{"id":"https://openalex.org/W15747656","doi":null,"title":"Accelerated infusion of streptokinase in acute myocardial infarction results in better TIMI flow grade in infarct-related artery.","display_name":"Accelerated infusion of streptokinase in acute myocardial infarction results in better TIMI flow grade in infarct-related artery.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W15747656","mag":"15747656","pmid":"https://pubmed.ncbi.nlm.nih.gov/10820932"},"language":"en","primary_location":{"id":"pmid:10820932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10820932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian heart journal","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112738350","display_name":"S.K. Dwivedi","orcid":"https://orcid.org/0000-0001-8046-7169","observed_orcids":["https://orcid.org/0000-0001-8046-7169"]},"institutions":[{"id":"https://openalex.org/I280994","display_name":"King George's Medical University","ror":"https://ror.org/00gvw6327","country_code":"IN","type":"education","lineage":["https://openalex.org/I280994"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S K Dwivedi","raw_affiliation_strings":["Department of Cardiology, King George's Medical College, Lucknow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, King George's Medical College, Lucknow","institution_ids":["https://openalex.org/I280994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113497708","display_name":"R. K. Saran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R K Saran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044300716","display_name":"V.S. Narain","orcid":"https://orcid.org/0000-0003-0754-0088","observed_orcids":["https://orcid.org/0000-0003-0754-0088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V S Narain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038404744","display_name":"Sandeep Bansal","orcid":"https://orcid.org/0000-0002-1607-4077","observed_orcids":["https://orcid.org/0000-0002-1607-4077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Bansal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R Gupta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088791955","display_name":"Puri Vk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V K Puri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00169384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":"1","first_page":"40","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptokinase","display_name":"streptokinase","score":0.9369999766349792},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.8809999823570251},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/infusion-rate","display_name":"infusion rate","score":0.7250000238418579},{"id":"https://openalex.org/keywords/timi-flow-grade","display_name":"TIMI flow","score":0.9120000004768372},{"id":"https://openalex.org/keywords/infarct-related-artery-patency","display_name":"infarct-related artery patency","score":0.9300000071525574},{"id":"https://openalex.org/keywords/coronary-angiography","display_name":"coronary angiography","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.796999990940094},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.7239999771118164},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.8109999895095825},{"id":"https://openalex.org/keywords/myocardial-reperfusion","display_name":"myocardial reperfusion","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2777995511","wikidata":"https://www.wikidata.org/wiki/Q2897649","display_name":"TIMI","level":4,"score":0.9754555225372314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9621257781982422},{"id":"https://openalex.org/C2776336681","wikidata":"https://www.wikidata.org/wiki/Q416485","display_name":"Streptokinase","level":3,"score":0.9045451283454895},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7922025322914124},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.7874880433082581},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5864113569259644},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.5687000155448914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5556907057762146},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5054402351379395},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.4528147578239441},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4269979000091553}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010960","descriptor_name":"Plasminogen Activators","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013300","descriptor_name":"Streptokinase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017023","descriptor_name":"Coronary Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10820932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10820932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian heart journal","raw_type":"Clinical Trial"},{"id":"mag:15747656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10820932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2556837901","https://openalex.org/W4231641115","https://openalex.org/W2412264021","https://openalex.org/W2399494360","https://openalex.org/W1576523207","https://openalex.org/W4306788104","https://openalex.org/W2168917196","https://openalex.org/W2402310259","https://openalex.org/W7218278616","https://openalex.org/W2410782375"],"abstract_inverted_index":{"Bolus":[0],"followed":[1],"by":[2],"rapid":[3],"infusion":[4,41,375],"of":[5,13,31,52,76,100,107,156,162,231,258,273,286,350,362],"tissue":[6],"plasminogen":[7],"activator":[8],"results":[9,358],"in":[10,16,45,128,132,136,174,178,186,196,202,205,213,229,246,264,269,312,326,331,344,359,365],"higher":[11,360],"grade":[12,161,193],"TIMI":[14,163,192,363],"flow":[15,164,195,364],"infarct-related":[17,158,198,367],"artery":[18,159,168,199,368],"as":[19,181,208,369],"compared":[20,38,182,209,370],"to":[21,71,140,183,210,244,371],"slow":[22],"infusion.":[23],"In":[24],"the":[25,110,143,157,197,314,322,366,372],"present":[26,201],"study,":[27],"an":[28],"accelerated":[29,323],"regimen":[30,324],"streptokinase":[32,77,339],"given":[33,340],"over":[34,42,79,88,341],"15":[35,80,342],"minutes":[36,81,291,343],"was":[37,126,169,200,220,309,318],"with":[39,321],"conventional":[40],"one":[43,89],"hour":[44,90],"47":[46],"patients":[47,57,111,130,177,345],"presenting":[48,346],"within":[49,347],"12":[50,184,263,348],"hours":[51,104,121,349],"acute":[53,151,351],"myocardial":[54,152,261,352],"infarction.":[55],"Forty-seven":[56],"(44":[58],"males,":[59],"3":[60,194,330],"females;":[61],"mean":[62,98],"age":[63],"54.0":[64],"+/-":[65,102,147,235,240,249,254,301,305],"1.1":[66],"years)":[67],"were":[68,165],"randomly":[69],"allocated":[70],"receive":[72],"1.5":[73],"million":[74],"units":[75],"either":[78],"(group":[82,91],"1,":[83,134],"n":[84,93],"=":[85,94,217,335],"24)":[86],"or":[87],"2,":[92],"23)":[95],"at":[96,275,289],"a":[97],"interval":[99],"5.4":[101],"3.6":[103],"after":[105,122,150],"onset":[106],"symptoms.":[108],"All":[109],"received":[112],"aspirin":[113],"and":[114,154,160,227,295,357],"intravenous":[115],"heparin":[116],"(1000":[117],"U/hr)":[118],"for":[119],"96":[120],"thrombolysis.":[123],"Coronary":[124],"angiography":[125],"performed":[127],"43":[129],"(22":[131],"group":[133,137,179,187,206,214,225,265,270,327,332],"21":[135],"2)":[138],"prior":[139],"discharge":[141],"from":[142],"hospital":[144,247],"(mean":[145,233],"7":[146,211],"2.1":[148],"days":[149],"infarction)":[153],"patency":[155],"determined.":[166],"Infarct-related":[167],"patent":[170],"(TIMI":[171],"2/3":[172],"flow)":[173],"19":[175],"(86.4%)":[176],"1":[180,207,226,266,328],"(57.1%)":[185],"2":[188,215,228],"(p":[189,216],"<":[190],"0.05).":[191],"13":[203],"(59.1%)":[204],"(33.3%)":[212],"0.1).":[218],"There":[219],"no":[221],"significant":[222],"difference":[223],"between":[224],"time":[230,243],"presentation":[232],"5.3":[234],"3.9":[236],"hrs":[237],"vs":[238,252,267,279,293,303,329],"5.5":[239],"3.2":[241],"hrs),":[242],"needle":[245],"(25.6":[248],"11.2":[250],"min":[251,277],"26.3":[253],"6.2":[255],"min),":[256],"site":[257],"infarct":[259],"(anterior":[260],"infarction":[262,353],"11":[268],"2),":[271],"relief":[272],"pain":[274],"90":[276,290],"(13":[278],"12),":[280],"more":[281,319],"than":[282],"50":[283],"percent":[284],"reduction":[285],"ST":[287],"elevation":[288],"(17":[292],"12)":[294],"left":[296],"ventricular":[297],"ejection":[298],"fraction":[299],"(48.8":[300],"9.1%":[302],"49.8":[304],"16.0%),":[306],"respectively.":[307],"Streptokinase":[308],"well":[310,355],"tolerated":[311,356],"both":[313],"groups,":[315],"although":[316],"hypotension":[317],"common":[320],"(5":[325],"2;":[333],"p":[334],"NS).":[336],"Thus,":[337],"'accelerated'":[338],"is":[354],"grades":[361],"\"conventional\"":[373],"one-hour":[374],"regimen.":[376]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
