{"id":"https://openalex.org/W1576843844","doi":null,"title":"Characterization of intestinal alkaline phosphatase expression and the tumorigenic potential of gamma-irradiated HeLa x fibroblast cell hybrids.","display_name":"Characterization of intestinal alkaline phosphatase expression and the tumorigenic potential of gamma-irradiated HeLa x fibroblast cell hybrids.","publication_year":1991,"publication_date":"1991-08-15","ids":{"openalex":"https://openalex.org/W1576843844","mag":"1576843844","pmid":"https://pubmed.ncbi.nlm.nih.gov/1868467"},"language":"en","primary_location":{"id":"pmid:1868467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1868467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101461494","display_name":"Marc S. Mendonca","orcid":"https://orcid.org/0000-0001-9139-1964","observed_orcids":["https://orcid.org/0000-0001-9139-1964"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M S Mendonca","raw_affiliation_strings":["Department of Radiological Sciences, University of California, Irvine 92717","University of California, at Irvine#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Sciences, University of California, Irvine 92717","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, at Irvine#TAB#","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005663791","display_name":"Ronald J. Antoniono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Antoniono","raw_affiliation_strings":["University of California, at Irvine#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, at Irvine#TAB#","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081754264","display_name":"Kathryn M. Latham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K M Latham","raw_affiliation_strings":["University of California, at Irvine#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, at Irvine#TAB#","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052269548","display_name":"Eric J. Stanbridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E J Stanbridge","raw_affiliation_strings":["University of California, at Irvine#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, at Irvine#TAB#","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113734861","display_name":"J. Leslie Redpath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Redpath","raw_affiliation_strings":["University of California, at Irvine#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, at Irvine#TAB#","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":1.3653,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.78108344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"51","issue":"16","first_page":"4455","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-alkaline-phosphatase","display_name":"intestinal alkaline phosphatase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7670000195503235},{"id":"https://openalex.org/keywords/chromosome-11","display_name":"chromosome 11","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.902999997138977},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5550000071525574},{"id":"https://openalex.org/keywords/nude-mouse-xenograft","display_name":"nude mouse xenograft","score":0.7080000042915344},{"id":"https://openalex.org/keywords/tumor-growth-rate","display_name":"tumor growth rate","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6529544591903687},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.6513990163803101},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6053634881973267},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5929490327835083},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4989049434661865},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.48792216181755066},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.45515650510787964},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44851425290107727},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.445279598236084},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.43032222986221313},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.417180597782135},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38878369331359863},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3616190254688263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16337114572525024},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13615885376930237},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12600579857826233}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002459","descriptor_name":"Cell Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1868467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1868467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1576843844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1868467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W101106793","https://openalex.org/W973784641","https://openalex.org/W1541661673","https://openalex.org/W1675673684","https://openalex.org/W1689494938","https://openalex.org/W1831319429","https://openalex.org/W1964623084","https://openalex.org/W1970440374","https://openalex.org/W1977031949","https://openalex.org/W1977442544","https://openalex.org/W1988088718","https://openalex.org/W2003591846","https://openalex.org/W2005106104","https://openalex.org/W2012034467","https://openalex.org/W2014206927","https://openalex.org/W2023189798","https://openalex.org/W2057167298","https://openalex.org/W2078571699","https://openalex.org/W2082895851","https://openalex.org/W2085362415","https://openalex.org/W2089991257","https://openalex.org/W2093419817","https://openalex.org/W2106346662","https://openalex.org/W2130813854","https://openalex.org/W2142150081","https://openalex.org/W2146642286","https://openalex.org/W2158333896","https://openalex.org/W2163565167","https://openalex.org/W2166160962","https://openalex.org/W2320196404","https://openalex.org/W2409420296","https://openalex.org/W2412672267"],"related_works":["https://openalex.org/W264764068","https://openalex.org/W1495118609","https://openalex.org/W7096947642","https://openalex.org/W1984544759","https://openalex.org/W2166160962","https://openalex.org/W2142150081","https://openalex.org/W2439352499","https://openalex.org/W4301322077","https://openalex.org/W2416435751","https://openalex.org/W2156103592"],"abstract_inverted_index":{"Fusion":[0],"of":[1,31,34,42,45,52,80,91,106,129,134,140,144,170,213,233],"tumorigenic":[2],"HeLa":[3,22,62,94],"cells":[4],"with":[5,50,230,239],"human":[6,46],"skin":[7,96],"fibroblasts":[8],"results":[9],"in":[10,167,226,306],"genetically":[11],"stable":[12],"hybrids":[13],"which":[14],"are":[15],"nontumorigenic":[16,36,93],"and":[17,54,71,117,132,155,220,236,275,277],"no":[18],"longer":[19,192],"express":[20],"the":[21,35,40,81,92,111,118,145,168,177,181,194,234,262,268,282,288],"tumor-associated":[23],"antigen,":[24],"intestinal":[25],"alkaline":[26],"phosphatase":[27],"(IAP).":[28],"Previous":[29],"analysis":[30],"spontaneous":[32],"segregants":[33],"hybrid":[37,98,309],"have":[38,85,125],"implicated":[39],"loss":[41],"one":[43],"copy":[44],"fibroblast":[47,97],"chromosome":[48,69],"11":[49,70],"reexpression":[51,105,274],"IAP":[53,82,107,115,135,196,214,224,241,249,273,289],"tumorigenicity.":[55],"This":[56],"observation":[57],"suggests":[58,292],"that":[59,72,100,207,247,281,293],"a":[60,77,126,138,210],"putative":[61,119],"tumor":[63,120,163,188,218,231,258,283,304],"suppressor":[64,121,284],"gene(s)":[65],"is":[66,166,209,252],"located":[67],"on":[68],"this":[73,307],"gene":[74,297],"may":[75,285,299],"be":[76,160,300],"negative":[78],"regulator":[79],"gene.":[83],"We":[84],"isolated":[86],"several":[87],"gamma-ray-induced":[88],"mutants":[89],"(GIMs)":[90],"x":[95],"CGL1":[99],"were":[101,157],"specifically":[102],"selected":[103],"for":[104,175,217,222,295,302],"to":[108,159,172,184,255,267,278],"further":[109],"investigate":[110],"potential":[112],"linkage":[113],"between":[114,272],"regulation":[116],"locus.":[122],"The":[123,142,162],"GIMs":[124,146,235],"wide":[127],"range":[128,169],"cell":[130,178,308],"morphology":[131],"level":[133,212],"expression":[136,215,225,244,250],"(nearly":[137],"factor":[139],"40).":[141],"tumorigenicity":[143,276],"was":[147,190,198],"examined":[148],"by":[149],"s.c.":[150],"injection":[151],"into":[152],"nude":[153],"mice":[154],"all":[156,176],"found":[158],"tumorigenic.":[161],"volume-doubling":[164],"time":[165,183],"4":[171],"8":[173],"days":[174],"lines;":[179],"however,":[180],"lag":[182],"reach":[185],"500":[186],"mm3":[187],"volume":[189],"significantly":[191],"when":[193],"GIM":[195],"activity":[197],"low":[199],"(less":[200],"than":[201],"20%":[202],"relative":[203],"activity),":[204],"suggesting":[205],"perhaps":[206],"there":[208],"threshold":[211],"required":[216],"formation":[219],"selection":[221,294],"high":[223,248],"vivo.":[227],"However,":[228],"studies":[229,238],"reconstitutes":[232],"transfection":[237],"an":[240],"complementary":[242],"DNA":[243],"vector":[245],"indicate":[246],"alone":[251],"not":[253],"sufficient":[254],"confer":[256],"rapid":[257],"growth.":[259],"Therefore,":[260],"while":[261],"data":[263],"lend":[264],"strong":[265],"support":[266],"continued":[269],"tight":[270],"correlation":[271],"our":[279],"proposal":[280],"negatively":[286],"regulate":[287],"gene,":[290],"it":[291],"other":[296],"activities":[298],"responsible":[301],"aggressive":[303],"growth":[305],"system.":[310]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}