{"id":"https://openalex.org/W1574540908","doi":null,"title":"Lymphocytes and liver fibrosis in HIV & HCV coinfection","display_name":"Lymphocytes and liver fibrosis in HIV & HCV coinfection","publication_year":2014,"publication_date":"2014-03-13","ids":{"openalex":"https://openalex.org/W1574540908","mag":"1574540908"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/290606","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/290606","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/290606","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022335603","display_name":"Thijs Feuth","orcid":"https://orcid.org/0000-0001-6691-556X","observed_orcids":["https://orcid.org/0000-0001-6691-556X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thijs Feuth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022335603"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-hcv-coinfection","display_name":"HIV/HCV coinfection","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9459999799728394},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.8629999756813049},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cd56bright-nk-cells","display_name":"CD56bright NK cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.9660000205039978},{"id":"https://openalex.org/keywords/granzyme-b","display_name":"granzyme B","score":0.9259999990463257},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transient-elastography","display_name":"transient elastography","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.9129999876022339},{"id":"https://openalex.org/keywords/noninvasive-fibrosis-markers","display_name":"non-invasive fibrosis markers","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hcv-viraemia","display_name":"HCV viraemia","score":0.7039999961853027},{"id":"https://openalex.org/keywords/innate-and-adaptive-immunity","display_name":"innate and adaptive immunity","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7340433597564697},{"id":"https://openalex.org/C2777813720","wikidata":"https://www.wikidata.org/wiki/Q1243018","display_name":"Coinfection","level":3,"score":0.7263258695602417},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.712649941444397},{"id":"https://openalex.org/C183193105","wikidata":"https://www.wikidata.org/wiki/Q425068","display_name":"Granzyme","level":5,"score":0.5983967781066895},{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.5838974714279175},{"id":"https://openalex.org/C2780380082","wikidata":"https://www.wikidata.org/wiki/Q12646460","display_name":"Granzyme B","level":4,"score":0.581541895866394},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.578033447265625},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5197876691818237},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.491446852684021},{"id":"https://openalex.org/C2779968557","wikidata":"https://www.wikidata.org/wiki/Q12646459","display_name":"Granzyme A","level":5,"score":0.481625497341156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4783203601837158},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.47284963726997375},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.45947781205177307},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.43986907601356506},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.4170284867286682},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32099711894989014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3185725212097168},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3100946545600891},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.204265296459198},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1170872151851654},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.08167073130607605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/290606","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/290606","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/290606","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/290606","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/290606","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/290606","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:1574540908","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/290606","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/290606","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/290606","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":282,"referenced_works":["https://openalex.org/W24617280","https://openalex.org/W24917482","https://openalex.org/W132076971","https://openalex.org/W146744780","https://openalex.org/W966906763","https://openalex.org/W1486797447","https://openalex.org/W1499740654","https://openalex.org/W1504038693","https://openalex.org/W1518307931","https://openalex.org/W1539792978","https://openalex.org/W1550341443","https://openalex.org/W1556867369","https://openalex.org/W1574174694","https://openalex.org/W1575837553","https://openalex.org/W1582747522","https://openalex.org/W1601980510","https://openalex.org/W1603918837","https://openalex.org/W1604557454","https://openalex.org/W1741012896","https://openalex.org/W1766512274","https://openalex.org/W1836073275","https://openalex.org/W1845250843","https://openalex.org/W1881009043","https://openalex.org/W1961215690","https://openalex.org/W1964179737","https://openalex.org/W1964695166","https://openalex.org/W1965598643","https://openalex.org/W1966184156","https://openalex.org/W1966700067","https://openalex.org/W1967261754","https://openalex.org/W1967413593","https://openalex.org/W1967894078","https://openalex.org/W1967982404","https://openalex.org/W1968141301","https://openalex.org/W1969187681","https://openalex.org/W1969562548","https://openalex.org/W1969814796","https://openalex.org/W1973452228","https://openalex.org/W1973491977","https://openalex.org/W1974393084","https://openalex.org/W1975699571","https://openalex.org/W1976828138","https://openalex.org/W1978105087","https://openalex.org/W1978196981","https://openalex.org/W1979412006","https://openalex.org/W1980432563","https://openalex.org/W1981136135","https://openalex.org/W1982448824","https://openalex.org/W1983820911","https://openalex.org/W1984144981","https://openalex.org/W1985442918","https://openalex.org/W1985680307","https://openalex.org/W1986308149","https://openalex.org/W1986551392","https://openalex.org/W1986568749","https://openalex.org/W1986642050","https://openalex.org/W1986696487","https://openalex.org/W1989421637","https://openalex.org/W1989618496","https://openalex.org/W1991455654","https://openalex.org/W1991966230","https://openalex.org/W1993037363","https://openalex.org/W1993941350","https://openalex.org/W1994838458","https://openalex.org/W1995594396","https://openalex.org/W1996036561","https://openalex.org/W1996113052","https://openalex.org/W1996434966","https://openalex.org/W1996459980","https://openalex.org/W1997849135","https://openalex.org/W1998685789","https://openalex.org/W2000307707","https://openalex.org/W2000572138","https://openalex.org/W2002697587","https://openalex.org/W2002733542","https://openalex.org/W2003139849","https://openalex.org/W2003616999","https://openalex.org/W2004021600","https://openalex.org/W2004241753","https://openalex.org/W2004602615","https://openalex.org/W2006309458","https://openalex.org/W2006469679","https://openalex.org/W2007057009","https://openalex.org/W2008132884","https://openalex.org/W2008424097","https://openalex.org/W2008757142","https://openalex.org/W2009547326","https://openalex.org/W2011713980","https://openalex.org/W2013597238","https://openalex.org/W2013716066","https://openalex.org/W2013740977","https://openalex.org/W2014555321","https://openalex.org/W2014572186","https://openalex.org/W2015336471","https://openalex.org/W2016168268","https://openalex.org/W2016398782","https://openalex.org/W2016453064","https://openalex.org/W2018253571","https://openalex.org/W2018300031","https://openalex.org/W2018311806","https://openalex.org/W2018798881","https://openalex.org/W2019400070","https://openalex.org/W2019792586","https://openalex.org/W2020898162","https://openalex.org/W2021199098","https://openalex.org/W2021535457","https://openalex.org/W2024842370","https://openalex.org/W2025689551","https://openalex.org/W2025741354","https://openalex.org/W2026051181","https://openalex.org/W2026614040","https://openalex.org/W2026647673","https://openalex.org/W2027470770","https://openalex.org/W2027498662","https://openalex.org/W2027593625","https://openalex.org/W2027625151","https://openalex.org/W2028223567","https://openalex.org/W2029180341","https://openalex.org/W2031235649","https://openalex.org/W2031956798","https://openalex.org/W2032140312","https://openalex.org/W2032980717","https://openalex.org/W2033554088","https://openalex.org/W2034501752","https://openalex.org/W2034694403","https://openalex.org/W2038924400","https://openalex.org/W2039777415","https://openalex.org/W2042989205","https://openalex.org/W2043519223","https://openalex.org/W2043976325","https://openalex.org/W2044082703","https://openalex.org/W2046491426","https://openalex.org/W2047325790","https://openalex.org/W2047686172","https://openalex.org/W2048187419","https://openalex.org/W2048548385","https://openalex.org/W2049236281","https://openalex.org/W2049619994","https://openalex.org/W2049711062","https://openalex.org/W2051989463","https://openalex.org/W2052325775","https://openalex.org/W2054119257","https://openalex.org/W2055207797","https://openalex.org/W2056376819","https://openalex.org/W2057686712","https://openalex.org/W2058538904","https://openalex.org/W2058817056","https://openalex.org/W2059660457","https://openalex.org/W2059677564","https://openalex.org/W2060902798","https://openalex.org/W2061712496","https://openalex.org/W2061843974","https://openalex.org/W2062563125","https://openalex.org/W2063285149","https://openalex.org/W2063935688","https://openalex.org/W2065996123","https://openalex.org/W2069648965","https://openalex.org/W2070862399","https://openalex.org/W2071470683","https://openalex.org/W2071670416","https://openalex.org/W2072160870","https://openalex.org/W2072818859","https://openalex.org/W2073560433","https://openalex.org/W2076457786","https://openalex.org/W2076781435","https://openalex.org/W2078404799","https://openalex.org/W2079164650","https://openalex.org/W2079501827","https://openalex.org/W2080869790","https://openalex.org/W2083410657","https://openalex.org/W2083676790","https://openalex.org/W2084446925","https://openalex.org/W2085288050","https://openalex.org/W2086250098","https://openalex.org/W2086414517","https://openalex.org/W2087877138","https://openalex.org/W2087954998","https://openalex.org/W2088534886","https://openalex.org/W2089532460","https://openalex.org/W2090308367","https://openalex.org/W2090803484","https://openalex.org/W2091172564","https://openalex.org/W2091671016","https://openalex.org/W2092958774","https://openalex.org/W2093430922","https://openalex.org/W2094639617","https://openalex.org/W2094952606","https://openalex.org/W2095232654","https://openalex.org/W2097135837","https://openalex.org/W2097246425","https://openalex.org/W2097855813","https://openalex.org/W2098930452","https://openalex.org/W2100710476","https://openalex.org/W2100943457","https://openalex.org/W2102383018","https://openalex.org/W2102422505","https://openalex.org/W2104010560","https://openalex.org/W2105804574","https://openalex.org/W2106374963","https://openalex.org/W2106544064","https://openalex.org/W2106791445","https://openalex.org/W2108182672","https://openalex.org/W2108362208","https://openalex.org/W2108794117","https://openalex.org/W2109472785","https://openalex.org/W2110252008","https://openalex.org/W2110525565","https://openalex.org/W2110925966","https://openalex.org/W2111335059","https://openalex.org/W2111359040","https://openalex.org/W2113026795","https://openalex.org/W2113331651","https://openalex.org/W2114254561","https://openalex.org/W2115657078","https://openalex.org/W2116026000","https://openalex.org/W2117080826","https://openalex.org/W2117397373","https://openalex.org/W2117407070","https://openalex.org/W2119896120","https://openalex.org/W2119978135","https://openalex.org/W2122483069","https://openalex.org/W2123111996","https://openalex.org/W2124394465","https://openalex.org/W2125963799","https://openalex.org/W2126183492","https://openalex.org/W2126302947","https://openalex.org/W2126544953","https://openalex.org/W2126560378","https://openalex.org/W2128366104","https://openalex.org/W2129348532","https://openalex.org/W2129457251","https://openalex.org/W2129971278","https://openalex.org/W2130603879","https://openalex.org/W2130624256","https://openalex.org/W2130854591","https://openalex.org/W2131790808","https://openalex.org/W2132557478","https://openalex.org/W2132734105","https://openalex.org/W2133228617","https://openalex.org/W2133543557","https://openalex.org/W2134916334","https://openalex.org/W2136034795","https://openalex.org/W2136255250","https://openalex.org/W2136690222","https://openalex.org/W2136976433","https://openalex.org/W2137929296","https://openalex.org/W2138048624","https://openalex.org/W2142988890","https://openalex.org/W2143559032","https://openalex.org/W2144373841","https://openalex.org/W2145626047","https://openalex.org/W2146313292","https://openalex.org/W2146828787","https://openalex.org/W2151712474","https://openalex.org/W2152441233","https://openalex.org/W2153895006","https://openalex.org/W2154381591","https://openalex.org/W2154396361","https://openalex.org/W2155602724","https://openalex.org/W2157342679","https://openalex.org/W2159583680","https://openalex.org/W2163592552","https://openalex.org/W2165079722","https://openalex.org/W2165374230","https://openalex.org/W2165374636","https://openalex.org/W2165575329","https://openalex.org/W2166019938","https://openalex.org/W2166164361","https://openalex.org/W2166947839","https://openalex.org/W2167565289","https://openalex.org/W2168231169","https://openalex.org/W2169375105","https://openalex.org/W2170034555","https://openalex.org/W2189297094","https://openalex.org/W2316455095","https://openalex.org/W2318755291","https://openalex.org/W2319885499","https://openalex.org/W2325791202","https://openalex.org/W2401379062","https://openalex.org/W2414561002","https://openalex.org/W2417989506","https://openalex.org/W2418847381"],"related_works":["https://openalex.org/W1996113052","https://openalex.org/W2973834767","https://openalex.org/W2883465738","https://openalex.org/W2562718338","https://openalex.org/W4214533314","https://openalex.org/W3205773072","https://openalex.org/W2019400070","https://openalex.org/W2341334351","https://openalex.org/W1979401595","https://openalex.org/W2514230214"],"abstract_inverted_index":{"Coinfection":[0,139],"with":[1,33,43,51,66,140,144,224,228,235,255,297],"HIV":[2,141],"has":[3,245,262,284],"an":[4,252,267,309],"important":[5],"impact":[6,287],"on":[7,119,218,288,354],"immunity":[8,360],"against":[9],"hepatitis":[10],"C":[11],"virus":[12],"(HCV).":[13],"In":[14],"the":[15,23,80,96,134,167,172,176,185,214,236,301,329,345],"present":[16],"dissertation,":[17,279],"phenotypes":[18],"of":[19,26,40,54,72,82,106,125,136,148,163,213,230,295,333,356,378],"lymphocytes":[20,41,56,74,127,164],"derived":[21],"from":[22],"peripheral":[24,149],"blood":[25],"HCV-infected":[27],"patients":[28,296],"were":[29,104],"studied":[30],"into":[31],"detail,":[32],"special":[34],"attention":[35],"to":[36,59,79,123,166,195,323],"changes":[37],"in":[38,57,95,133,277,316,326,336,348,361,381],"phenotype":[39],"associated":[42,50,65,143,227],"HIV-coinfection":[44],"and":[45,70,75,93,102,241,293,358,364,367],"liver":[46,107,137,250,271,314,379],"fibrosis.":[47,108,138,272],"HCV-infection":[48,62],"was":[49,63,77,142,306],"increased":[52,67],"apoptosis":[53],"T":[55,73,90,98,126,150,303,370],"comparison":[58],"healthy":[60],"controls.":[61],"also":[64],"cell":[68,91,174,304,371],"activation":[69,92,101,152],"exhaustion":[71,94,103],"this":[76,278,320,349],"correlated":[78],"level":[81],"HCV-viraemia,":[83],"suggesting":[84],"that":[85,205,281],"HCV":[86,117,154,225,317,362,382],"directly":[87],"causes":[88],"non-specific":[89,129],"periphery.":[97],"lymphocyte":[99,151],"apoptosis,":[100],"independent":[105],"Together":[109],"these":[110],"findings":[111],"suggest":[112],"that,":[113],"if":[114],"left":[115],"untreated,":[116],"might":[118,331],"long":[120],"term":[121],"contribute":[122],"dysfunction":[124],"through":[128],"immune":[130,169],"activation,":[131],"even":[132,145],"absence":[135],"higher":[146],"levels":[147,212],"than":[153],"monoinfection.":[155,318,383],"Natural":[156],"killer":[157],"(NK)":[158],"cells":[159,179,192,208],"are":[160,193],"a":[161,374],"type":[162],"belonging":[165],"innate":[168,357],"system.":[170],"Of":[171],"NK":[173,178,191,207],"subsets,":[175],"CD56dim":[177],"have":[180],"generally":[181],"been":[182,247,264],"considered":[183],"as":[184,232,234,266,308,373],"primarily":[186],"cytotoxic":[187,215,237],"subset,":[188],"whereas":[189],"CD56bright":[190,206],"thought":[194],"merely":[196],"exert":[197],"cytokine-producing":[198],"activity.":[199],"Surprisingly,":[200],"Feuth":[201],"et":[202],"al":[203],"demonstrate":[204],"typically":[209],"display":[210],"high":[211],"molecule":[216],"FasL":[217,231],"their":[219],"surface.":[220],"Furthermore,":[221],"chronic":[222],"infection":[223],"is":[226,322,341],"upregulation":[229],"well":[233],"molecules":[238],"granzyme":[239],"B":[240],"perforin.":[242],"Liver":[243],"fibrosis":[244,315,380],"traditionally":[246],"diagnosed":[248],"by":[249],"biopsy,":[251],"invasive":[253],"method":[254],"rare":[256],"but":[257],"severe":[258],"complications.":[259],"Transient":[260],"elastography":[261,283,340],"recently":[263],"implemented":[265],"non-invasive":[268,311,376],"measurement":[269],"for":[270,313],"A":[273],"retrospective":[274],"analysis,":[275],"presented":[276,347],"demonstrated":[280],"transient":[282,339],"major":[285],"clinical":[286,289],"decision-making":[290],"concerning":[291],"treatment":[292],"follow-up":[294],"viral":[298],"hepatitis.":[299],"Lastly,":[300],"CD4/CD8":[302,369],"ratio":[305,372],"identified":[307],"alternative":[310],"marker":[312,330,377],"If":[319],"finding":[321],"be":[324,332],"confirmed":[325],"larger":[327],"studies,":[328],"value":[334],"especially":[335],"settings":[337],"where":[338],"not":[342],"available.":[343],"Altogether,":[344],"studies":[346],"dissertation":[350],"shed":[351],"new":[352],"light":[353],"regulation":[355],"adaptive":[359],"monoinfection":[363],"HIV-HCV":[365],"coinfection":[366],"identify":[368],"promising":[375]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}