{"id":"https://openalex.org/W1576177409","doi":"https://doi.org/10.1074/jbc.m112.421040","title":"Direct Binding and Regulation of RhoA Protein by Cyclic GMP-dependent Protein Kinase I\u03b1","display_name":"Direct Binding and Regulation of RhoA Protein by Cyclic GMP-dependent Protein Kinase I\u03b1","publication_year":2012,"publication_date":"2012-10-14","ids":{"openalex":"https://openalex.org/W1576177409","doi":"https://doi.org/10.1074/jbc.m112.421040","mag":"1576177409","pmid":"https://pubmed.ncbi.nlm.nih.gov/23066013","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3510832"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112.421040","doi":"https://doi.org/10.1074/jbc.m112.421040","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.421040","pdf_url":"http://www.jbc.org/article/S002192582043933X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192582043933X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003726970","display_name":"Mikio Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikio Kato","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA","From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045311058","display_name":"Robert M. Blanton","orcid":"https://orcid.org/0000-0002-6837-2076","observed_orcids":["https://orcid.org/0000-0002-6837-2076"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Blanton","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107917202","display_name":"Guangrong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guang-Rong Wang","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027077931","display_name":"Timothy J. Judson","orcid":"https://orcid.org/0000-0001-8376-6260","observed_orcids":["https://orcid.org/0000-0001-8376-6260"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. Judson","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105367396","display_name":"Yuich Abe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuich Abe","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111973864","display_name":"Masafumi Myoishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masafumi Myoishi","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102904713","display_name":"Richard H. Karas","orcid":"https://orcid.org/0000-0001-7799-091X","observed_orcids":["https://orcid.org/0000-0001-7799-091X"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard H. Karas","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112005916","display_name":"Michael E. Mendelsohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Mendelsohn","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"From the Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045311058"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.6761,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.91275743,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"287","issue":"49","first_page":"41342","last_page":"41351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.6169999837875366},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8149999976158142},{"id":"https://openalex.org/keywords/myosin-light-chain-phosphorylation","display_name":"myosin light chain phosphorylation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nitric-oxide-signaling","display_name":"nitric oxide signaling","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cgmp-signaling","display_name":"cGMP signaling","score":0.6639999747276306},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8309999704360962},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.9758304953575134},{"id":"https://openalex.org/C2779938346","wikidata":"https://www.wikidata.org/wiki/Q1956701","display_name":"Myosin-light-chain phosphatase","level":4,"score":0.798763632774353},{"id":"https://openalex.org/C156860981","wikidata":"https://www.wikidata.org/wiki/Q2565229","display_name":"Leucine zipper","level":4,"score":0.698439359664917},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5607964992523193},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5517048835754395},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5511255264282227},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5061799883842468},{"id":"https://openalex.org/C2779408958","wikidata":"https://www.wikidata.org/wiki/Q7251492","display_name":"Protein phosphatase 1","level":4,"score":0.4910299777984619},{"id":"https://openalex.org/C201800478","wikidata":"https://www.wikidata.org/wiki/Q24721770","display_name":"Rho-associated protein kinase","level":3,"score":0.4375843405723572},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4265096187591553},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4256078004837036},{"id":"https://openalex.org/C199217515","wikidata":"https://www.wikidata.org/wiki/Q24720987","display_name":"cGMP-dependent protein kinase","level":5,"score":0.42180880904197693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37529677152633667},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3286460041999817},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32667073607444763},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15425893664360046},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.12927204370498657},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054460","descriptor_name":"rho-Associated Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062965","descriptor_name":"Cyclic GMP-Dependent Protein Kinase Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m112.421040","doi":"https://doi.org/10.1074/jbc.m112.421040","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.421040","pdf_url":"http://www.jbc.org/article/S002192582043933X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2825932","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3510832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3510832","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3510832","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:23066013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23066013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m112.421040","doi":"https://doi.org/10.1074/jbc.m112.421040","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.421040","pdf_url":"http://www.jbc.org/article/S002192582043933X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4281654130","display_name":"Nitric Oxide Signaling Mechanisms in Vascular Cells","funder_award_id":"R01HL055309","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7793911648","display_name":"Cardiac Myocycte-Role of PKG I Alpha in Aging-Dependent Cardiac Remodeling","funder_award_id":"R03AG042367","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1576177409.pdf","grobid_xml":"https://content.openalex.org/works/W1576177409.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1597663953","https://openalex.org/W1597787921","https://openalex.org/W1650177910","https://openalex.org/W1965842309","https://openalex.org/W1973082528","https://openalex.org/W1973500184","https://openalex.org/W1983583299","https://openalex.org/W1997120729","https://openalex.org/W2034832260","https://openalex.org/W2042963487","https://openalex.org/W2052156502","https://openalex.org/W2062129029","https://openalex.org/W2077298757","https://openalex.org/W2080814134","https://openalex.org/W2085220858","https://openalex.org/W2085253569","https://openalex.org/W2089742414","https://openalex.org/W2106143041","https://openalex.org/W2112832183","https://openalex.org/W2121452261","https://openalex.org/W2125590987","https://openalex.org/W2134603143","https://openalex.org/W2137528739","https://openalex.org/W2169991415","https://openalex.org/W2175642831"],"related_works":["https://openalex.org/W2102779162","https://openalex.org/W2149858051","https://openalex.org/W2159155436","https://openalex.org/W2121452261","https://openalex.org/W2054162629","https://openalex.org/W1997120729","https://openalex.org/W2085220858","https://openalex.org/W3012231172","https://openalex.org/W657669091","https://openalex.org/W2042963487"],"abstract_inverted_index":{"Vascular":[0],"smooth":[1],"muscle":[2],"cell":[3],"(VSMC)":[4],"tone":[5],"is":[6,18,58,85,229,242],"regulated":[7,21],"by":[8,22,69],"the":[9,23,39,100,150,158,165,248],"state":[10],"of":[11,42,62,94,115,139,153,162,168,211,237,247],"myosin":[12],"light":[13],"chain":[14],"(MLC)":[15],"phosphorylation,":[16],"which":[17,37,67,172],"in":[19,75],"turn":[20],"balance":[24],"between":[25,149],"MLC":[26,29,43,47,95],"kinase":[27,81,251],"and":[28,50,53,65,118,130,135,141,164,192,221,233],"phosphatase":[30,48],"(MLCP)":[31],"activities.":[32],"RhoA":[33,111,140,154,202,214,219,228,241],"activates":[34],"Rho":[35,89,250],"kinase,":[36,90],"phosphorylates":[38],"regulatory":[40],"subunit":[41],"phosphatase,":[44,96],"thereby":[45,77],"inhibiting":[46,127],"activity":[49],"increasing":[51,70],"contraction":[52],"vascular":[54],"tone.":[55],"Nitric":[56],"oxide":[57],"an":[59],"important":[60],"mediator":[61],"VSMC":[63,249],"relaxation":[64],"vasodilation,":[66],"acts":[68],"cyclic":[71],"GMP":[72],"(cGMP)":[73],"levels":[74],"VSMC,":[76],"activating":[78],"cGMP-dependent":[79],"protein":[80,133],"I\u03b1":[82],"(PKGI\u03b1).":[83],"PKGI":[84],"known":[86],"to":[87,125,200,240,244],"phosphorylate":[88],"preventing":[91],"Rho-mediated":[92],"inhibition":[93,246],"promoting":[97],"vasorelaxation,":[98],"although":[99],"molecular":[101],"mechanisms":[102],"that":[103,121,186,227,234],"mediate":[104],"this":[105],"are":[106],"unclear.":[107],"Here":[108],"we":[109],"identify":[110],"as":[112],"a":[113,146,174,193,207,230],"target":[114,232],"activated":[116,188,238],"PKGI\u03b1":[117,122,142,169,189,197,212,231,239],"show":[119],"further":[120],"binds":[123,190],"directly":[124],"RhoA,":[126,163,191],"its":[128],"activation":[129,220],"translocation.":[131,222],"In":[132],"pulldown":[134],"immunoprecipitation":[136],"experiments,":[137],"binding":[138,236],"was":[143,198],"demonstrated":[144],"via":[145],"direct":[147,235],"interaction":[148],"amino":[151,166],"terminus":[152,167],"(residues":[155,170],"1-44),":[156],"containing":[157],"switch":[159],"I":[160],"domain":[161],"1-59),":[171],"includes":[173],"leucine":[175,194],"zipper":[176,195],"heptad":[177],"repeat":[178],"motif.":[179],"Affinity":[180],"assays":[181],"using":[182],"cGMP-immobilized":[183],"agarose":[184],"showed":[185],"only":[187],"mutant":[196,210],"unable":[199],"bind":[201],"even":[203],"if":[204],"activated.":[205],"Furthermore,":[206],"catalytically":[208],"inactive":[209],"bound":[213],"but":[215],"did":[216],"not":[217],"prevent":[218],"Collectively,":[223],"these":[224],"results":[225],"support":[226],"central":[243],"cGMP-mediated":[245],"contractile":[252],"pathway.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
