{"id":"https://openalex.org/W1571362334","doi":null,"title":"No association of the I1307K APC allele with ovarian cancer risk in Ashkenazi Jews.","display_name":"No association of the I1307K APC allele with ovarian cancer risk in Ashkenazi Jews.","publication_year":1998,"publication_date":"1998-07-15","ids":{"openalex":"https://openalex.org/W1571362334","mag":"1571362334","pmid":"https://pubmed.ncbi.nlm.nih.gov/9679945"},"language":"en","primary_location":{"id":"pmid:9679945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9679945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063713207","display_name":"John Abrahamson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801816099","display_name":"Women's College Hospital","ror":"https://ror.org/03cw63y62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801816099"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J Abrahamson","raw_affiliation_strings":["Women's College Hospital, The Centre for Research in Women's Health, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's College Hospital, The Centre for Research in Women's Health, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801816099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063682125","display_name":"Roxana Moslehi","orcid":"https://orcid.org/0000-0003-3904-4863","observed_orcids":["https://orcid.org/0000-0003-3904-4863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Moslehi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106082171","display_name":"D Vesprini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Vesprini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082993956","display_name":"Beth Y. Karlan","orcid":"https://orcid.org/0000-0002-9451-2933","observed_orcids":["https://orcid.org/0000-0002-9451-2933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Karlan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090335114","display_name":"David M. Fishman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Fishman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037528815","display_name":"David Smotkin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Smotkin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108494530","display_name":"Y. Ben David","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ben David","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024484286","display_name":"Haim Biran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Biran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043607435","display_name":"Abbie L. Fields","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Fields","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104054344","display_name":"Jean\u2010S\u00e9bastien Brunet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Brunet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110033313","display_name":"S A Narod","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Narod","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8139,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.90450782,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"58","issue":"14","first_page":"2919","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apc-gene","display_name":"APC gene","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ovarian-cancer-risk","display_name":"ovarian cancer risk","score":0.6890000104904175},{"id":"https://openalex.org/keywords/ashkenazi-jews","display_name":"Ashkenazi Jews","score":0.9520000219345093},{"id":"https://openalex.org/keywords/familial-adenomatous-polyposis","display_name":"familial adenomatous polyposis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7609999775886536},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.6330000162124634},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.5720000267028809},{"id":"https://openalex.org/keywords/first-degree-relatives","display_name":"first-degree relatives","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5888336896896362},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5746518969535828},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5707014799118042},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.5476967692375183},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5422545075416565},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5255640745162964},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5235990285873413},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4924834668636322},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.48467615246772766},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.473665326833725},{"id":"https://openalex.org/C2779862289","wikidata":"https://www.wikidata.org/wiki/Q25098571","display_name":"First-degree relatives","level":3,"score":0.4293504059314728},{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.4124261736869812},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35695701837539673},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2931627333164215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16590893268585205},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.15597867965698242},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11088237166404724},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007585","descriptor_name":"Jews","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9679945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9679945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1571362334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9679945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7787417839","display_name":"RISK FACTOR ANALYSIS OF BRCA1 AND BRCA2 CARRIERS","funder_award_id":"R01CA063678","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2006874765","https://openalex.org/W2017312736","https://openalex.org/W2018348035","https://openalex.org/W2033193225","https://openalex.org/W2052165838","https://openalex.org/W2058403714","https://openalex.org/W2059813946","https://openalex.org/W2093531978","https://openalex.org/W2160063700"],"related_works":["https://openalex.org/W1605229390","https://openalex.org/W1971106681","https://openalex.org/W2160063700","https://openalex.org/W2158714839","https://openalex.org/W2103987317","https://openalex.org/W2067052539","https://openalex.org/W4366386300","https://openalex.org/W2113315866","https://openalex.org/W1515593042","https://openalex.org/W2130227635"],"abstract_inverted_index":{"Familial":[0],"adenomatous":[1],"polyposis":[2],"is":[3,37,241],"a":[4,48,150,183],"dominantly":[5],"inherited":[6],"colon":[7],"cancer":[8,76,95,102,154,190,216,249,252],"syndrome":[9],"associated":[10],"with":[11,57,144],"germ-line":[12],"mutations":[13],"in":[14,29,78,87,104,253],"the":[15,25,32,41,62,67,73,84,107,117,127,145,163,179,196,203,234,238,245],"APC":[16,21],"tumor":[17],"suppressor":[18],"gene.":[19],"An":[20],"gene":[22],"sequence":[23],"alteration,":[24],"I1307K":[26,63,85,108,146,164,180,204,239],"allele,":[27],"occurs":[28],"6%":[30],"of":[31,50,69,90,92,100,106,135,139,142,152,157,160,178,185,200,202,213,215,217,225,247,251],"Ashkenazi":[33,52,235],"Jewish":[34,236],"population":[35,49],"and":[36,65,229],"reported":[38],"to":[39,191,195,243],"double":[40],"risk":[42,74,184,197,246],"for":[43,61,75,119,187,198],"colorectal":[44,136,153],"cancer.":[45],"We":[46,82],"screened":[47],"190":[51],"women":[53],"who":[54],"were":[55,132],"diagnosed":[56],"epithelial":[58],"ovarian":[59,94,101,248],"carcinoma":[60],"variant":[64],"measured":[66],"effect":[68],"this":[70],"allele":[71,86,109,147,165,205,240],"on":[72],"development":[77],"their":[79],"first-degree":[80,129],"relatives.":[81],"identified":[83],"7.9%":[88],"(15":[89],"190)":[91],"our":[93],"cases.":[96],"The":[97,210],"average":[98,211],"age":[99,118,192,212],"diagnosis":[103,214],"carriers":[105,181,226],"(57.5":[110],"years)":[111,228],"was":[112,220],"not":[113,221],"statistically":[114],"different":[115,222],"than":[116],"noncarriers":[120,201,230],"(56.4":[121],"years;":[122],"P":[123,174,207],"=":[124,175,208],"0.70).":[125],"Among":[126],"1087":[128],"relatives,":[130],"there":[131],"23":[133],"cases":[134],"cancer;":[137],"3":[138],"100":[140],"relatives":[141,159,199,224],"probands":[143,161],"(3.0%)":[148],"had":[149,182],"history":[151],"versus":[155],"20":[156],"987":[158],"without":[162],"(2.1%;":[166],"relative":[167],"risk,":[168],"1.48;":[169],"95%":[170],"confidence":[171],"interval,":[172],"0.45-4.88;":[173],"0.462).":[176],"Relatives":[177],"38.0%":[186],"developing":[188],"any":[189,218],"80,":[193],"similar":[194],"(42.1%;":[206],"0.86).":[209],"type":[219],"between":[223],"(59.0":[227],"(60.4":[231],"years).":[232],"In":[233],"population,":[237],"unlikely":[242],"increase":[244],"or":[250],"general.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}