{"id":"https://openalex.org/W15763465","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_846-a","title":"Abstract 3722: Multimodality Cardiovascular Imaging Detects Improvment Of Subclinical Microvascular Dysfunction With Continuous Positive Airway Pressure Therapy In Obstructive Sleep Apnea Patients: A Prospective, Randomized, Double-blinded Study","display_name":"Abstract 3722: Multimodality Cardiovascular Imaging Detects Improvment Of Subclinical Microvascular Dysfunction With Continuous Positive Airway Pressure Therapy In Obstructive Sleep Apnea Patients: A Prospective, Randomized, Double-blinded Study","publication_year":2007,"publication_date":"2007-10-16","ids":{"openalex":"https://openalex.org/W15763465","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_846-a","mag":"15763465"},"language":"en","primary_location":{"id":"doi:10.1161/circ.116.suppl_16.ii_846-a","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_846-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.116.suppl_16.ii_846-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067003133","display_name":"Chandra K. Katikireddy","orcid":"https://orcid.org/0000-0001-5410-1884","observed_orcids":["https://orcid.org/0000-0001-5410-1884"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra Katikireddy","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021285860","display_name":"Patricia Kim Phuong Nguyen","orcid":"https://orcid.org/0000-0001-7170-9787","observed_orcids":["https://orcid.org/0000-0001-7170-9787"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Nguyen","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004225422","display_name":"Christine H. J. Won","orcid":"https://orcid.org/0000-0002-8568-8849","observed_orcids":["https://orcid.org/0000-0002-8568-8849"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Won","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045730513","display_name":"Chia-Yu Cardell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Yu Cardell","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000294974","display_name":"Deborah A. Nichols","orcid":"https://orcid.org/0009-0005-0886-1707","observed_orcids":["https://orcid.org/0009-0005-0886-1707"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Nichols","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073097180","display_name":"Eileen B. Leary","orcid":"https://orcid.org/0000-0002-7389-6384","observed_orcids":["https://orcid.org/0000-0002-7389-6384"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eileen Leary","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064279763","display_name":"Michael V. McConnell","orcid":"https://orcid.org/0000-0001-8743-0932","observed_orcids":["https://orcid.org/0000-0001-8743-0932"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael McConnell","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007825628","display_name":"Tyson H. Holmes","orcid":"https://orcid.org/0000-0002-5512-4583","observed_orcids":["https://orcid.org/0000-0002-5512-4583"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyson H Holmes","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056529315","display_name":"Clete A. Kushida","orcid":"https://orcid.org/0000-0002-9430-3752","observed_orcids":["https://orcid.org/0000-0002-9430-3752","https://orcid.org/0000-0002-7535-1986"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clete A Kushida","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004282291","display_name":"Phillip Chung-Ming Yang","orcid":"https://orcid.org/0000-0002-6274-895X","observed_orcids":["https://orcid.org/0000-0002-6274-895X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip Yang","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"suppl_16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":1.0},{"id":"https://openalex.org/keywords/continuous-positive-airway-pressure","display_name":"continuous positive airway pressure","score":0.9879999756813049},{"id":"https://openalex.org/keywords/subclinical-cardiovascular-disease","display_name":"subclinical cardiovascular disease","score":0.9150000214576721},{"id":"https://openalex.org/keywords/microvascular-dysfunction","display_name":"microvascular dysfunction","score":0.9340000152587891},{"id":"https://openalex.org/keywords/myocardial-perfusion-reserve","display_name":"myocardial perfusion reserve","score":0.9559999704360962},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9340000152587891},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"ejection fraction","score":0.6740000247955322},{"id":"https://openalex.org/keywords/coronary-vasoreactivity","display_name":"coronary vasoreactivity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sham-cpap","display_name":"sham CPAP","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.960036039352417},{"id":"https://openalex.org/C2779547634","wikidata":"https://www.wikidata.org/wiki/Q5165502","display_name":"Continuous positive airway pressure","level":3,"score":0.8054447174072266},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7578111886978149},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7233279347419739},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.6818405389785767},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.6063400506973267},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5059694647789001},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.4972875416278839},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.4510003924369812},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.420685350894928},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.41654306650161743},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2557818293571472}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.116.suppl_16.ii_846-a","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_846-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.116.suppl_16.ii_846-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2169694209","https://openalex.org/W2005023848","https://openalex.org/W2097714474","https://openalex.org/W116923238","https://openalex.org/W2724460450","https://openalex.org/W3108024083","https://openalex.org/W2097813278","https://openalex.org/W4313339495","https://openalex.org/W2022628333","https://openalex.org/W1951099030"],"abstract_inverted_index":{"Background:":[0],"Several":[1],"observational":[2],"studies":[3,73,139],"suggest":[4,227],"that":[5,39,228],"obstructive":[6],"sleep":[7],"apnea":[8],"(OSA)":[9],"is":[10,21],"associated":[11],"with":[12,57,154],"an":[13],"increased":[14],"risk":[15],"of":[16,28,106,128,133,143,163,202,210,235],"cardiovascular":[17,29,47,70,145,220,237],"disease.":[18,146],"However,":[19],"there":[20],"little":[22],"data":[23],"on":[24],"early":[25],"subclinical":[26,46,144,219,236],"development":[27,142],"disease":[30,48,238],"in":[31,49,152,177,222,239],"OSA":[32,50,61,223,240],"patients.":[33,51,224,241],"Hypothesis:":[34],"We":[35],"tested":[36],"the":[37,107,125,197,218,233],"hypothesis":[38],"continuous":[40],"positive":[41],"airway":[42],"pressure":[43],"(CPAP)":[44],"improves":[45],"Methods:":[52],"Sixteen":[53],"consecutive":[54],"patients":[55,153],"diagnosed":[56],"moderate":[58],"to":[59,82,113,140,158,216],"severe":[60],"were":[62,80,111,175],"recruited":[63],"into":[64],"a":[65],"double-blinded,":[66],"prospective":[67],"study.":[68],"Multimodality":[69],"imaging":[71],"(CVI)":[72],"(cardiac":[74],"MRI,":[75],"echocardiography,":[76],"and":[77,87,102,120,192,206],"vascular":[78],"ultrasound)":[79],"performed":[81],"assess":[83,141],"LV":[84,86,178,181,187],"mass,":[85],"RV":[88,184],"ejection":[89],"fraction":[90],"(EF),":[91],"adenosine":[92],"stress":[93],"myocardial":[94],"perfusion":[95],"reserve":[96],"(MPR),":[97],"nitroglycerin":[98],"mediated":[99],"coronary":[100,193],"vasoreactivity,":[101],"flow-mediated":[103],"vasodilatation":[104],"(FMD)":[105],"brachial":[108,164],"artery.":[109],"Patients":[110],"randomized":[112],"either":[114],"CPAP":[115,118,155,170,229],"or":[116],"sham":[117],"therapy":[119,156,230],"monitored":[121],"for":[122],"compliance":[123],"during":[124],"entire":[126],"period":[127],"treatment.":[129],"After":[130],"3":[131],"months":[132],"therapy,":[134],"they":[135],"underwent":[136],"follow-up":[137],"CVI":[138],"Results:":[147],"MPR":[148],"significantly":[149,167],"improved":[150,166],"(p=0.02)":[151],"compared":[157],"those":[159],"without.":[160],"Similarly,":[161],"FMD":[162],"artery":[165],"(p=0.04)":[168],"following":[169],"therapy.":[171],"No":[172],"significant":[173],"differences":[174],"observed":[176],"mass":[179],"(p=0.31),":[180],"EF":[182,185],"(p=0.17),":[183],"(p=0.09),":[186],"diastolic":[188],"function":[189],"(E/A)":[190],"(p=0.67),":[191],"vasoreactivity":[194],"(p=0.25)":[195],"between":[196],"two":[198],"groups.":[199],"Conclusions:":[200],"Impairment":[201],"endothelial":[203],"dependent":[204],"FMD,":[205],"MPR,":[207],"surrogate":[208],"markers":[209],"microvascualr":[211],"function,":[212],"has":[213],"been":[214],"shown":[215],"be":[217],"effects":[221],"Our":[225],"findings":[226],"may":[231],"prevent":[232],"progression":[234]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
