{"id":"https://openalex.org/W1574483226","doi":"https://doi.org/10.1111/j.1440-1746.2011.06756.x","title":"Pathogenesis of alcohol\u2010induced liver disease: Classical concepts and recent advances","display_name":"Pathogenesis of alcohol\u2010induced liver disease: Classical concepts and recent advances","publication_year":2011,"publication_date":"2011-05-04","ids":{"openalex":"https://openalex.org/W1574483226","doi":"https://doi.org/10.1111/j.1440-1746.2011.06756.x","mag":"1574483226","pmid":"https://pubmed.ncbi.nlm.nih.gov/21545524"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1746.2011.06756.x","doi":"https://doi.org/10.1111/j.1440-1746.2011.06756.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1746.2011.06756.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1746.2011.06756.x","source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1746.2011.06756.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082846744","display_name":"Devanshi Seth","orcid":"https://orcid.org/0000-0001-5614-1599","observed_orcids":["https://orcid.org/0000-0001-5614-1599"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2799732068","display_name":"Royal Prince Alfred Hospital","ror":"https://ror.org/05gpvde20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799732068"]},{"id":"https://openalex.org/I2800664540","display_name":"Centenary Institute","ror":"https://ror.org/05gvja138","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2800664540"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Devanshi Seth","raw_affiliation_strings":["Drug Health Services, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia. d.seth@sydney.edu.au","Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia","Discipline of Addiction Medicine and Clinical Medicine, University of Sydney, Sydney, New South Wales, Australia","Drug Health Services, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Health Services, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia. d.seth@sydney.edu.au","institution_ids":["https://openalex.org/I2799732068"]},{"raw_affiliation_string":"Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia","institution_ids":["https://openalex.org/I2799732068","https://openalex.org/I2800664540"]},{"raw_affiliation_string":"Discipline of Addiction Medicine and Clinical Medicine, University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Drug Health Services, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia","institution_ids":["https://openalex.org/I2799732068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071884095","display_name":"Paul Haber","orcid":"https://orcid.org/0000-0001-8915-8872","observed_orcids":["https://orcid.org/0000-0001-8915-8872"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2799732068","display_name":"Royal Prince Alfred Hospital","ror":"https://ror.org/05gpvde20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799732068"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul S Haber","raw_affiliation_strings":["Discipline of Addiction Medicine and Clinical Medicine, University of Sydney, Sydney, New South Wales, Australia","Drug Health Services, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Addiction Medicine and Clinical Medicine, University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Drug Health Services, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia","institution_ids":["https://openalex.org/I2799732068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110563301","display_name":"Wing\u2010Kin Syn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Wing\u2010Kin Syn","raw_affiliation_strings":["Centre for Liver Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK","Department of Physiology, University of the Basque Country, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Liver Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Physiology, University of the Basque Country, Bilbao, Spain","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020766248","display_name":"Anna Mae Diehl","orcid":"https://orcid.org/0000-0003-1859-089X","observed_orcids":["https://orcid.org/0000-0003-1859-089X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Mae Diehl","raw_affiliation_strings":["Duke University Medical Center, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101918789","display_name":"Christopher Paul Day","orcid":"https://orcid.org/0000-0001-7161-0293","observed_orcids":["https://orcid.org/0000-0001-7161-0293","https://orcid.org/0000-0003-1458-0045"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher P Day","raw_affiliation_strings":["Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Newcastle, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Newcastle, UK","institution_ids":["https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5082846744"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2799732068","https://openalex.org/I2800664540"],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":2.1671,"has_fulltext":true,"cited_by_count":165,"citation_normalized_percentile":{"value":0.90931174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"26","issue":"7","first_page":"1089","last_page":"1105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"alcoholic liver disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/alcohol-metabolism","display_name":"alcohol metabolism","score":0.9160000085830688},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9929999709129333},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hepatic-fibrogenesis","display_name":"hepatic fibrogenesis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/myofibroblast-transformation","display_name":"myofibroblast transformation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta-smad-signaling-pathway","display_name":"TGF-\u03b2/Smad signaling","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8659999966621399},{"id":"https://openalex.org/keywords/epigenomics","display_name":"epigenomics","score":0.8410000205039978},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.7590000033378601},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.742168664932251},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.6751288175582886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6091064214706421},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5075465440750122},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.49517813324928284},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4751874506473541},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4576181471347809},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.42807555198669434},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.4231516718864441},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3913405239582062},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.3678094148635864},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3324449956417084},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2953648567199707},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.2807808220386505},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27689194679260254},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25908005237579346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17239218950271606}],"mesh":[{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014943","descriptor_name":"Global Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1440-1746.2011.06756.x","doi":"https://doi.org/10.1111/j.1440-1746.2011.06756.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1746.2011.06756.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1746.2011.06756.x","source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:21545524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21545524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology and hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/7dddd43b-8d78-4439-b7da-6396e4d2065d","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/7dddd43b-8d78-4439-b7da-6396e4d2065d","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Seth, D, Haber, PS, Syn, W-K, Diehl, AM & Day, CP 2011, 'Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances', Journal of Gastroenterology and Hepatology, vol. 26, no. 7, pp. 1089-1105. https://doi.org/10.1111/j.1440-1746.2011.06756.x","raw_type":"article"},{"id":"doi:10.25405/ncl.34226859","doi":"https://doi.org/10.25405/ncl.34226859","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34226859","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34226859.v1","doi":"https://doi.org/10.25405/ncl.34226859.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34226859.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1111/j.1440-1746.2011.06756.x","doi":"https://doi.org/10.1111/j.1440-1746.2011.06756.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1746.2011.06756.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1746.2011.06756.x","source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1094187567","display_name":"TNF Alpha and Recovery from Alchoholic Liver Injury","funder_award_id":"5r37aa010154-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G875905115","display_name":null,"funder_award_id":"R37 AA-010154","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1574483226.pdf","grobid_xml":"https://content.openalex.org/works/W1574483226.grobid-xml"},"referenced_works_count":217,"referenced_works":["https://openalex.org/W155042973","https://openalex.org/W179089402","https://openalex.org/W189920682","https://openalex.org/W204043746","https://openalex.org/W1501176525","https://openalex.org/W1507879124","https://openalex.org/W1510287206","https://openalex.org/W1528321309","https://openalex.org/W1532089538","https://openalex.org/W1586321932","https://openalex.org/W1589430668","https://openalex.org/W1592749565","https://openalex.org/W1808578277","https://openalex.org/W1848772619","https://openalex.org/W1858395638","https://openalex.org/W1914476337","https://openalex.org/W1944984946","https://openalex.org/W1961883110","https://openalex.org/W1964082391","https://openalex.org/W1964216244","https://openalex.org/W1967351091","https://openalex.org/W1968422415","https://openalex.org/W1968460020","https://openalex.org/W1970734591","https://openalex.org/W1971486154","https://openalex.org/W1974580919","https://openalex.org/W1977442551","https://openalex.org/W1978690375","https://openalex.org/W1978774658","https://openalex.org/W1980093649","https://openalex.org/W1983417944","https://openalex.org/W1985257452","https://openalex.org/W1986904544","https://openalex.org/W1986939620","https://openalex.org/W1988065964","https://openalex.org/W1988358352","https://openalex.org/W1988613128","https://openalex.org/W1990247687","https://openalex.org/W1990319295","https://openalex.org/W1991863368","https://openalex.org/W1992506857","https://openalex.org/W1993342291","https://openalex.org/W1994301088","https://openalex.org/W1995546729","https://openalex.org/W1996383717","https://openalex.org/W1997064567","https://openalex.org/W1998388102","https://openalex.org/W1998582290","https://openalex.org/W2000194765","https://openalex.org/W2000963707","https://openalex.org/W2001668931","https://openalex.org/W2003122301","https://openalex.org/W2003268732","https://openalex.org/W2004372194","https://openalex.org/W2006187783","https://openalex.org/W2006877529","https://openalex.org/W2011908601","https://openalex.org/W2012303274","https://openalex.org/W2013081324","https://openalex.org/W2014185375","https://openalex.org/W2015337271","https://openalex.org/W2015352268","https://openalex.org/W2015533398","https://openalex.org/W2017511982","https://openalex.org/W2017730825","https://openalex.org/W2017851289","https://openalex.org/W2017918116","https://openalex.org/W2018643603","https://openalex.org/W2018935685","https://openalex.org/W2019048359","https://openalex.org/W2019056125","https://openalex.org/W2019619326","https://openalex.org/W2020344975","https://openalex.org/W2020540515","https://openalex.org/W2021192988","https://openalex.org/W2021372965","https://openalex.org/W2023218063","https://openalex.org/W2023826348","https://openalex.org/W2025108897","https://openalex.org/W2026614040","https://openalex.org/W2028386875","https://openalex.org/W2032106211","https://openalex.org/W2033271766","https://openalex.org/W2034188379","https://openalex.org/W2035086157","https://openalex.org/W2036143395","https://openalex.org/W2037038225","https://openalex.org/W2037068771","https://openalex.org/W2037741920","https://openalex.org/W2038430559","https://openalex.org/W2038946905","https://openalex.org/W2039506171","https://openalex.org/W2039567228","https://openalex.org/W2040148868","https://openalex.org/W2040552715","https://openalex.org/W2040624227","https://openalex.org/W2041658899","https://openalex.org/W2042583579","https://openalex.org/W2042593224","https://openalex.org/W2043795836","https://openalex.org/W2046439628","https://openalex.org/W2046669555","https://openalex.org/W2048442535","https://openalex.org/W2053045890","https://openalex.org/W2054912517","https://openalex.org/W2058843590","https://openalex.org/W2059602687","https://openalex.org/W2060516408","https://openalex.org/W2060624748","https://openalex.org/W2060762673","https://openalex.org/W2060900336","https://openalex.org/W2062140428","https://openalex.org/W2062549773","https://openalex.org/W2063949300","https://openalex.org/W2065769269","https://openalex.org/W2065828665","https://openalex.org/W2067394045","https://openalex.org/W2068536063","https://openalex.org/W2068636462","https://openalex.org/W2070234320","https://openalex.org/W2070349393","https://openalex.org/W2070647828","https://openalex.org/W2070680921","https://openalex.org/W2070719888","https://openalex.org/W2071489477","https://openalex.org/W2073659110","https://openalex.org/W2073741175","https://openalex.org/W2074542832","https://openalex.org/W2075267181","https://openalex.org/W2077927355","https://openalex.org/W2081514607","https://openalex.org/W2082967998","https://openalex.org/W2084388692","https://openalex.org/W2085990872","https://openalex.org/W2086396801","https://openalex.org/W2086414517","https://openalex.org/W2086486284","https://openalex.org/W2087051893","https://openalex.org/W2087459059","https://openalex.org/W2089904066","https://openalex.org/W2092229583","https://openalex.org/W2092660611","https://openalex.org/W2092973330","https://openalex.org/W2093157637","https://openalex.org/W2094053196","https://openalex.org/W2096314064","https://openalex.org/W2096650959","https://openalex.org/W2097033993","https://openalex.org/W2097489402","https://openalex.org/W2097692976","https://openalex.org/W2100598350","https://openalex.org/W2104101154","https://openalex.org/W2104193042","https://openalex.org/W2104277391","https://openalex.org/W2105580261","https://openalex.org/W2106711665","https://openalex.org/W2109128406","https://openalex.org/W2109990573","https://openalex.org/W2110118982","https://openalex.org/W2111071424","https://openalex.org/W2111651135","https://openalex.org/W2114168045","https://openalex.org/W2122029377","https://openalex.org/W2123832762","https://openalex.org/W2124345456","https://openalex.org/W2124464501","https://openalex.org/W2126568409","https://openalex.org/W2126798872","https://openalex.org/W2127496022","https://openalex.org/W2128065481","https://openalex.org/W2128827916","https://openalex.org/W2130846480","https://openalex.org/W2133392152","https://openalex.org/W2134116694","https://openalex.org/W2135155547","https://openalex.org/W2137562588","https://openalex.org/W2141381634","https://openalex.org/W2142349229","https://openalex.org/W2142480558","https://openalex.org/W2143479226","https://openalex.org/W2144200599","https://openalex.org/W2145874740","https://openalex.org/W2146904153","https://openalex.org/W2148911584","https://openalex.org/W2149129350","https://openalex.org/W2149385661","https://openalex.org/W2149642592","https://openalex.org/W2150919283","https://openalex.org/W2150989762","https://openalex.org/W2153023641","https://openalex.org/W2153107993","https://openalex.org/W2153909270","https://openalex.org/W2155794657","https://openalex.org/W2159988033","https://openalex.org/W2160958456","https://openalex.org/W2162664755","https://openalex.org/W2164171936","https://openalex.org/W2164180982","https://openalex.org/W2164296994","https://openalex.org/W2164778116","https://openalex.org/W2165682201","https://openalex.org/W2168898273","https://openalex.org/W2170096497","https://openalex.org/W2172281772","https://openalex.org/W2175221334","https://openalex.org/W2185617898","https://openalex.org/W2258378225","https://openalex.org/W2272564146","https://openalex.org/W2275806076","https://openalex.org/W2277064933","https://openalex.org/W2333740675","https://openalex.org/W2409959321","https://openalex.org/W2782641499","https://openalex.org/W4236842068","https://openalex.org/W4238581030","https://openalex.org/W4239692799","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1997268363","https://openalex.org/W2095541534","https://openalex.org/W4383681499","https://openalex.org/W2342470960","https://openalex.org/W2132672261","https://openalex.org/W4205422651","https://openalex.org/W2884425470","https://openalex.org/W2051939090","https://openalex.org/W2580400995","https://openalex.org/W625624356"],"abstract_inverted_index":{"Alcoholic":[0],"liver":[1,19],"disease":[2,20],"(ALD)":[3],"is":[4,26,117,192],"a":[5,27,118,194],"primary":[6],"consequence":[7],"of":[8,18,24,43,63,69,86,90,115,144,165],"heavy":[9],"and":[10,29,36,48,57,129,139,142,154,160,176,186,208],"prolonged":[11],"drinking.":[12],"ALD":[13,25,44,64,116,153],"contributes":[14],"to":[15,92,122,182,200],"the":[16,83,112,205],"bulk":[17],"burden":[21],"worldwide.":[22],"Progression":[23],"multifactorial":[28],"multistep":[30],"process":[31],"that":[32,109,152],"includes":[33],"many":[34],"genetic":[35,161],"environmental":[37],"risk":[38,119],"factors.":[39],"The":[40,60,150],"molecular":[41,206],"pathogenesis":[42],"involves":[45],"alcohol":[46],"metabolism":[47],"secondary":[49],"mechanisms":[50,203],"such":[51],"as":[52,66,98],"oxidative":[53],"stress,":[54],"endotoxin,":[55],"cytokines":[56,146],"immune":[58],"regulators.":[59],"histopathological":[61],"manifestation":[62],"occurs":[65],"an":[67,100],"outcome":[68],"complex":[70],"but":[71,88],"controlled":[72],"interactions":[73],"between":[74],"hepatic":[75,104,148],"cell":[76],"types.":[77],"Hepatic":[78],"stellate":[79],"cells":[80,97],"(HSCs)":[81],"are":[82],"key":[84],"drivers":[85],"fibrogenesis,":[87],"transformation":[89],"hepatocytes":[91],"myofibroblastoids":[93],"also":[94,193],"implicate":[95],"parenchymal":[96],"playing":[99],"active":[101],"role":[102],"in":[103,147],"fibrogenesis.":[105,149],"Recent":[106],"discoveries":[107],"indicate":[108],"lipogenesis":[110],"during":[111],"early":[113],"stages":[114],"for":[120,189,196],"advancement":[121],"cirrhosis.":[123],"Other":[124],"recently":[125],"identified":[126],"novel":[127,145,184],"molecules":[128],"physiological/cell":[130],"signaling":[131],"pathways":[132,159],"include":[133],"fibrinolysis,":[134],"osteopontin,":[135],"transforming":[136],"growth":[137],"factor-\u03b2-SMAD":[138],"hedgehog":[140],"signaling,":[141],"involvement":[143],"observation":[151],"non-alcoholic":[155],"steatohepatitis":[156],"share":[157],"common":[158],"polymorphisms":[162],"suggests":[163],"operation":[164],"parallel":[166],"pathogenic":[167,202],"mechanisms.":[168],"Future":[169],"research":[170],"involving":[171],"genomics,":[172],"epigenomics,":[173],"deep":[174],"sequencing":[175],"non-coding":[177],"regulatory":[178],"elements":[179],"holds":[180],"promise":[181],"identify":[183],"diagnostic":[185],"therapeutic":[187],"targets":[188],"ALD.":[190],"There":[191],"need":[195],"adequate":[197],"animal":[198],"models":[199],"study":[201],"at":[204],"level":[207],"targeted":[209],"therapy.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
