{"id":"https://openalex.org/W1573768673","doi":null,"title":"Presence of extensive intraductal component in patients undergoing breast conservative surgery predicts presence of residual disease in subsequent completion mastectomy.","display_name":"Presence of extensive intraductal component in patients undergoing breast conservative surgery predicts presence of residual disease in subsequent completion mastectomy.","publication_year":2009,"publication_date":"2009-04-20","ids":{"openalex":"https://openalex.org/W1573768673","mag":"1573768673","pmid":"https://pubmed.ncbi.nlm.nih.gov/19493411"},"language":"en","primary_location":{"id":"pmid:19493411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19493411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053533744","display_name":"Christopher C P Yiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094964","display_name":"Unimed Medical Institute","ror":"https://ror.org/00mjzz278","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Christopher C P Yiu","raw_affiliation_strings":["UNIMED Medical Institute Comprehensive Centre for Breast Diseases, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIMED Medical Institute Comprehensive Centre for Breast Diseases, Hong Kong, China","institution_ids":["https://openalex.org/I4210094964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110005283","display_name":"Wings T.Y. Loo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wings T Y Loo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049541799","display_name":"Candace Lam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C K Lam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110931584","display_name":"Louis W.C. Chow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louis W C Chow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.108,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.49970346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"122","issue":"8","first_page":"900","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extensive-intraductal-component","display_name":"extensive intraductal component","score":0.9649999737739563},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.7770000100135803},{"id":"https://openalex.org/keywords/completion-mastectomy","display_name":"completion mastectomy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/residual-disease","display_name":"residual disease","score":0.8970000147819519},{"id":"https://openalex.org/keywords/invasive-breast-cancer","display_name":"invasive breast cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.8220000267028809},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.6769999861717224},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c-erbb-2","display_name":"c-erbB-2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.7689999938011169},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8848519325256348},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.7705037593841553},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6456339359283447},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5622093677520752},{"id":"https://openalex.org/C2778740770","wikidata":"https://www.wikidata.org/wiki/Q6708283","display_name":"Lymphovascular invasion","level":4,"score":0.4608343243598938},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4513244032859802},{"id":"https://openalex.org/C2781467025","wikidata":"https://www.wikidata.org/wiki/Q4959754","display_name":"Breast-conserving surgery","level":5,"score":0.4233195185661316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3092787265777588},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27810877561569214},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.08652821183204651}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008408","descriptor_name":"Mastectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015412","descriptor_name":"Mastectomy, Segmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19493411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19493411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:1573768673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19493411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3147616619","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85656X/200908/30181649.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541197","display_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W40782235","https://openalex.org/W1782647475","https://openalex.org/W1888411879","https://openalex.org/W1923770335","https://openalex.org/W1950764026","https://openalex.org/W1968767144","https://openalex.org/W1980984976","https://openalex.org/W1982623790","https://openalex.org/W1982699018","https://openalex.org/W1989555626","https://openalex.org/W2015608043","https://openalex.org/W2019972414","https://openalex.org/W2027537605","https://openalex.org/W2031431770","https://openalex.org/W2042620601","https://openalex.org/W2045742295","https://openalex.org/W2058128032","https://openalex.org/W2058294801","https://openalex.org/W2071651121","https://openalex.org/W2076429848","https://openalex.org/W2083610791","https://openalex.org/W2092882833","https://openalex.org/W2101603546","https://openalex.org/W2109030089","https://openalex.org/W2118003745","https://openalex.org/W2123707649","https://openalex.org/W2127670401","https://openalex.org/W2130872475","https://openalex.org/W2145207352","https://openalex.org/W2172480593","https://openalex.org/W2295247208","https://openalex.org/W2316011039","https://openalex.org/W2415844373","https://openalex.org/W2442616415","https://openalex.org/W2468561808","https://openalex.org/W2470893214","https://openalex.org/W2487513034"],"related_works":["https://openalex.org/W7098025018","https://openalex.org/W7117468836","https://openalex.org/W2049225508","https://openalex.org/W2057772690","https://openalex.org/W1995234845","https://openalex.org/W4387977984","https://openalex.org/W3028842669","https://openalex.org/W2061896859","https://openalex.org/W4387134928","https://openalex.org/W2203091303"],"abstract_inverted_index":{"BACKGROUND:":[0],"Local":[1],"recurrence":[2,164],"remains":[3],"a":[4,52,89,137,199],"serious":[5],"problem":[6],"among":[7],"patients":[8,34,50,119,183,207,223],"undergoing":[9],"breast":[10,24,37,42,131,209,228],"conservative":[11,25,43,210,229],"surgery.":[12,26,211],"This":[13,28],"study":[14,30],"aimed":[15],"at":[16],"identifying":[17],"risk":[18,76,139,155,201,234],"factors":[19,156],"for":[20,157,182,203],"residual":[21,68,125,141,160,186,204],"disease":[22,69,105,142,187,205],"after":[23,177,208],"METHODS:":[27],"retrospective":[29],"was":[31,106,115,134,165],"based":[32],"on":[33],"with":[35,136,224],"invasive":[36],"cancer":[38],"who":[39,184,190],"have":[40],"received":[41],"surgery":[44,133,230],"and":[45,73,82,101,170,174,188],"subsequent":[46,236],"completion":[47,71,144,178,220],"mastectomy.":[48],"All":[49],"had":[51,124,185,191],"clear":[53],"resection":[54],"margin":[55],"in":[56,108,117,167,206,222],"the":[57,62,65,74,171,216,233],"initial":[58,227],"operation.":[59],"We":[60],"analyzed":[61],"association":[63],"between":[64],"presence":[66,83,158,195],"of":[67,84,96,111,121,128,140,159,196,219,235],"during":[70,130,143,226],"mastectomy":[72,145,179,221],"following":[75],"factors:":[77],"T":[78],"staging,":[79],"young":[80],"age,":[81],"extensive":[85],"intraductal":[86],"component":[87],"(EIC),":[88],"close":[90],"margin,":[91],"lymphovascular":[92],"permeation":[93],"(LVP),":[94],"positivity":[95],"estrogen":[97],"receptor,":[98,100],"progesterone":[99],"c-erbB-2.":[102],"RESULTS:":[103],"Residual":[104],"encountered":[107],"21":[109],"(45.7%)":[110],"46":[112],"patients;":[113],"EIC":[114,129,197,225],"present":[116],"28":[118],"(60.9%),":[120],"whom":[122],"17":[123],"disease.":[126,161],"Presence":[127],"conservation":[132],"associated":[135],"higher":[138],"(P":[146],"=":[147],"0.011).":[148],"Other":[149],"variables":[150],"were":[151,180],"not":[152],"statistically":[153],"significant":[154,200],"No":[162],"local":[163,237],"recorded":[166],"our":[168],"cohort,":[169],"disease-free":[172],"survival":[173,176],"overall":[175],"similar":[181],"those":[189],"not.":[192],"CONCLUSIONS:":[193],"The":[194],"is":[198],"factor":[202],"Our":[212],"findings":[213],"may":[214],"suggest":[215],"indicated":[217],"value":[218],"to":[231],"decrease":[232],"failure.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}