{"id":"https://openalex.org/W157240402","doi":"https://doi.org/10.1177/030089160609200108","title":"Long-Term Results of Conventional Radiotherapy versus Accelerated Hyperfractionated Radiotherapy versus Concomitant Radiotherapy and Chemotherapy in Locoregionally Advanced Carcinoma of the Oropharynx","display_name":"Long-Term Results of Conventional Radiotherapy versus Accelerated Hyperfractionated Radiotherapy versus Concomitant Radiotherapy and Chemotherapy in Locoregionally Advanced Carcinoma of the Oropharynx","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W157240402","doi":"https://doi.org/10.1177/030089160609200108","mag":"157240402","pmid":"https://pubmed.ncbi.nlm.nih.gov/16683383"},"language":"en","primary_location":{"id":"doi:10.1177/030089160609200108","doi":"https://doi.org/10.1177/030089160609200108","is_oa":false,"landing_page_url":"https://doi.org/10.1177/030089160609200108","pdf_url":null,"source":{"id":"https://openalex.org/S4210189328","display_name":"Tumori Journal","issn_l":"0300-8916","issn":["0300-8916","2038-2529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075219078","display_name":"Carlo Fallai","orcid":"https://orcid.org/0000-0001-8070-0282","observed_orcids":["https://orcid.org/0000-0001-8070-0282"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Fallai","raw_affiliation_strings":["Radioterapia 2, Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radioterapia 2, Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064312115","display_name":"Andrea Bolner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Bolner","raw_affiliation_strings":["Radioterapia Oncologica, AO S Chiara, Trento, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radioterapia Oncologica, AO S Chiara, Trento, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110869291","display_name":"Marco Andrea Signor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126152","display_name":"Ospedale Santa Maria della Misericordia di Udine","ror":"https://ror.org/02zpc2253","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126152"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Signor","raw_affiliation_strings":["Radioterapia Oncologica, AO S Maria della Misericordia, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radioterapia Oncologica, AO S Maria della Misericordia, Udine, Italy","institution_ids":["https://openalex.org/I4210126152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039028664","display_name":"Alessandro Gava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146018","display_name":"Ca' Foncello Hospital","ror":"https://ror.org/04cb4je22","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146018"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Gava","raw_affiliation_strings":["Istituto di Radioterapia, Ospedale C\u00e0 Foncello, ASL 9, Treviso, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Radioterapia, Ospedale C\u00e0 Foncello, ASL 9, Treviso, Italy","institution_ids":["https://openalex.org/I4210146018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071354389","display_name":"Giovanni Franchin","orcid":"https://orcid.org/0000-0003-1988-2739","observed_orcids":["https://orcid.org/0000-0003-1988-2739"]},"institutions":[{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Franchin","raw_affiliation_strings":["Oncologia Radioterapica, INT-CRO, Aviano (PN), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncologia Radioterapica, INT-CRO, Aviano (PN), Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105885758","display_name":"Pietro Ponticelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142789","display_name":"Ospedale San Donato","ror":"https://ror.org/043ppnw54","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210142789"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Ponticelli","raw_affiliation_strings":["Radioterapia, USL 8, Ospedale S Donato, Arezzo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radioterapia, USL 8, Ospedale S Donato, Arezzo, Italy","institution_ids":["https://openalex.org/I4210142789"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021308927","display_name":"Raffaella Taino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raffaella Taino","raw_affiliation_strings":["Oncologia Medica, Ospedali Riuniti, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncologia Medica, Ospedali Riuniti, Bergamo, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056479414","display_name":"Francesca Rossi","orcid":"https://orcid.org/0000-0002-1254-7850","observed_orcids":["https://orcid.org/0000-0002-1254-7850"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Rossi","raw_affiliation_strings":["Radioterapia, AO Careggi, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radioterapia, AO Careggi, Firenze, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109872016","display_name":"Alessandro Ardizzoia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Ardizzoia","raw_affiliation_strings":["Radioterapia Oncologica, AO S Gerardo, Monza (MI), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radioterapia Oncologica, AO S Gerardo, Monza (MI), Italy","institution_ids":["https://openalex.org/I4210110840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020826396","display_name":"Maria Oggionni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Oggionni","raw_affiliation_strings":["Anatomia Patologica C, Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomia Patologica C, Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019583292","display_name":"Sergio Crispino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergio Crispino","raw_affiliation_strings":["Oncologia Medica, USL 7, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncologia Medica, USL 7, Siena, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057308721","display_name":"Patrizia Olmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Patrizia Olmi","raw_affiliation_strings":["Radioterapia 1, Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radioterapia 1, Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":3.3701,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.91234375,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"92","issue":"1","first_page":"41","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hyperfractionated-accelerated-radiotherapy","display_name":"accelerated hyperfractionated radiotherapy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/split-course-radiotherapy","display_name":"split-course radiotherapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/concurrent-chemoradiotherapy","display_name":"concurrent chemoradiotherapy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.925000011920929},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9959999918937683},{"id":"https://openalex.org/keywords/locoregional-control","display_name":"locoregional control","score":0.7590000033378601},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.703000009059906},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.8240000009536743},{"id":"https://openalex.org/keywords/late-toxicity","display_name":"late toxicity","score":0.531000018119812},{"id":"https://openalex.org/keywords/radiation-esophagitis","display_name":"radiation esophagitis","score":0.47200000286102295},{"id":"https://openalex.org/keywords/radiation-induced-dysphagia","display_name":"radiation-induced dysphagia","score":0.5820000171661377},{"id":"https://openalex.org/keywords/oropharyngeal-squamous-cell-carcinoma","display_name":"oropharyngeal squamous cell carcinoma","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8663280010223389},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.790676474571228},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.6790727376937866},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6748809218406677},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5813232660293579},{"id":"https://openalex.org/C155806632","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Dose fractionation","level":3,"score":0.5249069929122925},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.508185863494873},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.46448832750320435},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4565770626068115},{"id":"https://openalex.org/C2908786992","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Hyperfractionation","level":4,"score":0.42732298374176025},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4138604402542114},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4070693850517273},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3686216473579407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29378777742385864},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.1615341305732727}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/030089160609200108","doi":"https://doi.org/10.1177/030089160609200108","is_oa":false,"landing_page_url":"https://doi.org/10.1177/030089160609200108","pdf_url":null,"source":{"id":"https://openalex.org/S4210189328","display_name":"Tumori Journal","issn_l":"0300-8916","issn":["0300-8916","2038-2529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori Journal","raw_type":"journal-article"},{"id":"pmid:16683383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16683383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1578776449","https://openalex.org/W1759636304","https://openalex.org/W1904941427","https://openalex.org/W1912423223","https://openalex.org/W1963831893","https://openalex.org/W1967953274","https://openalex.org/W1970114719","https://openalex.org/W1970561448","https://openalex.org/W1972794145","https://openalex.org/W1974452235","https://openalex.org/W1985058018","https://openalex.org/W1986884101","https://openalex.org/W1986997901","https://openalex.org/W1990116660","https://openalex.org/W1992956169","https://openalex.org/W2006723414","https://openalex.org/W2010481352","https://openalex.org/W2010715392","https://openalex.org/W2014586942","https://openalex.org/W2015593642","https://openalex.org/W2016393433","https://openalex.org/W2017236734","https://openalex.org/W2018994731","https://openalex.org/W2021345476","https://openalex.org/W2022025987","https://openalex.org/W2023746142","https://openalex.org/W2027434100","https://openalex.org/W2029359014","https://openalex.org/W2029537185","https://openalex.org/W2033572589","https://openalex.org/W2036005555","https://openalex.org/W2037383172","https://openalex.org/W2039287264","https://openalex.org/W2040630035","https://openalex.org/W2046315328","https://openalex.org/W2046339703","https://openalex.org/W2057325997","https://openalex.org/W2057616012","https://openalex.org/W2059568450","https://openalex.org/W2063297264","https://openalex.org/W2066115699","https://openalex.org/W2069653944","https://openalex.org/W2071958377","https://openalex.org/W2072793624","https://openalex.org/W2075761683","https://openalex.org/W2080922660","https://openalex.org/W2084575565","https://openalex.org/W2091573051","https://openalex.org/W2093747887","https://openalex.org/W2095423625","https://openalex.org/W2096294606","https://openalex.org/W2101841725","https://openalex.org/W2104360803","https://openalex.org/W2114071348","https://openalex.org/W2120046399","https://openalex.org/W2120068217","https://openalex.org/W2123560400","https://openalex.org/W2127445711","https://openalex.org/W2132702599","https://openalex.org/W2133555954","https://openalex.org/W2139230093","https://openalex.org/W2139554459","https://openalex.org/W2142101692","https://openalex.org/W2142817261","https://openalex.org/W2145078756","https://openalex.org/W2149447281","https://openalex.org/W2151415400","https://openalex.org/W2152609192","https://openalex.org/W2160634338","https://openalex.org/W2162171882","https://openalex.org/W2169908969","https://openalex.org/W2171770771","https://openalex.org/W2172200669","https://openalex.org/W2237853490","https://openalex.org/W2278556698","https://openalex.org/W2322298424","https://openalex.org/W2407359433","https://openalex.org/W2409076712","https://openalex.org/W2616889400","https://openalex.org/W2942944405","https://openalex.org/W4388165701"],"related_works":["https://openalex.org/W2037383172","https://openalex.org/W2001368991","https://openalex.org/W2033572589","https://openalex.org/W4404438769","https://openalex.org/W2389378236","https://openalex.org/W2777426171","https://openalex.org/W2049827774","https://openalex.org/W2127903844","https://openalex.org/W2805581593","https://openalex.org/W4390399112"],"abstract_inverted_index":{"AIMS":[0],"AND":[1,45],"BACKGROUND:":[2],"To":[3],"compare":[4],"conventional":[5],"fractionation":[6],"(CF)":[7],"radiation":[8],"therapy":[9],"(RT),":[10],"arm":[11,20,28,109,140,190,194,199,216,220,225,251,255,260,268,281,284,313],"A,":[12,191,217],"versus":[13,22,319],"a":[14,72,98,103,129,132,229,303,461],"split-course":[15],"accelerated":[16],"hyperfractionated":[17],"schedule":[18],"(S-AHF),":[19],"B,":[21,110,195,221],"CFRT":[23],"plus":[24],"concomitant":[25],"chemotherapy":[26],"(CT),":[27],"C,":[29,84,252],"in":[30,71,89,119,181,208,250,254,259,292,312,324,400,475],"terms":[31,209],"of":[32,41,122,146,149,210,316,321,394,412,446,463,469,485],"five-year":[33,182,211,234,431],"survival":[34,184,329,435],"and":[35,51,61,67,83,102,151,161,196,222,257,275,339,345,375,384,414,436,465,478],"toxicity":[36],"for":[37,100,189,193,198,215,219,224,240,453],"squamous":[38,443],"cell":[39,444],"tumors":[40,335,471],"the":[42,111,142,241,293,385,401,410,430,447,454,483],"oropharynx.":[43],"METHODS":[44],"STUDY":[46],"DESIGN:":[47],"Between":[48],"January":[49],"1993":[50],"June":[52],"1998,":[53],"192":[54],"previously":[55],"untreated":[56],"patients":[57,244,477],"with":[58,131,272,302,343,409,417,441,460],"stage":[59],"III":[60,76],"IV":[62],"oropharyngeal":[63],"carcinoma":[64],"(excluding":[65],"T1N1":[66],"T2N1)":[68],"were":[69,248,289,336,340,381,389],"enrolled":[70],"multicenter":[73],"randomized":[74],"phase":[75],"trial":[77],"(ORO":[78],"93-01).":[79],"In":[80,108,139],"arms":[81,273,295,325],"A":[82,256,274],"66":[85],"to":[86,91,105,116,159,169,482],"70":[87],"Gy":[88,118,124],"33":[90],"35":[92],"fractions":[93,121],"was":[94,114,179,203,228,264,270,330,398],"administered":[95],"five":[96,127],"days":[97,128,157,167],"week":[99],"six":[101],"half":[104],"seven":[106],"weeks.":[107],"dose":[112],"delivered":[113],"64":[115],"67.2":[117],"two":[120,350,352],"1.6":[123],"every":[125,171],"day,":[126],"week,":[130],"planned":[133],"two-week":[134],"split":[135],"at":[136],"38.4":[137],"Gy.":[138],"C":[141,269,285,314,364],"CT":[143,413],"regimen":[144],"consisted":[145],"three":[147,294,402],"cycles":[148],"carboplatin":[150],"5-fluorouracil":[152],"(CBDCA":[153],"75":[154],"mg/m2":[155,164],"on":[156,166],"1":[158,168],"4":[160,170],"5-FU":[162],"1000":[163],"i.v.":[165],"28":[172],"days).":[173],"RESULTS:":[174],"No":[175],"statistically":[176,205],"significant":[177,206,378],"difference":[178,207],"found":[180],"overall":[183,432],"(P":[185,237,278],"=":[186,238,279],"0.39):":[187],"21%":[188,192,253],"40%":[197],"C.":[200,226],"Similarly,":[201],"there":[202],"no":[204],"relapse-free":[212,434],"survival:":[213],"15%":[214],"17%":[218],"36%":[223],"There":[227],"slight":[230],"trend":[231],"towards":[232,305],"better":[233,266],"locoregional":[235,246,437],"control":[236,263,438],"0.07)":[239],"combined":[242,277,426,455],"arm:":[243],"without":[245],"relapse":[247],"48%":[249],"18%":[258],"B.":[261],"Locoregional":[262],"significantly":[265],"when":[267],"compared":[271,416],"B":[276],"0.02;":[280],"A+B":[282],"20%;":[283],"48%).":[286],"Distant":[287],"metastases":[288],"fairly":[290],"balanced":[291],"(A:":[296],"14;":[297],"B:":[298],"9;":[299],"C:":[300],"11),":[301],"tendency":[304],"more":[306,367],"frequent":[307],"isolated":[308],"distant":[309],"metastasis":[310],"development":[311],"(8":[315],"11":[317],"[72%]":[318],"7":[320],"23":[322],"[30%]":[323],"A+B).":[326],"Five-year":[327],"second-tumor-free":[328],"85%.":[331],"The":[332,392,406,467],"13":[333],"second":[334,470],"equally":[337],"distributed":[338],"mainly":[341],"correlated":[342],"tobacco":[344],"alcohol":[346],"consumption":[347],"(five":[348],"lung,":[349],"esophagus,":[351],"oral":[353],"cavity,":[354],"one":[355,357,359,361],"larynx,":[356],"pancreas,":[358],"hepatocarcinoma,":[360],"myeloma).":[362],"Arm":[363],"showed":[365],"slightly":[366],"G3+":[368],"late":[369,379],"side":[370,387],"effects":[371,388],"involving":[372],"subcutaneous":[373],"tissues":[374],"mucosa,":[376],"although":[377],"sequelae":[380],"relatively":[382,473],"uncommon":[383],"mucosal":[386],"mostly":[390],"transient.":[391],"occurrence":[393,468],"persistent":[395],"G3":[396],"xerostomia":[397],"comparable":[399],"treatment":[403,427],"arms.":[404],"CONCLUSIONS:":[405],"results":[407],"obtained":[408],"combination":[411,462],"RT":[415,418],"alone":[419],"did":[420],"not":[421],"reach":[422],"statistical":[423],"significance,":[424],"but":[425],"almost":[428],"doubled":[429],"survival,":[433],"rate.":[439],"Patients":[440],"advanced":[442],"carcinomas":[445],"oropharynx":[448],"who":[449],"are":[450],"medically":[451],"suitable":[452],"approach":[456],"should":[457],"be":[458],"treated":[459],"radiotherapy":[464],"chemotherapy.":[466],"is":[472],"common":[474],"these":[476],"may":[479],"contribute":[480],"substantially":[481],"causes":[484],"death.":[486]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}