{"id":"https://openalex.org/W157398291","doi":null,"title":"Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition","display_name":"Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W157398291","mag":"157398291"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-206120","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206120","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052342874","display_name":"E\u2010Jean Tan","orcid":"https://orcid.org/0000-0002-4631-174X","observed_orcids":["https://orcid.org/0000-0002-4631-174X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E\u2010Jean Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052342874"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":1.0},{"id":"https://openalex.org/keywords/hmga2","display_name":"HMGA2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.902999997138977},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.7070000171661377},{"id":"https://openalex.org/keywords/smad","display_name":"Smad","score":0.5709999799728394},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.9309999942779541},{"id":"https://openalex.org/keywords/twist","display_name":"Twist","score":0.9850000143051147},{"id":"https://openalex.org/keywords/zeb","display_name":"ZEB","score":0.9449999928474426},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8240000009536743},{"id":"https://openalex.org/keywords/emt-transcription-factors","display_name":"EMT transcription factors","score":0.6800000071525574},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.746999979019165},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6840000152587891},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.800000011920929},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.675014853477478},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5203944444656372},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4785350263118744},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.46511510014533997},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.4636251926422119},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.45480865240097046},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.41524872183799744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3963576853275299},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35524895787239075},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3274616003036499},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28328564763069153},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2813832461833954},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2700226306915283}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-206120","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206120","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:157398291","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:643590/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-206120","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206120","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":161,"referenced_works":["https://openalex.org/W26894586","https://openalex.org/W29399532","https://openalex.org/W1501874273","https://openalex.org/W1520671195","https://openalex.org/W1529816420","https://openalex.org/W1536326448","https://openalex.org/W1856194852","https://openalex.org/W1880466029","https://openalex.org/W1938875781","https://openalex.org/W1964081206","https://openalex.org/W1967133987","https://openalex.org/W1968008181","https://openalex.org/W1969575777","https://openalex.org/W1970098795","https://openalex.org/W1972232373","https://openalex.org/W1973759523","https://openalex.org/W1973816411","https://openalex.org/W1976324983","https://openalex.org/W1976626368","https://openalex.org/W1979953062","https://openalex.org/W1980051146","https://openalex.org/W1981354816","https://openalex.org/W1983991097","https://openalex.org/W1984189354","https://openalex.org/W1985339653","https://openalex.org/W1986471913","https://openalex.org/W1987557775","https://openalex.org/W1989261729","https://openalex.org/W1991537633","https://openalex.org/W1992618022","https://openalex.org/W1992968941","https://openalex.org/W1995293599","https://openalex.org/W1996427377","https://openalex.org/W1997511372","https://openalex.org/W1998466286","https://openalex.org/W1999132074","https://openalex.org/W2002784328","https://openalex.org/W2005983388","https://openalex.org/W2008869198","https://openalex.org/W2008933729","https://openalex.org/W2009229545","https://openalex.org/W2009410973","https://openalex.org/W2009842916","https://openalex.org/W2012315992","https://openalex.org/W2014526918","https://openalex.org/W2014622924","https://openalex.org/W2014691022","https://openalex.org/W2015600689","https://openalex.org/W2016360721","https://openalex.org/W2017201371","https://openalex.org/W2020310925","https://openalex.org/W2022916389","https://openalex.org/W2024585236","https://openalex.org/W2025647419","https://openalex.org/W2026460094","https://openalex.org/W2027860197","https://openalex.org/W2028324018","https://openalex.org/W2028919524","https://openalex.org/W2032093572","https://openalex.org/W2032912275","https://openalex.org/W2033550998","https://openalex.org/W2033964863","https://openalex.org/W2036008499","https://openalex.org/W2036174481","https://openalex.org/W2037692396","https://openalex.org/W2037920955","https://openalex.org/W2037995476","https://openalex.org/W2039214381","https://openalex.org/W2040239915","https://openalex.org/W2040516688","https://openalex.org/W2040754208","https://openalex.org/W2041686632","https://openalex.org/W2042773343","https://openalex.org/W2043422368","https://openalex.org/W2043797012","https://openalex.org/W2047529648","https://openalex.org/W2048835818","https://openalex.org/W2051940224","https://openalex.org/W2053213384","https://openalex.org/W2053421436","https://openalex.org/W2057539625","https://openalex.org/W2058437379","https://openalex.org/W2066419333","https://openalex.org/W2068087430","https://openalex.org/W2069266255","https://openalex.org/W2069414088","https://openalex.org/W2071852394","https://openalex.org/W2071970475","https://openalex.org/W2072177644","https://openalex.org/W2072363222","https://openalex.org/W2072488296","https://openalex.org/W2072784374","https://openalex.org/W2074826254","https://openalex.org/W2076375511","https://openalex.org/W2083798214","https://openalex.org/W2084885369","https://openalex.org/W2086040324","https://openalex.org/W2086204811","https://openalex.org/W2087472062","https://openalex.org/W2089370460","https://openalex.org/W2090757807","https://openalex.org/W2094013368","https://openalex.org/W2095605427","https://openalex.org/W2096083625","https://openalex.org/W2096662041","https://openalex.org/W2098891057","https://openalex.org/W2099987999","https://openalex.org/W2100010244","https://openalex.org/W2103031848","https://openalex.org/W2104209180","https://openalex.org/W2106482095","https://openalex.org/W2106670703","https://openalex.org/W2108118664","https://openalex.org/W2109998353","https://openalex.org/W2110167662","https://openalex.org/W2110935705","https://openalex.org/W2111391000","https://openalex.org/W2112575854","https://openalex.org/W2113638068","https://openalex.org/W2113989947","https://openalex.org/W2117111440","https://openalex.org/W2117247812","https://openalex.org/W2117587692","https://openalex.org/W2118650242","https://openalex.org/W2119111772","https://openalex.org/W2119584041","https://openalex.org/W2121986702","https://openalex.org/W2123032740","https://openalex.org/W2124207075","https://openalex.org/W2127690474","https://openalex.org/W2130808015","https://openalex.org/W2131596261","https://openalex.org/W2133452708","https://openalex.org/W2134406847","https://openalex.org/W2136280424","https://openalex.org/W2137465688","https://openalex.org/W2139964260","https://openalex.org/W2141860100","https://openalex.org/W2144578935","https://openalex.org/W2146445411","https://openalex.org/W2148043102","https://openalex.org/W2148583445","https://openalex.org/W2149914697","https://openalex.org/W2153203105","https://openalex.org/W2155131748","https://openalex.org/W2155244534","https://openalex.org/W2156927848","https://openalex.org/W2158028316","https://openalex.org/W2159164310","https://openalex.org/W2161186807","https://openalex.org/W2161728771","https://openalex.org/W2162937786","https://openalex.org/W2165798632","https://openalex.org/W2165899098","https://openalex.org/W2166644606","https://openalex.org/W2169055032","https://openalex.org/W2170335587","https://openalex.org/W2170647698","https://openalex.org/W2171078009","https://openalex.org/W2172098727","https://openalex.org/W2259938310"],"related_works":["https://openalex.org/W2127690474","https://openalex.org/W2086204811","https://openalex.org/W7096230896","https://openalex.org/W2028324018","https://openalex.org/W2105439591","https://openalex.org/W2150585673","https://openalex.org/W2155244534","https://openalex.org/W2915242355","https://openalex.org/W2060510577","https://openalex.org/W4391444222"],"abstract_inverted_index":{"The":[0,87],"transforming":[1],"growth":[2,67],"factor":[3],"beta":[4],"(TGF\u03b2)":[5],"is":[6,101,128],"a":[7,11,41,45,49,62,102,110,139,166,223],"cytokine":[8],"that":[9,163,257],"regulates":[10,165],"plethora":[12],"of":[13,57,119,132,168,176,245],"cellular":[14],"processes":[15],"such":[16,123,173],"as":[17,44,61,96,124,174,222],"cell":[18],"proliferation,":[19],"differentiation,":[20],"migration":[21,115],"and":[22,30,48,70,85,116,126,180,201,219,228,238,248,275],"apoptosis.":[23,72],"TGF\u03b2":[24,39,59,77,89,134],"signals":[25],"via":[26],"serine/threonine":[27],"kinase":[28],"receptors":[29],"activates":[31,202],"the":[32,153,177,203,262],"Smads":[33],"to":[34,79,192,272],"regulate":[35],"gene":[36],"expression.":[37,196],"Enigmatically,":[38],"has":[40],"dichotomous":[42],"role":[43],"tumor":[46,50,63,80],"suppressor":[47,64],"promoter":[51],"in":[52,217,233,250],"cancer.":[53],"At":[54],"early":[55],"stages":[56],"tumorigenesis,":[58],"acts":[60],"by":[65,82,137,156],"exerting":[66],"inhibitory":[68],"effects":[69],"inducing":[71],"However,":[73],"at":[74],"advanced":[75],"stages,":[76],"contributes":[78],"malignancy":[81],"promoting":[83],"invasion":[84],"metastasis.":[86],"pro-tumorigenic":[88],"potently":[90],"triggers":[91],"an":[92,129],"embryonic":[93],"program":[94],"known":[95],"epithelial-mesenchymal":[97],"transition":[98],"(EMT).":[99],"EMT":[100,136,169,225,274],"dynamic":[103],"process":[104],"whereby":[105],"polarized":[106],"epithelial":[107,210],"cells":[108,211,235],"adapt":[109],"mesenchymal":[111,216],"morphology,":[112],"thereby":[113],"facilitating":[114],"invasion.":[117,276],"Downregulation":[118],"cell-cell":[120],"adhesion":[121],"molecules,":[122],"E-cadherin":[125,263],"ZO-1,":[127],"eminent":[130],"feature":[131],"EMT.":[133,160,185],"induces":[135],"upregulating":[138],"non-histone":[140],"chromatin":[141],"factor,":[142],"high":[143],"mobility":[144],"group":[145],"A2":[146],"(HMGA2).":[147],"This":[148],"thesis":[149],"focuses":[150],"on":[151],"elucidating":[152],"molecular":[154],"mechanisms":[155],"which":[157,214],"HMGA2":[158,164,186,197,258,267],"elicits":[159],"We":[161,206],"found":[162],"network":[167],"transcription":[170],"factors":[171],"(EMT-TFs),":[172],"members":[175],"Snail,":[178],"ZEB":[179],"Twist":[181,204,229,249],"families,":[182],"during":[183,236],"TGF\u03b2-induced":[184],"can":[187,259],"interact":[188],"with":[189],"Smad":[190],"complexes":[191],"synergistically":[193],"induce":[194],"Snail":[195,227,247],"also":[198,255],"directly":[199],"binds":[200],"promoter.":[205],"used":[207],"mouse":[208],"mammary":[209],"overexpressing":[212],"HMGA2,":[213],"are":[215],"morphology":[218],"highly":[220],"invasive,":[221],"constitutive":[224],"model.":[226],"have":[230],"complementary":[231],"roles":[232],"HMGA2-mesenchymal":[234],"EMT,":[237],"tight":[239],"junctions":[240],"were":[241],"restored":[242],"upon":[243],"silencing":[244],"both":[246],"these":[251],"cells.":[252],"Finally,":[253],"we":[254],"demonstrate":[256],"epigenetically":[260],"silence":[261],"gene.":[264],"In":[265],"summary,":[266],"modulates":[268],"multiple":[269],"reprogramming":[270],"events":[271],"promote":[273]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}