{"id":"https://openalex.org/W1577129178","doi":null,"title":"Inotropic and vasoactive drug treatment of interleukin 2 induced hypotension in sheep.","display_name":"Inotropic and vasoactive drug treatment of interleukin 2 induced hypotension in sheep.","publication_year":1989,"publication_date":"1989-08-15","ids":{"openalex":"https://openalex.org/W1577129178","mag":"1577129178","pmid":"https://pubmed.ncbi.nlm.nih.gov/2787205"},"language":"en","primary_location":{"id":"pmid:2787205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2787205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109974584","display_name":"Stuart Zeilender","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Zeilender","raw_affiliation_strings":["Pulmonary Division, Medical College of Virginia/McGuire Veterans Administration Hospitals, Richmond 23298-0050"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Division, Medical College of Virginia/McGuire Veterans Administration Hospitals, Richmond 23298-0050","institution_ids":["https://openalex.org/I2801770128","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Davis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109200622","display_name":"R. Paul Fairman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R P Fairman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046911718","display_name":"Frederick L. Glauser","orcid":"https://orcid.org/0000-0002-1582-4083","observed_orcids":["https://orcid.org/0000-0002-1582-4083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F L Glauser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.1009253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"49","issue":"16","first_page":"4423","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8669999837875366},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8610000014305115},{"id":"https://openalex.org/keywords/inotropic-agents","display_name":"inotropic agents","score":0.7519999742507935},{"id":"https://openalex.org/keywords/vasoactive-drugs","display_name":"vasoactive drugs","score":0.8539999723434448},{"id":"https://openalex.org/keywords/dobutamine","display_name":"dobutamine","score":0.7649999856948853},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amrinone","display_name":"amrinone","score":0.9459999799728394},{"id":"https://openalex.org/keywords/calcium-chloride","display_name":"calcium chloride","score":0.8149999976158142},{"id":"https://openalex.org/keywords/methoxamine","display_name":"methoxamine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.8149999976158142},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oxygen-delivery","display_name":"oxygen delivery","score":0.7559999823570251},{"id":"https://openalex.org/keywords/capillary-leak","display_name":"capillary leak syndrome","score":0.7689999938011169},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.5659999847412109},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C2780745239","wikidata":"https://www.wikidata.org/wiki/Q685119","display_name":"Methoxamine","level":4,"score":0.7981815338134766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7661533951759338},{"id":"https://openalex.org/C2781185063","wikidata":"https://www.wikidata.org/wiki/Q422782","display_name":"Dobutamine","level":3,"score":0.702330470085144},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.6622397303581238},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.6184262633323669},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5250651240348816},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.46601417660713196},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4184490442276001},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4043942093849182},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3205082416534424},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.2892017066478729},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.14953258633613586},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06847590208053589}],"mesh":[{"descriptor_ui":"D000676","descriptor_name":"Amrinone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002122","descriptor_name":"Calcium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004280","descriptor_name":"Dobutamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2787205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2787205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1577129178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2787205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2398366793","https://openalex.org/W2073325079","https://openalex.org/W2094619261","https://openalex.org/W2148820527","https://openalex.org/W2143732220","https://openalex.org/W2040614620","https://openalex.org/W4244637329","https://openalex.org/W2143367489","https://openalex.org/W1971932281","https://openalex.org/W1981087388"],"abstract_inverted_index":{"The":[0],"side":[1],"effects":[2],"associated":[3],"with":[4,72],"recombinant":[5,88,98],"interleukin":[6,89,99],"2":[7,100,216],"administration,":[8],"including":[9],"systemic":[10,44,123,140],"hypotension":[11,38],"and":[12,27,43,57,76,154,183,215,234,242],"a":[13,58,103,119,136,155],"vascular":[14,124],"leak":[15],"syndrome,":[16],"may":[17],"limit":[18],"therapy":[19],"before":[20],"reaching":[21],"maximum":[22],"doses":[23],"of":[24,83,97,210,213,220],"this":[25,37,249],"innovative":[26],"promising":[28],"treatment":[29],"for":[30,255],"cancer.":[31],"In":[32],"an":[33,228],"attempt":[34],"to":[35,70,92,114,131,148,166,187,217,236,263],"reverse":[36],"without":[39,176,194],"decreasing":[40],"cardiac":[41,107,192,204,232],"output":[42,108,193,205],"oxygen":[45,243],"delivery":[46],"(DO2),":[47],"we":[48],"studied":[49],"several":[50],"inotropic":[51],"agents,":[52],"dobutamine,":[53,182],"dopamine,":[54],"amrinone,":[55],"CaCl2,":[56],"pure":[59],"alpha-adrenergic":[60],"vasoconstrictor,":[61],"methoxamine.":[62],"These":[63],"were":[64],"administered":[65],"singly":[66],"or":[67],"in":[68,106,122,138,157,179,227,230],"combination":[69,209,251],"sheep":[71],"chronically":[73],"implanted":[74],"arterial":[75],"pulmonary":[77],"artery":[78],"catheters":[79],"following":[80],"24":[81,95],"h":[82,96],"3":[84,218],"x":[85],"10(5)":[86],"units/kg":[87],"2.":[90],"Compared":[91],"baseline":[93,188,237],"values,":[94],"infusion":[101],"caused":[102],"significant":[104,120],"increase":[105,229],"from":[109,127,144,162],"4.4":[110],"+/-":[111,116,129,133,146,150,164,168],"0.9":[112],"(SD)":[113],"5.0":[115],"0.6":[117],"liters/min,":[118],"fall":[121],"resistance":[125],"(SVR)":[126],"21":[128],"7":[130],"15":[132,224],"5":[134],"units,":[135],"decrease":[137,156],"mean":[139],"blood":[141],"pressure":[142],"(SBP)":[143],"88":[145],"9":[147],"78":[149],"6":[151,169],"mm":[152],"Hg,":[153],"left":[158],"ventricular":[159],"stroke":[160],"work":[161],"51.5":[163],"8":[165],"49":[167],"gram":[170],"meters":[171],"(P":[172],"less":[173],"than":[174],"0.05)":[175],"any":[177],"change":[178],"DO2.":[180],"Dopamine,":[181],"CaCl2":[184],"returned":[185],"SBP":[186,199],"values":[189,238],"by":[190,200],"increasing":[191,195,201],"SVR.":[196],"Methoxamine":[197],"increased":[198],"SVR,":[202],"but":[203],"decreased":[206],"significantly.":[207],"A":[208],"12":[211],"micrograms/kg/min":[212],"dopamine":[214],"mg":[219],"methoxamine":[221],"infused":[222],"over":[223],"min":[225],"resulted":[226],"SBP,":[231],"output,":[233],"SVR":[235],"while":[239],"maintaining":[240],"DO2":[241],"consumption":[244],"(VO2).":[245],"We":[246],"suggest":[247],"that":[248],"latter":[250],"would":[252],"be":[253],"appropriate":[254],"clinical":[256],"use":[257],"since":[258],"it":[259],"returns":[260],"physiological":[261],"parameters":[262],"normal.":[264]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}