{"id":"https://openalex.org/W1574499135","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.797.8","title":"Activation of Endothelial NLRP3 Inflammasomes associated with Acid Sphingomyelinase\u2010dependent Formation of Membrane Raft Redox Signaling Platforms","display_name":"Activation of Endothelial NLRP3 Inflammasomes associated with Acid Sphingomyelinase\u2010dependent Formation of Membrane Raft Redox Signaling Platforms","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1574499135","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.797.8","mag":"1574499135"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.797.8","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.797.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.797.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021719486","display_name":"Min Xia","orcid":"https://orcid.org/0000-0001-5330-6466","observed_orcids":["https://orcid.org/0000-0001-5330-6466"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Xia","raw_affiliation_strings":["Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondVAUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondVAUnited States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024658133","display_name":"Krishna Murthy Boini","orcid":"https://orcid.org/0000-0003-4284-0780","observed_orcids":["https://orcid.org/0000-0003-4284-0780"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna Boini","raw_affiliation_strings":["Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondVAUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondVAUnited States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350371","display_name":"Yang Chen","orcid":"https://orcid.org/0000-0001-7661-5923","observed_orcids":["https://orcid.org/0000-0001-7661-5923"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Chen","raw_affiliation_strings":["Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondVAUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondVAUnited States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100354659","display_name":"Yang Zhang","orcid":"https://orcid.org/0000-0002-2739-1916","observed_orcids":["https://orcid.org/0000-0002-2739-1916","https://orcid.org/0000-0002-0789-4938","https://orcid.org/0000-0003-1405-0212"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Zhang","raw_affiliation_strings":["Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondVAUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondVAUnited States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003769038","display_name":"Pin\u2010Lan Li","orcid":"https://orcid.org/0000-0002-0797-8947","observed_orcids":["https://orcid.org/0000-0002-0797-8947"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pin\u2010Lan Li","raw_affiliation_strings":["Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondVAUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondVAUnited States","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.1287,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49256028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/acid-sphingomyelinase","display_name":"acid sphingomyelinase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.921999990940094},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.8109999895095825},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/7-ketocholesterol","display_name":"7-ketocholesterol","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cholesterol-crystals","display_name":"cholesterol crystals","score":0.9980000257492065},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.75},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/txnip","display_name":"TXNIP","score":0.7400000095367432},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.728729248046875},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7286409735679626},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6641739010810852},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.6489670872688293},{"id":"https://openalex.org/C2781457462","wikidata":"https://www.wikidata.org/wiki/Q16245045","display_name":"Acid sphingomyelinase","level":4,"score":0.6233282685279846},{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.6088473200798035},{"id":"https://openalex.org/C2781070647","wikidata":"https://www.wikidata.org/wiki/Q413230","display_name":"Sphingomyelin phosphodiesterase","level":4,"score":0.5249980688095093},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.4894648790359497},{"id":"https://openalex.org/C139964883","wikidata":"https://www.wikidata.org/wiki/Q14901964","display_name":"Caspase 1","level":4,"score":0.4586520195007324},{"id":"https://openalex.org/C2781427627","wikidata":"https://www.wikidata.org/wiki/Q410503","display_name":"Pyocyanin","level":5,"score":0.430732786655426},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4168437123298645},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3661693334579468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33209842443466187},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.24196571111679077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17773687839508057},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15178564190864563},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.797.8","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.797.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.797.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2741232661","https://openalex.org/W2166144151","https://openalex.org/W1978813781","https://openalex.org/W2887557093","https://openalex.org/W2155722482","https://openalex.org/W2977826553","https://openalex.org/W2053871805","https://openalex.org/W2012362471","https://openalex.org/W2625992838","https://openalex.org/W1973803874"],"abstract_inverted_index":{"There":[0],"is":[1],"evidence":[2,201],"that":[3,37,61,131,203],"endothelial":[4,27,78,207],"NLRP3":[5,28,56,72,87,98,126,208],"inflammasomes":[6,29,73,209],"are":[7],"activated":[8],"by":[9,25,83,106,145,169,210,217],"atherogenic":[10],"stimuli":[11],"such":[12],"as":[13,81,143],"cholesterol":[14],"crystals":[15],"(CHC),":[16],"7-ketocholesterol":[17],"(7-":[18],"Keto)":[19],"and":[20,42,69,94,101,118,153,180,192],"visfatin.":[21],"However,":[22],"the":[23,52,67,158,198,204],"mechanism":[24],"which":[26,165],"remains":[30],"poorly":[31],"understood.":[32],"The":[33],"present":[34],"study":[35],"hypothesized":[36],"acid":[38],"sphingomyelinase":[39],"(ASM)-mediated":[40],"ceramide":[41],"associated":[43],"membrane":[44,132],"redox":[45,162,222],"signaling":[46,163,223],"platforms":[47],"may":[48,214],"be":[49,215],"one":[50],"of":[51,55,71,86,151,160,172,206],"triggering":[53],"mechanisms":[54],"inflammasomes.":[57],"We":[58],"first":[59,199],"demonstrated":[60],"7-Keto":[62,185,211],"or":[63,90,115,155,186,212],"CHC":[64,213],"markedly":[65,104],"increased":[66,84,142],"formation":[68,100,159],"activation":[70,102,205],"in":[74,123,189],"mouse":[75],"carotid":[76],"arterial":[77],"cells":[79],"(CAECs),":[80],"shown":[82,144],"colocalization":[85],"with":[88,125,136],"ASC":[89,110],"caspase-1,":[91],"caspase-1":[92,107,190],"activity":[93,191],"IL-1\u03b2":[95,193],"levels.":[96],"This":[97],"inflammasome":[99,127],"were":[103],"attenuated":[105],"inhibitor":[108,182],"YVAD,":[109],"siRNA,":[111],"ASM":[112],"inhibitor,":[113],"amitriptyline":[114],"its":[116],"siRNA":[117],"CAECs":[119,124],"from":[120,220],"ASM-/-.":[121],"Furthermore,":[122],"formation,":[128],"we":[129],"found":[130],"raft":[133,174],"(MR)":[134],"clustering":[135],"NADPH":[137],"oxidase":[138],"subunits":[139],"was":[140,166],"remarkably":[141],"more":[146],"than":[147],"10":[148],"folds":[149],"enhancement":[150],"CTXB":[152],"gp91phox":[154],"p47phox,":[156],"indicating":[157],"MR":[161,221],"platforms,":[164],"further":[167],"confirmed":[168],"inhibitory":[170],"effects":[171],"lipid":[173],"disruptor":[175],"(MCD),":[176],"ROS":[177,218],"scavenger":[178],"(TEMPOL+catalase)":[179],"TXNIP":[181],"(verapamil)":[183],"on":[184],"CHC-induced":[187],"increase":[188],"production.":[194],"These":[195],"results":[196],"provide":[197],"direct":[200],"showing":[202],"triggered":[216],"derived":[219],"platforms.":[224]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}