{"id":"https://openalex.org/W1573629481","doi":null,"title":"Expression of serine protease inhibitor 3 in ocular tissues in endotoxin-induced uveitis in rat.","display_name":"Expression of serine protease inhibitor 3 in ocular tissues in endotoxin-induced uveitis in rat.","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W1573629481","mag":"1573629481","pmid":"https://pubmed.ncbi.nlm.nih.gov/11581179"},"language":"en","primary_location":{"id":"pmid:11581179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11581179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009299506","display_name":"Akira Takamiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Takamiya","raw_affiliation_strings":["Department of Anatomy, Asahikawa Medical College, Asahikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Asahikawa Medical College, Asahikawa, Japan","institution_ids":["https://openalex.org/I147809708"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Takeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Takeda","raw_affiliation_strings":["Ophthalmology, Asahikawa Medical College, Asahikawa; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Asahikawa Medical College, Asahikawa; and","institution_ids":["https://openalex.org/I147809708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102714674","display_name":"Akitoshi Yoshida","orcid":"https://orcid.org/0000-0001-8923-525X","observed_orcids":["https://orcid.org/0000-0001-8923-525X"]},"institutions":[{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Yoshida","raw_affiliation_strings":["Ophthalmology, Asahikawa Medical College, Asahikawa; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Asahikawa Medical College, Asahikawa; and","institution_ids":["https://openalex.org/I147809708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075627852","display_name":"Hiroshi Kiyama","orcid":"https://orcid.org/0000-0001-5963-046X","observed_orcids":["https://orcid.org/0000-0001-5963-046X"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Kiyama","raw_affiliation_strings":["Department of Anatomy, Osaka City University Graduate School of Medicine, Abeno-ku Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Osaka City University Graduate School of Medicine, Abeno-ku Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"42","issue":"11","first_page":"2427","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxin-induced-uveitis","display_name":"endotoxin-induced uveitis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ocular-inflammation","display_name":"ocular inflammation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/retinal-astrocytes","display_name":"retinal astrocytes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ox-42","display_name":"OX-42","score":0.9160000085830688},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.7818270325660706},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.7046493887901306},{"id":"https://openalex.org/C2778434524","wikidata":"https://www.wikidata.org/wiki/Q1048080","display_name":"Ciliary body","level":2,"score":0.6571406126022339},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6401460766792297},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.5874534249305725},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5661174058914185},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.48917558789253235},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.48707273602485657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48471808433532715},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4727015495300293},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.4123415946960449},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3324301838874817},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15624260902404785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0972108542919159},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002924","descriptor_name":"Ciliary Body","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007498","descriptor_name":"Iris","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030161","descriptor_name":"Avian Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051926","descriptor_name":"Basigin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11581179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11581179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.323.5283","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.5283","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iovs.org/content/42/11/2427.full.pdf","raw_type":"text"},{"id":"mag:1573629481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11581179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W27558630","https://openalex.org/W71051318","https://openalex.org/W71290712","https://openalex.org/W84452131","https://openalex.org/W951760830","https://openalex.org/W1232970536","https://openalex.org/W1458582449","https://openalex.org/W1493793044","https://openalex.org/W1511167640","https://openalex.org/W1552548126","https://openalex.org/W1567817045","https://openalex.org/W1569809977","https://openalex.org/W1581555608","https://openalex.org/W1595797136","https://openalex.org/W1675594938","https://openalex.org/W1796364413","https://openalex.org/W1876185986","https://openalex.org/W1971304093","https://openalex.org/W1992096122","https://openalex.org/W1999028040","https://openalex.org/W2008526568","https://openalex.org/W2012144305","https://openalex.org/W2019836892","https://openalex.org/W2021310874","https://openalex.org/W2029974988","https://openalex.org/W2062721618","https://openalex.org/W2069368135","https://openalex.org/W2081983561","https://openalex.org/W2090819414","https://openalex.org/W2094111001","https://openalex.org/W2094519414","https://openalex.org/W2113828544","https://openalex.org/W2123401321","https://openalex.org/W2134812217","https://openalex.org/W2144634347","https://openalex.org/W2150857908","https://openalex.org/W2159872853","https://openalex.org/W2290107761","https://openalex.org/W2300847779","https://openalex.org/W2403150670","https://openalex.org/W2405523860"],"related_works":["https://openalex.org/W7099706342","https://openalex.org/W2084289726","https://openalex.org/W2295812893","https://openalex.org/W2545368097","https://openalex.org/W2521388616","https://openalex.org/W1524070237","https://openalex.org/W7057207307","https://openalex.org/W27558630","https://openalex.org/W2090352892","https://openalex.org/W2158450596"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"ascribe":[2],"the":[3,37,43,68,109,120,152,158,163,173,207,220,230,233,247],"serine":[4],"protease":[5],"inhibitor":[6],"3":[7],"(SPI-3)":[8],"as":[9],"an":[10,22],"ocular":[11,44,126],"acute":[12],"inflammatory":[13,276],"molecule":[14],"and":[15,36,53,61,73,92,103,114,131,137,154,157,185,192,216,222],"to":[16,66],"clarify":[17],"its":[18],"producing":[19],"cells":[20,150,174,218],"in":[21,42,49,125,148,189,213,219,243,249,257,267],"endotoxin-induced":[23],"uveitis":[24],"(EIU)":[25],"model.":[26],"METHODS:":[27],"Male":[28],"Wistar":[29],"rats":[30],"were":[31,64,178,187],"injected":[32],"with":[33,169],"lipopolysaccharide":[34],"(LPS),":[35],"expression":[38,83,121,194,209,254],"of":[39,59,70,84,100,112,122,151,200,210,229,235,238],"SPI-3":[40,71,101,123,165,176,183,201,211,253,261],"mRNA":[41,72,102,124,144,166,177,184,212],"tissues":[45,127],"was":[46,88,105,128,146,167],"examined":[47,107],"by":[48,90,108,275],"situ":[50],"hybridization":[51],"(ISH)":[52],"Northern":[54],"blot":[55,94],"analysis.":[56],"A":[57],"combination":[58],"ISH":[60,113],"immunohistochemistry":[62],"(IHC)":[63],"performed":[65],"prove":[67],"colocalization":[69,99],"either":[74],"glial":[75],"fibrillary":[76],"acidic":[77],"protein":[78],"(GFAP)":[79],"or":[80],"OX-42.":[81],"The":[82,98],"phosphorylated":[85],"STAT3":[86,236],"(pSTAT3)":[87],"demonstrated":[89],"IHC":[91],"Western":[93],"after":[95,140],"LPS":[96,118,181],"injection.":[97,141],"pSTAT3":[104,186,193],"finally":[106],"double":[110],"labeling":[111],"IHC.":[115],"RESULTS:":[116],"After":[117,180],"injection,":[119],"quickly":[129],"upregulated":[130],"reached":[132],"a":[133,258],"peak":[134],"between":[135],"12":[136],"24":[138],"hours":[139],"An":[142],"intense":[143],"signal":[145],"observed":[147],"epithelial":[149,217],"iris":[153,221],"ciliary":[155,223],"body":[156],"innermost":[159],"retinal":[160,190,214],"layer.":[161],"In":[162],"retina,":[164],"colocalized":[168,188],"GFAP,":[170],"demonstrating":[171],"that":[172,199,252],"expressing":[175],"astrocytes.":[179,244],"treatment,":[182],"astrocytes,":[191],"appeared":[195],"slightly":[196,241],"earlier":[197,242],"than":[198],"mRNA.":[202],"CONCLUSIONS:":[203],"Ocular":[204],"inflammation":[205],"induced":[206,256,274],"transient":[208],"astrocytes":[215],"body,":[224],"particularly":[225],"during":[226],"early":[227],"phase":[228],"inflammation.":[231],"Simultaneously,":[232],"activation":[234],"(phosphorylation":[237],"STAT3)":[239],"occurred":[240],"This":[245],"supports":[246],"previous":[248],"vitro":[250],"results":[251],"is":[255,273],"STAT3-mediated":[259],"manner.":[260],"may":[262],"have":[263],"some":[264,269],"crucial":[265],"roles":[266],"preventing":[268],"degenerative":[270],"proteolysis,":[271],"which":[272],"stimuli.":[277]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}