{"id":"https://openalex.org/W1573420482","doi":null,"title":"Suramin inhibits growth of human osteosarcoma xenografts in nude mice.","display_name":"Suramin inhibits growth of human osteosarcoma xenografts in nude mice.","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W1573420482","mag":"1573420482","pmid":"https://pubmed.ncbi.nlm.nih.gov/2054794"},"language":"en","primary_location":{"id":"pmid:2054794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2054794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T M Walz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"T M Walz","raw_affiliation_strings":["Department of Cell Biology, Faculty of Health Sciences, University of Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Faculty of Health Sciences, University of Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054152279","display_name":"Avni Abdiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Abdiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023332828","display_name":"Sten Wingren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Wingren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111870332","display_name":"Staffan Smeds","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Smeds","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102165084","display_name":"Sven\u2010Erik Larsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S E Larsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022948168","display_name":"\u00c5ke Wasteson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Wasteson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6343,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.90617377,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"51","issue":"13","first_page":"3585","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/suramin","display_name":"suramin","score":1.0},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8669999837875366},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cytostatic-effect","display_name":"cytostatic activity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2776182878","wikidata":"https://www.wikidata.org/wiki/Q425946","display_name":"Suramin","level":3,"score":0.9916802048683167},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6271688342094421},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.6084954738616943},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5114056468009949},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4917290508747101},{"id":"https://openalex.org/C2777928079","wikidata":"https://www.wikidata.org/wiki/Q2677027","display_name":"Rat\u00f3n","level":2,"score":0.48923420906066895},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.45386552810668945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4517400562763214},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3903607726097107},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3809890151023865},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37833189964294434},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37519216537475586},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3745047450065613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32374686002731323},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2433590590953827},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18825840950012207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18121647834777832},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09300512075424194}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013498","descriptor_name":"Suramin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2054794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2054794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1573420482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2054794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065861582","https://openalex.org/W2014655876","https://openalex.org/W1977176706","https://openalex.org/W2009251966","https://openalex.org/W2411675560","https://openalex.org/W2377190980","https://openalex.org/W4242759377","https://openalex.org/W2059395653","https://openalex.org/W3149493384","https://openalex.org/W1991675923"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,57,60,66,80,88,110,120,138,158],"suramin":[3,76,105,154],"on":[4],"tumor":[5,67,104],"growth":[6,46,109,157],"and":[7,17,85,96,131,136],"morphology":[8],"in":[9,21,47,82,92,117],"two":[10],"different":[11],"human":[12,159],"osteosarcoma":[13,44],"xenografts":[14],"(L-I":[15],"OSM":[16,95,103],"L-II":[18,97,102],"OSM)":[19],"grown":[20],"BALB/cA-nu/nu":[22],"mice":[23],"was":[24],"studied.":[25],"Suramin":[26],"(total":[27],"dose,":[28],"720":[29],"mg/kg)":[30],"given":[31],"by":[32,70,144,161],"i.p.":[33],"injection":[34],"(60":[35],"mg/kg/dose)":[36],"for":[37],"up":[38],"to":[39,114,122],"9":[40],"weeks":[41],"significantly":[42],"inhibited":[43,107],"cell":[45,90],"both":[48,93],"tumors,":[49],"suramin-treated":[50],"tumors":[51],"showing":[52],"only":[53],"one-third":[54],"or":[55],"less":[56],"the":[58,83,89,100,108,118,132,139,151,156],"volume":[59],"nontreated":[61],"controls.":[62],"Cell":[63],"cycle":[64],"distribution":[65],"cells":[68,81],"measured":[69],"DNA":[71],"flow":[72],"cytometry":[73],"demonstrated":[74],"that":[75,153],"treated":[77,140],"caused":[78],"accumulation":[79],"S":[84],"G2":[86],"phases":[87],"cycle,":[91],"L-I":[94],"OSM.":[98],"In":[99],"aneuploid":[101,111,121],"preferentially":[106],"cells,":[112],"leading":[113],"a":[115],"decrease":[116],"ratio":[119],"diploid":[123],"cells.":[124],"Both":[125],"osteosarcomas":[126,160],"retained":[127],"their":[128],"histological":[129],"appearance":[130],"liver,":[133],"spleen,":[134],"heart,":[135],"kidneys":[137],"animals":[141],"were":[142],"unaffected":[143],"suramin.":[145],"These":[146],"results":[147],"are":[148],"compatible":[149],"with":[150],"view":[152],"inhibits":[155],"cytostatic":[162],"effects.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
