{"id":"https://openalex.org/W1574774598","doi":null,"title":"The neural cell adhesion molecule NCAM promotes maturation of the presynaptic endocytic machinery by switching synaptic vesicle recycling from AP3- to AP2-dependent mechanism in mice (Mus musculus, strain C57Bl/6J).","display_name":"The neural cell adhesion molecule NCAM promotes maturation of the presynaptic endocytic machinery by switching synaptic vesicle recycling from AP3- to AP2-dependent mechanism in mice (Mus musculus, strain C57Bl/6J).","publication_year":2008,"publication_date":"2008-05-26","ids":{"openalex":"https://openalex.org/W1574774598","mag":"1574774598"},"language":"en","primary_location":{"id":"mag:1574774598","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2008/3669/pdf/230408.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103581562","display_name":"Aparna Shetty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aparna Shetty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103581562"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0995,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43351674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.9710000157356262},{"id":"https://openalex.org/keywords/synaptic-vesicle-recycling","display_name":"synaptic vesicle recycling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/adaptor-protein-2","display_name":"adaptor protein 2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/synaptic-maturation","display_name":"synapse maturation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/synaptic-vesicle-endocytosis","display_name":"synaptic vesicle endocytosis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/central-nervous-system-neurons","display_name":"central nervous system neurons","score":0.6980000138282776},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.718999981880188},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C122871604","wikidata":"https://www.wikidata.org/wiki/Q2248886","display_name":"Neural cell adhesion molecule","level":4,"score":0.7988641262054443},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.7331017255783081},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6227295398712158},{"id":"https://openalex.org/C2908668639","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle recycling","level":5,"score":0.5667080879211426},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.5440525412559509},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5138676166534424},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5050056576728821},{"id":"https://openalex.org/C206592519","wikidata":"https://www.wikidata.org/wiki/Q1437419","display_name":"L1","level":3,"score":0.43993037939071655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38017696142196655},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.2928202152252197},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.25526225566864014},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.250155508518219},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.22657179832458496},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2181243896484375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19541001319885254},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1574774598","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2008/3669/pdf/230408.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":218,"referenced_works":["https://openalex.org/W249315217","https://openalex.org/W988244293","https://openalex.org/W1535731511","https://openalex.org/W1547546944","https://openalex.org/W1548959511","https://openalex.org/W1550341559","https://openalex.org/W1556199795","https://openalex.org/W1564531279","https://openalex.org/W1564784444","https://openalex.org/W1604181713","https://openalex.org/W1625394695","https://openalex.org/W1656523230","https://openalex.org/W1882729571","https://openalex.org/W1955097856","https://openalex.org/W1956143364","https://openalex.org/W1963727074","https://openalex.org/W1964027828","https://openalex.org/W1965592709","https://openalex.org/W1965831612","https://openalex.org/W1967302106","https://openalex.org/W1969529880","https://openalex.org/W1969908945","https://openalex.org/W1970049494","https://openalex.org/W1970916177","https://openalex.org/W1971468151","https://openalex.org/W1972087498","https://openalex.org/W1972288588","https://openalex.org/W1973524445","https://openalex.org/W1973582174","https://openalex.org/W1973583404","https://openalex.org/W1975356184","https://openalex.org/W1975364281","https://openalex.org/W1977267381","https://openalex.org/W1978274366","https://openalex.org/W1978577901","https://openalex.org/W1981951679","https://openalex.org/W1982376498","https://openalex.org/W1982988172","https://openalex.org/W1984210761","https://openalex.org/W1984653721","https://openalex.org/W1985318722","https://openalex.org/W1985685023","https://openalex.org/W1987281935","https://openalex.org/W1987672004","https://openalex.org/W1989396363","https://openalex.org/W1990386283","https://openalex.org/W1991343953","https://openalex.org/W1991721037","https://openalex.org/W1993054972","https://openalex.org/W1994128601","https://openalex.org/W1994863160","https://openalex.org/W1995275795","https://openalex.org/W1996862455","https://openalex.org/W1998084411","https://openalex.org/W1999382407","https://openalex.org/W1999851893","https://openalex.org/W2000678571","https://openalex.org/W2000814812","https://openalex.org/W2001207936","https://openalex.org/W2002204065","https://openalex.org/W2003560862","https://openalex.org/W2004404376","https://openalex.org/W2005022545","https://openalex.org/W2005537077","https://openalex.org/W2007202084","https://openalex.org/W2007487855","https://openalex.org/W2007741088","https://openalex.org/W2009566320","https://openalex.org/W2010415744","https://openalex.org/W2011625746","https://openalex.org/W2013902743","https://openalex.org/W2014234175","https://openalex.org/W2015539743","https://openalex.org/W2020091793","https://openalex.org/W2020129299","https://openalex.org/W2025277319","https://openalex.org/W2025336218","https://openalex.org/W2025543143","https://openalex.org/W2026790970","https://openalex.org/W2027516631","https://openalex.org/W2028807809","https://openalex.org/W2029055584","https://openalex.org/W2029873308","https://openalex.org/W2030360428","https://openalex.org/W2031049200","https://openalex.org/W2032118018","https://openalex.org/W2033021180","https://openalex.org/W2033165803","https://openalex.org/W2033500343","https://openalex.org/W2034418817","https://openalex.org/W2036402923","https://openalex.org/W2037050570","https://openalex.org/W2037237842","https://openalex.org/W2037593531","https://openalex.org/W2039994681","https://openalex.org/W2040996008","https://openalex.org/W2041520211","https://openalex.org/W2042127371","https://openalex.org/W2042986453","https://openalex.org/W2043646028","https://openalex.org/W2044643509","https://openalex.org/W2045464110","https://openalex.org/W2046378363","https://openalex.org/W2046793076","https://openalex.org/W2048878540","https://openalex.org/W2048995910","https://openalex.org/W2050120618","https://openalex.org/W2050953183","https://openalex.org/W2052742495","https://openalex.org/W2053469492","https://openalex.org/W2053471168","https://openalex.org/W2053606589","https://openalex.org/W2056189730","https://openalex.org/W2056281513","https://openalex.org/W2057823315","https://openalex.org/W2058301850","https://openalex.org/W2058907411","https://openalex.org/W2058973001","https://openalex.org/W2060208608","https://openalex.org/W2061971808","https://openalex.org/W2062894759","https://openalex.org/W2063102296","https://openalex.org/W2064539708","https://openalex.org/W2067245921","https://openalex.org/W2068437038","https://openalex.org/W2068881539","https://openalex.org/W2069142370","https://openalex.org/W2070616723","https://openalex.org/W2071003200","https://openalex.org/W2072070715","https://openalex.org/W2073030545","https://openalex.org/W2077686137","https://openalex.org/W2078965564","https://openalex.org/W2080037386","https://openalex.org/W2080264482","https://openalex.org/W2082015899","https://openalex.org/W2082289133","https://openalex.org/W2082411508","https://openalex.org/W2083466698","https://openalex.org/W2083807583","https://openalex.org/W2083948102","https://openalex.org/W2084732116","https://openalex.org/W2087474239","https://openalex.org/W2089157578","https://openalex.org/W2089554293","https://openalex.org/W2092079020","https://openalex.org/W2093553507","https://openalex.org/W2096575464","https://openalex.org/W2096630683","https://openalex.org/W2098485024","https://openalex.org/W2099153019","https://openalex.org/W2100837269","https://openalex.org/W2103281540","https://openalex.org/W2107853353","https://openalex.org/W2108339073","https://openalex.org/W2108836535","https://openalex.org/W2109103923","https://openalex.org/W2109790584","https://openalex.org/W2112842826","https://openalex.org/W2113783405","https://openalex.org/W2116129077","https://openalex.org/W2116638184","https://openalex.org/W2119260049","https://openalex.org/W2119575179","https://openalex.org/W2120683418","https://openalex.org/W2121173569","https://openalex.org/W2122093151","https://openalex.org/W2123557321","https://openalex.org/W2124277156","https://openalex.org/W2126169302","https://openalex.org/W2126331563","https://openalex.org/W2127453466","https://openalex.org/W2127961356","https://openalex.org/W2128573075","https://openalex.org/W2128840474","https://openalex.org/W2132520995","https://openalex.org/W2135719485","https://openalex.org/W2136060822","https://openalex.org/W2136101171","https://openalex.org/W2136282768","https://openalex.org/W2136646687","https://openalex.org/W2137231887","https://openalex.org/W2140983793","https://openalex.org/W2144230507","https://openalex.org/W2144634347","https://openalex.org/W2145677474","https://openalex.org/W2146282045","https://openalex.org/W2147149482","https://openalex.org/W2147909046","https://openalex.org/W2148188096","https://openalex.org/W2150058209","https://openalex.org/W2150555863","https://openalex.org/W2150600698","https://openalex.org/W2151249393","https://openalex.org/W2154100802","https://openalex.org/W2155151508","https://openalex.org/W2156806698","https://openalex.org/W2157463295","https://openalex.org/W2158759811","https://openalex.org/W2159422521","https://openalex.org/W2160180703","https://openalex.org/W2161650160","https://openalex.org/W2161993137","https://openalex.org/W2163046615","https://openalex.org/W2163597027","https://openalex.org/W2165305160","https://openalex.org/W2165435442","https://openalex.org/W2166348969","https://openalex.org/W2167511682","https://openalex.org/W2169473035","https://openalex.org/W2170758516","https://openalex.org/W2170758609","https://openalex.org/W2172095199","https://openalex.org/W2172226184","https://openalex.org/W2412698662","https://openalex.org/W4214891130","https://openalex.org/W4300750028","https://openalex.org/W4321429492"],"related_works":["https://openalex.org/W1971126467","https://openalex.org/W1973109495","https://openalex.org/W165234687","https://openalex.org/W1486090849","https://openalex.org/W2126709019","https://openalex.org/W2947177527","https://openalex.org/W2158759811","https://openalex.org/W2790944062","https://openalex.org/W1972755945","https://openalex.org/W1970233336"],"abstract_inverted_index":{"Newly":[0],"formed":[1],"synapses":[2],"undergo":[3],"maturation":[4,17],"during":[5,79],"ontogenetic":[6],"development":[7],"via":[8],"mechanisms":[9],"that":[10,16],"remain":[11],"poorly":[12],"understood.":[13],"We":[14],"show":[15],"of":[18,30,52,62,66,75,81,97,108,132],"the":[19,31,39,49,53,73,109,122],"presynaptic":[20,40,69,85],"endocytic":[21],"machinery":[22,87],"in":[23,90,99,112,137,152,175,185,264,278,303],"central":[24],"nervous":[25],"system":[26],"neurons":[27,114],"requires":[28],"substitution":[29,74],"adaptor":[32],"protein":[33],"3":[34,194],"(AP3)":[35,195],"with":[36,48,117,150],"AP2":[37,46,63,78,98,124,199,209,242,261],"at":[38],"plasma":[41],"membrane.":[42],"In":[43,205,248],"mature":[44,82],"synapses,":[45],"associates":[47],"intracellular":[50],"domain":[51],"neural":[54],"cell":[55],"adhesion":[56],"molecule":[57],"NCAM.":[58,153],"NCAM":[59,104,120,217,219],"promotes":[60],"binding":[61,65,125],"over":[64],"AP3":[67,76,95,240,263],"to":[68,128,146],"membranes,":[70],"thus":[71,144],"favoring":[72],"for":[77],"formation":[80],"synapses.":[83],"The":[84],"endocytotic":[86],"remains":[88],"immature":[89],"adult":[91],"NCAM-deficient":[92],"mice":[93],"accumulating":[94],"instead":[96],"synaptic":[100,133,138],"membranes":[101],"and":[102,141],"vesicles.":[103],"deficiency":[105],"or":[106],"disruption":[107],"NCAM/AP2":[110],"complex":[111],"NCAM+/+":[113,279],"by":[115],"transfection":[116],"a":[118],"dominant-negative":[119],"containing":[121],"mutated":[123],"site":[126],"leads":[127],"less":[129],"efficient":[130],"endocytosis":[131,140],"vesicle":[134,139],"membranes.":[135],"Abnormalities":[136],"recycling":[142],"may":[143],"contribute":[145],"neurological":[147],"disorders":[148],"associated":[149],"mutations":[151],"\nIm":[155],"Verlauf":[156],"der":[157,176,180,201,211,244,254,265,299,304],"ontogenetischen":[158],"Entwicklung":[159],"unterliegen":[160],"neu":[161],"geformte":[162],"Synapsen":[163,207],"einem":[164],"Reifungsprozess":[165,181],"durch":[166,196,241,281],"bislang":[167],"nur":[168],"unzureichend":[169],"aufgeklarte":[170],"Mechanismen.":[171],"Wir":[172],"zeigen":[173],"nun":[174],"vorliegenden":[177],"Arbeit,":[178],"dass":[179],"des":[182,187,192,214,276],"prasynaptischen":[183,202],"Endozytose-mechanismus":[184],"Neuronen":[186,280],"zentralen":[188],"Nervensystems":[189],"den":[190,269],"Austausch":[191],"Adapter-proteins":[193],"das":[197],"Protein":[198],"an":[200,230],"Plasmamembran":[203],"erfordert.":[204],"ausgereiften":[206],"ist":[208],"mit":[210],"intrazellularen":[212],"Domane":[213],"neuralen":[215],"Zelladhasionsmolekuls":[216],"assoziiert.":[218],"unterstutzt":[220],"somit":[221],"die":[222,231,237,274,282,317],"Bindung":[223],"von":[224,228,239,260],"AP2,":[225],"aber":[226],"nicht":[227],"AP3,":[229],"prasynaptische":[232,255],"Membran":[233,267],"und":[234,268,308],"begunstigt":[235],"dadurch":[236],"Substitution":[238],"bei":[243],"Ausbildung":[245],"reifer":[246],"Synapsen.":[247],"adulten":[249],"NCAM-":[250,286,320],"defizienten":[251],"Mausen":[252],"bleibt":[253],"Endozytosemechanismus":[256],"jedoch":[257],"unausgereift.":[258],"Anstelle":[259],"wird":[262],"synaptischen":[266,300],"Vesikeln":[270],"akkumuliert.":[271],"NCAM-Defizienz":[272],"sowie":[273],"Zerstorung":[275],"NCAM/AP2-Komplexes":[277],"Transfektion":[283],"eines":[284],"dominant-negativen":[285],"Molekuls,":[287],"welches":[288],"eine":[289,319],"mutierte":[290],"AP2-Bindestelle":[291],"enthalt,":[292],"fuhren":[293],"zu":[294,313],"einer":[295],"weniger":[296],"effizienten":[297],"Endozytose":[298,305],"Vesikelmembranen.":[301],"Abnormalitaten":[302],"synaptischer":[306],"Vesikel":[307],"im":[309],"Recycling":[310],"konnten":[311],"daher":[312],"neurologischen":[314],"Storungen":[315],"beitragen,":[316],"auf":[318],"Mutation":[321],"zuruckgehen":[322]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}