{"id":"https://openalex.org/W1576829053","doi":null,"title":"Cellular fate and functions of glucosylceramide","display_name":"Cellular fate and functions of glucosylceramide","publication_year":2006,"publication_date":"2006-04-21","ids":{"openalex":"https://openalex.org/W1576829053","mag":"1576829053"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/8675","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/8675","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/8675","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031382955","display_name":"Jasja Wolthoorn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jasja Wolthoorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031382955"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.2224999964237213,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucosylceramide","display_name":"glucosylceramide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sphingomyelin-synthesis","display_name":"sphingomyelin synthesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/glycosphingolipids","display_name":"glycosphingolipids","score":0.8579999804496765},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.9539999961853027},{"id":"https://openalex.org/keywords/protein-glycosylation","display_name":"protein glycosylation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/sphingolipid-homeostasis","display_name":"sphingolipid homeostasis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/gaucher-disease","display_name":"Gaucher disease","score":0.9459999799728394},{"id":"https://openalex.org/keywords/farber-disease","display_name":"Farber disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.7250000238418579},{"id":"https://openalex.org/keywords/oculocutaneous-albinism","display_name":"oculocutaneous albinism","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pigmentation","display_name":"pigmentation","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.9079207181930542},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.773250937461853},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6538490056991577},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.6308461427688599},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.547792911529541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5312625765800476},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5161798596382141},{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.488546222448349},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.4124807119369507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3604189455509186},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21271681785583496},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.1525869369506836},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/8675","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/8675","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/8675","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/8675","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:1576829053","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/1874/8675/1/abbr.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/8675","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/8675","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":265,"referenced_works":["https://openalex.org/W1368384","https://openalex.org/W6960735","https://openalex.org/W54758711","https://openalex.org/W62534473","https://openalex.org/W75573225","https://openalex.org/W122226182","https://openalex.org/W150816671","https://openalex.org/W187359374","https://openalex.org/W1481538026","https://openalex.org/W1483874824","https://openalex.org/W1508039723","https://openalex.org/W1512187347","https://openalex.org/W1513295024","https://openalex.org/W1520839822","https://openalex.org/W1531514263","https://openalex.org/W1535569627","https://openalex.org/W1536374844","https://openalex.org/W1539102283","https://openalex.org/W1541236883","https://openalex.org/W1550422390","https://openalex.org/W1552530881","https://openalex.org/W1556265505","https://openalex.org/W1556766638","https://openalex.org/W1564861448","https://openalex.org/W1566480668","https://openalex.org/W1583090955","https://openalex.org/W1588043332","https://openalex.org/W1594345523","https://openalex.org/W1595875268","https://openalex.org/W1603071178","https://openalex.org/W1696267199","https://openalex.org/W1795202973","https://openalex.org/W1815261168","https://openalex.org/W1873398942","https://openalex.org/W1886325990","https://openalex.org/W1917834902","https://openalex.org/W1922854094","https://openalex.org/W1953668033","https://openalex.org/W1964495368","https://openalex.org/W1966442417","https://openalex.org/W1968107961","https://openalex.org/W1968733935","https://openalex.org/W1970290833","https://openalex.org/W1971392424","https://openalex.org/W1971886804","https://openalex.org/W1972308264","https://openalex.org/W1972549325","https://openalex.org/W1972759684","https://openalex.org/W1972866768","https://openalex.org/W1973583404","https://openalex.org/W1975672381","https://openalex.org/W1975783279","https://openalex.org/W1976608130","https://openalex.org/W1977004640","https://openalex.org/W1978103505","https://openalex.org/W1978564700","https://openalex.org/W1978982003","https://openalex.org/W1980045097","https://openalex.org/W1980334501","https://openalex.org/W1981622999","https://openalex.org/W1981728390","https://openalex.org/W1982054175","https://openalex.org/W1982362005","https://openalex.org/W1983071332","https://openalex.org/W1983592682","https://openalex.org/W1983748179","https://openalex.org/W1987485284","https://openalex.org/W1988672861","https://openalex.org/W1990286006","https://openalex.org/W1990927663","https://openalex.org/W1991241713","https://openalex.org/W1991593966","https://openalex.org/W1992586088","https://openalex.org/W1994425718","https://openalex.org/W1996149510","https://openalex.org/W1997469380","https://openalex.org/W1998697778","https://openalex.org/W1998987638","https://openalex.org/W1999955296","https://openalex.org/W2000764878","https://openalex.org/W2001814436","https://openalex.org/W2001828696","https://openalex.org/W2001956269","https://openalex.org/W2001985026","https://openalex.org/W2003268284","https://openalex.org/W2003709444","https://openalex.org/W2004234948","https://openalex.org/W2005537077","https://openalex.org/W2005775461","https://openalex.org/W2006992169","https://openalex.org/W2008078894","https://openalex.org/W2008291568","https://openalex.org/W2009480162","https://openalex.org/W2011987706","https://openalex.org/W2012455036","https://openalex.org/W2013905125","https://openalex.org/W2013954651","https://openalex.org/W2014456011","https://openalex.org/W2014614188","https://openalex.org/W2014646585","https://openalex.org/W2016740239","https://openalex.org/W2017115591","https://openalex.org/W2017184203","https://openalex.org/W2018415759","https://openalex.org/W2019235505","https://openalex.org/W2019404217","https://openalex.org/W2019497539","https://openalex.org/W2021505229","https://openalex.org/W2021836407","https://openalex.org/W2023125175","https://openalex.org/W2023560082","https://openalex.org/W2024156929","https://openalex.org/W2025574036","https://openalex.org/W2026240439","https://openalex.org/W2026394997","https://openalex.org/W2026590190","https://openalex.org/W2026638965","https://openalex.org/W2028781651","https://openalex.org/W2028811272","https://openalex.org/W2030480923","https://openalex.org/W2031577863","https://openalex.org/W2032256155","https://openalex.org/W2032315776","https://openalex.org/W2032416398","https://openalex.org/W2032804339","https://openalex.org/W2033936610","https://openalex.org/W2034167933","https://openalex.org/W2034336581","https://openalex.org/W2034529478","https://openalex.org/W2034851272","https://openalex.org/W2035337456","https://openalex.org/W2036822252","https://openalex.org/W2037735248","https://openalex.org/W2037773086","https://openalex.org/W2037959158","https://openalex.org/W2039999794","https://openalex.org/W2045367891","https://openalex.org/W2046585193","https://openalex.org/W2047176381","https://openalex.org/W2048747800","https://openalex.org/W2048792813","https://openalex.org/W2048869016","https://openalex.org/W2051341245","https://openalex.org/W2054714286","https://openalex.org/W2055864348","https://openalex.org/W2056301675","https://openalex.org/W2056975354","https://openalex.org/W2057370535","https://openalex.org/W2058459036","https://openalex.org/W2061397088","https://openalex.org/W2061477086","https://openalex.org/W2063423234","https://openalex.org/W2064055192","https://openalex.org/W2064954911","https://openalex.org/W2065403501","https://openalex.org/W2065886456","https://openalex.org/W2066160116","https://openalex.org/W2067827045","https://openalex.org/W2069291325","https://openalex.org/W2069701870","https://openalex.org/W2072033208","https://openalex.org/W2072299980","https://openalex.org/W2072384875","https://openalex.org/W2072903097","https://openalex.org/W2076107153","https://openalex.org/W2076141931","https://openalex.org/W2076238417","https://openalex.org/W2076844242","https://openalex.org/W2077511050","https://openalex.org/W2077513922","https://openalex.org/W2077753375","https://openalex.org/W2078955605","https://openalex.org/W2080951298","https://openalex.org/W2081625461","https://openalex.org/W2082312089","https://openalex.org/W2082514969","https://openalex.org/W2082571338","https://openalex.org/W2083273192","https://openalex.org/W2084480802","https://openalex.org/W2084889888","https://openalex.org/W2090515621","https://openalex.org/W2091399531","https://openalex.org/W2091737333","https://openalex.org/W2093354787","https://openalex.org/W2093406710","https://openalex.org/W2094326163","https://openalex.org/W2095704842","https://openalex.org/W2097323575","https://openalex.org/W2098485024","https://openalex.org/W2098782828","https://openalex.org/W2098799558","https://openalex.org/W2100076132","https://openalex.org/W2101277681","https://openalex.org/W2101840841","https://openalex.org/W2102238970","https://openalex.org/W2106370142","https://openalex.org/W2106508078","https://openalex.org/W2106533399","https://openalex.org/W2106782182","https://openalex.org/W2111942304","https://openalex.org/W2111946681","https://openalex.org/W2112235909","https://openalex.org/W2115052984","https://openalex.org/W2115569175","https://openalex.org/W2116920082","https://openalex.org/W2118504182","https://openalex.org/W2118809078","https://openalex.org/W2119468178","https://openalex.org/W2120838559","https://openalex.org/W2121936687","https://openalex.org/W2122473183","https://openalex.org/W2123224737","https://openalex.org/W2123417037","https://openalex.org/W2123912667","https://openalex.org/W2125620567","https://openalex.org/W2127031535","https://openalex.org/W2129237528","https://openalex.org/W2129927698","https://openalex.org/W2129937373","https://openalex.org/W2130621335","https://openalex.org/W2131879548","https://openalex.org/W2132202507","https://openalex.org/W2133388060","https://openalex.org/W2133991651","https://openalex.org/W2135147739","https://openalex.org/W2135156962","https://openalex.org/W2136259733","https://openalex.org/W2137825215","https://openalex.org/W2138529060","https://openalex.org/W2140120588","https://openalex.org/W2140258025","https://openalex.org/W2142699394","https://openalex.org/W2144692413","https://openalex.org/W2144764000","https://openalex.org/W2145011111","https://openalex.org/W2146429642","https://openalex.org/W2148251929","https://openalex.org/W2148351021","https://openalex.org/W2150339227","https://openalex.org/W2154026288","https://openalex.org/W2154115123","https://openalex.org/W2154424770","https://openalex.org/W2154734157","https://openalex.org/W2156520020","https://openalex.org/W2161281789","https://openalex.org/W2161900691","https://openalex.org/W2162613182","https://openalex.org/W2162868704","https://openalex.org/W2162876369","https://openalex.org/W2163407551","https://openalex.org/W2164477711","https://openalex.org/W2165148465","https://openalex.org/W2165743932","https://openalex.org/W2167603249","https://openalex.org/W2168295234","https://openalex.org/W2170278179","https://openalex.org/W2170832451","https://openalex.org/W2171895487","https://openalex.org/W2184457366","https://openalex.org/W2332317055","https://openalex.org/W2414338879","https://openalex.org/W2419630678","https://openalex.org/W2427215153","https://openalex.org/W3120442083","https://openalex.org/W3192085238"],"related_works":["https://openalex.org/W2101083445","https://openalex.org/W1982362005","https://openalex.org/W1983571376","https://openalex.org/W3114126147","https://openalex.org/W7096510595","https://openalex.org/W150353197","https://openalex.org/W2123605780","https://openalex.org/W4399433945","https://openalex.org/W2586844278","https://openalex.org/W4241015892"],"abstract_inverted_index":{"The":[0,51],"organization":[1],"of":[2,5,48,54,86,98,117,120,130,133],"the":[3,8,12,26,41,95,112,115,118,138],"synthesis":[4],"sphingomyelin":[6],"and":[7,37,72,91,100],"simple":[9],"glycosphingolipids":[10],"in":[11,25,40,122],"Golgi":[13,28,42],"appears":[14],"to":[15,126],"be":[16],"highly":[17],"important":[18],"not":[19],"only":[20],"for":[21,31,84,136],"creating":[22],"sphingolipid/cholesterol":[23],"rafts":[24],"late":[27],"but":[29],"also":[30],"regulating":[32],"numerous":[33],"protein":[34],"glycosylation,":[35],"processing":[36],"sorting":[38],"steps":[39],"lumen":[43],"via":[44,106],"an":[45,79,107],"intricate":[46],"mechanism":[47,140],"pH":[49,73,121],"regulation.":[50,74],"universal":[52],"character":[53],"this":[55],"regulatory":[56],"system":[57],"predicts":[58],"that":[59],"it":[60],"represents":[61],"one":[62],"basic":[63],"link":[64],"between":[65],"very":[66],"different":[67],"physiological":[68],"parameters,":[69],"sphingolipid":[70,87],"homeostasis":[71],"This":[75],"discovery":[76,116],"may":[77,102,124],"have":[78],"impact":[80],"on":[81,109],"developing":[82],"cures":[83],"diseases":[85],"metabolism,":[88],"like":[89],"Gaucher":[90],"Farber":[92],"disease,":[93],"where":[94],"cellular":[96],"accumulations":[97],"glucosylceramide":[99],"ceramide":[101],"actually":[103],"induce":[104],"pathogenesis":[105],"effect":[108],"pH.":[110],"On":[111],"other":[113],"hand,":[114],"role":[119],"pigmentation":[123],"contribute":[125],"a":[127],"better":[128],"understanding":[129],"various":[131],"forms":[132],"oculocutaneous":[134],"albinism":[135],"which":[137],"disease":[139],"had":[141],"remained":[142],"unclear.":[143]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}