{"id":"https://openalex.org/W1574489576","doi":"https://doi.org/10.1016/s0021-9258(18)53769-8","title":"Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.","display_name":"Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.","publication_year":1993,"publication_date":"1993-02-01","ids":{"openalex":"https://openalex.org/W1574489576","doi":"https://doi.org/10.1016/s0021-9258(18)53769-8","mag":"1574489576","pmid":"https://pubmed.ncbi.nlm.nih.gov/8428901"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)53769-8","doi":"https://doi.org/10.1016/s0021-9258(18)53769-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)53769-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1574489576"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)53769-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035903604","display_name":"Ray Truant","orcid":"https://orcid.org/0000-0003-2542-6641","observed_orcids":["https://orcid.org/0000-0003-2542-6641"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. Truant","raw_affiliation_strings":["Banting and Best Institute of Medical Research, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banting and Best Institute of Medical Research, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016053889","display_name":"Hua Xiao","orcid":"https://orcid.org/0000-0002-2831-0436","observed_orcids":["https://orcid.org/0000-0002-2831-0436"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"H. Xiao","raw_affiliation_strings":["Banting and Best Institute of Medical Research, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banting and Best Institute of Medical Research, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071657470","display_name":"C. James Ingles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C.J. Ingles","raw_affiliation_strings":["Banting and Best Institute of Medical Research, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banting and Best Institute of Medical Research, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110909724","display_name":"Jack Greenblatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Greenblatt","raw_affiliation_strings":["Banting and Best Institute of Medical Research, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banting and Best Institute of Medical Research, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":21.7187,"has_fulltext":false,"cited_by_count":202,"citation_normalized_percentile":{"value":0.9962149,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"268","issue":"4","first_page":"2284","last_page":"2287"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.2167000025510788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tata-binding-protein","display_name":"TATA-binding protein","score":0.9380000233650208},{"id":"https://openalex.org/keywords/transactivation-domain","display_name":"transactivation domain","score":0.9100000262260437},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tfiid","display_name":"TFIID","score":0.8899999856948853},{"id":"https://openalex.org/keywords/rna-polymerase-ii-transcription","display_name":"RNA polymerase II transcription","score":0.7900000214576721},{"id":"https://openalex.org/keywords/friend-leukemia-virus","display_name":"Friend leukemia virus","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.628000020980835},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2780055153","wikidata":"https://www.wikidata.org/wiki/Q14878262","display_name":"TATA-binding protein","level":5,"score":0.6899926662445068},{"id":"https://openalex.org/C2909959438","wikidata":"https://www.wikidata.org/wiki/Q14878262","display_name":"TATA-Box Binding Protein","level":5,"score":0.6620423793792725},{"id":"https://openalex.org/C65888428","wikidata":"https://www.wikidata.org/wiki/Q1413955","display_name":"TATA box","level":5,"score":0.6558808088302612},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5098897218704224},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.48448464274406433},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4639299511909485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4563473165035248},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4289410710334778},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.42449820041656494},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4016018509864807},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.387889564037323},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3736805319786072},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.37206506729125977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29801276326179504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2912536561489105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16019222140312195},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12546414136886597},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07834264636039734},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.07314887642860413},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016385","descriptor_name":"TATA Box","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035181","descriptor_name":"TATA-Box Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)53769-8","doi":"https://doi.org/10.1016/s0021-9258(18)53769-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)53769-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8428901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8428901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)53769-8","doi":"https://doi.org/10.1016/s0021-9258(18)53769-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)53769-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W18314034","https://openalex.org/W1489183905","https://openalex.org/W1522425622","https://openalex.org/W1554072136","https://openalex.org/W1564956131","https://openalex.org/W1834138950","https://openalex.org/W1846936111","https://openalex.org/W1975993749","https://openalex.org/W1980066350","https://openalex.org/W1982756681","https://openalex.org/W1992315201","https://openalex.org/W1995856480","https://openalex.org/W1999345627","https://openalex.org/W1999745373","https://openalex.org/W2004429299","https://openalex.org/W2010026543","https://openalex.org/W2015408193","https://openalex.org/W2015560811","https://openalex.org/W2020484813","https://openalex.org/W2027570258","https://openalex.org/W2028338381","https://openalex.org/W2033777731","https://openalex.org/W2036931150","https://openalex.org/W2037569268","https://openalex.org/W2053700118","https://openalex.org/W2057058623","https://openalex.org/W2059185804","https://openalex.org/W2060490849","https://openalex.org/W2068446924","https://openalex.org/W2072114372","https://openalex.org/W2072581924","https://openalex.org/W2074624482","https://openalex.org/W2083522684","https://openalex.org/W2084041730","https://openalex.org/W2086532812","https://openalex.org/W2102823703","https://openalex.org/W2130880119","https://openalex.org/W2148397104","https://openalex.org/W2150097377","https://openalex.org/W2171672241","https://openalex.org/W2204395690","https://openalex.org/W2298653305","https://openalex.org/W2314225431","https://openalex.org/W2418492732","https://openalex.org/W2424226310"],"related_works":["https://openalex.org/W1860047937","https://openalex.org/W2121013761","https://openalex.org/W1607419610","https://openalex.org/W2027216514","https://openalex.org/W2063158632","https://openalex.org/W2115986380","https://openalex.org/W2103247252","https://openalex.org/W2007676349","https://openalex.org/W2076059928","https://openalex.org/W2121220886"],"abstract_inverted_index":{"The":[0,70,193],"human":[1,23,109,194],"p53":[2,75,89,136,160,174],"tumor":[3],"suppressor":[4],"gene":[5],"product":[6],"can":[7],"activate":[8,129,165,182,220],"transcription":[9,60,183,221],"by":[10,103,222],"RNA":[11],"polymerase":[12],"II":[13],"in":[14,22,99,141,178,197,215],"the":[15,37,42,58,104,119,133,147,151,157,204],"yeast,":[16],"Saccharomyces":[17],"cerevisiae,":[18],"as":[19,21,91,187,189],"well":[20,188],"cells.":[24],"Several":[25],"viral":[26],"transcriptional":[27,93],"activator":[28,218],"proteins":[29,219],"have":[30],"been":[31],"shown":[32],"to":[33,55,78,128,137,161,181,203],"directly":[34,64],"contact":[35,162],"TBP,":[36],"TATA":[38],"box-binding":[39],"subunit":[40],"of":[41,74,88,114,122,135,150,159,173,207],"general":[43,213],"initiation":[44],"factor,":[45,61],"TFIID.":[46],"In":[47,167],"this":[48],"report,":[49],"we":[50],"use":[51],"protein":[52,152],"affinity":[53],"chromatography":[54],"show":[56],"that":[57,175],"cellular":[59],"p53,":[62,115,123],"interacts":[63],"and":[65,96,153,164],"specifically":[66],"with":[67,156,224],"yeast":[68,139,185],"TBP.":[69,225],"TBP":[71,140,163,186,195],"binding":[72],"domain":[73,95,121,206],"was":[76],"localized":[77],"its":[79,126,179],"N-terminal":[80],"73":[81],"amino":[82],"acids.":[83],"This":[84,143],"highly":[85],"acidic":[86],"portion":[87],"functions":[90],"a":[92,169,198,212],"activation":[94,120,205],"is":[97,176],"deleted":[98],"some":[100],"tumors":[101],"induced":[102],"Friend":[105],"leukemia":[106],"virus.":[107],"A":[108],"tumor-derived":[110],"oncogenic":[111,171],"point":[112],"mutation":[113,144],"which":[116,216],"lies":[117],"outside":[118],"but":[124],"reduces":[125],"ability":[127,134,158,180],"transcription,":[130],"greatly":[131],"reduced":[132],"bind":[138],"vitro.":[142],"probably":[145],"affects":[146],"overall":[148],"conformation":[149],"indirectly":[154],"interferes":[155],"transcription.":[166],"contrast,":[168],"mutated":[170],"form":[172],"unaffected":[177],"bound":[184,202],"wild":[190],"type":[191],"p53.":[192,208],"activity":[196],"HeLa":[199],"extract":[200],"also":[201],"Our":[209],"data":[210],"support":[211],"model":[214],"DNA-bound":[217],"interacting":[223]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
