{"id":"https://openalex.org/W1576813285","doi":null,"title":"Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness.","display_name":"Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness.","publication_year":1991,"publication_date":"1991-05-15","ids":{"openalex":"https://openalex.org/W1576813285","mag":"1576813285","pmid":"https://pubmed.ncbi.nlm.nih.gov/2021945"},"language":"en","primary_location":{"id":"pmid:2021945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2021945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029344208","display_name":"Erik W. Thompson","orcid":"https://orcid.org/0000-0002-9723-4924","observed_orcids":["https://orcid.org/0000-0002-9723-4924"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E W Thompson","raw_affiliation_strings":["Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, NIH, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, NIH, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008178871","display_name":"Sho Nakamura","orcid":"https://orcid.org/0000-0002-5709-2298","observed_orcids":["https://orcid.org/0000-0002-5709-2298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T B Shima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T B Shima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017643774","display_name":"Antonella Melchiori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Melchiori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"G R Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G R Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Z Salahuddin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Z Salahuddin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006749029","display_name":"Robert C. Gallo","orcid":"https://orcid.org/0000-0002-3797-7910","observed_orcids":["https://orcid.org/0000-0002-3797-7910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R C Gallo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031245175","display_name":"Adriana Albini","orcid":"https://orcid.org/0000-0002-9624-5103","observed_orcids":["https://orcid.org/0000-0002-9624-5103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Albini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7897,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95540126,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"51","issue":"10","first_page":"2670","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aids-associated-kaposi-s-sarcoma","display_name":"AIDS-related Kaposi's sarcoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/endothelial-cell-chemotaxis","display_name":"endothelial cell chemotaxis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/endothelial-cell-invasion","display_name":"endothelial cell invasion","score":0.9649999737739563},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/basement-membrane-invasion","display_name":"basement membrane invasion","score":0.7369999885559082},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.6420000195503235},{"id":"https://openalex.org/keywords/collagenase-iv","display_name":"collagenase IV","score":0.9459999799728394},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.6949999928474426},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.6740000247955322},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.9192923307418823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5586392879486084},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.547049880027771},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5456966757774353},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5419981479644775},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.48557040095329285},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4812307357788086},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.45979544520378113},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4271323084831238},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.42189162969589233},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3977871835231781},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.375300794839859},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37309902906417847},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3168983459472656},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.31157559156417847},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27207234501838684},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11241841316223145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06892070174217224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012514","descriptor_name":"Sarcoma, Kaposi","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012514","descriptor_name":"Sarcoma, Kaposi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012514","descriptor_name":"Sarcoma, Kaposi","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:2021945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2021945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.qut.edu.au:71833","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/51/10/2670.abstract","pdf_url":null,"source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":"Contribution to Journal"},{"id":"mag:1576813285","doi":null,"is_oa":false,"landing_page_url":"https://eprints.qut.edu.au/71833/","pdf_url":null,"source":{"id":"https://openalex.org/S4306510307","display_name":"Faculty of Health","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Health","raw_type":null},{"id":"mag:2151707532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2021945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W160739290","https://openalex.org/W346443449","https://openalex.org/W1486545677","https://openalex.org/W1493792841","https://openalex.org/W1506310415","https://openalex.org/W1518786659","https://openalex.org/W1664407857","https://openalex.org/W1906450972","https://openalex.org/W1938617858","https://openalex.org/W1971759007","https://openalex.org/W1974491777","https://openalex.org/W1974634230","https://openalex.org/W1980871364","https://openalex.org/W1980913429","https://openalex.org/W1981547526","https://openalex.org/W1982261213","https://openalex.org/W1985528986","https://openalex.org/W1987015242","https://openalex.org/W1992960364","https://openalex.org/W1993246798","https://openalex.org/W1994091018","https://openalex.org/W1994099157","https://openalex.org/W1995289448","https://openalex.org/W1996910230","https://openalex.org/W1997605512","https://openalex.org/W2005659153","https://openalex.org/W2015648732","https://openalex.org/W2017724386","https://openalex.org/W2024374396","https://openalex.org/W2027338293","https://openalex.org/W2029433609","https://openalex.org/W2033161411","https://openalex.org/W2036830225","https://openalex.org/W2039213845","https://openalex.org/W2039364065","https://openalex.org/W2049042095","https://openalex.org/W2053372645","https://openalex.org/W2056676975","https://openalex.org/W2071806319","https://openalex.org/W2073571146","https://openalex.org/W2077038019","https://openalex.org/W2079473945","https://openalex.org/W2088468623","https://openalex.org/W2131905126","https://openalex.org/W2144712422","https://openalex.org/W2145539666","https://openalex.org/W2146901767","https://openalex.org/W2153729695","https://openalex.org/W2162740250","https://openalex.org/W2163540795","https://openalex.org/W2163774665","https://openalex.org/W2233792934","https://openalex.org/W2323512743","https://openalex.org/W2327310097","https://openalex.org/W2332289066","https://openalex.org/W2396133897","https://openalex.org/W2398609730","https://openalex.org/W2407579301","https://openalex.org/W2411455165","https://openalex.org/W2416246826","https://openalex.org/W2417080910","https://openalex.org/W2419184423","https://openalex.org/W2465901880","https://openalex.org/W2615426481","https://openalex.org/W2909258545"],"related_works":["https://openalex.org/W1980871364","https://openalex.org/W2031932660","https://openalex.org/W2027844970","https://openalex.org/W2046998348","https://openalex.org/W2031770529","https://openalex.org/W2759847172","https://openalex.org/W2139525028","https://openalex.org/W2111383959","https://openalex.org/W1995289448","https://openalex.org/W2079473945"],"abstract_inverted_index":{"Kaposi's":[0],"sarcoma":[1],"(KS)":[2],"in":[3,11,31,42,54,86,97,120,128,174,248,310],"general,":[4],"and":[5,17,35,74,92,141,172,227,273,281,299,306,316],"acquired":[6],"immunodeficiency":[7],"syndrome-related":[8],"KS":[9,255,305],"(AIDS-KS)":[10],"particular,":[12],"is":[13],"a":[14,98,158,266,292],"highly":[15,84,284],"invasive":[16,85,118,188,297],"intensely":[18],"angiogenic":[19,300],"neoplasm":[20],"of":[21,39,57,68,76,132,139,153,204,220,225,235,242,260,269,302,313,319],"unknown":[22],"cellular":[23],"origin.":[24],"We":[25],"have":[26,51],"recently":[27],"established":[28],"AIDS-KS":[29,61,81,110,213,244],"cells":[30,82,104,115,145,214,247,256],"long":[32],"term":[33],"culture":[34],"reported":[36],"the":[37,53,66,72,87,129,133,137,187,192,201,212,217,240,243,282,296,311],"development":[38],"KS-like":[40],"lesions":[41],"nude":[43],"mice":[44],"inoculated":[45],"with":[46,149],"these":[47,175,249],"cells.":[48,80],"Here,":[49],"we":[50],"examined":[52],"vitro":[55],"invasiveness":[56,75,241,274],"basement":[58,236],"membrane":[59,237],"by":[60,191,211],"cells,":[62],"as":[63,65],"well":[64],"effect(s)":[67],"their":[69],"supernatants":[70],"on":[71,108],"migration":[73,138],"human":[77,140,303],"vascular":[78,143],"endothelial":[79,103,114,144,169,246,270],"were":[83,185],"Boyden":[88,134],"chamber":[89],"invasion":[90,173],"assay":[91],"formed":[93],"invasive,":[94],"branching":[95],"colonies":[96],"3-dimensional":[99],"gel":[100],"(Matrigel).":[101],"Normal":[102],"form":[105,117],"tube-like":[106],"structures":[107],"Matrigel.":[109],"cell-conditioned":[111],"media":[112,194],"induced":[113,190],"to":[116,122,180,258,290,294],"clusters":[119],"addition":[121],"tubes.":[123],"KS-cell-conditioned":[124],"media,":[125],"when":[126,178],"placed":[127],"lower":[130],"compartment":[131],"chamber,":[135],"stimulated":[136],"bovine":[142],"across":[146],"filters":[147],"coated":[148],"either":[150],"small":[151],"amounts":[152],"collagen":[154],"IV":[155,229],"(chemotaxis)":[156],"or":[157],"Matrigel":[159],"barrier":[160],"(invasion).":[161],"Basic":[162],"fibroblast":[163,182,206],"growth":[164,183,207],"factor":[165,184],"could":[166,276],"also":[167],"induce":[168],"cell":[170,271],"chemotaxis":[171,272],"assays.":[176,250],"However,":[177],"antibodies":[179],"basic":[181,205],"used":[186],"activity":[189],"AIDS-KS-cell-conditioned":[193],"was":[195],"only":[196],"marginally":[197],"inhibited,":[198],"suggesting":[199],"that":[200,254],"large":[202],"quantities":[203],"factor-like":[208],"material":[209],"released":[210],"are":[215],"not":[216],"main":[218],"mediators":[219,315],"this":[221],"effect.":[222],"Specific":[223],"inhibitors":[224,318],"laminin":[226],"collagenase":[228],"action,":[230],"which":[231,275],"represent":[232],"critical":[233],"determinants":[234],"invasion,":[238],"blocked":[239],"cell-activated":[245],"These":[251,287],"data":[252],"indicate":[253],"appear":[257,289],"be":[259,277,291],"smooth":[261],"muscle":[262],"origin":[263],"but":[264],"secrete":[265],"potent":[267],"inducer":[268],"responsible":[278],"for":[279],"angiogenesis":[280],"resulting":[283],"vascularized":[285],"lesions.":[286],"assays":[288],"model":[293],"study":[295],"spread":[298],"capacity":[301],"AIDS-related":[304],"should":[307],"prove":[308],"useful":[309],"identification":[312],"molecular":[314],"potential":[317],"neoplastic":[320],"neovascularization.":[321]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}