{"id":"https://openalex.org/W1574433403","doi":"https://doi.org/10.23970/ahrqepcerta160","title":"Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes","display_name":"Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1574433403","doi":"https://doi.org/10.23970/ahrqepcerta160","mag":"1574433403","pmid":"https://pubmed.ncbi.nlm.nih.gov/18457476"},"language":"en","primary_location":{"id":"doi:10.23970/ahrqepcerta160","doi":"https://doi.org/10.23970/ahrqepcerta160","is_oa":false,"landing_page_url":"https://doi.org/10.23970/ahrqepcerta160","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Johns Hopkins University Evidence-based Practice Center","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4781418","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079978893","display_name":"Luigi Marchionni","orcid":"https://orcid.org/0000-0002-7336-8071","observed_orcids":["https://orcid.org/0000-0002-7336-8071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luigi Marchionni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062226918","display_name":"Ren\u00e9e F Wilson","orcid":"https://orcid.org/0000-0003-0786-1017","observed_orcids":["https://orcid.org/0000-0003-0786-1017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renee F Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081904779","display_name":"Spyridon S Marinopoulos","orcid":"https://orcid.org/0000-0002-5859-9146","observed_orcids":["https://orcid.org/0000-0002-5859-9146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Spyridon S Marinopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026024346","display_name":"Antonio C. Wolff","orcid":"https://orcid.org/0000-0003-3734-1063","observed_orcids":["https://orcid.org/0000-0003-3734-1063"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio C Wolff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050977500","display_name":"Giovanni Parmigiani","orcid":"https://orcid.org/0000-0002-8783-5961","observed_orcids":["https://orcid.org/0000-0002-8783-5961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovanni Parmigiani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056638016","display_name":"Eric B Bass","orcid":"https://orcid.org/0000-0001-9106-527X","observed_orcids":["https://orcid.org/0000-0001-9106-527X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric B Bass","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059008211","display_name":"Steven N. Goodman","orcid":"https://orcid.org/0000-0002-3872-5723","observed_orcids":["https://orcid.org/0000-0002-3872-5723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven N Goodman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"160","first_page":"1","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/gene-expression-assay","display_name":"gene expression assay","score":0.8679999709129333},{"id":"https://openalex.org/keywords/oncotype-dx","display_name":"Oncotype DX","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mammaprint","display_name":"MammaPrint","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-accuracy","display_name":"prognostic accuracy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/clinical-validation","display_name":"clinical validation","score":0.5569999814033508},{"id":"https://openalex.org/keywords/clinical-utility","display_name":"clinical utility","score":0.8240000009536743},{"id":"https://openalex.org/keywords/chemotherapy-benefit-prediction","display_name":"chemotherapy benefit prediction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.7670000195503235},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.8209999799728394},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6269999742507935},{"id":"https://openalex.org/keywords/decision-analysis","display_name":"decision analysis","score":0.5509999990463257},{"id":"https://openalex.org/keywords/health-care-costs","display_name":"health care costs","score":0.5460000038146973},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.4569999873638153},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.5550000071525574},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.723607063293457},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.714402973651886},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6130528450012207},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.5998269319534302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.490085244178772},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.477812796831131},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.43789157271385193},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4311329424381256},{"id":"https://openalex.org/C2910080358","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Oestrogen receptor","level":4,"score":0.4209164083003998},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.322198748588562},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2868673801422119},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.23970/ahrqepcerta160","doi":"https://doi.org/10.23970/ahrqepcerta160","is_oa":false,"landing_page_url":"https://doi.org/10.23970/ahrqepcerta160","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Johns Hopkins University Evidence-based Practice Center","raw_type":"report"},{"id":"pmid:18457476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18457476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence report/technology assessment","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4781418","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4781418","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Evid Rep Technol Assess (Full Rep)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4781418","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4781418","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Evid Rep Technol Assess (Full Rep)","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4000000059604645,"display_name":"Peace, justice, and strong institutions","id":"https://metadata.un.org/sdg/16"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2172254302","https://openalex.org/W2464051959","https://openalex.org/W2015092588","https://openalex.org/W1771722205","https://openalex.org/W2998725311","https://openalex.org/W2027175481","https://openalex.org/W2103643613","https://openalex.org/W2126511903","https://openalex.org/W2971293366","https://openalex.org/W2091599823"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"assess":[2],"the":[3,31,39,45,60,100,104,142,153,160,166,169,192,271,293,315,322,340,389,409],"evidence":[4,32,64,163,291,305,346,373],"that":[5,145,191,347],"three":[6,34],"marketed":[7,167],"gene":[8,35,56,155,327],"expression-based":[9],"assays":[10,37],"improve":[11],"prognostic":[12,73,202],"accuracy,":[13],"treatment":[14,82,302,370],"choice,":[15],"and":[16,44,54,75,90,107,122,207,223,226,270,330,352,388,430],"health":[17,91],"outcomes":[18],"in":[19,195,212,256,267,275,280,363,416],"women":[20],"diagnosed":[21],"with":[22,183,214,258,343,368,385],"early":[23],"stage":[24],"breast":[25,325],"cancer.":[26],"REVIEW":[27],"METHODS:":[28],"We":[29,62],"evaluated":[30],"for":[33,55,165,306,312,374],"expression":[36,57,328],"on":[38,86,99,434],"market;":[40],"Oncotype":[41,105,161,297,335,386],"DX,":[42,387],"MammaPrint":[43,108,205,313,379],"Breast":[46],"Cancer":[47],"Profiling":[48],"(BCP":[49],"or":[50,152,314],"H/I":[51,316,400],"ratio)":[52],"test,":[53,168,193],"signatures":[58],"underlying":[59,154],"assays.":[61],"sought":[63],"on:":[65],"analytic":[66,101],"performance":[67],"of":[68,81,103,159,177,220,232,278,292,296,324,377,411],"tests,":[69,109,408],"clinical":[70,77,87,133,294,307,366,375],"validity":[71,102],"(i.e.,":[72,79],"accuracy":[74],"discrimination),":[76],"utility":[78,295,308],"prediction":[80],"benefit),":[83],"harms,":[84],"impact":[85],"decision":[88,250,319],"making":[89],"care":[92],"costs.":[93],"RESULTS:":[94],"Few":[95],"papers":[96],"were":[97,254,332],"found":[98,311],"DX":[106,162,298,336],"but":[110,237,304],"these":[111],"showed":[112,190,227],"reasonable":[113],"within-laboratory":[114,130],"replicability.":[115],"Pre-analytic":[116],"issues":[117],"related":[118],"to":[119,138,150,200,299,355,391,413,432],"sample":[120],"storage":[121],"preparation":[123],"may":[124],"play":[125],"a":[126,178,184,196,228,276,356,364],"larger":[127],"role":[128],"than":[129],"variation.":[131],"For":[132,406],"validity,":[134],"studies":[135,213],"differed":[136],"according":[137],"whether":[139],"they":[140],"examined":[141,211,266,321],"actual":[143],"test":[144,208,263,402],"is":[146,337],"currently":[147],"being":[148,173],"offered":[149],"patients":[151,233,433],"signature.":[156],"Almost":[157],"all":[158,407],"was":[164,210,239,265,273,309,380],"strongest":[170],"validation":[171,341],"study":[172,189],"from":[174],"one":[175,268],"arm":[176],"randomized":[179,284],"controlled":[180,285],"trial":[181,286],"(NSABP-14)":[182],"clinically":[185,197,215,229,357],"homogeneous":[186],"population.":[187],"This":[188],"added":[194],"meaningful":[198],"manner":[199],"standard":[201,361],"indices.":[203,260],"The":[204,261,372,399],"signature":[206,272],"itself":[209,264],"heterogeneous":[216],"populations":[217,418],"(e.g.,":[218],"mix":[219],"ER":[221],"positivity":[222],"tamoxifen":[224],"treatment)":[225],"relevant":[230,358],"separation":[231],"into":[234],"risk":[235,415],"categories,":[236],"it":[238,348],"not":[240,310,381,396],"clear":[241,369,383],"exactly":[242],"how":[243],"many":[244],"predictions":[245],"would":[246],"be":[247],"shifted":[248],"across":[249],"thresholds":[251],"if":[252],"this":[253],"used":[255],"combination":[257],"traditional":[259],"BCP":[262],"study,":[269,422],"tested":[274],"variety":[277],"formulations":[279],"several":[281],"studies.":[282],"One":[283],"provided":[287],"high":[288],"quality":[289],"retrospective":[290,345],"predict":[300,392],"chemotherapy":[301,353,393],"benefit,":[303],"ratio.":[317],"Three":[318],"analyses":[320],"cost-effectiveness":[323],"cancer":[326],"assays,":[329],"overall":[331],"inconclusive.":[333],"CONCLUSIONS:":[334],"furthest":[338],"along":[339],"pathway,":[342],"strong":[344],"predicts":[349],"distant":[350],"spread":[351],"benefit":[354,394],"extent":[359],"over":[360],"predictors,":[362],"well-defined":[365],"subgroup":[367],"implications.":[371],"implications":[376],"using":[378],"as":[382,384,423],"ability":[390],"does":[395,424],"yet":[397],"exist.":[398],"ratio":[401],"requires":[403],"further":[404,421],"validation.":[405],"relationship":[410],"predicted":[412],"observed":[414],"different":[417],"still":[419],"needs":[420],"their":[425],"incremental":[426],"contribution,":[427],"optimal":[428],"implementation,":[429],"relevance":[431],"current":[435],"therapies.":[436]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
