{"id":"https://openalex.org/W157160099","doi":"https://doi.org/10.1038/npre.2009.3896.1","title":"Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD).","display_name":"Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD).","publication_year":2009,"publication_date":"2009-10-26","ids":{"openalex":"https://openalex.org/W157160099","doi":"https://doi.org/10.1038/npre.2009.3896.1","mag":"157160099"},"language":"en","primary_location":{"id":"doi:10.1038/npre.2009.3896.1","doi":"https://doi.org/10.1038/npre.2009.3896.1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/npre.2009.3896.1","pdf_url":"https://www.nature.com/articles/npre.2009.3896.1.pdf","source":{"id":"https://openalex.org/S48744551","display_name":"Nature Precedings","issn_l":"1756-0357","issn":["1756-0357"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Precedings","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.nature.com/articles/npre.2009.3896.1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012553649","display_name":"Petroula Proitsi","orcid":"https://orcid.org/0000-0002-2553-6974","observed_orcids":["https://orcid.org/0000-0002-2553-6974"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Petroula Proitsi","raw_affiliation_strings":["King\u2019s College London, Institute of Psychiatry, Neuroscience https://www.nature.com/nature","King\u2019s College London, Institute of Psychiatry, Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Neuroscience https://www.nature.com/nature","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Neuroscience","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017531759","display_name":"Michelle K. Lupton","orcid":"https://orcid.org/0000-0002-7274-7299","observed_orcids":["https://orcid.org/0000-0002-7274-7299"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michelle Lupton","raw_affiliation_strings":["King\u2019s College London, Institute of Psychiatry, Neuroscience https://www.nature.com/nature","King\u2019s College London, Institute of Psychiatry, Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Neuroscience https://www.nature.com/nature","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Neuroscience","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035979012","display_name":"Suzanne Reeves","orcid":"https://orcid.org/0000-0001-8053-7024","observed_orcids":["https://orcid.org/0000-0001-8053-7024"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Suzanne Reeves","raw_affiliation_strings":["King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry https://www.nature.com/nature","King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry https://www.nature.com/nature","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102843626","display_name":"Gillian Hamilton","orcid":"https://orcid.org/0000-0002-1043-8634","observed_orcids":["https://orcid.org/0000-0002-1043-8634"]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gillian Hamilton","raw_affiliation_strings":["Molecular Medicine Centre, Medical Genetics, Western General Hospital, University of Edinburgh https://www.nature.com/nature","Molecular Medicine Centre, Medical Genetics, Western General Hospital, University of Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Centre, Medical Genetics, Western General Hospital, University of Edinburgh https://www.nature.com/nature","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Molecular Medicine Centre, Medical Genetics, Western General Hospital, University of Edinburgh","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082614852","display_name":"Nicola J. Archer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicola Archer","raw_affiliation_strings":["King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry https://www.nature.com/nature","King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry https://www.nature.com/nature","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020525495","display_name":"Belinda M. Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Belinda Martin","raw_affiliation_strings":["King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry https://www.nature.com/nature","King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry https://www.nature.com/nature","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036497300","display_name":"Paul Hollingworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97429440","display_name":"University of Wales","ror":"https://ror.org/01se4f844","country_code":"GB","type":"education","lineage":["https://openalex.org/I97429440"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul hollingworth","raw_affiliation_strings":["University of Wales College of Medicine, Department of Psychological Medicine https://www.nature.com/nature","University of Wales College of Medicine, Department of Psychological Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wales College of Medicine, Department of Psychological Medicine https://www.nature.com/nature","institution_ids":["https://openalex.org/I97429440"]},{"raw_affiliation_string":"University of Wales College of Medicine, Department of Psychological Medicine","institution_ids":["https://openalex.org/I97429440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068208678","display_name":"Brian Lawlord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204442077","display_name":"Trinity College","ror":"https://ror.org/019dhar59","country_code":"CA","type":"education","lineage":["https://openalex.org/I204442077"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brian Lawlord","raw_affiliation_strings":["Mercer\u2019s Institute for Research on Aging, St. James\u2019s Hospital and Trinity College https://www.nature.com/nature","Mercer\u2019s Institute for Research on Aging, St. James\u2019s Hospital and Trinity College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mercer\u2019s Institute for Research on Aging, St. James\u2019s Hospital and Trinity College https://www.nature.com/nature","institution_ids":["https://openalex.org/I204442077"]},{"raw_affiliation_string":"Mercer\u2019s Institute for Research on Aging, St. James\u2019s Hospital and Trinity College","institution_ids":["https://openalex.org/I204442077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106497970","display_name":"Michael Gill","orcid":"https://orcid.org/0000-0003-0206-5337","observed_orcids":["https://orcid.org/0000-0003-0206-5337","https://orcid.org/0000-0002-9657-1451"]},"institutions":[{"id":"https://openalex.org/I204442077","display_name":"Trinity College","ror":"https://ror.org/019dhar59","country_code":"CA","type":"education","lineage":["https://openalex.org/I204442077"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Gill","raw_affiliation_strings":["Mercer\u2019s Institute for Research on Aging, St. James\u2019s Hospital and Trinity College https://www.nature.com/nature","Mercer\u2019s Institute for Research on Aging, St. James\u2019s Hospital and Trinity College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mercer\u2019s Institute for Research on Aging, St. James\u2019s Hospital and Trinity College https://www.nature.com/nature","institution_ids":["https://openalex.org/I204442077"]},{"raw_affiliation_string":"Mercer\u2019s Institute for Research on Aging, St. James\u2019s Hospital and Trinity College","institution_ids":["https://openalex.org/I204442077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026352442","display_name":"Michael John Owen","orcid":"https://orcid.org/0000-0003-4798-0862","observed_orcids":["https://orcid.org/0000-0003-4798-0862"]},"institutions":[{"id":"https://openalex.org/I97429440","display_name":"University of Wales","ror":"https://ror.org/01se4f844","country_code":"GB","type":"education","lineage":["https://openalex.org/I97429440"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Owen","raw_affiliation_strings":["University of Wales College of Medicine, Department of Psychological Medicine https://www.nature.com/nature","University of Wales College of Medicine, Department of Psychological Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wales College of Medicine, Department of Psychological Medicine https://www.nature.com/nature","institution_ids":["https://openalex.org/I97429440"]},{"raw_affiliation_string":"University of Wales College of Medicine, Department of Psychological Medicine","institution_ids":["https://openalex.org/I97429440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049840252","display_name":"Julie H. Williams","orcid":"https://orcid.org/0000-0002-4069-0259","observed_orcids":["https://orcid.org/0000-0002-4069-0259"]},"institutions":[{"id":"https://openalex.org/I97429440","display_name":"University of Wales","ror":"https://ror.org/01se4f844","country_code":"GB","type":"education","lineage":["https://openalex.org/I97429440"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julie Williams","raw_affiliation_strings":["University of Wales College of Medicine, Department of Psychological Medicine https://www.nature.com/nature","University of Wales College of Medicine, Department of Psychological Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wales College of Medicine, Department of Psychological Medicine https://www.nature.com/nature","institution_ids":["https://openalex.org/I97429440"]},{"raw_affiliation_string":"University of Wales College of Medicine, Department of Psychological Medicine","institution_ids":["https://openalex.org/I97429440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002493210","display_name":"Simon Lovestone","orcid":"https://orcid.org/0000-0003-0473-4565","observed_orcids":["https://orcid.org/0000-0003-0473-4565"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Lovestone","raw_affiliation_strings":["King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry https://www.nature.com/nature","King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry https://www.nature.com/nature","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Old Age Psychiatry","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011932191","display_name":"John F. Powell","orcid":"https://orcid.org/0000-0001-6124-439X","observed_orcids":["https://orcid.org/0000-0001-6124-439X"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Powell","raw_affiliation_strings":["King\u2019s College London, Institute of Psychiatry, Neuroscience https://www.nature.com/nature","King\u2019s College London, Institute of Psychiatry, Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Neuroscience https://www.nature.com/nature","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"King\u2019s College London, Institute of Psychiatry, Neuroscience","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5012553649"],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/behavioral-and-psychological-symptoms-of-dementia","display_name":"behavioral and psychological symptoms of dementia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/serotonergic-system","display_name":"serotonergic system","score":0.8610000014305115},{"id":"https://openalex.org/keywords/dopaminergic-system","display_name":"dopaminergic system","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7929999828338623},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8840000033378601},{"id":"https://openalex.org/keywords/drd4","display_name":"DRD4","score":0.9850000143051147},{"id":"https://openalex.org/keywords/5-httlpr","display_name":"5-HTTLPR","score":0.9169999957084656},{"id":"https://openalex.org/keywords/comt-val158met","display_name":"COMT Val158Met","score":0.996999979019165},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.722000002861023},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/agitation","display_name":"agitation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mood","display_name":"mood","score":0.41600000858306885},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.7440000176429749},{"id":"https://openalex.org/keywords/apathy","display_name":"apathy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/npi","display_name":"NPI","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5255659818649292},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4490188956260681},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.4359474778175354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38989901542663574},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.32871943712234497},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2909574508666992},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24688443541526794},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.211615651845932},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.13291805982589722},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/npre.2009.3896.1","doi":"https://doi.org/10.1038/npre.2009.3896.1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/npre.2009.3896.1","pdf_url":"https://www.nature.com/articles/npre.2009.3896.1.pdf","source":{"id":"https://openalex.org/S48744551","display_name":"Nature Precedings","issn_l":"1756-0357","issn":["1756-0357"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Precedings","raw_type":"journal-article"},{"id":"pmh:oai:nature.com:10101/npre.2009.3896.1","doi":null,"is_oa":true,"landing_page_url":"http://precedings.nature.com/documents/3896/version/1","pdf_url":null,"source":{"id":"https://openalex.org/S48744551","display_name":"Nature Precedings","issn_l":"1756-0357","issn":["1756-0357"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Precedings","raw_type":"Manuscript"}],"best_oa_location":{"id":"doi:10.1038/npre.2009.3896.1","doi":"https://doi.org/10.1038/npre.2009.3896.1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/npre.2009.3896.1","pdf_url":"https://www.nature.com/articles/npre.2009.3896.1.pdf","source":{"id":"https://openalex.org/S48744551","display_name":"Nature Precedings","issn_l":"1756-0357","issn":["1756-0357"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Precedings","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311198","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320317015","display_name":"Alzheimer's Society","ror":"https://ror.org/0472gwq90"},{"id":"https://openalex.org/F4320319841","display_name":"Alzheimer's Research Trust","ror":"https://ror.org/02ymzm013"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W157160099.pdf","grobid_xml":"https://content.openalex.org/works/W157160099.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W73668461","https://openalex.org/W1601690727","https://openalex.org/W1688235741","https://openalex.org/W1828731864","https://openalex.org/W1847168837","https://openalex.org/W1964835551","https://openalex.org/W1965828393","https://openalex.org/W1973796603","https://openalex.org/W1975285245","https://openalex.org/W1977672139","https://openalex.org/W1980325750","https://openalex.org/W1980877514","https://openalex.org/W1981555150","https://openalex.org/W1984096877","https://openalex.org/W1989611948","https://openalex.org/W1991688849","https://openalex.org/W1996398917","https://openalex.org/W2007863088","https://openalex.org/W2008113854","https://openalex.org/W2010487430","https://openalex.org/W2015775451","https://openalex.org/W2018049458","https://openalex.org/W2018990521","https://openalex.org/W2023506257","https://openalex.org/W2025572510","https://openalex.org/W2027584553","https://openalex.org/W2039813120","https://openalex.org/W2044784291","https://openalex.org/W2056134436","https://openalex.org/W2057218956","https://openalex.org/W2059334100","https://openalex.org/W2061968416","https://openalex.org/W2068110177","https://openalex.org/W2068609871","https://openalex.org/W2070775561","https://openalex.org/W2073544062","https://openalex.org/W2074485067","https://openalex.org/W2075505507","https://openalex.org/W2076527769","https://openalex.org/W2077067029","https://openalex.org/W2078323174","https://openalex.org/W2079288585","https://openalex.org/W2083020792","https://openalex.org/W2083980029","https://openalex.org/W2086982304","https://openalex.org/W2088749345","https://openalex.org/W2092001235","https://openalex.org/W2098349177","https://openalex.org/W2103093164","https://openalex.org/W2106188731","https://openalex.org/W2108695299","https://openalex.org/W2109542500","https://openalex.org/W2111287669","https://openalex.org/W2115725384","https://openalex.org/W2122813545","https://openalex.org/W2132185464","https://openalex.org/W2138883123","https://openalex.org/W2151219788","https://openalex.org/W2152914034","https://openalex.org/W2156220037","https://openalex.org/W2159822596","https://openalex.org/W2161633633","https://openalex.org/W2165501402","https://openalex.org/W2166643169","https://openalex.org/W2166844839","https://openalex.org/W2401206973"],"related_works":["https://openalex.org/W2110897038","https://openalex.org/W2070775561","https://openalex.org/W2582153582","https://openalex.org/W3049299716","https://openalex.org/W2101627758","https://openalex.org/W1965828393","https://openalex.org/W2123934417","https://openalex.org/W935291931","https://openalex.org/W2076527769","https://openalex.org/W2068110177"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"there":[2],"is":[3],"evidence":[4],"for":[5],"the":[6,16,19,39,52,58,84,92,101,180,187],"involvement":[7],"of":[8,10,18,54,86,94,103,186],"genes":[9],"serotonergic":[11,59],"and":[12,21,41,60,71,100,117,127,132,136,139,150,157,166,172,177,194],"dopaminergic":[13,61],"systems":[14],"in":[15,24,57],"manifestation":[17],"Behavioural":[20],"Psychological":[22],"Symptoms":[23],"Dementia":[25],"(BPSD),":[26],"genetic":[27,190],"association":[28,85,93,102],"studies":[29],"are":[30],"contradictory.":[31],"We":[32],"used":[33],"1008":[34],"probable":[35],"AD":[36],"patients":[37],"from":[38],"UK":[40],"applied":[42],"a":[43],"Multiple":[44,46],"Indicators":[45],"Causes":[47],"(MIMIC)":[48],"approach":[49],"to":[50],"investigate":[51],"effect":[53],"11":[55],"polymorphisms":[56],"systems,":[62],"on":[63,77],"four":[64],"behavioural":[65,192],"sub-phenotypes,":[66],"namely":[67],"\"psychosis\",\"":[68],"moods\",":[69],"\"agitation\"":[70,98,170],"\"behavioural":[72],"dyscontrol\",":[73],"as":[74,76],"well":[75],"12":[78],"NPI":[79],"items.":[80],"Significant":[81],"findings":[82],"included":[83],"DRD1":[87,115],"A48G":[88,116],"with":[89,97,105,120,152,159,169,179],"\"psychosis\"":[90,153,160],"(p=0.037),":[91],"DAT1":[95,118,163,174],"VNTR":[96,119,165,176],"(p=0.006)":[99],"DRD4":[104,131],"\"moods\"":[106,181],"sub-phenotype":[107],"(p=0.008).":[108],"In":[109],"addition,":[110],"associations":[111],"were":[112,145],"identified":[113],"between":[114,130,137,147,155,162,173,189],"aberrant":[121],"motor":[122],"behaviour":[123],"(AMB)":[124],"symptoms":[125,193],"(p=0.001":[126],"p=0.015":[128],"respectively),":[129],"sleep":[133],"disturbances":[134],"(p=0.018)":[135],"5HTTLPR":[138,151,178],"apathy":[140],"(p=0.033).":[141],"Finally,":[142],"significant":[143],"interactions":[144],"observed":[146],"COMT":[148,167],"Val158Met":[149,168],"(p=0.026),":[154],"HTTLPR":[156],"STin2":[158],"(p=0.005),":[161],"3'UTR":[164,175],"(p=0.0001)":[171],"factor":[182],"(p=0.0027).":[183],"The":[184],"complexity":[185],"interrelations":[188],"variation,":[191],"clinical":[195],"variables":[196],"was":[197],"efficiently":[198],"captured":[199],"by":[200],"this":[201],"MIMIC":[202],"model.":[203]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
