{"id":"https://openalex.org/W1576890338","doi":"https://doi.org/10.1002/9781118015377.ch17","title":"Slow\u2010Onset Kinetics of HIV Integrase Inhibitors and Proposed Molecular Model","display_name":"Slow\u2010Onset Kinetics of HIV Integrase Inhibitors and Proposed Molecular Model","publication_year":2011,"publication_date":"2011-09-09","ids":{"openalex":"https://openalex.org/W1576890338","doi":"https://doi.org/10.1002/9781118015377.ch17","mag":"1576890338"},"language":"en","primary_location":{"id":"doi:10.1002/9781118015377.ch17","doi":"https://doi.org/10.1002/9781118015377.ch17","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781118015377.ch17","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HIV\u20101 Integrase","raw_type":"other"},"volume":{"id":"https://openalex.org/W2482172194","display_name":"HIV\u20101 Integrase"},"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110166075","display_name":"Edward P. Garvey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward P. Garvey","raw_affiliation_strings":["Department of Virology, Infectious Disease Center for Excellence in Drug Discovery, GlaxoSmithKline, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Infectious Disease Center for Excellence in Drug Discovery, GlaxoSmithKline, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044054259","display_name":"Benjamin J. Schwartz","orcid":"https://orcid.org/0000-0003-3257-9152","observed_orcids":["https://orcid.org/0000-0003-3257-9152"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Schwartz","raw_affiliation_strings":["Department of Biological Reagents and Assay Development, Molecular Discovery Research, GlaxoSmithKline, Upper Merion, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Reagents and Assay Development, Molecular Discovery Research, GlaxoSmithKline, Upper Merion, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210114143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210114143"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"255","last_page":"263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-integrase-inhibitors","display_name":"HIV integrase inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/time-dependent-inhibition","display_name":"time-dependent inhibition","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.9275294542312622},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.786483883857727},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.7073243260383606},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.5648705363273621},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41528576612472534},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40001145005226135},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3329671323299408},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3255450427532196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3200130760669708},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.30904123187065125},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1616446077823639},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.09075981378555298},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9781118015377.ch17","doi":"https://doi.org/10.1002/9781118015377.ch17","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781118015377.ch17","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HIV\u20101 Integrase","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W180725227","https://openalex.org/W1501954618","https://openalex.org/W1689188863","https://openalex.org/W1989276338","https://openalex.org/W1991395228","https://openalex.org/W1994293556","https://openalex.org/W2006572311","https://openalex.org/W2007831756","https://openalex.org/W2010533762","https://openalex.org/W2025444624","https://openalex.org/W2039619756","https://openalex.org/W2040729797","https://openalex.org/W2042761408","https://openalex.org/W2043450267","https://openalex.org/W2050310420","https://openalex.org/W2052170989","https://openalex.org/W2053125329","https://openalex.org/W2056699675","https://openalex.org/W2065208435","https://openalex.org/W2072692397","https://openalex.org/W2077557314","https://openalex.org/W2084595883","https://openalex.org/W2088424911","https://openalex.org/W2109455981","https://openalex.org/W2109881786","https://openalex.org/W2110661303","https://openalex.org/W2117959947","https://openalex.org/W2126573810","https://openalex.org/W2137646827","https://openalex.org/W2148026374","https://openalex.org/W2151389386","https://openalex.org/W2154190260","https://openalex.org/W2157746949","https://openalex.org/W2164778451","https://openalex.org/W2166428694","https://openalex.org/W2171711893","https://openalex.org/W2171813035","https://openalex.org/W4249631582","https://openalex.org/W6607400712"],"related_works":["https://openalex.org/W2040729797","https://openalex.org/W1608364094","https://openalex.org/W1592451418","https://openalex.org/W2272147162","https://openalex.org/W1539177598","https://openalex.org/W7222869551","https://openalex.org/W1965505177","https://openalex.org/W1973113822","https://openalex.org/W2039619756","https://openalex.org/W2617941282"],"abstract_inverted_index":{"This":[0],"chapter":[1],"contains":[2],"sections":[3],"titled:":[4],"Introduction":[5],"Time-Dependent":[6],"Inhibition":[7],"of":[8],"HIV":[9],"Integrase":[10],"Discussion":[11],"and":[12,19],"Model":[13],"for":[14],"INI":[15],"Slow-Binding":[16],"Kinetics":[17],"Conclusions":[18],"Future":[20],"Studies":[21],"Acknowledgments":[22],"References":[23]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}