{"id":"https://openalex.org/W15723285","doi":"https://doi.org/10.1161/circ.120.suppl_18.s1154-a","title":"Abstract 5813: Hyperhomocysteinemia Enhances Bone Marrow-derived and Vessel Resident Ly6C Inflammatory Monocyte Differentiation Contributing to Atherogenesis","display_name":"Abstract 5813: Hyperhomocysteinemia Enhances Bone Marrow-derived and Vessel Resident Ly6C Inflammatory Monocyte Differentiation Contributing to Atherogenesis","publication_year":2009,"publication_date":"2009-11-03","ids":{"openalex":"https://openalex.org/W15723285","doi":"https://doi.org/10.1161/circ.120.suppl_18.s1154-a","mag":"15723285"},"language":"en","primary_location":{"id":"doi:10.1161/circ.120.suppl_18.s1154-a","doi":"https://doi.org/10.1161/circ.120.suppl_18.s1154-a","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.120.suppl_18.s1154-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Daqing Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daqing Zhang","raw_affiliation_strings":["Temple Univ, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014977626","display_name":"Xiaohua Jiang","orcid":"https://orcid.org/0000-0003-3325-6531","observed_orcids":["https://orcid.org/0000-0003-3325-6531"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohua Jiang","raw_affiliation_strings":["Temple Univ, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jodene K Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jodene K Moore","raw_affiliation_strings":["Temple Univ, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074296319","display_name":"Remus M. Berretta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Remus M Berretta","raw_affiliation_strings":["Temple Univ, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew I Schafer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew I Schafer","raw_affiliation_strings":["Weill Cornell Med College, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Med College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067892109","display_name":"Steven R. Houser","orcid":"https://orcid.org/0000-0001-6359-5425","observed_orcids":["https://orcid.org/0000-0001-6359-5425"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R Houser","raw_affiliation_strings":["Temple Univ, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070064210","display_name":"William Durante","orcid":"https://orcid.org/0000-0001-6715-4352","observed_orcids":["https://orcid.org/0000-0001-6715-4352"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Durante","raw_affiliation_strings":["Univ of Missouri, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Missouri, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaofeng Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Yang","raw_affiliation_strings":["Temple Univ, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["Temple Univ, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":"suppl_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.7699999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.7699999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.219200000166893,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":1.0},{"id":"https://openalex.org/keywords/ly6c-monocytes","display_name":"Ly6C+ monocytes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/bone-marrow-derived-monocytes","display_name":"bone marrow-derived monocytes","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cystathionine-beta-synthase-deficiency","display_name":"cystathionine beta-synthase deficiency","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ldl-receptor-deficiency","display_name":"LDL receptor deficiency","score":0.8930000066757202},{"id":"https://openalex.org/keywords/high-methionine-diet","display_name":"high methionine diet","score":0.7900000214576721},{"id":"https://openalex.org/keywords/vitamin-b6","display_name":"vitamin B6","score":0.4740000069141388},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.6729999780654907},{"id":"https://openalex.org/keywords/monocyte-subsets","display_name":"monocyte subsets","score":0.5070000290870667},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6480000019073486},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6420000195503235},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9555186033248901},{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.8084955215454102},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6935327649116516},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6357704997062683},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49578985571861267},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3824608027935028},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3647976517677307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2925901710987091},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.24922823905944824}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.120.suppl_18.s1154-a","doi":"https://doi.org/10.1161/circ.120.suppl_18.s1154-a","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.120.suppl_18.s1154-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2127424973","https://openalex.org/W2060997281","https://openalex.org/W3175073847","https://openalex.org/W2126604626","https://openalex.org/W7099080908","https://openalex.org/W2156660851","https://openalex.org/W181663946","https://openalex.org/W2077999009","https://openalex.org/W2135085238","https://openalex.org/W2158380859"],"abstract_inverted_index":{"Background:":[0],"We":[1,35],"recently":[2],"reported":[3],"that":[4,110,132],"hyperhomocysteinemia":[5],"(HHcy)":[6],"enriched":[7],"circulating":[8],"Ly6C":[9,25,118,178,222,281,304,337,352],"monocytes":[10],"(MCs)":[11],"independent":[12],"of":[13,22,319],"hyperlipidemia.":[14],"Here":[15],"we":[16],"studied":[17],"the":[18,122,156,172,301],"effect":[19],"and":[20,28,33,45,94,115,137,148,152,176,189,203,217,221,233,252,266,291,314,331,334],"mechanism":[21],"HHcy":[23,86,112,134,327],"on":[24,126],"MC":[26,119,140,160,180,194,224,268,283,306,339,354],"function":[27],"differentiation":[29,340,355],"in":[30,121,155,237,309,351],"aorta.":[31,238],"Methods":[32],"Results:":[34],"generated":[36],"a":[37,68],"mouse":[38],"model":[39],"with":[40,171,245],"cystathionine":[41],"\u03b2":[42],"-synthase":[43],"(CBS)":[44],"LDLr":[46,48],"deficiencies.":[47],"\u2212":[49,51,53,144,184,212,228],"/":[50],"CBS":[52],"/+":[54],"mice":[55,65],"(8wk)":[56],"received":[57],"BM":[58],"transplantation":[59],"from":[60,150],"EGFP":[61],"mice.":[62],"The":[63,158],"chimeric":[64],"were":[66,242],"fed":[67],"high":[69],"fat":[70],"(HF)":[71],"diet":[72,82,97],"as":[73,98],"control":[74],"(Hcy,":[75],"10.1":[76],"\u03bc":[77,88,102,275,298],"M),":[78,89],"HF/high":[79],"methionine":[80],"(HM)":[81],"to":[83,146,342],"induce":[84],"severe":[85,111,133,168],"(275.6":[87],"or":[90],"HF/HM/high":[91],"vitamin":[92],"B-6/12":[93],"folic":[95],"acid":[96],"Hcy-lowering":[99,256],"therapy":[100,257],"(39.0":[101],"M)":[103,276,299],"for":[104],"another":[105],"8wk.":[106],"Morphological":[107],"analysis":[108,125],"exhibited":[109],"accelerated":[113],"atherosclerosis":[114],"increased":[116,135,174,300],"BM-derived":[117,136,175,333],"accumulation":[120],"lesion.":[123],"FACS":[124],"whole":[127],"aortic":[128,267],"cell":[129],"suspension":[130],"showed":[131],"resident":[138,177,336],"putative":[139,159],"(CD11b":[141],"+":[142,198],"Ly6G":[143],")":[145],"4872":[147],"3761":[149],"1332":[151],"599":[153],"cells/aorta":[154],"control.":[157],"was":[161,286],"further":[162],"divided":[163],"into":[164],"4":[165],"distinct":[166],"subsets,":[167],"HHcy,":[169],"compared":[170],"control,":[173],"hi":[179,182,196],"(Ly6C":[181,195,209,225],"F4/80":[183,197,211,227],",":[185,199,213,229],"816":[186],"vs":[187,191,201,205,215,219,231,235],"43":[188,202],"842":[190],"115),":[192],"differentiating":[193],"558":[200],"784":[204],"28),":[206],"differentiated":[207],"macrophage":[208],"low":[210,223,226],"1874":[214],"766":[216],"1095":[218],"92),":[220],"1624":[230],"480":[232],"1040":[234],"365)":[236],"Plasma":[239],"Hcy":[240],"levels":[241,265],"significantly":[243,258,315],"correlated":[244],"plasma":[246,262],"TNF":[247],"\u03b1":[248],"(r=0.650),":[249],"IL-6":[250],"(r=0.594)":[251],"MCP-1":[253],"(r=0.591)":[254],"levels.":[255],"reduced":[259],"atherosclerotic":[260],"lesion,":[261],"inflammatory":[263,338,353],"cytokine":[264],"differentiation.":[269],"In":[270],"vitro,":[271],"L-Hcy":[272,296],"(100":[273],"\u2013500":[274],"enhanced":[277,316],"IFN":[278,310,320],"\u03b3":[279,311,321],"-induced":[280],"hi+mid":[282,305],"differentiation,":[284],"which":[285],"abolished":[287],"by":[288,307,357],"Tiron,":[289],"SOD/catalase,":[290],"NADPH":[292,345],"oxidase":[293,346],"inhibitor":[294],"apocynin.":[295],"(500":[297],"TNFa/IL-6":[302],"cytokine-producing":[303],"3-fold":[308],"-treated":[312,322],"cells":[313],"transendothelial":[317],"migration":[318],"THP1":[323],"cells.":[324],"Conclusions:":[325],"Severe":[326],"induces":[328],"systemic":[329],"inflammation":[330],"promotes":[332],"vessel":[335],"leading":[341],"exacerbated":[343],"atherosclerosis.":[344],"mediated":[347],"oxidative":[348],"stress":[349],"participates":[350],"induced":[356],"Hcy.":[358]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}