{"id":"https://openalex.org/W1572965104","doi":"https://doi.org/10.1158/1538-7445.am2014-616","title":"Abstract 616: Transcription-regulating kinases CDK8 and CDK19 as novel therapeutic targets for advanced prostate cancer","display_name":"Abstract 616: Transcription-regulating kinases CDK8 and CDK19 as novel therapeutic targets for advanced prostate cancer","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1572965104","doi":"https://doi.org/10.1158/1538-7445.am2014-616","mag":"1572965104"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-616","doi":"https://doi.org/10.1158/1538-7445.am2014-616","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-616","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028090148","display_name":"Mengqian Chen","orcid":"https://orcid.org/0000-0003-1706-9509","observed_orcids":["https://orcid.org/0000-0003-1706-9509"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengqian Chen","raw_affiliation_strings":["1University of South Carolina, Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of South Carolina, Columbia, SC;","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043295429","display_name":"Vimala Kaza","orcid":"https://orcid.org/0009-0006-3534-5481","observed_orcids":["https://orcid.org/0009-0006-3534-5481"]},"institutions":[{"id":"https://openalex.org/I4210157231","display_name":"Senex Biotechnology (United States)","ror":"https://ror.org/05w1q8228","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157231"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vimala Kaza","raw_affiliation_strings":["2Senex Biotechnology Inc., Columbia, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Senex Biotechnology Inc., Columbia, SC","institution_ids":["https://openalex.org/I4210157231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103191968","display_name":"Jiaxin Liang","orcid":"https://orcid.org/0000-0003-2129-3626","observed_orcids":["https://orcid.org/0000-0003-2129-3626"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaxin Liang","raw_affiliation_strings":["1University of South Carolina, Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of South Carolina, Columbia, SC;","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000509598","display_name":"Martina S.J. McDermott","orcid":"https://orcid.org/0000-0001-5737-7202","observed_orcids":["https://orcid.org/0000-0001-5737-7202"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martina McDermott","raw_affiliation_strings":["1University of South Carolina, Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of South Carolina, Columbia, SC;","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006208805","display_name":"Igor B. Roninson","orcid":"https://orcid.org/0000-0002-9211-1327","observed_orcids":["https://orcid.org/0000-0002-9211-1327"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor Roninson","raw_affiliation_strings":["1University of South Carolina, Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of South Carolina, Columbia, SC;","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"616","last_page":"616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk8","display_name":"CDK8","score":0.972000002861023},{"id":"https://openalex.org/keywords/cdk19","display_name":"CDK19","score":1.0},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8560000061988831},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/androgen-receptor-degradation","display_name":"androgen receptor degradation","score":0.5490000247955322},{"id":"https://openalex.org/keywords/enzalutamide-resistance","display_name":"enzalutamide resistance","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8510000109672546},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.75},{"id":"https://openalex.org/keywords/cxcl1","display_name":"CXCL1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":1.0},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9399999976158142},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7110000252723694},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7386123538017273},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6919136047363281},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6803408265113831},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6054348349571228},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.530962347984314},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.5227606296539307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.507834255695343},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.4568499028682709},{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.4404650330543518},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4173751473426819},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37938109040260315},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3577594757080078},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3264678716659546},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.321564644575119},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29946619272232056},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16956990957260132},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14698472619056702},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07972970604896545},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.052865445613861084}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-616","doi":"https://doi.org/10.1158/1538-7445.am2014-616","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-616","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389227743","https://openalex.org/W7036467570","https://openalex.org/W4282958474","https://openalex.org/W4393278360","https://openalex.org/W3159792978","https://openalex.org/W3093612331","https://openalex.org/W3083205911","https://openalex.org/W2508487267","https://openalex.org/W2992423378","https://openalex.org/W2991983039"],"abstract_inverted_index":{"Abstract":[0],"Most":[1],"of":[2,25,62,68,86,95,115,150,234,237,313,318],"castration-refractory":[3],"prostate":[4,97,251,308],"cancers":[5,43],"(CRPC)":[6],"continue":[7],"to":[8,208],"express":[9],"androgen":[10,34,151],"receptor":[11],"(AR)":[12],"that":[13,44,55,110,226,247,264],"maintains":[14],"its":[15],"activity":[16],"at":[17],"low":[18],"levels":[19],"or":[20,38],"even":[21],"in":[22,130,141,156,162,179,204,214,217],"the":[23,50,80,84,93,116,148,188,209,257,314,319],"absence":[24],"androgen,":[26],"driving":[27],"tumor":[28],"cell":[29,123,159,202,279],"proliferation.":[30],"Androgen-depleting":[31],"drugs":[32],"and":[33,91,136,145,161,200,216,244,254,281,300],"antagonists":[35],"have":[36,223],"little":[37],"no":[39],"effect":[40,67],"against":[41],"AR+":[42,142,157],"are":[45,119,138],"fully":[46],"androgen-independent":[47],"(AI).":[48],"On":[49],"other":[51,113,282],"hand,":[52],"experimental":[53],"compounds":[54],"cause":[56],"AR":[57,90,198],"degradation":[58],"prevent":[59],"AR-mediated":[60,176,189],"repression":[61,85],"tumor-promoting":[63,238],"genes,":[64],"a":[65,72,218,235],"tumor-suppressive":[66],"AR.":[69],"We":[70,222],"report":[71],"novel":[73,167,303],"druggable":[74],"target":[75,102,271],"for":[76,122,272,306,322],"CRPC,":[77],"which":[78,275],"mediates":[79],"induction":[81],"but":[82,126,184],"not":[83,120,186],"gene":[87,190],"expression":[88],"by":[89],"inhibits":[92,196],"growth":[94,203],"AI":[96,201],"cancer":[98,252],"(PCa)":[99],"cells.":[100],"This":[101],"is":[103,154,266],"two":[104],"closely":[105],"related":[106],"transcription-regulating":[107],"kinases":[108,298],"CDK8/CDK19":[109],"unlike":[111],"some":[112],"members":[114],"CDK":[117],"family":[118],"required":[121],"cycle":[124],"progression":[125],"play":[127],"critical":[128],"roles":[129],"several":[131],"transcriptional":[132,177,232],"signaling":[133],"pathways.":[134,284],"CDK8":[135,299],"CDK19":[137,153,301],"highly":[139],"expressed":[140],"PCa":[143,158,182],"cells":[144,183,206],"elevated":[146],"under":[147],"conditions":[149],"deprivation;":[152],"overexpressed":[155],"lines":[160],"metastatic":[163],"clinical":[164],"PCa.":[165],"A":[166],"selective":[168],"CDK8/19":[169,193,227,248,265],"kinase":[170],"inhibitor":[171,194],"(Senexin":[172],"B)":[173],"blocks":[174],"ligand-induced":[175],"activation":[178,199,233],"androgen-dependent":[180],"(AD)":[181],"does":[185],"affect":[187],"repression.":[191],"The":[192,260],"also":[195,224],"ligand-independent":[197],"AI-PCa":[205],"resistant":[207],"anti-androgenic":[210],"drug":[211],"enzalutamide,":[212],"both":[213,277],"vitro":[215],"mouse":[219],"xenograft":[220],"model.":[221],"discovered":[225],"inhibition":[228],"decreases":[229],"NF\u03baB":[230,258],"mediated":[231],"group":[236],"chemokines,":[239],"such":[240],"as":[241,302],"CXCL1,":[242],"CXCL2":[243],"IL8,":[245],"suggesting":[246],"may":[249],"promote":[250],"chemoresistance":[253],"metastasis":[255],"through":[256],"pathway.":[259],"above":[261],"results":[262],"suggest":[263],"an":[267],"especially":[268],"attractive":[269],"therapeutic":[270,304],"advanced":[273,307],"PCa,":[274],"controls":[276],"AR-driven":[278],"proliferation":[280],"oncogenic":[283],"Citation":[285],"Format:":[286],"Mengqian":[287],"Chen,":[288],"Vimala":[289],"Kaza,":[290],"Jiaxin":[291],"Liang,":[292],"Martina":[293],"McDermott,":[294],"Igor":[295],"Roninson.":[296],"Transcription-regulating":[297],"targets":[305],"cancer.":[309],"[abstract].":[310],"In:":[311],"Proceedings":[312],"105th":[315],"Annual":[316],"Meeting":[317],"American":[320],"Association":[321],"Cancer":[323,334],"Research;":[324],"2014":[325],"Apr":[326],"5-9;":[327],"San":[328],"Diego,":[329],"CA.":[330],"Philadelphia":[331],"(PA):":[332],"AACR;":[333],"Res":[335],"2014;74(19":[336],"Suppl):Abstract":[337],"nr":[338],"616.":[339],"doi:10.1158/1538-7445.AM2014-616":[340]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
