{"id":"https://openalex.org/W157374177","doi":null,"title":"Removal of potentially confounding phenotypes from a Siamese-derived feline glaucoma breeding colony.","display_name":"Removal of potentially confounding phenotypes from a Siamese-derived feline glaucoma breeding colony.","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W157374177","mag":"157374177","pmid":"https://pubmed.ncbi.nlm.nih.gov/21819695","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123758"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3123758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123758","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123758","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034722509","display_name":"Michelle M. Rutz-Mendicino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle M Rutz-Mendicino","raw_affiliation_strings":["Department of Animal Science and the Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science and the Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063529721","display_name":"Elizabeth M. Snella","orcid":"https://orcid.org/0000-0003-1482-2876","observed_orcids":["https://orcid.org/0000-0003-1482-2876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth M Snella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060591555","display_name":"Jackie K. Jens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jackie K Jens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024789676","display_name":"Barbara Gandolfi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Gandolfi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071194019","display_name":"Steven A. Carlson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven A Carlson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007951385","display_name":"Markus H. Kuehn","orcid":"https://orcid.org/0000-0003-3940-198X","observed_orcids":["https://orcid.org/0000-0003-3940-198X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus H Kuehn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073709588","display_name":"Gillian J. McLellan","orcid":"https://orcid.org/0000-0002-6505-7476","observed_orcids":["https://orcid.org/0000-0002-6505-7476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gillian J McLellan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068306424","display_name":"Norman Matthew Ellinwood","orcid":"https://orcid.org/0000-0002-1701-5052","observed_orcids":["https://orcid.org/0000-0002-1701-5052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Matthew Ellinwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2991,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.62993222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"61","issue":"3","first_page":"251","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/siamese-cats","display_name":"Siamese cats","score":0.9449999928474426},{"id":"https://openalex.org/keywords/coat-color-genetics","display_name":"coat color inheritance","score":0.7720000147819519},{"id":"https://openalex.org/keywords/glb1","display_name":"GLB1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cep290","display_name":"CEP290","score":1.0},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.5460000038146973},{"id":"https://openalex.org/keywords/homozygosity","display_name":"homozygosity","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.8624897003173828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7803707122802734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.691125750541687},{"id":"https://openalex.org/C2777817576","wikidata":"https://www.wikidata.org/wiki/Q1817674","display_name":"Coat","level":2,"score":0.6484687328338623},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6459981799125671},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5274206399917603},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4642738699913025},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.41375842690467834},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.293925940990448},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001947","descriptor_name":"Breeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007756","descriptor_name":"Laboratory Animal Science","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018703","descriptor_name":"Founder Effect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3123758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123758","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},{"id":"pmid:21819695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21819695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Journal Article"},{"id":"mag:157374177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21819695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3123758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123758","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2414754873","display_name":"Structural and Functional Characterization of a Novel Model for Glaucoma Research","funder_award_id":"K08EY018609","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000865174","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY016665","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W110122724","https://openalex.org/W161300286","https://openalex.org/W2395935945","https://openalex.org/W2416495597","https://openalex.org/W2416505443"],"related_works":["https://openalex.org/W2100382193","https://openalex.org/W7100153660","https://openalex.org/W2123237622","https://openalex.org/W2071169720","https://openalex.org/W3034397234","https://openalex.org/W2109758707","https://openalex.org/W4385298391","https://openalex.org/W4399887188","https://openalex.org/W2158279486","https://openalex.org/W2912024262"],"abstract_inverted_index":{"Feline":[0],"breeding":[1],"colonies":[2],"face":[3],"genetic":[4],"constraints":[5],"involving":[6],"founder":[7],"effects.":[8,205],"A":[9,90,103],"Siamese-founded":[10],"colony":[11,85],"used":[12,77],"to":[13,22,80,156,218,236],"study":[14],"primary":[15],"congenital":[16],"glaucoma":[17,194],"displayed":[18],"coat":[19,240],"colors":[20],"additional":[21],"the":[23,47,52,56,61,68,87,97,100,108,111,148,171,179,193,225],"Siamese":[24,53,105,125,134,166],"coat.":[25],"Genes":[26],"affecting":[27],"pigment":[28],"can":[29],"exhibit":[30],"pleiotropy":[31],"on":[32,192],"ocular":[33],"development":[34],"and":[35,49,67,118,132,190,228],"function.":[36],"To":[37],"remove":[38,202],"potentially":[39,203,220],"confounding":[40,204,221],"phenotypes":[41,167,189],"from":[42],"our":[43,84],"colony,":[44,211],"we":[45],"documented":[46],"source":[48,98,109],"frequency":[50],"of":[51,99,110,159,181,187],"allele":[54,63,70],"at":[55,64,71,127,138,143],"gene":[57],"for":[58,86,120,170,233],"tyrosinase":[59],"(TYR),":[60],"dilution":[62],"melanophilin":[65],"(MLPH),":[66],"brown":[69,112],"tyrosinase-related":[72],"protein":[73],"1":[74],"(TYRP1).":[75],"We":[76],"PCR-RFLP":[78],"diagnostics":[79],"genotype":[81],"cats":[82,126,161],"in":[83,124,178],"published":[88],"alleles.":[89,183],"commercially":[91],"acquired":[92],"phenotypically":[93],"normal":[94,137],"tom":[95],"was":[96,107],"dilute":[101],"allele.":[102,113,150,174],"founding":[104,209],"queen":[106],"Founders":[114],"also":[115],"were":[116,136],"blood-typed":[117],"screened":[119,217],"disease-associated":[121],"alleles":[122,191,234],"segregating":[123],"3":[128],"loci":[129,140],"(ASB,":[130],"GLB1,":[131],"CEP290).":[133],"founders":[135],"all":[139],"except":[141],"ASB,":[142],"which":[144],"both":[145],"animals":[146],"carried":[147],"hypomorpic":[149],"Current":[151],"stock":[152,212,232],"is":[153,196],"being":[154],"managed":[155],"limit":[157,219],"production":[158],"glaucomatous":[160],"with":[162,239],"brown,":[163],"dilute,":[164],"or":[165,168,216],"homozygosity":[169],"ASB":[172],"hypomorphic":[173],"Genotyping":[175],"will":[176,201],"aid":[177],"elimination":[180,200],"these":[182,188],"The":[184],"clinical":[185],"effect":[186],"phenotype":[195],"uncertain,":[197],"but":[198],"their":[199],"In":[206],"conclusion,":[207],"when":[208],"a":[210],"should":[213],"be":[214,237,243],"selected":[215],"phenotypes.":[222],"When":[223],"studying":[224],"immune,":[226],"nervous,":[227],"visual":[229],"systems,":[230],"screening":[231],"known":[235],"associated":[238],"color":[241],"may":[242],"warranted.":[244]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}