{"id":"https://openalex.org/W157670028","doi":null,"title":"Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections","display_name":"Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections","publication_year":2007,"publication_date":"2007-02-28","ids":{"openalex":"https://openalex.org/W157670028","mag":"157670028"},"language":"en","primary_location":{"id":"pmh:oai:eprints.unica.it:130","doi":null,"is_oa":false,"landing_page_url":"http://veprints.unica.it/130/1/manca_maria_letizia.pdf","pdf_url":"http://veprints.unica.it/130/1/manca_maria_letizia.pdf","source":{"id":"https://openalex.org/S4406922883","display_name":"VEprints - Universita degli Studi di Cagliari","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Tesi di dottorato"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11584/265866","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023387530","display_name":"Mar\u00eda Letizia Manca","orcid":"https://orcid.org/0000-0002-3787-257X","observed_orcids":["https://orcid.org/0000-0002-3787-257X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Manca, Maria Letizia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023387530"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.3937999904155731,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.8920000195503235},{"id":"https://openalex.org/keywords/chitosan-microparticles","display_name":"chitosan microspheres","score":0.875},{"id":"https://openalex.org/keywords/plga-microspheres","display_name":"PLGA microspheres","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pulmonary-mycobacterial-disease","display_name":"pulmonary mycobacterial infection","score":0.7139999866485596},{"id":"https://openalex.org/keywords/nebulization","display_name":"nebulization","score":0.8619999885559082},{"id":"https://openalex.org/keywords/freeze-drying-stability","display_name":"freeze-drying stability","score":0.8830000162124634},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.968999981880188},{"id":"https://openalex.org/keywords/mucoadhesion","display_name":"mucoadhesion","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9300000071525574},{"id":"https://openalex.org/keywords/glutaraldehyde-crosslinking","display_name":"glutaraldehyde crosslinking","score":0.9459999799728394},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.8370238542556763},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7992760539054871},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.6509764194488525},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6204863786697388},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5921761393547058},{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.5406344532966614},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.5036715865135193},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.48199501633644104},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.45036953687667847},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4345536231994629},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.41496992111206055},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2765050530433655},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.241193950176239},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.1513570249080658},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14159804582595825},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10496565699577332},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09848877787590027}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.unica.it:130","doi":null,"is_oa":false,"landing_page_url":"http://veprints.unica.it/130/1/manca_maria_letizia.pdf","pdf_url":"http://veprints.unica.it/130/1/manca_maria_letizia.pdf","source":{"id":"https://openalex.org/S4406922883","display_name":"VEprints - Universita degli Studi di Cagliari","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Tesi di dottorato"},{"id":"pmh:oai:iris.unica.it:11584/265866","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11584/265866","pdf_url":"http://hdl.handle.net/11584/265866","source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:iris.unica.it:11584/265866","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11584/265866","pdf_url":"http://hdl.handle.net/11584/265866","source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310968","display_name":"University of Patras","ror":"https://ror.org/017wvtq80"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W157670028.pdf","grobid_xml":"https://content.openalex.org/works/W157670028.grobid-xml"},"referenced_works_count":207,"referenced_works":["https://openalex.org/W1014416","https://openalex.org/W4912677","https://openalex.org/W47511650","https://openalex.org/W66745206","https://openalex.org/W90942100","https://openalex.org/W112445417","https://openalex.org/W114303568","https://openalex.org/W156207140","https://openalex.org/W160640617","https://openalex.org/W183986218","https://openalex.org/W188879743","https://openalex.org/W216844364","https://openalex.org/W217664762","https://openalex.org/W657174950","https://openalex.org/W1037202305","https://openalex.org/W1483336725","https://openalex.org/W1485302340","https://openalex.org/W1493342259","https://openalex.org/W1497392903","https://openalex.org/W1542999082","https://openalex.org/W1544389379","https://openalex.org/W1548751297","https://openalex.org/W1556402227","https://openalex.org/W1557661275","https://openalex.org/W1578085517","https://openalex.org/W1578379961","https://openalex.org/W1581836002","https://openalex.org/W1669000153","https://openalex.org/W1798329352","https://openalex.org/W1821728214","https://openalex.org/W1833083113","https://openalex.org/W1894512109","https://openalex.org/W1928630110","https://openalex.org/W1928650375","https://openalex.org/W1964037120","https://openalex.org/W1964062508","https://openalex.org/W1967748130","https://openalex.org/W1968247071","https://openalex.org/W1969939375","https://openalex.org/W1970867860","https://openalex.org/W1971235476","https://openalex.org/W1975795986","https://openalex.org/W1976081868","https://openalex.org/W1978004290","https://openalex.org/W1979358687","https://openalex.org/W1980306833","https://openalex.org/W1980534497","https://openalex.org/W1980803266","https://openalex.org/W1982096781","https://openalex.org/W1982491379","https://openalex.org/W1982572529","https://openalex.org/W1985019144","https://openalex.org/W1987160457","https://openalex.org/W1989182317","https://openalex.org/W1992629480","https://openalex.org/W1992646030","https://openalex.org/W1996676954","https://openalex.org/W2000138260","https://openalex.org/W2000839907","https://openalex.org/W2001990407","https://openalex.org/W2003831977","https://openalex.org/W2004482027","https://openalex.org/W2005173893","https://openalex.org/W2005610781","https://openalex.org/W2008268170","https://openalex.org/W2008754290","https://openalex.org/W2009338923","https://openalex.org/W2009523551","https://openalex.org/W2010079313","https://openalex.org/W2010790915","https://openalex.org/W2011931107","https://openalex.org/W2012996762","https://openalex.org/W2013787151","https://openalex.org/W2014430464","https://openalex.org/W2015639818","https://openalex.org/W2017795881","https://openalex.org/W2021626030","https://openalex.org/W2021670659","https://openalex.org/W2022981155","https://openalex.org/W2024257504","https://openalex.org/W2024732378","https://openalex.org/W2025237170","https://openalex.org/W2025373577","https://openalex.org/W2025852082","https://openalex.org/W2027079661","https://openalex.org/W2029705383","https://openalex.org/W2030845723","https://openalex.org/W2031190569","https://openalex.org/W2031713503","https://openalex.org/W2033612649","https://openalex.org/W2034783507","https://openalex.org/W2035338985","https://openalex.org/W2038211892","https://openalex.org/W2039248354","https://openalex.org/W2039427369","https://openalex.org/W2040904252","https://openalex.org/W2042186520","https://openalex.org/W2043970785","https://openalex.org/W2048274021","https://openalex.org/W2048379750","https://openalex.org/W2048425029","https://openalex.org/W2048525644","https://openalex.org/W2049202565","https://openalex.org/W2049803349","https://openalex.org/W2050204005","https://openalex.org/W2052023868","https://openalex.org/W2052295083","https://openalex.org/W2053559208","https://openalex.org/W2053801760","https://openalex.org/W2053944183","https://openalex.org/W2055416976","https://openalex.org/W2055482526","https://openalex.org/W2059454640","https://openalex.org/W2060344491","https://openalex.org/W2061362207","https://openalex.org/W2061504558","https://openalex.org/W2063276424","https://openalex.org/W2063766636","https://openalex.org/W2063915040","https://openalex.org/W2067085792","https://openalex.org/W2068566312","https://openalex.org/W2068784611","https://openalex.org/W2071026921","https://openalex.org/W2071103044","https://openalex.org/W2071504541","https://openalex.org/W2071901295","https://openalex.org/W2072515072","https://openalex.org/W2072624182","https://openalex.org/W2079682800","https://openalex.org/W2080860769","https://openalex.org/W2081476059","https://openalex.org/W2082757320","https://openalex.org/W2083669220","https://openalex.org/W2084565429","https://openalex.org/W2086370773","https://openalex.org/W2088122330","https://openalex.org/W2089997464","https://openalex.org/W2092451592","https://openalex.org/W2093666660","https://openalex.org/W2094638669","https://openalex.org/W2094947929","https://openalex.org/W2095041477","https://openalex.org/W2098455636","https://openalex.org/W2098500666","https://openalex.org/W2099445482","https://openalex.org/W2102505175","https://openalex.org/W2105665653","https://openalex.org/W2108528189","https://openalex.org/W2114424736","https://openalex.org/W2114918609","https://openalex.org/W2119603196","https://openalex.org/W2128635872","https://openalex.org/W2131140312","https://openalex.org/W2133702235","https://openalex.org/W2135219694","https://openalex.org/W2135298892","https://openalex.org/W2137502223","https://openalex.org/W2143661202","https://openalex.org/W2144362977","https://openalex.org/W2144965887","https://openalex.org/W2146362494","https://openalex.org/W2147078069","https://openalex.org/W2147500722","https://openalex.org/W2147871232","https://openalex.org/W2152386842","https://openalex.org/W2155186392","https://openalex.org/W2155552559","https://openalex.org/W2156112012","https://openalex.org/W2156311649","https://openalex.org/W2158023121","https://openalex.org/W2158480235","https://openalex.org/W2158776406","https://openalex.org/W2158899370","https://openalex.org/W2162206620","https://openalex.org/W2162426296","https://openalex.org/W2164213736","https://openalex.org/W2164951692","https://openalex.org/W2165633527","https://openalex.org/W2166233845","https://openalex.org/W2166500844","https://openalex.org/W2167540037","https://openalex.org/W2168197730","https://openalex.org/W2168698799","https://openalex.org/W2169224003","https://openalex.org/W2273327004","https://openalex.org/W2277632031","https://openalex.org/W2283227928","https://openalex.org/W2285285009","https://openalex.org/W2321053095","https://openalex.org/W2321423074","https://openalex.org/W2325822351","https://openalex.org/W2333670789","https://openalex.org/W2341113092","https://openalex.org/W2341862408","https://openalex.org/W2408127458","https://openalex.org/W2414190454","https://openalex.org/W2417413679","https://openalex.org/W2460328372","https://openalex.org/W2466165780","https://openalex.org/W2469848965","https://openalex.org/W2470322476","https://openalex.org/W2470949086","https://openalex.org/W2496041952","https://openalex.org/W2526197083","https://openalex.org/W4242132253","https://openalex.org/W4249756873","https://openalex.org/W4407197965"],"related_works":["https://openalex.org/W161908972","https://openalex.org/W1976512391","https://openalex.org/W2008671202","https://openalex.org/W2139231653","https://openalex.org/W7125409695","https://openalex.org/W2261226043","https://openalex.org/W2128835322","https://openalex.org/W2011664719","https://openalex.org/W2186584587","https://openalex.org/W2024763271"],"abstract_inverted_index":{"Various":[0],"types":[1],"of":[2],"rifampicin":[3],"(RIF)-loaded":[4],"microparticles":[5,19],"were":[6,21,44,62,149],"compared":[7,136,183],"for":[8,174],"their":[9],"stability":[10,38],"during":[11,39],"nebulization.":[12],"Poly(lactide-co-glycolide)":[13],"(PLGA),":[14],"chitosan":[15],"(CHT)":[16],"and":[17,51,59,77,110,129,134,157,176,181,196],"PLGA/CHT":[18,153,164],"(MPs)":[20],"prepared":[22],"by":[23,53,64,71,74,80,120],"emulsion,":[24],"precipitation":[25],"or":[26,95,168],"spray-drying":[27],"techniques.":[28],"MPs":[29,50,99,165],"ability":[30,133,180],"to":[31,88,137,184],"be":[32],"nebulized":[33],"(NE%)":[34],"as":[35,37],"well":[36],"freeze-drying":[40,86],"or/and":[41],"nebulization":[42,89,132,179],"(NEED%),":[43],"evaluated":[45],"after":[46],"RIF":[47,100,127,175],"extraction":[48],"from":[49],"determination":[52],"light":[54,66],"spectroscopy.":[55],"MP":[56,162,187],"mean":[57],"diameters":[58],"zeta-potential":[60],"values":[61],"measured":[63],"dynamic":[65],"scattering,":[67],"morphology":[68],"was":[69,113,118],"assessed":[70],"SEM,":[72],"cytotoxicity":[73],"MTT":[75],"method":[76],"mucoadhesive":[78,194],"properties":[79,195],"mucin":[81],"association.":[82],"In":[83,97],"all":[84,185],"cases,":[85],"prior":[87],"did":[90],"not":[91],"affect":[92],"EE%,":[93,155],"NE":[94],"NEED%.":[96],"CHT,":[98],"encapsulation":[101],"efficiency":[102],"(EE%)":[103],"decreased":[104],"with":[105,160,166],"increasing":[106,161],"CHT":[107,138,170],"concentration":[108],"(viscosity)":[109],"CHT-MP":[111],"NEED%":[112,158],"higher":[114,126,131,142],"when":[115,145],"the":[116,146,152],"polymer":[117],"crosslinked":[119],"glutaraldehyde.":[121],"PLGA":[122],"MPs,":[123,154],"exhibited":[124,171],"both":[125],"EE%":[128,173],"also":[130,141,177],"NEED%,":[135],"ones,":[139],"but":[140],"cytotoxicity.":[143,199],"However,":[144],"two":[147],"polymers":[148],"combined":[150],"in":[151],"NE%":[156],"increased":[159],"CHT-content.":[163],"0.50%":[167],"0.75%":[169],"highest":[172],"best":[178],"stability,":[182],"other":[186],"formulations":[188],"studied.":[189],"Additionally":[190],"they":[191],"had":[192],"good":[193],"comparably":[197],"low":[198],"\\n":[200]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}