravascular-injection","display_name":"intravascular injection","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C2776194381","wikidata":"https://www.wikidata.org/wiki/Q3965271","display_name":"Subclass","level":3,"score":0.8994448184967041},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.8968973159790039},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.7517150640487671},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7365024089813232},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6482882499694824},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.572925329208374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5509436130523682},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5453223586082458},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.5161939263343811},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.5075048804283142},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.467540442943573},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.23353424668312073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06526395678520203},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06331872940063477}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010322","descriptor_name":"Parvoviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jmv.21360","doi":"https://doi.org/10.1002/jmv.21360","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.21360","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},{"id":"pmid:19031458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19031458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical virology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:2782623","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2782623","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Virol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2782623","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2782623","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Virol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G6023877185","display_name":"Gene Therapy for Hemophilia","funder_award_id":"P01HL064190","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8487398984","display_name":"Immune Responses to AAV-Mediated FIX Gene Transfer","funder_award_id":"P01HL078810","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1487084354","https://openalex.org/W1885601830","https://openalex.org/W1907043719","https://openalex.org/W1969803547","https://openalex.org/W1973280547","https://openalex.org/W1975603969","https://openalex.org/W1976329054","https://openalex.org/W2001752918","https://openalex.org/W2004983645","https://openalex.org/W2007261697","https://openalex.org/W2010430983","https://openalex.org/W2013659283","https://openalex.org/W2015426350","https://openalex.org/W2021667501","https://openalex.org/W2048424691","https://openalex.org/W2056033198","https://openalex.org/W2067180101","https://openalex.org/W2067204822","https://openalex.org/W2076447914","https://openalex.org/W2079017842","https://openalex.org/W2091134968","https://openalex.org/W2093537294","https://openalex.org/W2107366983","https://openalex.org/W2130515212","https://openalex.org/W2135531519","https://openalex.org/W2139253759","https://openalex.org/W2140864706","https://openalex.org/W2145365087","https://openalex.org/W2148601484","https://openalex.org/W2155710930","https://openalex.org/W2157636936","https://openalex.org/W2158480664","https://openalex.org/W2166040205","https://openalex.org/W2170819733","https://openalex.org/W2263291280","https://openalex.org/W2273251931"],"related_works":["https://openalex.org/W4244631294","https://openalex.org/W2082025265","https://openalex.org/W2897401411","https://openalex.org/W2154038583","https://openalex.org/W2171988116","https://openalex.org/W2566984602","https://openalex.org/W609966434","https://openalex.org/W2170549121","https://openalex.org/W2079017842","https://openalex.org/W2502088097"],"abstract_inverted_index":{"Humoral":[0],"immune":[1],"responses":[2,17,24,37,69,90,125,135,174,196],"occur":[3],"following":[4],"exposure":[5],"to":[6,18,25,48,70,81,120,126,136,146,197],"Adeno-associated":[7],"virus":[8],"(AAV)":[9],"or":[10],"AAV":[11,26,55,62,71,121,127,137],"vectors.":[12,63],"Many":[13],"studies":[14],"characterized":[15],"antibody":[16,152],"AAV,":[19,50],"but":[20],"human":[21,45,97],"IgG":[22,35,67,111,124,132,134,183],"subclass":[23,36,68,184],"have":[27],"not":[28],"been":[29],"previously":[30],"described.":[31],"In":[32],"this":[33,179,198],"study,":[34],"were":[38,73,91,143,176],"examined":[39],"in":[40,75,94,112,139,169,178],"serum":[41],"samples":[42],"of":[43,66,107,115,129,149,155,162,182,186,195],"normal":[44,96,116],"subjects":[46,51,58,142],"exposed":[47,119],"wild-type":[49],"injected":[52,59],"intramuscularly":[53],"with":[54,61],"vectors":[56,122],"and":[57,88,100,153,172],"intravascularly":[60],"A":[64],"diversity":[65],"capsid":[72,110,128,138,164,188],"found":[74,80],"different":[76],"subjects.":[77],"IgG1":[78,165],"was":[79],"be":[82],"the":[83,104,147,156],"dominant":[84],"response.":[85],"IgG2,":[86,170],"IgG3,":[87,171],"IgG4":[89,173],"also":[92],"observed":[93,177],"most":[95],"subjects;":[98],"IgG2":[99],"IgG3":[101],"each":[102],"represented":[103],"major":[105],"fraction":[106],"total":[108],"anti-AAV":[109,151,163,187],"a":[113,191],"subset":[114],"donors.":[117],"Subjects":[118],"showed":[123],"all":[130],"four":[131],"subclasses.":[133],"clinical":[140],"trial":[141],"inversely":[144],"proportional":[145],"level":[148],"pre-existing":[150],"independent":[154],"vector":[157],"dose.":[158],"The":[159],"high":[160],"levels":[161],"can":[166],"mask":[167],"differences":[168],"that":[175],"study.":[180],"Analysis":[181],"distribution":[185],"antibodies":[189],"indicates":[190],"complex,":[192],"non-uniform":[193],"pattern":[194],"viral":[199],"antigen.":[200],"J.":[201],"Med.":[202],"Virol.":[203],"81:65-74,":[204],"2009.":[205],"(c)":[206],"2008":[207],"Wiley-Liss,":[208],"Inc.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
