{"id":"https://openalex.org/W1571702913","doi":"https://doi.org/10.1002/smll.201303433","title":"Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5\u2010associated Liposomes","display_name":"Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5\u2010associated Liposomes","publication_year":2014,"publication_date":"2014-03-05","ids":{"openalex":"https://openalex.org/W1571702913","doi":"https://doi.org/10.1002/smll.201303433","mag":"1571702913","pmid":"https://pubmed.ncbi.nlm.nih.gov/24596245"},"language":"en","primary_location":{"id":"doi:10.1002/smll.201303433","doi":"https://doi.org/10.1002/smll.201303433","is_oa":false,"landing_page_url":"https://doi.org/10.1002/smll.201303433","pdf_url":null,"source":{"id":"https://openalex.org/S94619837","display_name":"Small","issn_l":"1613-6810","issn":["1613-6810","1613-6829"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002447216","display_name":"Benjamin Michael Davis","orcid":"https://orcid.org/0000-0002-9883-7356","observed_orcids":["https://orcid.org/0000-0002-9883-7356","https://orcid.org/0000-0001-6121-1635"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benjamin M. Davis","raw_affiliation_strings":["UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","Visual Neuroscience, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Visual Neuroscience, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060629377","display_name":"Eduardo Maria Normando","orcid":"https://orcid.org/0000-0002-5774-8082","observed_orcids":["https://orcid.org/0000-0002-5774-8082"]},"institutions":[{"id":"https://openalex.org/I4210136817","display_name":"Western Eye Hospital","ror":"https://ror.org/04g0t2d47","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I4210136817"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eduardo M. Normando","raw_affiliation_strings":["UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","Western Eye Hospital Imperial College Healthcare NHSTrust  Marylebone Road London NW1 5QH UK","Visual Neuroscience, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Western Eye Hospital Imperial College Healthcare NHSTrust  Marylebone Road London NW1 5QH UK","institution_ids":["https://openalex.org/I4210136817"]},{"raw_affiliation_string":"Visual Neuroscience, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030736220","display_name":"Li Guo","orcid":"https://orcid.org/0000-0002-3124-4505","observed_orcids":["https://orcid.org/0000-0002-3124-4505"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Li Guo","raw_affiliation_strings":["UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","Visual Neuroscience, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Visual Neuroscience, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102714345","display_name":"Lisa Turner","orcid":"https://orcid.org/0000-0003-3586-8566","observed_orcids":["https://orcid.org/0000-0003-3586-8566"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210136817","display_name":"Western Eye Hospital","ror":"https://ror.org/04g0t2d47","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I4210136817"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lisa A. Turner","raw_affiliation_strings":["UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","Western Eye Hospital Imperial College Healthcare NHSTrust  Marylebone Road London NW1 5QH UK","Cell Biophysics Group, University of Nottingahm, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Western Eye Hospital Imperial College Healthcare NHSTrust  Marylebone Road London NW1 5QH UK","institution_ids":["https://openalex.org/I4210136817"]},{"raw_affiliation_string":"Cell Biophysics Group, University of Nottingahm, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090014791","display_name":"Shereen Nizari","orcid":"https://orcid.org/0000-0002-7245-7435","observed_orcids":["https://orcid.org/0000-0002-7245-7435"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shereen Nizari","raw_affiliation_strings":["UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","Cell biology, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Cell biology, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007902682","display_name":"Paul O\u2019Shea","orcid":"https://orcid.org/0000-0001-9313-8313","observed_orcids":["https://orcid.org/0000-0001-9313-8313"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul O'Shea","raw_affiliation_strings":["Cell Biophysics Group Institute of Biophysics Imaging and Optical Science University of Nottingham  NG7 2RD UK","School of Pharmacy, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biophysics Group Institute of Biophysics Imaging and Optical Science University of Nottingham  NG7 2RD UK","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"School of Pharmacy, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I4405283614","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068986246","display_name":"Stephen E. Moss","orcid":"https://orcid.org/0000-0002-7304-8879","observed_orcids":["https://orcid.org/0000-0002-7304-8879"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen E. Moss","raw_affiliation_strings":["Department of Cell Biology UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL","Visual Neuroscience, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Visual Neuroscience, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044232508","display_name":"Satyanarayana Somavarapu","orcid":"https://orcid.org/0000-0001-5361-4610","observed_orcids":["https://orcid.org/0000-0001-5361-4610"]},"institutions":[{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Satyanarayana Somavarapu","raw_affiliation_strings":["School of Pharmacy University College London  Brunswick Square London, UK WC1N 1AXrite UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy University College London  Brunswick Square London, UK WC1N 1AXrite UK","institution_ids":["https://openalex.org/I4405283614","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044451478","display_name":"Maria Francesca Cordeiro","orcid":"https://orcid.org/0000-0001-8663-6525","observed_orcids":["https://orcid.org/0000-0001-8663-6525"]},"institutions":[{"id":"https://openalex.org/I4210136817","display_name":"Western Eye Hospital","ror":"https://ror.org/04g0t2d47","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I4210136817"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M. Francesca Cordeiro","raw_affiliation_strings":["UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","Western Eye Hospital Imperial College Healthcare NHSTrust  Marylebone Road London NW1 5QH UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Ophthalmology University College London  Bath Street London EC1V 9EL UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Western Eye Hospital Imperial College Healthcare NHSTrust  Marylebone Road London NW1 5QH UK","institution_ids":["https://openalex.org/I4210136817"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044451478"],"corresponding_institution_ids":["https://openalex.org/I4210136817","https://openalex.org/I45129253"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":8.1958,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.99167328,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"10","issue":"8","first_page":"1575","last_page":"1584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/annexin-v","display_name":"annexin V","score":0.9399999976158142},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.906000018119812},{"id":"https://openalex.org/keywords/topical-ocular-drug-delivery","display_name":"topical ocular drug delivery","score":0.8830000162124634},{"id":"https://openalex.org/keywords/posterior-segment-of-the-eye","display_name":"posterior segment of the eye","score":0.8659999966621399},{"id":"https://openalex.org/keywords/retina","display_name":"retina","score":0.6909999847412109},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/corneal-epithelium","display_name":"corneal epithelium","score":0.8700000047683716},{"id":"https://openalex.org/keywords/transcytosis","display_name":"transcytosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/anionic-phospholipid-binding","display_name":"anionic phospholipid binding","score":0.7059999704360962},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6928906440734863},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.5880209803581238},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5061072707176208},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46278291940689087},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.45156481862068176},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.411197692155838},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30461227893829346},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2974735498428345},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16839957237243652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11642476916313171},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08276081085205078},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.043426841497421265},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.033875107765197754}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005452","descriptor_name":"Fluoresceins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009883","descriptor_name":"Ophthalmic Solutions","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009883","descriptor_name":"Ophthalmic Solutions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017304","descriptor_name":"Annexin A5","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057900","descriptor_name":"Transcytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057972","descriptor_name":"Posterior Eye Segment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/smll.201303433","doi":"https://doi.org/10.1002/smll.201303433","is_oa":false,"landing_page_url":"https://doi.org/10.1002/smll.201303433","pdf_url":null,"source":{"id":"https://openalex.org/S94619837","display_name":"Small","issn_l":"1613-6810","issn":["1613-6810","1613-6829"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small","raw_type":"journal-article"},{"id":"pmid:24596245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24596245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.lancs.ac.uk:126022","doi":null,"is_oa":false,"landing_page_url":"https://eprints.lancs.ac.uk/id/eprint/126022/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401916","display_name":"Lancaster EPrints (Lancaster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67415387","host_organization_name":"Lancaster University","host_organization_lineage":["https://openalex.org/I67415387"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1422555","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1422555/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Small , 10 (8) pp. 1575-1584. (2014)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W14379439","https://openalex.org/W125106425","https://openalex.org/W1485863323","https://openalex.org/W1978029175","https://openalex.org/W1978836176","https://openalex.org/W1983671192","https://openalex.org/W1986516374","https://openalex.org/W1993016994","https://openalex.org/W1997530284","https://openalex.org/W2002924107","https://openalex.org/W2004703863","https://openalex.org/W2005220285","https://openalex.org/W2007958170","https://openalex.org/W2011573538","https://openalex.org/W2015130824","https://openalex.org/W2015479437","https://openalex.org/W2016862697","https://openalex.org/W2017730532","https://openalex.org/W2018516156","https://openalex.org/W2022254881","https://openalex.org/W2029700899","https://openalex.org/W2029911161","https://openalex.org/W2034234194","https://openalex.org/W2034567133","https://openalex.org/W2037081137","https://openalex.org/W2038368604","https://openalex.org/W2041538901","https://openalex.org/W2052500741","https://openalex.org/W2058442785","https://openalex.org/W2058803632","https://openalex.org/W2059265707","https://openalex.org/W2061994413","https://openalex.org/W2062032422","https://openalex.org/W2068651491","https://openalex.org/W2072011053","https://openalex.org/W2074366880","https://openalex.org/W2082056939","https://openalex.org/W2089273334","https://openalex.org/W2090719004","https://openalex.org/W2103799960","https://openalex.org/W2116707429","https://openalex.org/W2117981102","https://openalex.org/W2126148550","https://openalex.org/W2126375207","https://openalex.org/W2135807668","https://openalex.org/W2157848273","https://openalex.org/W2408788590"],"related_works":["https://openalex.org/W3128274059","https://openalex.org/W2921487630","https://openalex.org/W4280545794","https://openalex.org/W7134937539","https://openalex.org/W2899208802","https://openalex.org/W2012260669","https://openalex.org/W3166609359","https://openalex.org/W2951438516","https://openalex.org/W4386415714","https://openalex.org/W7095077731"],"abstract_inverted_index":{"Effective":[0],"delivery":[1,85,184,189],"to":[2,19,80,147,154,175],"the":[3,9,31,41,54,92,107,123,155,158,183],"retina":[4,165],"is":[5,29,145],"presently":[6,30],"one":[7],"of":[8,24,34,56,115,125,134,152,157,185],"most":[10],"challenging":[11],"areas":[12],"in":[13,16,69,103,116,119],"drug":[14,84,104,136,188],"development":[15],"ophthalmology,":[17],"due":[18],"anatomical":[20],"barriers":[21],"preventing":[22],"entry":[23],"therapeutic":[25,197],"substances.":[26],"Intraocular":[27],"injection":[28],"only":[32],"route":[33],"administration":[35],"for":[36,64],"large":[37],"protein":[38,96],"therapeutics,":[39],"including":[40],"anti-Vascular":[42],"Endothelial":[43],"Growth":[44],"Factors":[45],"Lucentis":[46],"(ranibizumab)":[47],"and":[48,60,71,118,132,163],"Avastin":[49,153],"(bevacizumab).":[50],"Anti-VEGFs":[51],"have":[52,61,77,100,196],"revolutionised":[53],"management":[55],"age-related":[57],"macular":[58],"degeneration":[59],"increasing":[62],"indications":[63],"use":[65],"as":[66],"sight-saving":[67],"therapies":[68],"diabetes":[70],"retinal":[72],"vascular":[73],"disease.":[74],"Considerable":[75],"resources":[76],"been":[78,89],"allocated":[79],"develop":[81],"non-invasive":[82],"ocular":[83],"systems.":[86],"It":[87],"has":[88],"suggested":[90],"that":[91,122],"anionic":[93],"phospholipid":[94],"binding":[95],"annexin":[97,126,177],"A5,":[98],"may":[99,195],"a":[101,113],"role":[102],"delivery.":[105],"In":[106],"present":[108],"study":[109],"we":[110],"demonstrate,":[111],"using":[112],"combination":[114],"vitro":[117],"vivo":[120],"assays,":[121],"presence":[124],"A5":[127,178],"can":[128,181],"significantly":[129],"enhance":[130,182],"uptake":[131],"transcytosis":[133],"liposomal":[135],"carrier":[137],"systems":[138],"across":[139,191],"corneal":[140],"epithelial":[141],"barriers.":[142],"This":[143],"system":[144],"employed":[146],"deliver":[148],"physiologically":[149],"significant":[150],"concentrations":[151],"posterior":[156],"rat":[159],"eye":[160],"(127":[161],"ng/g)":[162,167],"rabbit":[164],"(18":[166],"after":[168],"topical":[169],"application.":[170],"Our":[171],"observations":[172],"provide":[173],"evidence":[174],"suggest":[176],"mediated":[179],"endocytosis":[180],"associated":[186],"lipidic":[187],"vehicles":[190],"biological":[192],"barriers,":[193],"which":[194],"implications.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}