{"id":"https://openalex.org/W15718139","doi":null,"title":"Divergence in CD8+ T cell epitopes of HIV -1 as an immune escape mechanism","display_name":"Divergence in CD8+ T cell epitopes of HIV -1 as an immune escape mechanism","publication_year":2007,"publication_date":"2007-09-27","ids":{"openalex":"https://openalex.org/W15718139","mag":"15718139"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:8831","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/8831/1/bonniecolleton2007.pdf","pdf_url":"http://d-scholarship.pitt.edu/8831/1/bonniecolleton2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/8831/1/bonniecolleton2007.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019559165","display_name":"Bonnie A. Colleton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bonnie A. Colleton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019559165"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00093743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.9649999737739563},{"id":"https://openalex.org/keywords/therapeutic-vaccines","display_name":"therapeutic vaccines","score":0.6069999933242798},{"id":"https://openalex.org/keywords/dendritic-cell-immunotherapy","display_name":"dendritic cell immunotherapy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hiv-1-quasispecies","display_name":"HIV-1 quasispecies","score":0.8339999914169312},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.6940000057220459},{"id":"https://openalex.org/keywords/primary-t-cell-response","display_name":"primary T cell response","score":0.7699999809265137},{"id":"https://openalex.org/keywords/viral-reservoir","display_name":"viral reservoir","score":0.7129999995231628},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/immunodominant-epitopes","display_name":"immunodominant epitopes","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6183395981788635},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6179279088973999},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.609825074672699},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.608597457408905},{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.5881900787353516},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5790366530418396},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5182966589927673},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5082166194915771},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.47980859875679016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46633481979370117},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4618918001651764},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.43519720435142517},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.42690175771713257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3376086354255676},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17175602912902832},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.08429089188575745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06996935606002808}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:8831","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/8831/1/bonniecolleton2007.pdf","pdf_url":"http://d-scholarship.pitt.edu/8831/1/bonniecolleton2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:15718139","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/8831/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:8831","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/8831/1/bonniecolleton2007.pdf","pdf_url":"http://d-scholarship.pitt.edu/8831/1/bonniecolleton2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W15718139.pdf","grobid_xml":"https://content.openalex.org/works/W15718139.grobid-xml"},"referenced_works_count":294,"referenced_works":["https://openalex.org/W4805378","https://openalex.org/W32966210","https://openalex.org/W46367124","https://openalex.org/W78320112","https://openalex.org/W82820957","https://openalex.org/W147448307","https://openalex.org/W309166525","https://openalex.org/W1490155859","https://openalex.org/W1493822493","https://openalex.org/W1503364994","https://openalex.org/W1505315838","https://openalex.org/W1509190187","https://openalex.org/W1513052585","https://openalex.org/W1519517175","https://openalex.org/W1523002822","https://openalex.org/W1547134586","https://openalex.org/W1561591381","https://openalex.org/W1570752474","https://openalex.org/W1598996496","https://openalex.org/W1601504908","https://openalex.org/W1602888306","https://openalex.org/W1603918837","https://openalex.org/W1617110473","https://openalex.org/W1633472206","https://openalex.org/W1639675205","https://openalex.org/W1646277151","https://openalex.org/W1646384754","https://openalex.org/W1653610605","https://openalex.org/W1661544713","https://openalex.org/W1667816862","https://openalex.org/W1675195038","https://openalex.org/W1679721892","https://openalex.org/W1766606622","https://openalex.org/W1768734130","https://openalex.org/W1906427088","https://openalex.org/W1928313731","https://openalex.org/W1930598094","https://openalex.org/W1963813930","https://openalex.org/W1964003691","https://openalex.org/W1964684295","https://openalex.org/W1965019797","https://openalex.org/W1965762540","https://openalex.org/W1965785158","https://openalex.org/W1965845165","https://openalex.org/W1965998502","https://openalex.org/W1969057879","https://openalex.org/W1973136419","https://openalex.org/W1973704411","https://openalex.org/W1975541761","https://openalex.org/W1975699571","https://openalex.org/W1976431061","https://openalex.org/W1977282539","https://openalex.org/W1978436252","https://openalex.org/W1981136135","https://openalex.org/W1981440980","https://openalex.org/W1981480494","https://openalex.org/W1981798833","https://openalex.org/W1982295797","https://openalex.org/W1982677586","https://openalex.org/W1983918344","https://openalex.org/W1985489508","https://openalex.org/W1986151024","https://openalex.org/W1986296710","https://openalex.org/W1987113078","https://openalex.org/W1988040111","https://openalex.org/W1988369057","https://openalex.org/W1988593172","https://openalex.org/W1988998247","https://openalex.org/W1990056394","https://openalex.org/W1991470697","https://openalex.org/W1993666283","https://openalex.org/W1994340919","https://openalex.org/W1994938942","https://openalex.org/W1994955528","https://openalex.org/W1995453338","https://openalex.org/W1996168633","https://openalex.org/W1996183144","https://openalex.org/W1996431251","https://openalex.org/W1996567630","https://openalex.org/W1997181100","https://openalex.org/W1997196319","https://openalex.org/W1998260902","https://openalex.org/W2000190148","https://openalex.org/W2001040937","https://openalex.org/W2001759740","https://openalex.org/W2002974382","https://openalex.org/W2004773897","https://openalex.org/W2005154465","https://openalex.org/W2005933763","https://openalex.org/W2006027051","https://openalex.org/W2006597943","https://openalex.org/W2007021820","https://openalex.org/W2008667095","https://openalex.org/W2008972431","https://openalex.org/W2009154064","https://openalex.org/W2009703634","https://openalex.org/W2011541285","https://openalex.org/W2011646391","https://openalex.org/W2011744761","https://openalex.org/W2012139740","https://openalex.org/W2013851631","https://openalex.org/W2015776459","https://openalex.org/W2016255773","https://openalex.org/W2016867991","https://openalex.org/W2017757156","https://openalex.org/W2018217171","https://openalex.org/W2019491800","https://openalex.org/W2019582452","https://openalex.org/W2020046379","https://openalex.org/W2020096299","https://openalex.org/W2020814485","https://openalex.org/W2021112267","https://openalex.org/W2022098233","https://openalex.org/W2023259585","https://openalex.org/W2024176973","https://openalex.org/W2025346994","https://openalex.org/W2025465431","https://openalex.org/W2026078176","https://openalex.org/W2026310715","https://openalex.org/W2028091596","https://openalex.org/W2028376975","https://openalex.org/W2032918869","https://openalex.org/W2034442342","https://openalex.org/W2035555649","https://openalex.org/W2035852466","https://openalex.org/W2035937996","https://openalex.org/W2035960239","https://openalex.org/W2036378811","https://openalex.org/W2037875327","https://openalex.org/W2041851366","https://openalex.org/W2042977980","https://openalex.org/W2043318695","https://openalex.org/W2045551237","https://openalex.org/W2046108120","https://openalex.org/W2046644881","https://openalex.org/W2047488334","https://openalex.org/W2047834455","https://openalex.org/W2048810850","https://openalex.org/W2051184702","https://openalex.org/W2053695022","https://openalex.org/W2055350602","https://openalex.org/W2056538898","https://openalex.org/W2060894064","https://openalex.org/W2064439998","https://openalex.org/W2064656497","https://openalex.org/W2065740427","https://openalex.org/W2067069532","https://openalex.org/W2067661858","https://openalex.org/W2068379381","https://openalex.org/W2070558900","https://openalex.org/W2071492067","https://openalex.org/W2073557733","https://openalex.org/W2074508421","https://openalex.org/W2075378388","https://openalex.org/W2076534074","https://openalex.org/W2076639605","https://openalex.org/W2076707296","https://openalex.org/W2078108658","https://openalex.org/W2078217617","https://openalex.org/W2078523699","https://openalex.org/W2078726939","https://openalex.org/W2079524810","https://openalex.org/W2080303593","https://openalex.org/W2080976763","https://openalex.org/W2081844025","https://openalex.org/W2083177852","https://openalex.org/W2085919513","https://openalex.org/W2086245354","https://openalex.org/W2086306363","https://openalex.org/W2088204382","https://openalex.org/W2090126383","https://openalex.org/W2090645887","https://openalex.org/W2092866733","https://openalex.org/W2094706980","https://openalex.org/W2095881540","https://openalex.org/W2095983332","https://openalex.org/W2096130477","https://openalex.org/W2098267542","https://openalex.org/W2098697496","https://openalex.org/W2099689198","https://openalex.org/W2100313593","https://openalex.org/W2100559181","https://openalex.org/W2104275641","https://openalex.org/W2104318155","https://openalex.org/W2104401164","https://openalex.org/W2105382508","https://openalex.org/W2106364242","https://openalex.org/W2107140931","https://openalex.org/W2108504053","https://openalex.org/W2109044040","https://openalex.org/W2109655912","https://openalex.org/W2110917275","https://openalex.org/W2111391629","https://openalex.org/W2111695773","https://openalex.org/W2112112221","https://openalex.org/W2112688771","https://openalex.org/W2112810894","https://openalex.org/W2114263643","https://openalex.org/W2116720206","https://openalex.org/W2116998344","https://openalex.org/W2118835251","https://openalex.org/W2119146367","https://openalex.org/W2119312822","https://openalex.org/W2119388106","https://openalex.org/W2119517715","https://openalex.org/W2119936827","https://openalex.org/W2121922797","https://openalex.org/W2123584222","https://openalex.org/W2123725988","https://openalex.org/W2124969212","https://openalex.org/W2125010485","https://openalex.org/W2125014261","https://openalex.org/W2125586839","https://openalex.org/W2125593632","https://openalex.org/W2126515754","https://openalex.org/W2128069859","https://openalex.org/W2128117338","https://openalex.org/W2129114331","https://openalex.org/W2129860342","https://openalex.org/W2130354820","https://openalex.org/W2132152854","https://openalex.org/W2132385533","https://openalex.org/W2133836223","https://openalex.org/W2134485724","https://openalex.org/W2136883672","https://openalex.org/W2137529550","https://openalex.org/W2137564018","https://openalex.org/W2137594178","https://openalex.org/W2138594667","https://openalex.org/W2139257243","https://openalex.org/W2140606947","https://openalex.org/W2140665904","https://openalex.org/W2141062864","https://openalex.org/W2141188376","https://openalex.org/W2141345451","https://openalex.org/W2141535477","https://openalex.org/W2142285575","https://openalex.org/W2144023036","https://openalex.org/W2144882745","https://openalex.org/W2146074801","https://openalex.org/W2146934604","https://openalex.org/W2147134928","https://openalex.org/W2147246759","https://openalex.org/W2147413871","https://openalex.org/W2148148789","https://openalex.org/W2149079955","https://openalex.org/W2149317992","https://openalex.org/W2150098469","https://openalex.org/W2151048651","https://openalex.org/W2153109187","https://openalex.org/W2153163225","https://openalex.org/W2153352288","https://openalex.org/W2154151185","https://openalex.org/W2154381591","https://openalex.org/W2154769499","https://openalex.org/W2155025120","https://openalex.org/W2155786171","https://openalex.org/W2156026365","https://openalex.org/W2156449737","https://openalex.org/W2156643487","https://openalex.org/W2159352573","https://openalex.org/W2159767232","https://openalex.org/W2159982240","https://openalex.org/W2160499349","https://openalex.org/W2161930366","https://openalex.org/W2162170852","https://openalex.org/W2162196408","https://openalex.org/W2162714346","https://openalex.org/W2162774944","https://openalex.org/W2163001100","https://openalex.org/W2166378622","https://openalex.org/W2166831581","https://openalex.org/W2166852908","https://openalex.org/W2168902753","https://openalex.org/W2169847792","https://openalex.org/W2170315872","https://openalex.org/W2170327206","https://openalex.org/W2170629469","https://openalex.org/W2170821252","https://openalex.org/W2170904230","https://openalex.org/W2171377431","https://openalex.org/W2186507474","https://openalex.org/W2318289184","https://openalex.org/W2320150009","https://openalex.org/W2320498484","https://openalex.org/W2323015980","https://openalex.org/W2327503296","https://openalex.org/W2339219218","https://openalex.org/W2406817099","https://openalex.org/W2411268952","https://openalex.org/W2412016747","https://openalex.org/W2412209157","https://openalex.org/W2417497667","https://openalex.org/W2469878034"],"related_works":["https://openalex.org/W2157063918","https://openalex.org/W40412525","https://openalex.org/W2410836045","https://openalex.org/W3026630602","https://openalex.org/W2160091655","https://openalex.org/W6887850616","https://openalex.org/W2903227817","https://openalex.org/W3097659364","https://openalex.org/W2323015004","https://openalex.org/W2130492317"],"abstract_inverted_index":{"More":[0],"than":[1],"40":[2],"million":[3],"people":[4,41],"are":[5,43,132],"living":[6],"with":[7,46,54,109],"human":[8],"immunodeficiency":[9],"virus-1":[10],"(HIV-1).":[11],"A":[12],"prophylactic":[13,33,343],"vaccine":[14,78],"inducing":[15],"a":[16,76,147,152,249,261,315],"'sterilizing":[17],"immunity'":[18],"is":[19,63,75,252],"desired":[20],"to":[21,30,93,159],"prevent":[22],"further":[23],"infections,":[24],"but":[25],"will":[26,35,80],"require":[27],"many":[28],"years":[29],"develop.":[31],"Moreover,":[32],"vaccines":[34,344],"not":[36],"help":[37],"the":[38,47,66,69,94,177,218,232,265,296,322],"millions":[39],"of":[40,169,181,220,234,264,282,288,300,342],"who":[42,50],"already":[44],"infected":[45,115],"virus,":[48],"and":[49,56,154,229,241,320,347],"face":[51],"life-long":[52],"treatment":[53],"expensive":[55],"toxic":[57],"antiretroviral":[58],"therapy":[59],"(ART).":[60],"This":[61,214,271],"dissertation":[62],"based":[64],"on":[65,329],"proposal":[67],"that":[68,79,103,140,172,191,193,231,253],"best":[70],"strategy":[71],"for":[72,278,340],"these":[73],"individuals":[74],"therapeutic":[77],"attack":[81],"residual":[82,120,289],"viral":[83,236],"reservoirs":[84],"by":[85,200,313],"expanding":[86],"HIV-1":[87,111,114,121,170,182,208,268,290,301,325,346],"specific,":[88],"primary":[89,242,274],"T":[90,124,130,144,156,195,243,293],"cell":[91,125,157,244],"responses":[92,245,276],"persons's":[95],"own,":[96],"autologous":[97,207,222,235,258],"virus.":[98],"Previously,":[99],"this":[100],"laboratory":[101],"demonstrated":[102],"mature":[104],"dendritic":[105],"cells":[106,131,145,196],"(DC)":[107],"loaded":[108],"immunodominant":[110],"peptides":[112,209],"or":[113],"apoptotic":[116],"bodies":[117],"can":[118,197],"activate":[119],"specific":[122,277,291],"memory":[123,129,240,292],"responses.":[126],"However,":[127],"such":[128],"only":[133],"partially":[134],"restored":[135],"during":[136,303],"ART.":[137,304,330],"I":[138,173],"hypothesized":[139],"targeting":[141],"naive":[142],"CD8\u207a":[143,194],"through":[146],"DC-based":[148],"immunotherapy":[149,163,228],"could":[150,256,272],"elicit":[151,273],"robust":[153],"broad":[155],"response":[158],"HIV-1.":[160],"Furthermore,":[161],"most":[162],"studies":[164],"have":[165],"used":[166],"consensus":[167],"strains":[168],"antigens":[171],"believe":[174],"inadequately":[175],"represent":[176],"host's":[178,266],"diverse":[179,267],"pool":[180],"quasispecies.":[183],"The":[184],"current":[185],"study":[186,215],"has":[187,308],"provided":[188],"initial":[189],"data":[190],"support":[192],"be":[198],"primed":[199],"in":[201,227,246,327,336],"vitro":[202,337],"engineered":[203],"DC,":[204],"even":[205],"against":[206,345],"representing":[210,260],"immune":[211,275,298],"escape":[212],"variants.":[213],"therefore":[216],"supports":[217],"concept":[219],"using":[221],"virus":[223,259],"as":[224,284,286,334],"an":[225,306,335],"antigen":[226,269],"demonstrates":[230],"use":[233,257],"sequences":[237],"expands":[238],"both":[239],"vitro.":[247],"Thus,":[248],"potential":[250],"advantage":[251],"future":[254],"immunotherapies":[255],"large":[262],"repertoire":[263],"pool.":[270],"each":[279],"patient's":[280],"quasispecies":[281],"HIV-1,":[283],"well":[285],"activation":[287],"cells,":[294],"giving":[295],"broadest":[297],"control":[299,323],"infection":[302,326],"Such":[305],"approach":[307],"important":[309],"public":[310],"health":[311],"implications":[312],"having":[314],"strong":[316],"positive":[317],"impact":[318],"on,":[319],"improve":[321],"of,":[324],"persons":[328],"It":[331],"also":[332],"serves":[333],"priming":[338],"model":[339],"development":[341],"other":[348],"infectious":[349],"agents.":[350]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}