{"id":"https://openalex.org/W1572369047","doi":null,"title":"ENHANCING DIAGNOSIS AND MANAGEMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS","display_name":"ENHANCING DIAGNOSIS AND MANAGEMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS","publication_year":2005,"publication_date":"2005-06-21","ids":{"openalex":"https://openalex.org/W1572369047","mag":"1572369047"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:6941","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6941/1/Danchenko_ETD_6_20_05.pdf","pdf_url":"http://d-scholarship.pitt.edu/6941/1/Danchenko_ETD_6_20_05.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/6941/1/Danchenko_ETD_6_20_05.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073972659","display_name":"Natalya Danchenko","orcid":"https://orcid.org/0009-0004-7247-1749","observed_orcids":["https://orcid.org/0009-0004-7247-1749","https://orcid.org/0000-0002-9106-7168"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Natalya Danchenko","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9106-7168","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073972659"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/lupus-diagnosis","display_name":"lupus diagnosis","score":0.6819999814033508},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7649999856948853},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.5929999947547913},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/coronary-artery-calcification","display_name":"coronary artery calcification","score":0.9810000061988831},{"id":"https://openalex.org/keywords/electron-beam-computed-tomography","display_name":"electron beam computed tomography","score":0.9879999756813049},{"id":"https://openalex.org/keywords/subclinical-vascular-disease","display_name":"subclinical vascular disease","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/lupus-complications","display_name":"lupus complications","score":0.6629999876022339},{"id":"https://openalex.org/keywords/african-american-women","display_name":"African American women","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7354748845100403},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7138165235519409},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6385313272476196},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.6323245167732239},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5186561942100525},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5085016489028931},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47499433159828186},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.44015058875083923},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.4159523844718933},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2294081151485443},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.14288455247879028},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:6941","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6941/1/Danchenko_ETD_6_20_05.pdf","pdf_url":"http://d-scholarship.pitt.edu/6941/1/Danchenko_ETD_6_20_05.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:1572369047","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/6941/1/Danchenko_ETD_6_20_05.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:6941","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6941/1/Danchenko_ETD_6_20_05.pdf","pdf_url":"http://d-scholarship.pitt.edu/6941/1/Danchenko_ETD_6_20_05.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332614","display_name":"Graduate School of Public Health, University of Pittsburgh","ror":"https://ror.org/01an3r305"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1572369047.pdf","grobid_xml":"https://content.openalex.org/works/W1572369047.grobid-xml"},"referenced_works_count":135,"referenced_works":["https://openalex.org/W45034057","https://openalex.org/W53018902","https://openalex.org/W55907310","https://openalex.org/W74824854","https://openalex.org/W75304703","https://openalex.org/W79253861","https://openalex.org/W82219056","https://openalex.org/W89057584","https://openalex.org/W1549151058","https://openalex.org/W1556757089","https://openalex.org/W1574593386","https://openalex.org/W1595289904","https://openalex.org/W1601263240","https://openalex.org/W1631919176","https://openalex.org/W1735315566","https://openalex.org/W1883538973","https://openalex.org/W1951045729","https://openalex.org/W1961991439","https://openalex.org/W1964568991","https://openalex.org/W1965683411","https://openalex.org/W1966296687","https://openalex.org/W1966735470","https://openalex.org/W1967833287","https://openalex.org/W1971084911","https://openalex.org/W1973948212","https://openalex.org/W1975307585","https://openalex.org/W1975555429","https://openalex.org/W1976619400","https://openalex.org/W1977680779","https://openalex.org/W1979287172","https://openalex.org/W1983227166","https://openalex.org/W1984237981","https://openalex.org/W1988468288","https://openalex.org/W1989192098","https://openalex.org/W1990898471","https://openalex.org/W1992404822","https://openalex.org/W1992739497","https://openalex.org/W1992999318","https://openalex.org/W1994092711","https://openalex.org/W2003048916","https://openalex.org/W2005012147","https://openalex.org/W2010547290","https://openalex.org/W2010633868","https://openalex.org/W2010760898","https://openalex.org/W2014914292","https://openalex.org/W2015878901","https://openalex.org/W2018655550","https://openalex.org/W2018800958","https://openalex.org/W2019273574","https://openalex.org/W2019527243","https://openalex.org/W2020854381","https://openalex.org/W2022946667","https://openalex.org/W2025603515","https://openalex.org/W2025998055","https://openalex.org/W2026216489","https://openalex.org/W2031185382","https://openalex.org/W2033496751","https://openalex.org/W2033590430","https://openalex.org/W2034201329","https://openalex.org/W2043526860","https://openalex.org/W2049844869","https://openalex.org/W2051928477","https://openalex.org/W2053933758","https://openalex.org/W2055759873","https://openalex.org/W2055760834","https://openalex.org/W2056096799","https://openalex.org/W2058331351","https://openalex.org/W2061768809","https://openalex.org/W2062320562","https://openalex.org/W2062802453","https://openalex.org/W2063131612","https://openalex.org/W2065122382","https://openalex.org/W2070436152","https://openalex.org/W2071538148","https://openalex.org/W2077272969","https://openalex.org/W2079509852","https://openalex.org/W2080975717","https://openalex.org/W2083318136","https://openalex.org/W2084252078","https://openalex.org/W2086404282","https://openalex.org/W2091321433","https://openalex.org/W2093300360","https://openalex.org/W2094930358","https://openalex.org/W2101150501","https://openalex.org/W2107673722","https://openalex.org/W2108905161","https://openalex.org/W2109789501","https://openalex.org/W2109976077","https://openalex.org/W2110314624","https://openalex.org/W2112324202","https://openalex.org/W2115146133","https://openalex.org/W2115253847","https://openalex.org/W2115818659","https://openalex.org/W2120491756","https://openalex.org/W2123412929","https://openalex.org/W2127396740","https://openalex.org/W2131690387","https://openalex.org/W2133031701","https://openalex.org/W2137107745","https://openalex.org/W2141870462","https://openalex.org/W2145572391","https://openalex.org/W2146203649","https://openalex.org/W2147698308","https://openalex.org/W2152660413","https://openalex.org/W2153276389","https://openalex.org/W2155897042","https://openalex.org/W2160859135","https://openalex.org/W2161979293","https://openalex.org/W2162975334","https://openalex.org/W2164868282","https://openalex.org/W2165779517","https://openalex.org/W2171118517","https://openalex.org/W2172053715","https://openalex.org/W2172062956","https://openalex.org/W2223996029","https://openalex.org/W2315112971","https://openalex.org/W2336809898","https://openalex.org/W2338986336","https://openalex.org/W2395525054","https://openalex.org/W2396393446","https://openalex.org/W2397113680","https://openalex.org/W2412982206","https://openalex.org/W2415320383","https://openalex.org/W2417501795","https://openalex.org/W2418181439","https://openalex.org/W2427377726","https://openalex.org/W2428690231","https://openalex.org/W2462545539","https://openalex.org/W2466249893","https://openalex.org/W2469432171","https://openalex.org/W2470805237","https://openalex.org/W2471897134","https://openalex.org/W2614904269","https://openalex.org/W2615584519","https://openalex.org/W2993051386"],"related_works":["https://openalex.org/W4224260357","https://openalex.org/W4320917748","https://openalex.org/W3032527340","https://openalex.org/W129681920","https://openalex.org/W2090721623","https://openalex.org/W2081621058","https://openalex.org/W2117307085","https://openalex.org/W7211997020","https://openalex.org/W2118089272","https://openalex.org/W4403135720"],"abstract_inverted_index":{"Systemic":[0],"lupus":[1,105],"erythematosus":[2],"(SLE)":[3],"affects":[4],"a":[5,128,161,190,245,261],"significant":[6],"portion":[7],"of":[8,11,18,60,82,90,109,119,124,131,134,141,147,156,164,187,193,204,234,248,264,287],"young":[9],"women":[10,276],"childbearing":[12],"age":[13],"worldwide,":[14],"in":[15,137,149,210,275,297],"particular":[16],"those":[17],"non-white":[19],"descent.":[20],"In":[21],"the":[22,25,57,83,132,142,185,200,205,218,224,232,288],"United":[23],"States,":[24],"incidence":[26],"ranges":[27],"8.1-11.4":[28],"per":[29,35,45,51],"100,000":[30,36,46,52],"among":[31,37,47,53,104],"African-American,":[32,48],"and":[33,49,70,79,86,102,144,154,170,250,301,310],"2.5-3.9":[34],"Caucasian":[38,54],"women.":[39,55],"The":[40,113,174,213,267],"prevalence":[41],"is":[42,89,116,199,240,283,294,302],"estimated":[43],"56-283":[44],"17-71":[50],"Understanding":[56],"natural":[58],"history":[59],"systemic":[61],"lupus,":[62],"its":[63,87],"major":[64,75,246,262],"complications":[65],"such":[66],"as":[67,189,244,260],"cardiovascular":[68],"disease":[69,84,152,195,274],"associated":[71,270],"risk":[72,268,312],"factors,":[73],"identifying":[74],"biomarkers":[76,121],"for":[77,122,231,314],"timely":[78],"accurate":[80],"diagnosis":[81,123],"itself":[85],"manifestations":[88],"great":[91],"public":[92],"health":[93],"importance,":[94],"since":[95],"this":[96,180],"will":[97],"help":[98],"to":[99,168,242,251,304],"reduce":[100],"morbidity":[101],"mortality":[103],"patients.The":[106],"dissertation":[107],"consists":[108],"three":[110,239],"relevant":[111],"chapters.":[112],"first":[114],"chapter":[115,175,198,211],"an":[117],"overview":[118],"candidate":[120],"SLE.":[125,173,237],"It":[126,282],"includes":[127],"brief":[129],"review":[130],"role":[133],"complement":[135,148,166,188],"molecules":[136],"SLE":[138,151,194,249,278,300],"pathogenesis,":[139],"evaluation":[140],"past":[143],"current":[145],"uses":[146],"monitoring":[150],"activity,":[153],"summary":[155],"recent":[157],"findings":[158],"that":[159,216,285],"propose":[160],"novel":[162,206,219],"method":[163,181],"measuring":[165],"activation":[167],"specifically":[169],"sensitively":[171],"diagnose":[172],"concludes":[176],"by":[177,255,292],"discussing":[178],"how":[179],"may":[182],"also":[183,280],"support":[184],"resurgence":[186],"valuable":[191],"biomarker":[192,208,221,263],"activity.The":[196],"second":[197],"cost":[201,229],"effectiveness":[202],"analysis":[203,214],"diagnostic":[207,220],"discussed":[209],"one.":[212],"shows":[215],"using":[217],"along":[222],"with":[223,271,277,299],"traditional":[225],"tests":[226],"can":[227],"be":[228],"effective":[230],"population":[233],"patients":[235,298],"contemplating":[236],"Chapter":[238],"devoted":[241],"atherosclerosis":[243,286],"complication":[247],"coronary":[252,289],"calcification":[253],"measured":[254],"electron":[256],"beam":[257],"tomography":[258],"(EBT)":[259],"subclinical":[265,272],"atherosclerosis.":[266],"factors":[269,313],"vascular":[273,315],"are":[279],"reported.":[281],"concluded":[284],"arteries":[290],"detected":[291],"EBT":[293],"highly":[295],"prevalent":[296],"related":[303],"many":[305],"potentially":[306],"modifiable":[307],"traditional,":[308],"SLE-specific":[309],"inflammatory":[311],"disease.":[316]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}