{"id":"https://openalex.org/W157338273","doi":null,"title":"Changes of androgen receptor and insulin-like growth factor-1 in LNCaP prostate cancer cells treated with sex hormones and flutamide.","display_name":"Changes of androgen receptor and insulin-like growth factor-1 in LNCaP prostate cancer cells treated with sex hormones and flutamide.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W157338273","mag":"157338273","pmid":"https://pubmed.ncbi.nlm.nih.gov/21338237"},"language":"en","primary_location":{"id":"pmid:21338237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21338237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079782720","display_name":"Da Yue Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Da Yue Tong","raw_affiliation_strings":["Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062422050","display_name":"Xing Wen","orcid":"https://orcid.org/0009-0004-9539-5945","observed_orcids":["https://orcid.org/0009-0004-9539-5945"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Qiao Wen","raw_affiliation_strings":["Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100754834","display_name":"Yi Jin","orcid":"https://orcid.org/0000-0001-8094-6899","observed_orcids":["https://orcid.org/0000-0001-8094-6899"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Jin","raw_affiliation_strings":["Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005487125","display_name":"Zhuo Wei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuo Wei Liu","raw_affiliation_strings":["Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002096365","display_name":"Hong Sun","orcid":"https://orcid.org/0000-0001-9015-0480","observed_orcids":["https://orcid.org/0000-0001-9015-0480"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Yu Sun","raw_affiliation_strings":["Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101781276","display_name":"Fang Zhou","orcid":"https://orcid.org/0000-0002-0291-1727","observed_orcids":["https://orcid.org/0000-0002-0291-1727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang Jian Zhou","raw_affiliation_strings":["Urology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031192469","display_name":"Xin Wu","orcid":"https://orcid.org/0000-0002-9081-3130","observed_orcids":["https://orcid.org/0000-0002-9081-3130"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Yao Wu","raw_affiliation_strings":["Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0975,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.47656007,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"6","first_page":"1805","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":1.0},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":1.0},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.9509999752044678},{"id":"https://openalex.org/keywords/estrone","display_name":"estrone","score":0.9929999709129333},{"id":"https://openalex.org/keywords/flutamide","display_name":"flutamide","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2778313021","wikidata":"https://www.wikidata.org/wiki/Q418669","display_name":"Flutamide","level":5,"score":0.9776260852813721},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.8558751344680786},{"id":"https://openalex.org/C2778656385","wikidata":"https://www.wikidata.org/wiki/Q414986","display_name":"Estrone","level":3,"score":0.8497828245162964},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.7507954835891724},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7276628017425537},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7145938277244568},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7014245390892029},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.5335692763328552},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.5328085422515869},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4897329807281494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4495089650154114},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.40334075689315796},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.39276596903800964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33453869819641113},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3308969736099243},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21868261694908142},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20521625876426697}],"mesh":[{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004970","descriptor_name":"Estrone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005485","descriptor_name":"Flutamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013196","descriptor_name":"Dihydrotestosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21338237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21338237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},{"id":"mag:157338273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21338237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1496924430","https://openalex.org/W1980955330","https://openalex.org/W2015711810","https://openalex.org/W2025865695","https://openalex.org/W2029320112","https://openalex.org/W2059972525","https://openalex.org/W2063333977","https://openalex.org/W2071347266","https://openalex.org/W2071675858","https://openalex.org/W2081576253","https://openalex.org/W2109694492","https://openalex.org/W2117503386","https://openalex.org/W2156854438","https://openalex.org/W2181344388","https://openalex.org/W2341691553","https://openalex.org/W2436386063","https://openalex.org/W3140002906"],"related_works":["https://openalex.org/W2081334960","https://openalex.org/W2062032920","https://openalex.org/W1976488936","https://openalex.org/W2034696434","https://openalex.org/W300066084","https://openalex.org/W1948931726","https://openalex.org/W2060284451","https://openalex.org/W1993940034","https://openalex.org/W2033507378","https://openalex.org/W1985229633"],"abstract_inverted_index":{"Changes":[0],"of":[1,34,43,49,57,85],"androgen":[2],"receptor":[3],"(AR)":[4],"and":[5,20,25,36,52,59,65,70,87,96],"insulin-like":[6],"growth":[7],"factor-1":[8],"(IGF-1)":[9],"were":[10,28],"investigated":[11],"in":[12,38,77,98],"LNCaP":[13,99],"cells":[14],"treated":[15],"with":[16,63],"5\u03b1-dihydrotestosterone":[17],"(DHT),":[18],"estrone":[19,51,95],"flutamide.":[21],"Real-time":[22],"PCR,":[23],"immunocytochemistry":[24],"western":[26],"blotting":[27],"used":[29],"to":[30,90],"detect":[31],"the":[32,39,55],"expression":[33,56,79,84],"AR":[35,58,78,86],"IGF-1":[37,88],"presence":[40],"or":[41],"absence":[42],"various":[44],"kinase":[45],"inhibitors.":[46],"Low":[47],"concentrations":[48],"DHT,":[50,94],"flutamide":[53,97],"increased":[54],"IGF-1,":[60],"especially":[61],"estrone,":[62],"concentration":[64],"time":[66],"dependence.":[67],"With":[68],"DHT":[69],"flutamide,":[71],"there":[72],"was":[73],"a":[74],"significant":[75],"alteration":[76],"(p<0.001).":[80],"The":[81],"results":[82],"indicated":[83],"genes":[89],"be":[91],"influenced":[92],"by":[93,102],"cells,":[100],"regulated":[101],"multiple":[103],"signal":[104],"pathways.":[105]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
